1,721 research outputs found

    An investigation to explore how gentle teaching can be embedded and sustained in a school culture

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    his thesis explores a humanistic intervention called Gentle Teaching and how a special residential school has attempted to embed this into its school culture. This thesis explores a range of concepts and as such a conceptual framework has been created to link each of these areas together. The conceptual framework is based upon Gentle Teaching, School Culture and Symbolic Interaction. Symbolic Interaction has been employed as a lens to explore the concepts of truth through the understanding of various factors that influence the understanding that people how regarding the meaning objects, interactions and words have for us. This is true still for the unique pupils within the school who express their own understanding of the school culture and what this feels like to them. This thesis has a series of sub-research questions to ascertain if Gentle Teaching is a natural ability or if this can be taught/learned, it also seeks to identify if the recipients of Gentle Teaching are aware of the process and finally, how Gentle Teaching can be embedded within a school culture. A qualitative methodological approach is employed to gather data from adult staff participants and the views and opinions from the students within the school. This thesis contributes to a modern exploration of the Gentle Teaching pedagogy. This thesis also gains insight into the views and opinions of an often overlooked and marginalised group of students and offers an illustration of what Gentle Teaching can offer to other schools as both a pedagogical and behavioural approach that could become an alternative to less humanistic approaches

    A new method to calibrate ionospheric pulse dispersion for UHE cosmic ray and neutrino detection using the Lunar Cherenkov technique

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    UHE particle detection using the lunar Cherenkov technique aims to detect nanosecond pulses of Cherenkov emission which are produced during UHE cosmic ray and neutrino interactions in the Moon's regolith. These pulses will reach Earth-based telescopes dispersed, and therefore reduced in amplitude, due to their propagation through the Earth's ionosphere. To maximise the received signal to noise ratio and subsequent chances of pulse detection, ionospheric dispersion must therefore be corrected, and since the high time resolution would require excessive data storage this correction must be made in real time. This requires an accurate knowledge of the dispersion characteristic which is parameterised by the instantaneous Total Electron Content (TEC) of the ionosphere. A new method to calibrate the dispersive effect of the ionosphere on lunar Cherenkov pulses has been developed for the LUNASKA lunar Cherenkov experiments. This method exploits radial symmetries in the distribution of the Moon's polarised emission to make Faraday rotation measurements in the visibility domain of synthesis array data (i. e. instantaneously). Faraday rotation measurements are then combined with geomagnetic field models to estimate the ionospheric TEC. This method of ionospheric calibration is particularly attractive for the lunar Cherenkov technique as it may be used in real time to estimate the ionospheric TEC along a line-of-sight to the Moon and using the same radio telescope.Comment: 4 pages, 2 figures, Proceedings of ARENA 2010, Nantes, France; doi:10.1016/j.nima.2010.10.12

    Prospects for radio detection of ultra-high energy cosmic rays and neutrinos

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    The origin and nature of the highest energy cosmic ray events is currently the subject of intense investigation by giant air shower arrays and fluorescent detectors. These particles reach energies well beyond what can be achieved in ground-based particle accelerators and hence they are fundamental probes for particle physics as well as astrophysics. Because of the scarcity of these high-energy particles, larger and larger ground-based detectors have been built. The new generation of digital radio telescopes may play an important role in this, if properly designed. Radio detection of cosmic ray showers has a long history but was abandoned in the 1970's. Recent experimental developments together with sophisticated air shower simulations incorporating radio emission give a clearer understanding of the relationship between the air shower parameters and the radio signal, and have led to resurgence in its use. Observations of air showers by the SKA could, because of its large collecting area, contribute significantly to measuring the cosmic ray spectrum at the highest energies. Because of the large surface area of the moon, and the expected excellent angular resolution of the SKA, using the SKA to detect radio Cherenkov emission from neutrino-induced cascades in lunar regolith will be potentially the most important technique for investigating cosmic ray origin at energies above the photoproduction cut-off. (abridged)Comment: latex, 26 pages, 17 figures, to appear in: "Science with the Square Kilometer Array," eds. C. Carilli and S. Rawlings, New Astronomy Reviews, (Elsevier: Amsterdam

    Experimental Limit on the Cosmic Diffuse Ultra-high Energy Neutrino Flux

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    We report results from 120 hours of livetime with the Goldstone Lunar Ultra-high energy neutrino Experiment (GLUE). The experiment searches for <10 ns microwave pulses from the lunar regolith, appearing in coincidence at two large radio telescopes separated by 22 km and linked by optical fiber. Such pulses would arise from subsurface electromagnetic cascades induced by interactions of >= 100 EeV neutrinos in the lunar regolith. No candidates are yet seen, and the implied limits constrain several current models for ultra-high energy neutrino fluxes.Comment: 4 pages, 4 figures, revtex4 style. New intro section, Fig. 2, Fig 4; in final PRL revie

    Peptide redesign for inhibition of the complement system: Targeting age-related macular degeneration.

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    PurposeTo redesign a complement-inhibiting peptide with the potential to become a therapeutic for dry and wet age-related macular degeneration (AMD).MethodsWe present a new potent peptide (Peptide 2) of the compstatin family. The peptide is developed by rational design, based on a mechanistic binding hypothesis, and structural and physicochemical properties derived from molecular dynamics (MD) simulation. The inhibitory activity, efficacy, and solubility of Peptide 2 are evaluated using a hemolytic assay, a human RPE cell-based assay, and ultraviolet (UV) absorption properties, respectively, and compared to the respective properties of its parent peptide (Peptide 1).ResultsThe sequence of Peptide 2 contains an arginine-serine N-terminal extension (a characteristic of parent Peptide 1) and a novel 8-polyethylene glycol (PEG) block C-terminal extension. Peptide 2 has significantly improved aqueous solubility compared to Peptide 1 and comparable complement inhibitory activity. In addition, Peptide 2 is more efficacious in inhibiting complement activation in a cell-based model that mimics the pathobiology of dry AMD.ConclusionsWe have designed a new peptide analog of compstatin that combines N-terminal polar amino acid extensions and C-terminal PEGylation extensions. This peptide demonstrates significantly improved aqueous solubility and complement inhibitory efficacy, compared to the parent peptide. The new peptide overcomes the aggregation limitation for clinical translation of previous compstatin analogs and is a candidate to become a therapeutic for the treatment of AMD

    VLA Observations of Candidate Supernova Remnants from the Clark Lake 30.9 MHz Galactic Plane Survey

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    We report the results of 1464 MHz continuum VLA observations of eight fields containing unidentified small-diameter objects associated with candidate supernova remnants from the Clark Lake 30.9 MHz galactic plane survey. The observations were made in the C configuration, giving a resolution of -12-20 arcsec, and a sensitivity of typically <0.5 mJy per beam. Polarization measurements were made as well. One of the 30.9 MHz candidates, G41.4+ 1.2, appears to be confirmed as a supernova remnant by our observations. Of the remaining seven fields observed, three were found to contain small-diameter objects which met some of the criteria for nonthermal origin, but will require further study to evaluate whether they are associated with the candidate supernova remnants. Two of the fields were found to contain groups of unresolved objects consistent with expectations for extragalactic background sources. In these cases the 30.9 MHz observations, which could not resolve the individual sources but would view them as a single extended source, may have mistakenly identified them as possible supernova remnants. Finally, two fields contained bright H II region
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