Self-consistent solutions for line-driven winds of hot massive stars: The m-CAK procedure

Massive stars present strong stellar winds that are described by the radiation driven wind theory. Accurate mass-loss rates are necessary to properly describe the stellar evolution across the Hertzsprung-Russel Diagram. We present a self-consistent procedure that coupled the hydrodynamics with calculations of the line-force, giving as results the line-force parameters, the velocity field, and the mass-loss rate. Our calculations contemplate the contribution to the line-force multiplier from more than ∼900,000 atomic transitions, an NLTE radiation flux from the photosphere and a quasi-LTE approximation for the occupational numbers. A full set of line-force parameters for T eff ≥ 32,000 K, surface gravities higher than 3.4 dex for two different metallicities are presented, with their corresponding wind parameters (terminal velocities and mass-loss rates). The already known dependence of line-force parameters on effective temperature is enhanced by the dependence on . The terminal velocities present a stepper scaling relation with respect to the escape velocity, this might explain the scatter values observed in the hot side of the bistability jump. Moreover, a comparison of self-consistent mass-loss rates with empirical values shows a good agreement. Self-consistent wind solutions are used as input in FASTWIND to calculate synthetic spectra. We show, comparing with the observed spectra for three stars, that varying the clumping factor, the synthetic spectra rapidly converge into the neighborhood region of the solution. It is important to stress that our self-consistent procedure significantly reduces the number of free parameters needed to obtain a synthetic spectrum.Fil: Gormaz Matamala, Alex C.. Universidad de Valparaíso; ChileFil: Curé, M.. Universidad de Valparaíso; ChileFil: Cidale, Lydia Sonia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica La Plata; ArgentinaFil: Venero, Roberto Oscar José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica La Plata; Argentin

¿Es realmente fiable la evaluación no individualizada en el trabajo cooperativo?

Se presentan y discuten los resultados de una experiencia de trabajo cooperativo empleando la plataforma BSCW en alumnos de la titulación de Maestro de Educación Infantil de la Universidad de Barcelona, con el fin de detectar posibles sesgos de las coevaluaciones y las autoevaluaciones, y para valorar la incidencia que tienen los comportamientos disruptivos en el proceso cooperativo de evaluación. Los resultados muestran que el alumnado es honesto en las calificaciones que otorga, y que los comportamientos disruptivos detectados en los distintos grupos de trabajo cooperativo, causados por una baja ciudadanía de equipo, no tienen una incidencia significativa en las calificaciones otorgadas por el grupo clase. Por tanto, se legitiman las coevaluaciones y las autoevaluaciones como instrumentos fiables de evaluación en un contexto de trabajo cooperativo

Evolution of massive stars with new hydrodynamic wind models

Here we present evolutionary models for a set of massive stars, introducing a new prescription for the mass-loss rate obtained from hydrodynamical calculations in which the wind velocity profile, $v(r)$, and the line-acceleration, $g_\text{line}$, are obtained in a self consistently way. Replacing mass-loss rates at the Main Sequence stage from the standard Vink's formula by our new recipe, we generate a new set of evolutionary tracks for $M_\text{ZAMS}=25,40,70$ and $120\,M_\odot$ and metallicities $Z=0.014$ (Galactic), $Z=0.006$ (LMC), and $Z=0.002$ (SMC). Our new derived formula for mass-loss rate predicts a dependence $\dot M\propto Z^a$, where $a$ is not longer constant but dependent on the stellar mass: ranging from $a\sim0.53$ when $M_*\sim120\;M_\odot$, to $a\sim1.02$ when $M_*\sim25\;M_\odot$. We found that models adopting the new recipe for $\dot M$ retain more mass during their evolution, which is expressed in larger radii and consequently more luminous tracks over the Hertzsprung-Russell diagram. These differences are more prominent for the cases of $M_\text{ZAMS}=70$ and 120 $M_\odot$ at solar metallicity, where we found self-consistent tracks are $\sim0.1$ dex brighter and keep extra mass up to 20 $M_\odot$, compared with the classical models using the previous formulation for mass-loss rate. Moreover, we observed remarkable differences for the evolution of the radionuclide isotope $^{26}$Al in the core and the surface of the star. Since $\dot M_\text{sc}$ are weaker than the commonly adopted values for evolutionary tracks, self-consistent tracks predict a later modification in the abundance number of $^{26}$Al in the stellar winds. This new behaviour could provide useful information about the real contribution of this isotope from massive stars to the Galactic interstellar medium.Comment: Accepted for publication in Astronomy & Astrophysic

Analytical solutions for radiation-driven winds in massive stars - II: The δ-slow regime

Accurate mass-loss rates and terminal velocities from massive stars winds are essential to obtain synthetic spectra from radiative transfer calculations and to determine the evolutionary path of massive stars. From a theoretical point of view, analytical expressions for the wind parameters and velocity profile would have many advantages over numerical calculations that solve the complex non-linear set of hydrodynamic equations. In a previous work, we obtained an analytical description for the fast wind regime. Now, we propose an approximate expression for the line-force in terms of new parameters and obtain a velocity profile closed-form solution (in terms of the Lambert W function) for the δ-slow regime. Using this analytical velocity profile, we were able to obtain the mass-loss rates based on the m-CAK theory. Moreover, we established a relation between this new set of line-force parameters with the known stellar and m-CAK line-force parameters. To this purpose, we calculated a grid of numerical hydrodynamical models and performed a multivariate multiple regression. The numerical and our descriptions lead to good agreement between their values.Fil: Araya, I.. Universidad Mayor; ChileFil: Christen, A.. Universidad de Valparaíso; ChileFil: Cure, M.. Universidad de Valparaíso; ChileFil: Cidale, Lydia Sonia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica La Plata; ArgentinaFil: Venero, Roberto Oscar José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica La Plata; ArgentinaFil: Arcos, C.. Universidad de Valparaíso; ChileFil: Gormaz Matamala, A.. Universidad de Valparaíso; Chile. Universidad Adolfo Ibañez; ChileFil: Haucke, Maximiliano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica La Plata; ArgentinaFil: Escarate, P.. Universidad Austral de Chile; ChileFil: Clavería, H.. Pontificia Universidad Católica de Valparaíso; Chil

Growth of Escherichia coli in human milk and powdered infant formula under various treatments and feeding conditions in neonatal units

Milk supplied to neonates in neonatal units is kept at room temperature for some time, which could influence microbial growth. This study aims to evaluate the growth of Escherichia coli in HM and PIF under various treatments and conditions, as well as to determine the influence of different thawing methods on microbial growth in HM. The number of E. coli generations appearing over a 4 h period at 22 °C in HM (frozen; frozen and pasteurized; and frozen, pasteurized, and fortified) and in PIF (four brands) was determined. E. coli counts in HM inoculated and thawed using different methods were also compared. In frozen HM and in pasteurized and frozen HM, significant differences were found after 2.5 h and 1.5 h, respectively. In PIF, differences were found between 1.5 and 3 h. With regard to the thawing process, the lowest microorganism counts were obtained at 4 °C overnight; thus, it seems advisable to store milk at room temperature for a maximum of 1 h during administration in neonatal units. Thawing HM at 4 °C overnight should be the method of choice

¿Es realmente fiable la evaluación no individualizada en el trabajo cooperativo?

Se presentan y discuten los resultados de una experiencia de trabajo cooperativo empleando la plataforma BSCW en alumnos de la titulación de Maestro de Educación Infantil de la Universidad de Barcelona, con el fin de detectar posibles sesgos de las coevaluaciones y las autoevaluaciones, y para valorar la incidencia que tienen los comportamientos disruptivos en el proceso cooperativo de evaluación. Los resultados muestran que el alumnado es honesto en las calificaciones que otorga, y que los comportamientos disruptivos detectados en los distintos grupos de trabajo cooperativo, causados por una baja ciudadanía de equipo, no tienen una incidencia significativa en las calificaciones otorgadas por el grupo clase. Por tanto, se legitiman las coevaluaciones y las autoevaluaciones como instrumentos fiables de evaluación en un contexto de trabajo cooperativo

Varespladib and cardiovascular events in patients with an acute coronary syndrome: the VISTA-16 randomized clinical trial

IMPORTANCE: Secretory phospholipase A2(sPLA2) generates bioactive phospholipid products implicated in atherosclerosis. The sPLA2inhibitor varespladib has favorable effects on lipid and inflammatory markers; however, its effect on cardiovascular outcomes is unknown. OBJECTIVE: To determine the effects of sPLA2inhibition with varespladib on cardiovascular outcomes. DESIGN, SETTING, AND PARTICIPANTS: A double-blind, randomized, multicenter trial at 362 academic and community hospitals in Europe, Australia, New Zealand, India, and North America of 5145 patients randomized within 96 hours of presentation of an acute coronary syndrome (ACS) to either varespladib (n = 2572) or placebo (n = 2573) with enrollment between June 1, 2010, and March 7, 2012 (study termination on March 9, 2012). INTERVENTIONS: Participants were randomized to receive varespladib (500 mg) or placebo daily for 16 weeks, in addition to atorvastatin and other established therapies. MAIN OUTCOMES AND MEASURES: The primary efficacy measurewas a composite of cardiovascular mortality, nonfatal myocardial infarction (MI), nonfatal stroke, or unstable angina with evidence of ischemia requiring hospitalization at 16 weeks. Six-month survival status was also evaluated. RESULTS: At a prespecified interim analysis, including 212 primary end point events, the independent data and safety monitoring board recommended termination of the trial for futility and possible harm. The primary end point occurred in 136 patients (6.1%) treated with varespladib compared with 109 patients (5.1%) treated with placebo (hazard ratio [HR], 1.25; 95%CI, 0.97-1.61; log-rank P = .08). Varespladib was associated with a greater risk of MI (78 [3.4%] vs 47 [2.2%]; HR, 1.66; 95%CI, 1.16-2.39; log-rank P = .005). The composite secondary end point of cardiovascular mortality, MI, and stroke was observed in 107 patients (4.6%) in the varespladib group and 79 patients (3.8%) in the placebo group (HR, 1.36; 95% CI, 1.02-1.82; P = .04). CONCLUSIONS AND RELEVANCE: In patients with recent ACS, varespladib did not reduce the risk of recurrent cardiovascular events and significantly increased the risk of MI. The sPLA2inhibition with varespladib may be harmful and is not a useful strategy to reduce adverse cardiovascular outcomes after ACS. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT01130246. Copyright 2014 American Medical Association. All rights reserved

Factors influencing gastrointestinal tract and microbiota immune interaction in preterm infants

The role of microbial colonization is indispensable for keeping a balanced immune response in life. However, the events that regulate the establishment of the microbiota, their timing, and the way in which they interact with the host are not yet fully understood. Factors such as gestational age, mode of delivery, environment, hygienic measures, and diet influence the establishment of microbiota in the perinatal period. Environmental microbes constitute the most important group of exogenous stimuli in this critical time frame. However, the settlement of a stable gut microbiota in preterm infants is delayed compared to term infants. Preterm infants have an immature gastrointestinal tract and immune system which predisposes to infectious morbidity. Neonatal microbial dynamics and alterations in early gut microbiota may precede and/or predispose to diseases such as necrotizing enterocolitis (NEC), late-onset sepsis or others. During this critical period, nutrition is the principal contributor for immunological and metabolic development, and microbiological programming. Breast milk is a known source of molecules that act synergistically to protect the gut barrier and enhance the maturation of the gut-related immune response. Host-microbe interactions in preterm infants and the protective role of diet focused on breast milk impact are beginning to be unveiled.M.C. acknowledges a “Rio Hortega” Research Fellowship Grant (CM13/0017) and M.V. acknowledges grants PI11/0313 and RD12/0026/0012 (Red SAMID) from the Instituto Carlos III (Spanish Ministry of Economy and Competitivity). M.C.C. and G.P-M. were supported by the grant AGL2013-47420-R from the Spanish Ministry of Science and Innovation.Peer reviewe

Plasma versus Erythrocyte Vitamin E in Renal Transplant Recipients, and Duality of Tocopherol Species

Redox imbalance is an adverse on-going phenomenon in renal transplant recipients (RTR). Vitamin E has important antioxidant properties that counterbalance its deleterious effects. However, plasma vitamin E affinity with lipids challenges interpretation of its levels. To test the hypothesis that erythrocyte membranes represent a lipids-independent specimen to estimate vitamin E status, we performed a cross-sectional study in a cohort of adult RTR (n = 113) recruited in a university setting (2015-2018). We compared crude and total lipids-standardized linear regression-derived coefficients of plasma and erythrocyte tocopherol species in relation to clinical and laboratory parameters. Strongly positive associations of fasting lipids with plasma tocopherol became inverse, rather than absent, in total lipids-standardized analyses, indicating potential overadjustment. Whilst, no variables from the lipids domain were associated with the tocopherol species measured from erythrocyte specimens. In relation to inflammatory status and clinical parameters with antioxidant activity, we found associations in directions that are consistent with either beneficial or adverse effects concerning alpha- or gamma-tocopherol, respectively. In conclusion, erythrocytes offer a lipids-independent alternative to estimate vitamin E status and investigate its relationship with parameters over other biological domains. In RTR, alpha- and gamma-tocopherol may serve as biomarkers of relatively lower or higher vulnerability to oxidative stress and inflammation, noticeably in opposite directions