18 research outputs found
Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial
- Author
- Abbas Jalal
- Abraham Sybil
- Ackert Jessica
- Adams Patricia
- Aggarwala Gaurav
- Aher Nutan
- Ahlqvist Jørn
- Ahn Chul Woo
- Akers Teresa
- Akhras Ronald
- Akhter Faiq
- Aksentyev Sergey
- Al Kawas Firas
- Alexander Karen
- Althouse Denise
- Altobelli Desma
- Alvarisqueta Andres
- Ambrosy Andrew
- Andersen James
- Andersen Ulla
- Anderson Michelle
- Anglade Moise
- Arbañil Hugo
- Arciszewska Malgorzata
- Argoud Georges
- Ariani Mehrdad
- Ashdji Reswan
- Avogaro Angelo
- Avramidis Iakovos
- Axthelm Christoph
- Aye Myint
- Babi Charleen
- Bachus Erasmus
- Baik Sei-Hyun
- Bailey Matt
- Bakhtari Ladan
- Baksi Arun
- Balasubramani Mathangi
- Baldovino Jorge
- Banach Marek
- Banerjee Subhash
- Bartlett Andrew
- Bartone Susan
- Baum Howard
- Bays Harold
- Bazhan Larysa
- Beasley Richard
- Beaudry Yves
- Beaulieu Gail
- Beboso Ronnie
- Bedard Jacques
- Beijerbacht Hugo Peter
- Belfort de Aguiar Renata
- Benjamin Sabrina
- Berger Dirk
- Berlingieri Joseph
- Berndtsson Blom Katarina
- Besada Diego
- Bethel M Angelyn
- Bhagwat Ravi
- Bhargava Anuj
- Bhosale Archana
- Bieler Tasso
- Bijata-Bronisz Renata
- Birkeland Kare
- Birkenfeld Andreas
- Blagden Mark
- Bloomfield Gerald
- Bode Bruce
- Boemi Massimo
- Bonadonna Riccardo
- Bondar Irina
- Bott Jochen
- Bousboulas Stavros
- Boye Alain
- Bratcher Christina
- Breneman Jody
- Briskin Toby
- Bristianou Magdalini
- Brockmyre Andrew
- Broughton Raymond
- Brown Judith
- Brown Kim
- Brychta Tomas
- Brønnum-Schou Jens
- Budhraja Madhusudan
- Bull Georgina
- Bundy Charles
- Burgess Lesley
- Busch Klaus
- Caca Karel
- Cadinot Didier
- Calderon Jorge
- Calella Pedro
- Califf Robert M
- Calvo Gómez Carlos
- Camacho Luis
- Cannon Kevin
- Cano Rodríguez Isidoro
- Cantero Maria Cecilia
- Carr Jewell
- Casson Ed
- Castaño Patricia
- Castro Conde Almudena
- Cathcart Harold
- Cavale Arvind
- Cech Vladimir
- Cequier Fillat Angel
- Cervantes-Escárcega Jose-Luis
- Cha Bong-Soo
- Chau Tuan
- Chaykin Louis
- Chehayeb Raja
- Chen David
- Chen Jung-Fu
- Chertkoff Alejandro
- Cheung Deanna
- Cheung Stephen
- Chevts Julia
- Chiang Chern-En
- Childress Richard
- Christian Tamra
- Chung Choon-Hee
- Coetzee Kathleen
- Cohen Allan
- Coker Rebecca
- Cole Joanna
- Collier Jeannie
- Condit Jonathan
- Consoli Agostino
- Conway James
- Cooksey Erin
- Cookson Tobias
- Cooper John
- Cooper Lauren
- Copland Allan
- Cornel Jan
- Cornett George Mitchell
- Crenier Laurent
- Cuadrado Jesus
- Cuatrecasas Cambra Guillem
- Cusson Jean
- D'Agostino Ralph B
- D'Agostino Ralph B.
- Daga Shruti
- Damyanova Velichka
- Dauber Ira
- Davila William
- Dawood Saleem
- De Armas Luis
- De Cosmo Salvatore
- De Loredo Luis
- De Teresa Parreño Luis
- de Álvaro Moreno Fernando
- Dean Julius
- Debroye Corinne
- Del Prato Stefano
- Del Prato Stefano
- Delgado Lista Javier
- Della Siega Anthony
- DeMets David
- Demidova Irina
- Derezinski Tadeusz
- Deshpande Sameer
- Detweiler Robert
- Devore Adam
- Di Bartolo Paolo
- Di Giovanna Michael
- Diaz Ernesto
- Dimitriadis Georgios
- Dimitrov Stefan
- Distiller Larry
- Dombrowski Keith
- Dominguez Andrea
- Domínguez Escribano José Ramón
- Donaldson Jill
- Donaubauer Torsten
- Dor Isaac
- Dotta Francesco
- Dreval Alexander
- Drummond Waymon
- Dumas Richard
- Dumbre Snehal
- Dungan Kathleen
- Durán García Santiago
- Duyck Francis
- Dvorakova Eva
- Dzongowski Peter
- Eagerton Donald
- Eapen Zubin
- Earl John
- Eaton Charles
- Ebo Geraldine
- Edelsberger Tomas
- Eliasson Bjorn
- Eliasson Ken
- Elisaf Moses
- Ellison Howard
- Elvira González Javier
- Emslie-Smith Alistair
- Endsley Patricia
- Enns Robert
- Erlinger Rudolf
- Ershova Olga
- Español Maria Vanesa
- Espinoza Augusto Dextre
- Farris Neil
- Ferguson Murdo
- Fernandez-Salazar Eva
- Fernández Rodríguez José María
- Fiel Thomas
- Finkelstein Hernan
- Firek Anthony
- First Brian
- Fleming John
- Flota-Cervera Luis Fernando
- Forgosh Les
- Frechtel Gustavo
- French William
- Fretes Jose
- Friedman Daniel
- Frontoni Simona
- Funke Klaus
- Fushtey Ivan
- Gadzinski Waldemar
- Gajek Jacek
- Galatius Søren
- Galetta Marianna
- Galstyan Gagik
- Gambineri Alessandra
- Gandy Winston
- Garcia Ronald
- Garganeeva Alla
- Garrido Santos Natalia
- Garrido Elizabeth
- Garvey Louisa
- Gaudet Daniel
- Gazzaruso Carmine
- Gentry Tracy
- Giaccari Andrea
- Gill Santosh
- Giorgino Francesco
- Goday Arno Alberto
- Godse Rupali
- Gomez Huelgas Ricardo
- Gonzales Rolando Vargas
- Gonzalez Joaquin
- González Juanatey José Ramón
- González-González José Gerardo
- Goodman Shaun
- Gordon Murray
- Gouet Didier
- Grachova Mariya
- Granger Christopher B
- Granger Christopher B.
- Green Fiona
- Green Jennifer B
- Green Jennifer B
- Greene Deb
- Greene Stephen
- Grondin Francois
- Grosskopf Josef
- Groutars Reginald G.E.J.
- Guerci Bruno
- Guice Michael
- Guimaraes Patricia
- Gulseth Hanne
- Gummadi Siva
- Gunstone Anthony
- Gupta Anil
- Gupta Milan
- Gupta Nikita
- Guttormsen Gaute
- Ha JuYoung
- Hackenyos Jonathan
- Haddock Trevorlyn
- Hagenow Andreas
- Hairston Kristen
- Hajdú Csaba
- Halciakova Katarina
- Halperin Frank
- Haluzik Martin
- Hamann Monika
- Hanson Lenita
- Haque Ghazala
- Harcsa Eleonóra
- Harris Tara
- Harrison Lindsay
- Harrison Rob
- Hartard Manfred
- Hartman Israel
- Heitner John
- Hejeebu Srini
- Henry Patrick
- Hereghty Belinda
- Hermany Paul
- Hernandez Mijares Antonio
- Hernandez Adrian F
- Hernandez Adrian F.
- Hernandez-Cassis Carlos
- Heymer Peter
- Hidalgo Horacio
- Higgins Alexander
- Hoek Boudewijn A
- Holman Rury
- Hoogslag Pieter A.M.
- Houle Pierre-Alain
- Hove Jens
- Howell Christina
- Hramiak Irene
- Huppertz Wolfgang
- Hutayanon Pisit
- Ibrahim Hassan
- Illies Gabriele
- Issa Basil
- Izmozherova Nadezhda
- Jackson-Voyzey Ewart
- Jacob Stephan
- Jacobs Shahram
- James Kourtnei
- James Rachel
- Jang Hak Chul
- Janmohamed Salim
- Janmohamed Salim
- Jarosz Marie
- Jenkins Wendy
- Jensen Jan Skov
- Jerjes-Díaz Carlos Sánchez
- Jiménez Díaz Víctor Alfonso
- Jintapakorn Woravut
- Jodar Gimeno Esteban
- Johnson Andrew
- Johnson David
- Johnson Megan
- Jones Michael
- Jones Nigel P
- Jones Nigel P
- Jordan Dedrick
- Joshi Parag
- Jung Thomas
- Kadgaonkar Neha
- Kahrmann Gerd
- Karetnikova Victoria
- Karka Mounika
- Karmalkar Anisha
- Kast Petra
- Kaster Steven
- Katerenchuk Vitaliy
- Kellerer Monika
- Kellum Daniel
- Kelly Aoife
- Kempe Hans-Peter
- Kessler Laurence
- Khandelwal Chaitali
- Kharakhulakh Marina
- Khariouzov Andrei
- Khokhlov Aleksandr
- Kim Chong-Jin
- Kim Christopher
- Kim Ellen
- Kim Hye Soon
- Kim In Joo
- Kirby William
- Klausmann Gerhard
- Klein Christiane
- Kleinecke-Pohl Uwe
- Kleinertz Klaus
- Klodawska Katarzyna
- Knouse Albert
- Kobalava Zhanna
- Kober Lars
- Koch Thorsten
- Kocsis Gyozo
- Kolls Brad
- Kong David
- Konyves Laszlo
- Kooy Adriaan
- Korpachev Vadym
- Kosch Christine
- Koshelskaya Olga
- Kosiborod Mikhail
- Koskinen Pekka
- Kosmacheva Elena
- Kostin Vladimir
- Kotsa Kalliopi
- Kouz Simon
- Kovacheva Snezhina
- Kovacs Christopher
- Koziolova Natalia
- Kragten Johannes A.
- Kravchun Nonna
- Kristiansen Ole Peter
- Krizova Jarmila
- Krzyzagorska Ewa
- Kulback Steven
- Kulkarni Mangesh
- Kumar Mariananda
- Kumar Rakesh
- Kumar Somesh
- Kumari Aditi
- Kuruvanka Tulsidas
- Kuzin Anatoly
- Labroo Ajay
- Lalau Jean-Daniel
- Landry Daniel
- Larin Oleksandr
- Larnefeldt Hans
- Lasswell William
- Lastuvka Jiri
- Lauder Steven
- Lauro Davide
- Lee Eun Young
- Lee Hyoung Woo
- Lee Kwan-Woo
- Lee Moon Kyu
- Leiter Lawrence A
- Leiter Lawrence A.
- Lentz John
- Lenzmeier Thomas
- Lesnov Victor
- Lewis David
- Li Wenyan
- Li Zhaoping
- Lieverse Aloysius G.
- Lif-Tiberg Cornelia
- Lillestol Michael
- Linderfalk Carina
- Lindsay Alistair
- Little Raymond
- Litvak Marcos
- Llamas Edmundo-Alfredo Bayram
- Lokhngina Yuliya
- Lombard Landman
- Longley Troy
- Lonn Eva
- Lopes Renato
- Lopez-Sendon Jose
- Lorimer Jamie
- Lorra Babette
- Lorraine Richard
- Loureyro Juan
- Lozanov Lachezar
- Lucas Morante Tomás
- Luedemann Joerg
- Luna Alejandro
- Lund Gustav
- Lund Per
- Lundman Pia
- Luttermann Matthias
- Lysenko Tatyana
- Maclean Malcolm
- Madej Andrzej
- Maffei Laura
- Makotoko Ellen
- Maldonado Natacha
- Mandal Trisha
- Mandawat Aditya
- Mankovsky Boris
- Manrique Helard
- Marazuela Monica
- Margaritov Viktor
- Markov Valentin
- Marquess Marsha
- Martell Claros Nieves
- Mathews Robin
- Mathieu Chantal
- Mauricio Puente Didac
- Maxeiner Stephan
- Mayorov Alexander
- McGuire Darren
- McKeown-Biagas Cecilia
- McKnight John
- McLaughlin Patricia
- McMurray John J.V.
- McMurray John J.V.
- McNeill Robert
- Mehta Anand
- Mehta Rajendra
- Melchior Thomas
- Melidonis Andreas
- Melloni Chiara
- Mena Ribas Elena
- Merino Torres Juan Francisco
- Mezquita Raya Pedro
- Mhambrey Ankita
- Miekus Pawel
- Migdalis Ilias
- Mihaylova-Shumkova Rositsa
- Milek Karsten
- Miller Alan
- Miller Diane
- Mitrakou Asimina
- Moelle Andrea
- Mohr Gasparini Diego
- Moiseev Sergey
- Moodley Rajendran
- Moon Keon-Woong
- Morales-Palomares Ellen
- Moran Joseph
- Morawski Emily
- Moris Linda
- Mucsi János
- Murphy Karen
- Muzulu Solomon
- Muñoz Ernesto German Cardona
- Myasoedova Svetlana
- Mykhalchyshyn Galyna
- Myshanych Halyna
- Nadar Madhumitha
- Nadar Venkatesh
- Naicker Pallavi
- Namgung June
- Nauck Michael
- Neumann Gerhard
- Nikolaeva Antoaneta
- Nischik Ruth
- Noronha Drusilla
- Nubiola Calonge Andreu
- Nyvad Ole
- O'Connell Ian
- O'Connor Thomas
- O'Mahony William
- Odio Alberto
- Oehrig-Pohl Edith
- Oleksyk Olga
- Olesinska-Mader Martyna
- Olsson Åke
- Oosthuysen Wessels
- Opiela Jaroslaw
- Ordoñez Sánchez Xavier
- Orio Silvia
- Orlenko Valeriia
- Orsi Emanuela
- Overton Robert
- Oyesile Babatunde
- Ozaki Risa
- Pagkalos Emmanouil
- Paolisso Giuseppe
- Papanas Nikolaos
- Pappas Angelos
- Park Kyong Soo
- Parker Reginald
- Pascoe-Gonzalez Sara
- Pascual Izuel Jose Maria
- Pashkovska Nataliia
- Patel Chetan
- Patel Prashant
- Patel Rajesh
- Patel Rajivkumar
- Patel Vickas
- Patil Ashwini P
- Patil Suradnya
- Patterson Catherine
- Pauker Zsolt
- Pearson Ewan
- Pelayo-Orozco Emilia Susana
- Perea Castilla Verónica
- Perez Manghi Federico
- Perez Soto Isabel
- Perez Kathleen
- Perriello Gabriele
- Pertseva Nataliia
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- Peterson Sean
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- Petró Gizella
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- Philip Sam
- Phillips Lawrence
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- Pinto Miguel
- Piperek Martin
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- Quesada Simón Angustias
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- Raclavska Lea
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- Raorane Amruta
- Rasouli Neda
- Rauzi Frank
- Rebrov Andrey
- Redón Mas Josep
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- Rego Iraeta Antonia
- Reich Dennis
- Rethaford Renee
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- Revoredo Frederick Massucco
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- Rieker Werner
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- Rivellese Angela Albarosa
- Rodriguez Alvarez Maria
- Rodriguez Papini Nelson
- Rodríguez Rodríguez Irene
- Roe Matthew
- Rohr Kathryn
- Romanczuk Piotr
- Rose Ludger
- Roseman Hal
- Rosenberg Anne
- Rosenberg Anne E
- Rosenbloom Alan
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- Sanmartin Berglund Johan
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- Schou Morten
- Schubert Jessica
- Schuchard Timothy
- Schultheis Ron
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- Schygiel Pablo
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- Segner Alexander
- Sensenbrenner John
- Sesti Giorgio
- Seufert Jochen
- Shaik Fayaz
- Shannon Jennifer
- Sharma Abhinav
- Sharma Richa
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- Shilkina Natalia
- Shinde Rakesh
- Shitut Aditi
- Shlesinger Yshay
- Siegel Anna
- Sigal Helena
- Sigmon Kristina
- Sigmon Kristina N
- Silhova Elena
- Sinay Isaac
- Singh Narendra
- Sivalingam Kanagaratnam
- Sjöberg Folke
- Skokowska Ewa
- Smirnov Ivan
- Smith Paul
- Smith Peter
- Soffer Joseph
- Sokolova Nadezhda
- Solanki Sheetal
- Somerville Matthew
- Somerville Matthew C
- Soto González Alfonso
- Sowell Margaret
- Sposetti Georgina
- Srimahachota Suphot
- St-Maurice Francois
- Stankiewicz Andrzej
- Stasinska Teresa
- Stead Janet
- Steindorf Joerg
- Stewart Murray
- Stockhausen Juergen
- Stone Allegra
- Stonesifer Larry
- Storey Daniel
- Stoyanova Zhasmina
- Stuebler Petra
- Suh David
- Sukumaran Usha
- Swart Hendrik P.
- Sándor Vangel
- Söderberg Stefan
- Taeschner Heidrun
- Taft Lin
- Tahir Mohammed
- Tan Anjanette
- Tan Choon Beng Kathryn
- Tan Marilyn
- Taylon Alain
- Tentolouris Nikolaos
- Tews Dietrich
- Thakkar Maitreya
- Thomas Betsy
- Thorpe Karl
- Thorpe Karl M
- Thuan Jean-Francois
- Tien Kai Jen
- Tinahones Madueno Francisco
- Tirador Louie
- Tonolo Giancarlo
- Torres-Colores Jose Juan
- Torstensson Ingemar
- Trescoli Serrano Carlos
- Trevisan Roberto
- Tricoci Pierluigi
- Tripathy Devjit
- Trznadel-Morawska Iwona
- Tsapas Apostolos
- Tschoepe Diethelm
- Tseng Shih-Ting
- Tu Shih-Te
- Tugwell Barna
- Tzatzagou Glykeria
- Ulied Armiñana Angels
- Ulla Maria
- Urbanek Robin
- Uwaifo Gabriel
- Van Gaal Luc
- Vandyne Beth
- Vaphare Ashok
- Vasilevskaya Olga
- Vass Viktor
- Vedere Amarnath
- Vemulapalli Sreekanth
- Venugopal Chandra
- Verbovaya Nelli
- Vercammen Chris
- Verra Fernando
- Vidrio-Velázquez Maricela
- Viergever Eric P.
- Villagordoa-Mesa Juan
- Vishneva Elena
- Vizel Saul
- Vlasenko Maryna
- Vo Anthony
- Voinot Christel
- Vorobyev Sergey
- Vorokhobina Natalya
- Vouillarmet Julien
- Vrkoc Jan
- Wang Chih-Yuan
- Wang Ji-Hung
- Watson Anthony
- Watson David
- Welch Michelle
- Welker James
- White Alexander
- Wilhelm Karl
- Willis John
- Wilson Matt
- Wilson Tim
- Witek Robert
- Wium Cecilie
- Womer Terese
- Woo Vincent
- Wraight Ella
- Wynne Alan
- Xing Weibing
- Yamwong Sukit
- Yazdani Shahram
- Ye June
- Yoo Soon Jib
- Yordanov Victor
- Yu Jaemyung
- Zabalua Silvina
- Zaidman Cesar
- Zang Eddie
- Zanozina Olga
- Zeller-Stefan Helga
- Zhdanova Elena
- Zlova Tetiana
- Zubiate Carlos
- Zykova Tatyana
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
Background:
Glucagon-like peptide 1 receptor agonists differ in chemical structure, duration of action, and in their effects on clinical outcomes. The cardiovascular effects of once-weekly albiglutide in type 2 diabetes are unknown. We aimed to determine the safety and efficacy of albiglutide in preventing cardiovascular death, myocardial infarction, or stroke.
Methods:
We did a double-blind, randomised, placebo-controlled trial in 610 sites across 28 countries. We randomly assigned patients aged 40 years and older with type 2 diabetes and cardiovascular disease (at a 1:1 ratio) to groups that either received a subcutaneous injection of albiglutide (30–50 mg, based on glycaemic response and tolerability) or of a matched volume of placebo once a week, in addition to their standard care. Investigators used an interactive voice or web response system to obtain treatment assignment, and patients and all study investigators were masked to their treatment allocation. We hypothesised that albiglutide would be non-inferior to placebo for the primary outcome of the first occurrence of cardiovascular death, myocardial infarction, or stroke, which was assessed in the intention-to-treat population. If non-inferiority was confirmed by an upper limit of the 95% CI for a hazard ratio of less than 1·30, closed testing for superiority was prespecified. This study is registered with ClinicalTrials.gov, number NCT02465515.
Findings:
Patients were screened between July 1, 2015, and Nov 24, 2016. 10 793 patients were screened and 9463 participants were enrolled and randomly assigned to groups: 4731 patients were assigned to receive albiglutide and 4732 patients to receive placebo. On Nov 8, 2017, it was determined that 611 primary endpoints and a median follow-up of at least 1·5 years had accrued, and participants returned for a final visit and discontinuation from study treatment; the last patient visit was on March 12, 2018. These 9463 patients, the intention-to-treat population, were evaluated for a median duration of 1·6 years and were assessed for the primary outcome. The primary composite outcome occurred in 338 (7%) of 4731 patients at an incidence rate of 4·6 events per 100 person-years in the albiglutide group and in 428 (9%) of 4732 patients at an incidence rate of 5·9 events per 100 person-years in the placebo group (hazard ratio 0·78, 95% CI 0·68–0·90), which indicated that albiglutide was superior to placebo (p<0·0001 for non-inferiority; p=0·0006 for superiority). The incidence of acute pancreatitis (ten patients in the albiglutide group and seven patients in the placebo group), pancreatic cancer (six patients in the albiglutide group and five patients in the placebo group), medullary thyroid carcinoma (zero patients in both groups), and other serious adverse events did not differ between the two groups. There were three (<1%) deaths in the placebo group that were assessed by investigators, who were masked to study drug assignment, to be treatment-related and two (<1%) deaths in the albiglutide group.
Interpretation:
In patients with type 2 diabetes and cardiovascular disease, albiglutide was superior to placebo with respect to major adverse cardiovascular events. Evidence-based glucagon-like peptide 1 receptor agonists should therefore be considered as part of a comprehensive strategy to reduce the risk of cardiovascular events in patients with type 2 diabetes.
Funding:
GlaxoSmithKline
COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study
- Author
- Abdukahil Sheryl Ann
- Abdukahil Sheryl,
- Abe Ryuzo
- Abel Laurent
- Abreu Julia Rodriguez
- Abreu Julia,
- Absil Lara
- Acker Andrew
- Adachi Shingo
- Adam Elisabeth
- Adrião Diana
- Ainscough Kate
- Akimoto Takako
- Al Qasim Eman
- Al-Dabbous Tala
- Al-Fares Abdulrahman
- Alalqam Razi
- Alex Beatrice
- Alexandre Kévin
- Alfoudri Huda
- Alidjnou Kazali Enagnon
- Alidjnou Kazali,
- Aliudin Jeffrey
- Allavena Clotilde
- Allou Nathalie
- Alves João
- Alves Rita
- Amaral Maria
- Ammerlaan Heidi
- Ampaw Phoebe
- Andini Roberto
- Andrejak Claire
- Angheben Andrea
- ANGOULVANT François
- Ansart Séverine
- Antonelli Massimo
- Arabi Yaseen
- Aragao Irene
- Arcadipane Antonio
- Arenz Lukas
- Arlet Jean-Benoît
- Arnold-Day Christel
- Arora Lovkesh
- Artaud-Macari Elise
- Asensio Angel
- Assie Jean Baptiste
- Assie Jean,
- Atique Anika
- Auchabie Johann
- Aumaitre Hugues
- Azemar Laurène
- Azoulay Cécile
- Bach Benjamin
- Bachelet Delphine
- Baillie J. Kenneth,
- Bak Erica
- Bakakos Agamemnon
- Banisadr Firouzé
- Barbalho Renata
- Barclay Wendy,
- Barnikel Michaela
- Barrelet Audrey
- Barrigoto Cleide
- Basmaci Romain
- Bassi Gianluigi Li
- Bassi Gianluigi,
- Bedossa Alexandra
- Behilill Sylvie
- Bekken Gry Kloumann
- Bekken Gry,
- Beljantsev Aleksandr
- Bellemare David
- Beltrame Anna
- Beluze Marine
- Benech Nicolas
- Benkerrou Dehbia
- Bennett Suzanne
- Bento Luís
- Berdal Jan-Erik
- Bergeaud Delphine
- Bertolino Lorenzo
- Bessis Simon
- Bevilcaqua Sybille
- Bhavsar Krishna
- Bissuel François
- Biston Patrick
- Bitker Laurent
- Blanco-Schweizer Pablo
- Blot Mathieu
- Boccia Filomena
- Bogaert Debby
- Bompart François
- Booth Gareth
- Borges Diogo
- Borie Raphaël
- Bos Jeannet
- Bosse Hans Martin
- Bosse Hans,
- Botelho-Nevers Elisabeth
- Bouadma Lila
- Bouchaud Olivier
- Bouchez Sabelline
- Bouhmani Dounia
- Bouhour Damien
- Bouiller Kévin
- Bouillet Laurence
- Bouisse Camille
- Boureau Anne-Sophie
- Bouscambert Maude
- Bouziotis Jason
- Boxma Bianca
- Boyer-Besseyre Marielle
- Boylan Maria
- Braga Cynthia
- Brandenburger Timo
- Brazzi Luca
- Breen Dorothy
- Breen Patrick
- Brickell Kathy
- Brozzi Nicolas
- Buchtele Nina
- Buesaquillo Christian
- Bugaeva Polina
- Buisson Marielle
- Burhan Erlina
- Bustos Ingrid,
- Butnaru Denis
- Cabie André
- Cabral Susana
- Caceres Eder
- Callahan Mia
- Calligy Kate
- Calvache Jose Andres
- Calvache Jose,
- Campana Valentine
- Campbell Paul
- Camões João
- Canepa Cecilia
- Cantero Mireia
- Caraux-Paz Pauline
- Cardoso Filipa
- Cardoso Filipe
- Cardoso Sofia
- Carelli Simone
- Carlier Nicolas
- Carney Gayle
- Carpenter Chloe
- Carret Marie-Christine
- Carrier François Martin
- Carrier François,
- Carson Gail
- Casanova Maire-Laure
- Cascão Mariana
- Casimiro José
- Cassandra Bailey
- Castanheira Nidyanara
- Castañeda Silvia
- Castor-Alexandre Guylaine
- Castrillón Henry
- Castro Ivo
- Catarino Ana
- Catherine François-Xavier
- Cavalin Roberta
- Cavalli Giulio Giovanni
- Cavalli Giulio,
- Cavayas Alexandros
- Ceccato Adrian
- Cervantes-Gonzalez Minerva
- Chair Anissa
- Chakveatze Catherine
- Chan Adrienne
- Chand Meera
- Chas Julie
- Chassin Camille
- Chen Anjellica
- Chen Yih-Sharng
- Cheng Matthew Pellan
- Cheng Matthew,
- Cheret Antoine
- Chiarabini Thibault
- Chica Julian
- Chirouze Catherine
- Chiumello Davide
- Cho Hwa Jin
- Cho Hwa,
- Cho Sung Min
- Cho Sung,
- Choez Xavier Sánchez
- Choez Xavier,
- Choileain Orna Ni
- Choileain Orna,
- Cholley Bernard
- Cidade Jose Pedro
- Cidade Jose,
- Citarella Barbara Wanjiru
- Citarella Barbara,
- Ciullo Anna
- Clarke Jennifer
- Clohisey Sara
- Codan Cassidy
- Cody Caitriona
- Coelho Alexandra
- Colin Gwenhaël
- Collins Michael
- Colombo Sebastiano Maria
- Colombo Sebastiano,
- Combs Pamela
- Connelly J.,
- Connor Marie
- Conrad Anne
- Contreras Sofía
- Cooke Graham,
- Copland Mary
- Cordel Hugues
- Corley Amanda
- Cormican Sarah
- Cornelis Sabine
- Corpuz Arianne Joy
- Corpuz Arianne,
- Corvaisier Grégory
- Couffignal Camille
- Couffin-Cadiergues Sandrine
- Courtois Roxane
- Croonen Sabine
- Crowl Gloria
- Crump Jonathan
- Cruz Claudina
- Csete Marc
- Cucino Alberto
- Cullen Caroline
- Cummings Matthew
- Curley Gerard
- Curlier Elodie
- Curto Elena Gallego
- Curto Elena,
- Custodio Paula
- Cárcel Sheila
- Da Silva Filipe Ana
- Da Silveira Charlene
- Dabaliz Al-Awwab
- Dagens Andrew,
- Dalton Heidi
- Dalton Jo
- Daneman Nick
- Dankwa Emmanuelle,
- Dantas Jorge
- De Araújo Mariz Carolline
- De Brito Carlos Alexandre Antunes
- De Brito Carlos,
- De Castro Nathalie
- De Mendoza Diego
- De Oliveira França Rafael Freitas
- De Oliveira França Rafael,
- De Rosa Rosanna
- De Silva Thushan
- De Vries Peter
- Dean David
- Debray Marie-Pierre
- Dechert William
- Deconninck Lauren
- Decours Romain
- Delacroix Isabelle
- Delavigne Karen
- Deligiannis Ionna
- Dell’amore Andrea
- Delobel Pierre
- Demonchy Elisa
- Denis Emmanuelle
- Deplanque Dominique
- Depuydt Pieter
- Desai Mehul
- Descamps Diane
- Desvallée Mathilde
- Devouge Eglantine Ferrand
- Devouge Eglantine,
- Dewayanti Santi Rahayu
- Dewayanti Santi,
- Diallo Alpha
- Diamantis Sylvain
- Dias André
- Diaz Juan Jose Diaz
- Diaz Juan,
- DIAZ Rodrigo
- Didier Kévin
- Diehl Jean-Luc
- Dieperink Wim
- Dimet Jérôme
- Dinot Vincent
- Diouf Alphonsine
- Dishon Yael
- Djossou Félix
- Docherty Annemarie,
- Dominguez Carmen Infante
- Dominguez Carmen,
- Dong Andy
- Donnelly Christl,
- Donnelly Maria
- Donohue Chloe
- Dorival Céline
- Douglas James Joshua
- Douglas James,
- Douma Renee
- Dournon Nathalie
- Downer Triona
- Downing Mark
- Drake Tom
- Dubee Vincent
- DUBOS François
- Ducancelle Alexandra
- Dudman Susanne
- Dunning Jake
- Duranti Silvia
- Durham Lucian
- Dussol Bertrand
- Duval Xavier
- Dyrhol-Riise Anne Margarita
- Dyrhol-Riise Anne,
- D’aragon Frédérick
- D’Orleans Charles Crepy
- D’orleans Charles,
- D’Ortenzio Eric
- Eid Charbel Maroun
- Eid Charbel,
- Eira Carla
- Elapavaluru Subbarao
- Elharrar Brigitte
- Elkheir Natalie
- Ellerbroek Jacobien
- Ellis Rachael
- Eloy Philippine
- Elshazly Tarek
- Enderle Isabelle
- Engelmann Ilka
- Enouf Vincent
- Epaulard Olivier
- Esperatti Mariano
- Esperou Hélène
- Esposito-Farese Marina
- Estevão João
- Etienne Manuel
- Ettalhaoui Nadia
- Everding Anna Greti
- Everding Anna,
- Evers Mirjam
- Fabre Isabelle
- Faheem Amna
- Fahy Arabella
- Fairfield Cameron,
- Faria Pedro
- Farshait Nataly
- Fatoni Arie Zainul
- Fatoni Arie,
- Faure Karine
- Fayed Mohamed
- Feely Niamh
- Fernandes Jorge
- Fernandes Marília
- Fernandes Susana
- Ferraz Mário
- Ferreira Benigno
- Ferrer-Roca Ricard
- Ferrão Joana
- Figueiredo-Mello Claudia
- Flateau Clara
- Fletcher Tom
- Florio Letizia Lucia
- Florio Letizia,
- Foley Claire
- Fomin Victor
- Fonseca Claudio Duarte
- Fonseca Claudio,
- Fonseca Tatiana
- Fontela Patricia
- Forsyth Simon
- Foti Giuseppe
- Fourn Erwan
- Fowler Rob
- Franch-Llasat Diego
- Fraser Christophe
- Fraser John
- Freire Marcela Vieira
- Freire Marcela,
- Friedrich Caren
- Fry Stéphane
- Fuentes Nora
- Fukuda Masahiro
- Gaborieau Valérie
- Gachet Benoît
- Gaci Rostane
- Gagliardi Massimo
- Gagnard Jean-Charles
- Gagneux-Brunon Amandine
- Gaião Sérgio
- Gallagher Phil
- Gamble Carrol
- Garan Arthur
- Garcia Rebekha
- Garcia-Gallo Esteban
- GarcÍa Ruth Noemí Jorge
- García Ruth,
- Garot Denis
- Garrait Valérie
- Gault Nathalie
- Gavin Aisling
- Gaymard Alexandre
- Gebauer Johannes
- Germano Nuno
- Ghosn Jade
- Giani Marco
- Giaquinto Carlo
- Gibson Jess
- Gigante Tristan
- Gilg Morgane
- Giordano Guillermo
- Girvan Michelle
- Gissot Valérie
- Giwangkancana Gezy
- Glikman Daniel
- Glybochko Petr
- Gnall Eric
- Goco Geraldine
- Goehringer François
- Goepel Siri
- Goffard Jean-Christophe
- Golob Jonathan
- Gorenne Isabelle
- Goujard Cécile
- Goulenok Tiphaine
- Grable Margarite
- Grandin Edward Wilson
- Grandin Edward,
- Granier Pascal
- Grasselli Giacomo
- Green Christopher,
- Greenhalf William
- Greffe Segolène
- Grieco Domenico Luca
- Grieco Domenico,
- Griffee Matthew
- Griffiths Fiona
- Grigoras Ioana
- Groenendijk Albert
- Gruner Heidi
- Gu Yusing
- Guedj Jérémie
- Guellec Dewi
- Guerguerian Anne-Marie
- Guerreiro Daniela
- Guery Romain
- Guillaumot Anne
- Guilleminault Laurent
- Guimard Thomas
- Gómez-Junyent Joan
- Haber Daniel
- Hakak Sheeba
- Hall Matthew
- Halpin Sophie
- Hamer Ansley
- Hamidfar Rebecca
- Hammond Terese
- Hardwick Hayley
- Harley Kristen
- Harrison Ewen,
- Harrison Janet
- Hays Leanne
- Heerman Jan
- Heggelund Lars
- Hendry Ross
- Hennessy Martina
- Henriquez-Trujillo Aquiles
- Hentzien Maxime
- Hernandez-Montfort Jaime
- Herreros Jose Miguel Cisneros
- Herreros Jose,
- Hidayah Astarini
- Higgins Dawn
- Higgins Eibhilin
- Hinton Samuel
- Hipólito-Reis Ana
- Hiraiwa Hiroaki
- Hiscox Julian,
- Ho Antonia Ying Wai
- Ho Antonia,
- Hoctin Alexandre
- Hoffmann Isabelle
- Hoiting Oscar
- Holt Rebecca
- Holten Aleksander Rygh
- Holten Aleksander,
- Holter Jan Cato
- Holter Jan,
- Horby Peter
- Horcajada Juan Pablo
- Horcajada Juan,
- Hoshino Koji
- Hoshino Kota
- Hough Catherine,
- Hssain Ali Ait
- Hssain Ali,
- Hsu Jimmy Ming-Yang
- Hulot Jean-Sébastien
- Humaid Felwa Bin
- Humaid Felwa,
- Ijaz Samreen
- Illes Hajnal-Gabriela
- Inácio Hugo
- Iosifidis Elias
- Irvine Lacey
- Isgett Sarah
- Isidoro Tiago
- Isnard Margaux
- Itai Junji
- Ivulich Daniel
- Jaafoura Salma
- Jabot Julien
- Jackson Clare
- Jamieson Nina
- Jaureguiberry Stéphane
- Javidfar Jeffrey
- Jean-Benoît Zabbe
- Jego Florence
- Jenum Synne
- Jimenez Juan Fernado Masa
- Jimenez Juan,
- Johal Simreen Kaur
- Johal Simreen,
- Joseph Cédric
- Joseph Mark
- Jouvet Philippe
- Jung Hanna
- Kafif Ouifiya
- Kaguelidou Florentia
- Kali Sabina
- Kalomoiri Smaragdi
- Kandamby Darshana Hewa
- Kandamby Darshana,
- Kandel Chris
- Kant Ravi
- Kartsonaki Christiana
- Kasugai Daisuke
- Katz Kevin
- Keating Sean
- Kelly Andrea
- Kelly Sadie
- Kennedy Lisa
- Kennon Kalynn
- Kerroumi Younes
- Kestelyn Evelyne
- Khalid Imrana
- Khalil Antoine
- Khan Coralie
- Khan Irfan
- Kho Michelle,
- Khoo Saye
- Kida Yuri
- Kiiza Peter
- Kildal Anders Benjamin
- Kildal Anders,
- Kimmoun Antoine
- Kindgen-Milles Detlef
- Kitamura Nobuya
- Klenerman Paul
- Knight Stephen
- Kobbe Robin
- Korten Volkan
- Kosgei Caroline
- Krawczyk Karolina
- KUMAR Deepali
- Kurtzman Ethan
- Kutsogiannis Demetrios
- Kyriakoulis Konstantinos
- LACHATRE Marie
- Lacoste Marie
- Laffey John,
- Lagrange Marie
- Laine Fabrice
- Lambert Marc
- Lamontagne François
- Langelot-Richard Marie
- Lantang Eka Yudha
- Lantang Eka,
- Lanza Marina
- Laouénan Cédric
- Laribi Samira
- Lariviere Delphine
- Launay Odile
- Lavie-Badie Yoan
- Law Andrew
- Le Bihan Clément
- Le Bris Cyril
- Le Coustumier Eve
- Le Falher Georges
- Le Gac Sylvie
- Le Hingrat Quentin
- Le Maréchal Marion
- Le Mestre Soizic
- Le Moing Vincent
- Le Nagard Hervé
- Le Turnier Paul
- Le Van Tan
- Le Minh
- Leal Ema
- Lee James
- Lee Su Hwan
- Lee Su,
- Lee Todd
- Leeming Gary
- Lefebvre Bénédicte
- Lefebvre Laurent
- Lefevre Benjamin
- Lellouche François
- Lemaignen Adrien
- Lemee Véronique
- Lemmink Gretchen
- Leone Michela
- Lepiller Quentin
- Lescure François-Xavier
- Lesens Olivier
- Lesouhaitier Mathieu
- Levy Bruno
- Levy Yves
- Levy-Marchal Claire
- León Rafael
- Liang Janet
- Lim Wei Shen
- Lim Wei,
- Lina Bruno
- Lind Andreas
- Lingas Guillaume
- Lion-Daolio Sylvie
- Liu Keibun
- Loforte Antonio
- Lolong Navy
- Lopes Diogo
- Lopez-Colon Dalia
- Lordemann Anja Grosse
- Lordemann Anja,
- Loubet Paul
- Lucet Jean Christophe
- Lucet Jean,
- Luna Carlos,
- Lungu Olguta
- Luong Liem
- Luton Dominique
- Lyons Ruth
- L’Her Erwan
- Maasikas Olavi
- Macdonald Sarah
- Machado Moïse
- Macheda Gabrielle
- Madhok Jai
- Mahieu Rafael
- Mahy Sophie
- Maier Lars Siegfrid
- Maier Lars,
- Maillet Mylène
- Maitre Thomas
- Malaque Ana
- Maldonado Hugo Miranda
- Maldonado Hugo,
- Malfertheiner Maximilian
- Malik Nadia
- Maltez Fernando
- Malvy Denis
- MAMBERT Marina
- Manda Victoria
- Mandei Jose,
- Mangoni Emanuele Durante
- Mangoni Emanuele,
- Manning Edmund
- Manuel Aldric
- Marino Flávio
- Marques Ana
- Marquis Catherine
- Marsh Brian
- Marsh Laura
- Marshall John
- Martelli Celina Turchi
- Martelli Celina,
- Martin Dori-Ann
- Martin Emily
- Martin-Blondel Guillaume
- Martin-Loeches Ignacio
- Martin-Quiros Alejandro
- Martinot Martin
- Martins Ana
- Martins João
- Martucci Gennaro
- Marwali Eva Miranda
- Marwali Eva,
- Maslove David
- Mason Sabina
- Matan Moshe
- Mathieu Daniel
- Mattei Mathieu
- Matulevics Romans
- Maulin Laurence
- Mc Evoy Natalie
- Mccarthy Aine
- Mccloskey Colin
- Mcconnochie Rachael
- Mcdermott Sherry
- McDonald Sarah
- Mcelwee Samuel
- Mcevoy Natalie
- McGeer Allison
- Mcguinness Niki
- Mclean Kenneth,
- Mcnicholas Bairbre
- Meaney Edel
- Mear-Passard Cécile
- Mechlin Maggie
- Mele Ferruccio
- Menon Kusum
- Mentré France
- Mentzer Alexander,
- Mercier Noémie
- Merckx Antoine
- Mergler Blake
- Merson Laura
- Mesquita António
- Meybeck Agnès
- Meynert Alison,
- Meyssonnier Vanina
- Meziane Amina
- Mezidi Medhi
- Michelanglei Céline
- Mihnovitš Vladislav
- Mohammed Nassima Si
- Mohammed Nassima,
- Moin Asma
- Molina David
- Molinos Elena
- Mone Mary
- Monteiro Agostinho
- Montes Claudia
- Montrucchio Giorgia
- Moore Sarah
- Moore Shona,
- Morales-Cely Lina
- Morlaes Louis Gerbaud
- Morlaes Louis,
- Moro Lucia
- Motos Ana
- Mouquet Hugo
- Moyet Julien
- Mullaert Jimmy
- Munblit Daniel
- Murphy Derek
- Murris Marlène
- Myrodia Dimitra Melia
- Myrodia Dimitra,
- Müller Fredrik
- Müller Karl Erik
- Müller Karl,
- Neant Nadège
- Neb Holger
- Nekliudov Nikita,
- Neto Raul
- Neumann Emily
- Neves Bernardo
- Ng Pauline Yeung
- Ng Pauline,
- Ng Wing Yiu
- Ng Wing,
- Nichol Alistair
- Nonas Stephanie
- Noret Marion
- Norman Lisa
- Notari Alessandra
- Noursadeghi Mahdad
- Nowicka Karolina
- Nseir Saad
- Nunez Jose,
- Nuñez Maria Angelica Rivera
- Nuñez Maria,
- Nyamankolly Elsa
- N’Guyen Yohan
- Occhipinti Giovanna
- Ogston Tawnya
- Ogura Takayuki
- Oh Tak-Hyuk
- Ohshimo Shinichiro
- Oinam Budha Charan Singh
- Oinam Budha,
- Oliveira Ana Pinho
- Oliveira Ana,
- Oliveira João
- Olliaro Piero
- Ong David,
- Oosthuyzen Wilna
- Openshaw Peter,
- Orozco-Chamorro Claudia Milena
- Orozco-Chamorro Claudia,
- Orquera Andrés
- Osatnik Javier
- Ouamara Nadia
- Ouissa Rachida
- Owyang Clark
- Oziol Eric
- O’donnell Max
- O’hearn Katie
- O’neil Conar
- Pagadoy Maïder
- Pages Justine
- Palacios Mario
- Palmarini Massimo
- Panarello Giovanna
- Panda Prasan Kumar
- Panda Prasan,
- Panigada Mauro
- Pansu Nathalie
- Papadopoulos Aurélie
- Parra Briseida
- Pasquier Jérémie
- Patauner Fabian
- Patrão Luís
- Paul Christelle
- Paul Mical
- Paulos Jorge
- Paxton William,
- Payen Jean-François
- Pearse India
- Peek Giles,
- Peelman Florent
- Peiffer-Smadja Nathan
- Peigne Vincent
- Pejkovska Mare
- Peltan Ithan,
- Pereira Rui
- Perez Daniel
- Perpoint Thomas
- Perrot Clara Mouton
- Perrot Clara,
- Pesenti Antonio
- Petroušová Lenka
- Petrov-Sanchez Ventzislava
- Peytavin Gilles
- Pharand Scott
- Piagnerelli Michael
- Picard Walter
- Picone Olivier
- Piel-Julian Marie
- Pierobon Carola
- Pimentel Carlos
- Piroth Lionel
- Pius Riinu
- Piva Simone
- Plantier Laurent
- Plotkin Daniel
- Poissy Julien
- Pokorska-Spiewak Maria
- Poli Sergio
- Pollakis Georgios
- Popielska Jolanta
- Postma Douwe,
- Povoa Pedro
- Powis Jeff
- Prapa Sofia
- Prebensen Christian
- Preiser Jean-Charles
- Prestre Vincent
- Price Nicholas
- Prinssen Anton
- Pritchard Mark,
- Proença Lúcia
- Purcell Gregory
- Puéchal Oriane
- Póvoas Diana
- Quesada Luisa
- Quist-Paulsen Else
- Quraishi Mohammed
- Rabaud Christian
- Rafiq Marie
- Ragazzo Gabrielle
- Rainieri Fernando
- Ramakrishnan Nagarajan
- Ramanathan Kollengode
- Rammaert Blandine
- Rapp Christophe
- Rasmin Menaldi
- Rau Cornelius
- Rebaudet Stanislas
- Redl Sarah
- Reeve Brenda
- Rego Caroline Martins
- Rego Caroline,
- Reid Liadain
- Reis Renato
- Remppis Jonathan
- Remy Martine
- Renk Hanna
- Resende Liliana
- Resseguier Anne-Sophie
- Revest Matthieu
- Rewa Oleksa
- Reyes Luis Felipe
- Reyes Luis,
- Ribeiro Ana Freitas
- Ribeiro Ana,
- Richardson David
- Richardson Denise
- Richier Laurent
- Riera Jordi
- Rincon Diego Fernando Bautista
- Rincon Diego,
- Rios Ana Lúcia
- Rios Ana,
- Rishu Asgar
- Rispal Patrick
- Risso Karine
- Rizer Nicholas
- Roberto André
- Roberts Stephanie
- Robertson David,
- Robineau Olivier
- Roche-Campo Ferran
- Rodari Paola
- Rodeia Simão
- Roilides Emmanuel
- Rojek Amanda
- Romaru Juliette
- Roncon-Albuquerque Roberto
- Roriz Mélanie
- Rosa-Calatrava Manuel
- Rose Michael
- Rosenberger Dorothea
- Rossanese Andrea
- Rossignol Bénédicte
- Rossignol Patrick
- Roy Carine
- Roze Benoît
- Russell Clark,
- Ryckaert Steffi
- Rätsep Indrek
- Rössler Bernhard
- Saba Isabela
- Sadat Musharaf
- Saidani Nadia
- Salazar Leonardo
- Sales Gabriele
- Sallaberry Stéphane
- Salvator Hélène
- Sanchez Juan Macias
- Sanchez Juan,
- Sanchez Olivier
- Sanchez-Miralles Angel
- Sancho-Shimizu Vanessa
- Sandhu Gyan
- Sandulescu Oana
- Sanharawi Mohammed El
- Sanharawi Mohammed,
- Sant Ceila Maria
- Sant Ceila,
- Santos Marlene
- Santos Marta Leal
- Santos Marta,
- Santos-Olmo Rosario Maria Torres
- Santos-Olmo Rosario,
- Sarfo-Mensah Shirley
- Sarton Benjamine
- Saviciute Egle
- Savvidou Parthena
- Scarsbrook Joshua
- Schermer Tjard
- Scherpereel Arnaud
- Schneider Marion
- Schroll Stephan
- Schwameis Michael
- Scott Janet,
- Scott-Brown James
- Sedillot Nicholas
- Seitz Tamara
- Semaille Caroline
- Semple Malcolm,
- Senneville Eric
- Sequeira Filipa
- Sequeira Tânia
- Shadowitz Ellen
- Shamsah Mohammad
- Sharma Pratima
- Shaw Catherine,
- Shaw Victoria
- Shiban Nisreen
- Shime Nobuaki
- Shimizu Hiroaki
- Shimizu Keiki
- Shrapnel Sally
- Shum Hoi Ping
- Shum Hoi,
- Sigfrid Louise
- Silva Catarina
- Silva Maria Joao
- Silva Maria,
- Sin Wai Ching
- Sin Wai,
- Skogen Vegard
- Smith Sue
- Smood Benjamin
- Smyth Michelle
- Snacken Morgane
- So Dominic
- Solis Monserrat
- Solomon Joshua
- Solomon Tom
- Somers Emily
- Sommet Agnès
- Song Myung Jin
- Song Myung,
- Song Rima
- Song Tae
- Sonntagbauer Michael
- Sotomayor Ruth Jimbo
- Sotomayor Ruth,
- Soum Edouard
- Sousa Marta
- Souza-Dantas Vicente
- Sperry Alexandra
- Sriskandan Shiranee
- Staudinger Thomas
- Stecher Stephanie-Susanne
- Stienstra Ymkje
- Stiksrud Birgitte
- Streinu-Cercel Adrian
- Streinu-Cercel Anca
- Strudwick Samantha
- Stuart Ami
- Stuart David
- Suen Jacky,
- Sultana Asfia
- Summers Charlotte
- Svistunov Magdalena Surovcová Andrey A.
- Svistunov Magdalena,
- Syrigos Konstantinos
- Sztajnbok Jaques
- Szuldrzynski Konstanty
- Tabrizi Shirin
- Tagherset Lysa
- Talarek Ewa
- Taleb Sara
- Talsma Jelmer
- Tamlihat Younes Ait
- Tamlihat Younes,
- Tanaka Hiroyuki
- Tanaka Taku
- Taniguchi Hayato
- Tardivon Coralie
- Tattevin Pierre
- Taufik M. Azhari,
- Tedder Richard,
- Teixeira João
- Tellier Marie-Capucine
- Terpstra Pleun
- Terrier Olivier
- Terzi Nicolas
- Tessier-Grenier Hubert
- Thibault V.
- Thiberville Simon-Djamel
- Thill Benoît
- Thompson A.,
- Thompson Shaun
- Thomson David
- Thomson Emma,
- Thuy Duong Bich
- Thuy Duong,
- Thwaites Ryan,
- Timashev Peter,
- Timsit Jean-François
- Toki Maria
- Tonby Kristian
- Torres Antoni
- Torres Margarida
- Trieu Huynh Trung
- Trieu Huynh,
- Trioux Théo
- Tromeur Cécile
- Trontzas Ioannis
- Troost Jonathan
- Trouillon Tiffany
- Tual Christelle
- Tubiana Sarah
- Tuite Helen
- Turtle Lance,
- Tutillo Diego Rolando Morocho
- Tutillo Diego,
- Twardowski Pawel
- Téoulé François
- Uchiyama Makoto
- Ullrich Roman
- Uribe Alberto
- Usman Asad
- Uva Maria Sousa
- Uva Maria,
- Val-Flores Luís
- Van De Velde Stijn
- Van Den Berge Marcel
- Van Der Feltz Machteld
- Van Der Vekens Nicky
- Van Der Voort Peter
- Van Der Werf Sylvie
- Van Dyk Marlice
- Van Gulik Laura
- Van Hattem Jarne
- Van Lelyveld Steven
- Van Netten Carolien
- Van Vinh Chau Nguyen
- Vanel Noémie
- Vanoverschelde Henk
- Vasconcelos Malte Kohns
- Vasconcelos Malte,
- Vauchy Charline
- Vecham Pavan Kumar
- Vecham Pavan,
- Veislinger Aurélie
- Velazco Jorge
- Ventura Sara
- Verbon Annelies
- Vidal José Ernesto
- Vidal José,
- Vieira César
- Vijayaraghavan Bharath Kumar Tirupakuzhi
- Vijayaraghavan Bharath,
- Villanueva Joy Ann
- Villanueva Joy,
- Villar Judit
- Villeneuve Pierre-Marc
- Villoldo Andrea
- Visseaux Benoit
- Visser Hannah
- Vuorinen Aapeli
- Vuotto Fanny
- Wang Chih-Hsien
- Wei Jia
- Weil Katharina
- Wesselius Sanne
- Wham Murray
- Whelan Bryan
- White Nicole
- Wiedemann Aurélie
- Wille Keith
- Wils Evert-Jan
- Xynogalas Ioannis
- Yacoub Sophie
- Yamazaki Masaki
- Yazdanpanah Yazdan
- Yelnik Cécile
- Yerkovich Stephanie
- Yokoyama Toshiki
- Yonis Hodane
- Young Paul
- Yuliarto Saptadi
- Zabbe Marion
- Zacharowski Kai
- Zahran Maram
- Zambon Maria
- Zanella Alberto
- Zawadka Konrad
- Zayyad Hiba
- Zoufaly Alexander
- Zucman David
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2021
- Field of study
Background:
The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms.
Methods:
International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms.
Results:
‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country.
Interpretation:
This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men
Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study
- Author
- A. Mohammed Kalakwa
- A. Nemer Ayoub
- Abantanga Francis A.
- Abatli Safa' Jamal
- Abbas Wisam
- Abbo Olivier
- Abdelbaqi Reem
- Abdelhady Dina Sobhy
- Abdelhafez Mohammad Omar Mohammad
- Abdelhamid Sultan S.
- Abdelmaksoud Sherif
- Abdelmoumen Roua
- Abdelmutalib Fakereldeen
- Abdul-Mumin Alhassan
- Abduljawad Fatima Mousa
- Abdullah Fizan
- Abdullah Mohd Yusof bin
- Abdulraheem Nurudeen
- Abdulrahman Alaa
- Abdulsalam Moruf Adekunle
- Abdunomonovich Dekhkonboev Avazjon
- Aboelela Ahmed
- Abouheba Mohamed
- Abrahamsson Kate
- Abrunhosa Matias Marcia
- Abu-Nejmah Fawzi
- Abuajaila Abdulsalam
- Abuattaya Adham Ashraf
- Abubakar Auwal M
- Abueideh Ahmad
- Abuhayyeh Husam Aldean
- Abuhlega Ma'aly A.
- Abukhalaf Sadi
- Abumunshar Ali Abdelhay
- Acuna Gaston
- Adams Stephen
- Adamu Sani
- Adanan Mohd Fitri Shukri bin Mohamed
- Adawi Ihda
- Adawi Samer
- Adawy Ahmad
- Ade-Ajayi Niyi
- Adegboyega Rilwan
- Ademuyiwa Adesoji
- Adesanya Opeoluwa
- Adhiwidjaja Cathline Freya
- Adofo-Ansong Nana
- Agboola Titiloye Hannah
- Agelebe Efeturi
- Aguilar Aguilar Faye
- Aguilar Gargurevich Prince Pamela
- Aguirre-Lopez Pastor
- Agulham Miguel Angelo
- Ahmad Hira
- Ahmad Zahidah Adlynee Haji
- Ahmed Hazem
- Ahmed Mahmoud Abdelfattah
- Ajai Olalekan Temitope
- Ajao Emmanuel Akinlabi
- Ajiboye Olalekan S.
- Ajrami Yara
- Ajwa Ahmad Elian Abu
- Akan M. Eren
- Akhbari Melika
- Akhter Nadeem
- Akova Fatih
- Al-Attar Hala M.
- Al-Halbouni Layana
- Al-Mamun Abdullah
- Al-Mayoof Ali Farooq
- Al-Momani Hashem M.
- Al-Mouakeh Ahmad
- Al-Rayyes Maisara
- Al-saleem Hasan Subhi Hasan Abu
- Al-Salhi Ashraf Ayman
- Al-Shwaikh Samar H.
- Al-Slaibi Ibrahim
- Al-Taher Raed Nael
- Al-Taher Raed Nael
- Al-Tammam Hiba
- Alakaloko Felix
- Alamrain Abdulwhhab Ayman Abu
- Alanguia Chipana Cathy Lee
- Alattas Khalid
- Alberto Carlos
- Albozidi Aya
- Alcántara Elvyn
- ALDIRAWI MOHAMMED A. M.
- Alebbini Mohanad Mutasem
- Alfoghi Mabroka
- Algabri Hayder Nadhim Obaid
- Alglaib Mohammed Meftah
- Alhamid Ahmad
- Alhamid Aos
- Alhassan Priscilla
- Ali Hassan
- Ali Karim Osamy
- Ali Liza
- Ali Mansour
- Alijla Sharif
- Alijla Sharif S.
- Aliwisat Ahmad Hasan
- Aljaboo Hajir
- Aljadidi Wesal Omar F. Saied
- Aljarad Ziad
- Alkareem Raghad mohammad abdu
- Almada Suad Ahmed
- Almadhoun Walaa
- Almasri Murad
- Almeida Aguiar Arthur
- Almeida Giovana
- Almengar Inas
- Almohamady Hisham
- Almosaibli Mohammad
- Almusleh Tasneem Fathi Hasan
- Alnaeri Ali
- Alnahhal Khaled
- Alonso Verónica
- Alosta Hasan Mustafa
- Alqarajeh Firas
- Alqor Mohammad Omar Ibrahim
- Alsaadi Nijmeh Nasser
- Alsaggaf Ameen
- Alsaied Amer
- Alser Mohammed
- Alser Osaid H.
- Alshaikhkhalil Haya Abdulnasser Ali
- Alshehri Abdullah
- Altaweel Ahmed
- Altın Merve
- Altokhais Tariq
- Altomi Mohamed
- Alturki Fahad
- Alvarado Zelada Jackelyne
- Alves Dutra da Silva Érika
- Alwadia Soha Marwan Salem
- Alwaggaa Nouriyah Ali
- Alzamari Ainaa Ata Mohammad
- Alzate Gallego Edgar
- Alzeer Asmahan Mohammad Suliman
- Alzerei Sulaiman T.
- Alzraikat Sayel H.
- Alzubair Afnan
- Alzughayyar Tareq Z.
- Amad Mohamed
- Amado Fernando
- Amaechi Chukwubinyelum
- Amah Christopher Chim
- Amarin Justin Z.
- Amarin Marzouq
- Ambriz-González Gabriela
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- Mohammad Mohammad Aminu
- Mohammed Abobaker
- Mohammed Azhar Arabi
- Mohammed Hanan Mahmoud
- Mohammed Mansour Mkayed
- Mohammed Ola Ahmed Abdulmjeed
- Moitt Natalie
- Molina Vazquez Maria Elena
- Molina Marcelo
- Molinelli Matilde
- Monawar Abdul Baqi
- Montalvo Marin Arturo
- Montoya Debora
- Mora Maria
- Moraes Mario
- Morales Adriana
- Morales Otto
- Moreno Maria Eugenia
- Moriya Eliane
- Morjan Mohammed
- Mose Moraa
- Motee Jethishka
- Motter Sarah Bueno
- Mounira Baghdadi Nour el islam
- Mouti Mohamad Bassel
- Mouttalib Sofia
- Mshelbwala Philip Mari
- Msuya David
- Mugambi Stanley
- Mugo Robert
- Muhic Amila
- Mulu Jack
- Mumtaz Uzma
- Muntean Liviu
- Murad Amir M. I.
- Muradi Teymursha
- Muragijimana Jean De Dieu
- Muraveji Qais
- Murillo Ericka
- Murshidi Raghad M.
- Murtadi Habib Mansour
- Murzaie Muhammad Yousuf
- Muslimovich Aliev Makhmudjan
- Mussein Haidar Mohammad
- Mustufa Hamassat
- Mutlu Mehmet
- Muñoz Guillermo
- Mvukiyehe Jean Paul
- Mwai Timothy
- Nageh Mohammad
- Nah Shireen Anne
- Naidoo Rasika
- Naim Nur Atifah binti Mohd
- Naim Samy Rafat Ramadan
- Naranjo Kelly
- Nassar Ismail
- Nataraja Ramesh M
- Naumeri Fatima
- Naunova Vesna Cvetanovska
- Ndata Albert
- Ndayishimiye Isaac
- Ndungu James
- Negash Samuel
- Negida Ahmed
- Negrete Amalia
- Nemer Rawan
- Nezerwa Yves Castar
- Ngerncham Monawat
- Ngwenya Sodumisa
- Nisar Muhammad Umar
- Niyukuri Alliance
- Nkuliza Delphine
- Nkunzimana Elysé
- Nofal Ahmed Hassan
- Nogueira Marques Geraldo Magela
- Noguez Castillo Monica
- Noor Wan Ruzaimie
- Nor Mohd. Tarmizi Mohd
- Norberto da Silva Juliana Antinarelli
- Nour Ibrahim
- Nour Ibrahim R.
- Nour Ibrahim Rabi
- Novochadlo Klüppel Elis
- Novotny Nathan
- Nunes Kist Iuri
- Nuntasunti Wasun
- Nwangwu Emmanuel Ifeanyi
- Nwankwo Elochukwu Perpetua
- O'Connor Jennifer
- O'Connor Zachary
- Obianyo Nene Elsie
- Ochieng Kevin
- Ochieng Roseline
- Odi Abd Al-Naser Bany
- Ogundoyin Olakayode
- Olabisi Osagie O
- Olanrewaju Moses
- Olayade Kayode
- Oliu San Miguel Detlef
- Oliveira de Andrade Susy
- Oliveira Danielle Paula de
- Olivos Perez Maricarmen
- Olori Samson
- Olulana Dare I.
- Omari Rand Y.
- Omendo Liyenzero Polycarp
- Omling Erik
- Ormeño Calderón Luis
- Orozco Perez Jamie
- Ortega Sotelo Luis
- Ortiz Argomedo María Rosa
- Osagie Olabisi
- Osazuwa Maryrose
- Oshiba Ahmed Mohamed
- Osman Marjmin
- Osorio Fory Ghordana
- Osowicka Marta
- Osuigwe Andrew N
- Osuoji Roland Iheanyichukwu
- Othman Mohd Yusran Bin
- Otuneye Adekunle T.
- Outani Oumaima
- Owiwi Yazeed
- Owusu Sheila
- Owusu-Sekyere Frank
- Oyebanji Lateef
- Oyinloye Adewale
- Ozen Mehmet Ali
- Pachl Max
- Pajouhandeh Fatemeh
- Palacios Nelly
- Pandit Ghuri Shankar
- Papa Adrian
- Pardo Liliana
- Pardo Lina Maria
- Pardy Caroline
- Paredes Espinoza Patricia
- Parigi Gian Battista
- Parker Samuel
- Parmentier Benoit
- Pasaoglu Mehmet
- Pasierbek Michal
- Pasqua Noemi
- Patel Azad
- Patiño Gonzalez Celeste Carolina
- Patkowski Dariusz
- Patzer Ludwig
- Pauzi Siti Farhan Moh
- Paz Soldan Carolina
- Pernik Mark N.
- Peycelon Matthieu
- Peña Padilla Christian
- Peñarrieta Daher Alejandro
- Phannua Ratiyaporn
- Philipo Godfrey Sama
- Piché Nelson
- Pigeolet Manon
- Pilkington Mercedes
- Pinar Brooke
- Piotrowska Aneta
- Planka Ladislav
- Poenaru Dan
- Ponce Fajardo Gabriela Yulissa
- Poocharoen Wannisa
- Popovic Nusret
- Porras Juan Domingo
- Pos Lucie
- Prabhu P Santosh
- Prat Jordi
- Prieto Vargas Osbaldo
- PT Sundeep
- Puentes Maria Consuelo
- Puglia Paul
- Puig Maria Gabriela
- Puligandla Pramod
- Putruele Daniel
- Qadomi Asef belal
- Qawwash Anas
- Qi Dr. Tammy Teoh Han
- Qudah Hamzah Abullah
- Quiles Corona Moises
- Qunaibi Moradallah Asad Fahmi
- Quran Thekraiat M. Al
- Qureshi Taimur
- Qutishat Hibah
- Qwaider Yasmeen Z.
- Raboe Enaam
- Racková Tereza
- Radwan Asaad saleh
- Raffaele Alessandro
- Raicevic Maja
- Raj Ankit
- Ramirez De La Cruz Raul
- Ramli Najua binti
- Ramos Paredes Erika
- Ramos Yna
- Rani Zarqa
- Rasaki Aliu
- Rashid Sakina
- Rashwan Hayssam
- Ravetta Pablo
- Ravi Krithi
- Raymond Kwizera Jean
- Raza Rafee
- Razak Rahilah binti Abd
- Reda Ahmed
- Rehman Wajeeh ur
- Renaux Petel Mariette
- Rengura Cecilia
- Reuter Cristina
- Rex Dean
- Rezende Rosa Bianca
- Rhodes Hannah
- Ribas Bianca
- Ribeiro de Fernández y Alcázar Fernanda
- Riboni Cristiana
- Rieth Anna
- Rincon Luis Carlos
- Rios Flores Izabel Maryalexandra
- Rissmann Anke
- Risteski Toni
- Rite Segundo
- Rivarola Nahuel Ignacio
- Rivera Altamirano Porfirio
- Rivera Alvarez Julio
- Roberts Charles A.
- Roberts Kiera
- Roberts Rebecca
- Rojas Nair
- Rolle Udo
- Romano Piero Giovanni
- Romero Manteola Enrique
- Roszkiewicz Anna
- Ruan Weiwei
- Rudolfson Niclas
- Ruiz de Temiño Bravo Mercedes
- Ruzgar Nensi
- Rygl Michal
- S. Alkali Yahya
- Saad Alshaimaa M.
- Saad Mahmoud M.
- Sabbatini Stella
- Sabic Adnan
- Sabti Shahad
- Sadagurschi Mariana
- Sadek Kareem
- Sadek Mirna
- Safa Nadia
- Sahnoun Lassaad
- Salah Mohammed
- Salawu Morayo Monsurat
- Salazar Karla
- Saldaña Lily
- Saleem Ayesha
- Saleem Muhammad
- Saleh Amr
- Saleh Mahmoud
- Salem Hosni khairy
- Salha Aya Azmi Shehda
- Salim Jamal Mohammed
- Salinas Barreto Juan Jose
- Salinas Vicente
- Salö Martin
- Samad Lubna
- Samadi Dr. Ahmad Zia
- Samanez Obeso Angel
- Samarah Yasmeen Ahmad
- Samarakkody Udaya
- Samy Doaa
- Sanchez Valladares Pablo
- Sanchez Alberto
- Sanchez Beatriz
- Sanchez Janina
- Sanchez Nancy
- Santana Ortiz Rafael
- Saousen Benmanseur
- Sara Nabti
- Saracevic Adna
- Sarhan Osama Abdul Kareem
- Sarıhan Haluk
- Sarkaz Taher L.
- Sartori Giovanoni Lais
- Sayeed Fatema
- Sbaih Mahmoud Fuad
- Scalabre Aurelien
- Scherl Humberto
- Schmedding Andrea
- Segura Calle Carlos
- Sehic Anesa
- Sehwiel Abrar Shaheen
- Sekyere Owusu
- Selak Nejra
- Semensato Carloni Isabela Cristina
- Sempertegui Denisse
- Serban Andreea Madalina
- Serezo Belen
- Sevdalis Nick
- Seyi-Olajide Justina
- Sferco Carlos Ariel
- Shabana Osaid Shaher
- Shahbal Swaleh
- Shaheen Ahmad Ashraf
- Shaheen Nureddin
- Shaklawoon Aisha
- Shalaby Amr
- Shalaby Hanin
- Shalluf Hawa Ahmed
- Shan Cheah Hui
- Sharabati Fadwa
- Sharabati Mutassem
- Sharif Muhammad
- Sharif Randa Alamen M
- Shaw Kenneth
- Shehada Mohammed
- Shehu Ibrahim
- Sheir Hesham
- Sherer Karen
- Sherzad Ajmal
- Shiha Eman Abu
- Shikha Anas
- Shinondo Patricia
- Shnishah Aya Essam
- Shokri Hajer Ali
- Shonubi Amo
- Shoubaki Ali
- Shu Qiang
- Shyaka Gashugi Ian
- Siddiqui Sabina M
- Sidler Daniel
- Sigalet David
- Sihem Brahimi
- Sikwete Guigui
- Siles Hinojosa Alexander
- Silva Beltrán Nathalia
- Silva dos Santos Carla
- Silva Ferreira dos Santos Marília
- Silva Elisângela
- Silva Julian
- Silva Karina Ilheu da
- Silva Yanina
- Sim Marcus
- Simeon Turatsinze
- Simon Soledad
- Sindi Omar
- Singer Georg
- Singh Michael
- Sivaraj Jayaram
- Sivasubramaniam Mithila
- Siyotula Thozama
- Slavkovi Andjelka
- Slavkovic Milan
- Smith Emily Rose
- Soares de Fraga José Carlos
- Sobrero Helena
- Soccorso Giampiero
- Sokolovic Emir
- Sola Juan
- Solanki Meghna
- Soliman Nourhan Akram
- Son Joonhyuk
- Song Eung song
- Soomro Aqil
- Sotelo Sanchez Jennifer
- Souhem Touabti
- Soula Enas
- Souza Barros Beatriz
- Souza Machado Ana Beatriz
- Sowe Babucarr
- Sriniworn Anan
- St-Louis Etienne
- St-Vil Dickens
- Stark Domitille
- Stojanovic Miona
- Stringer Mark
- Strumila Arunas
- Sueiras Ines
- Sulca Cruzado Gladys Johana
- Suleiman Faruk
- Sultana Sadia
- Suradi Haya H.
- Sutcliffe Jonathan
- Suzana Trein Cristine
- Suzen Alev
- Svensson Emma
- Svirsky Alexander
- Swessi Hisham
- Syed Shahnoor
- Syovata Francisa
- Szklarz Maria Tatiana
- Sánchez Paredes Vicente
- Sönmez Kaan
- T Shajin
- T. Sambo Yusuf
- Tababa Osama
- Tabari Ahmad Khaleghnejad
- Tabiri Stephen
- Tadesse Amezene
- Tahyneh Abdulraheem Adnan Abdulraheem
- Takrouney Mohammed Hamada
- Talat Nabila
- Tallaa Mohamed Anwer El
- Tamada Horácio
- Tamaddun Hafatin Fairos bt
- Tang Weibing
- Tanimola Adebayo Gbenga
- Tanming Patchareeporn
- Tanny Sharman Tan
- Tantush Sara Abobaker
- Tarabishi Ahmad Sankari
- Tarek Ahmed
- Tarmohamed Murad
- Tarniba Sara Ali
- Tarrado Xavier
- Tasker David
- Teague Warwick
- Telles Leila
- Temilade Bolarinwa Bolanle
- Teo Rufinah
- Teran Araceli
- Terzic Sabina
- Testoni Daniela
- Thaiwatcharamas Kanokrat
- Thiessen Jesh
- Thomas Amy Hughes
- Thomas Gordon
- Thomas Mark C
- Thompson Hannah
- Till Holger
- Tillig Bernd
- Tinoco Guzmán Nestor Julien
- Tobor Szymon
- Toczewski Krystian
- Tom Alan
- Toplicic Djordje
- Toral Eliana
- Torres Miranda Cesar
- Torres Picón Cintya Maria de Jesus
- Torres-Canchala Laura
- Toselli Luzia
- Touabti Souhem
- Toufik Iaiche Achour
- Tovar Gutierrez Natalia
- Trainba Sara
- Trigoso Mori Fernando
- Trindade Deyl Rafael
- Trojanová Barbora
- Trypens Agata
- Tumi Mohamed
- Tuyishime Eugene
- Türkyılmaz Canan
- Türkyılmaz Zafer
- Ubhi Harmony
- Ugwu Jideofor O
- Ugwunne Chuka A
- Ulasi Ikechukwu
- Ullrich Sarah
- Vacek Jonathan
- Vaitkiene Agota
- Valencia Santiago
- Valeria Pelussi
- Valerio-Vazquez Rafael
- Vanis Nedim
- Vaquila Justo
- Varela Maria Florencia
- Vasquez Matos Juan Pedro
- Vatta Fabrizio
- Vega Centen Stephany
- Velaña Junior
- Vellusamy V Muthualhagi M
- Venant Ntakarutimana
- Venkatraman Soundappan Sannappa
- Verdeata Roxana
- Verduga Ivan
- Verduga Leonardo
- Vergara Carolina
- Verkauskas Gilvydas
- Veronica Sofficci
- Vervoort Dominique
- Vianney Butoyi Jean Marie
- Vida Lucian
- Vidal Cristian R. Zalles
- Vierboom Liam
- Villalba Villalba Araceli
- Villegas Silva Raúl
- Vinskaite Asta
- Vos Corné de
- Vosoughi Armin
- Wafa Tamer
- Walker Gregor
- Wang Jinhu
- Wang Peng
- Waseem Basma
- Weeratunga Naveen
- Weiszewsk Alicja
- Wen Gang
- Werneck Raposo Juliana
- Wester Tomas
- Wijekoon Naveen
- Wilke Alexandra
- Williams Isabelle
- Williams Omolara
- Williams Regan
- Win Win Sabai Phyu
- Wishah Bisan D. M.
- Wishah Nidal
- Wissanji Hussein
- Wolak Przemyslaw
- Wolny Agnieszka
- Wong Janice
- Wong Marilyn
- Wright Naomi Jane
- Wu Guowei
- Wyrzykowski Dariusz
- Xiaodong Guo
- Xie Hua
- Yacoub Mina A.
- Yaghi Bashar
- Yaghi Dua Hasan
- Yalcinkaya Ali
- Yang Hee-Beom
- Yanis Ahmad H.
- Yanowsky Reyes Guillermo
- Yao Yang
- Yapo Benjamin
- Yarza Fernández Jessica
- Yeniay Aslı Öztürk
- Yola Mariya Mukhtar
- Yong Feng
- Youn Joong Kee
- Yousuf Hina
- Yu Mengnan
- Yu Raisa
- Yuen Quah Soong
- Yuldashev Rustam Z.
- Yunus Aayenah
- Za'nouneh Faris J. Abu
- Zaghlol Louay Y.
- Zahari Dato' Dr Zakaria bin
- Zain Mostafa
- Zaman Azrina SK
- Zanellato Josiane Bernartt
- Zarwawi Ahmad Zulhisyam bin
- Zea-Salazar Luis Enrique
- Zeinelabdeen Ali
- Zhao Xiaoxia
- Zhu Jianming
- Zhu Libin
- Zidan Mazen
- Zivanovic Dragoljub
- Zottis Barcelos Fabricio
- Zreeg Dafer abdulhakim . S.
- Zurikat Rajai O.
- Zvizdic Nada
- Zvizdic Zlatan
- Çekiç Bahanur
- Çelik Müge
- Özçelik Zerrin
- Şeref Kıvanç
- Šafus Antonín
- Škvařil Jan
- Štichhauer Radek
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
Summary
Background Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally.
Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies
have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of
the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income
countries globally, and identified factors associated with mortality.
Methods We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to
hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis,
exomphalos, anorectal malformation, and Hirschsprung’s disease. Recruitment was of consecutive patients for a
minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical
status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary
intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause,
in-hospital mortality for all conditions combined and each condition individually, stratified by country income status.
We did a complete case analysis.
Findings We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital
diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal
malformation, and 517 with Hirschsprung’s disease) from 264 hospitals (89 in high-income countries, 166 in middleincome
countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male.
Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3).
Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income
countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups).
Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in lowincome
countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries;
p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients
combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11],
p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20
[1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention
(ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety
checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed
(ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of
parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65
[0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality.
Interpretation Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between lowincome,
middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will
be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger
than 5 years by 2030
Mutational profile of primary breast diffuse large B-cell lymphoma
- Author
- Publication venue
- 'Impact Journals, LLC'
- Publication date
- 28/11/2017
- Field of study
Primary breast lymphoma is a rare form of extra-nodal lymphoid neoplasm. The most common histological type is the diffuse large B-cell lymphoma, which represents 60-80% of all the cases. Our study analyzes the mutational profile of the primary lymphoma of the breast through targeted massive sequencing with a panel of 38 genes in a group of 17 patients with primary breast diffuse large B-cell lymphoma. Seventy-point-five percent of the patients presented with stage IE and 29.5% with stage IIE. 44% of the cases correspond to lymphomas with germinal center phenotype and 33.3% to activated B-cell. The genes with a higher mutational frequency include PIM1 (in 50% of the analyzed samples), MYD88 (39%), CD79B, PRDM1 and CARD11 (17%), KMT2D, TNFIAP3 and CREBBP (11%). The profile of mutant genes involves mostly the NF kappa B signaling pathway. The high frequency of mutations in PIM1 compared with other lymphomas may have implications in the clinical presentation and evolution of this type of lymphoma
High rates of prescribing antimicrobials for prophylaxis in children and neonates : results from the antibiotic resistance and prescribing in European children point prevalence survey
- Author
- Abubakar Ismaela
- Al Azmi Aeshah Abdu Mubarak
- Al Maskari Zaina
- Al-Jardani Amina
- Al-Mousa Haifaa
- AlAjmi Jameela Ali
- Alexander John
- Alsalman Jameela
- Arenas-Lopez Sara
- Aston Jeff
- Awunyo Marah
- Barton Christopher
- Bell Emily
- Bielicki Julia
- Blumental Sophie
- Blyth Christopher C.
- Borg Michael A.
- Borgia Eleonora
- Brett Ana
- Briquet Caroline
- Burokiene Sigita
- Bustinza Amaya
- Caldwell Neil A.
- Calvo Cristina
- Cambrea Simona Claudia
- Cancino Martha E.
- Centenari Chiara
- Chan Si Min
- Cizman Milan
- Clark Julia
- Cooper Celia
- Cox Elaine
- Critselis Elena
- D'Argenio Patrizia
- De Luca Maia
- Doerholt Katja
- Dona Daniele
- Dramowski Angela
- Drapier Nico
- Drysdale Simon B.
- Dubos Francois
- Enimil Anthony
- Escosa-Garcia Luis
- Esposito Susanna
- Esteves Isabel
- Finlayson Heather
- Francis Joshua Reginald
- Gabriels Patrick
- Gahleitner Florian
- Gajdos Vincent
- Galli Luisa
- Garbash Mehdi
- Garg Garima
- Garg Pankaj
- Giaquinto Carlo
- Gkentzi Despoina
- Gonzalez Lozano Carlos Agustin
- Goossens Herman
- Gormley Cairine
- Gupta Richa
- Hargadon-Lowe Antonia
- Heginbothom Maggie
- Howe Rachel
- Hufnagel Markus
- Iosifidis Elias
- Isa Mas Suhaila
- Jafarpour Zahra
- Jansen Hilde
- Jensen Lise Heilmann
- Johnson Alison
- Kalavalapalli Durga Bhavani
- Kler Neelam
- Knuf Markus
- Kohlhoff Stephan
- Kouni Sofia
- Kovacevic Tanja
- Laan Mari
- Ladomenou Fani
- Lagree Marion
- Le Marechal Flore
- Lepage Philippe
- Liese Johannes
- Lo Vecchio Andrea
- Lopez-Varela Elisa
- Lorrot Mathie
- Luck Suzanne
- Lunn Andrew
- Mahieu Ludo
- Malviya Manoj
- Maria Calle Graciela
- Maria Rincon-Lopez Elena
- Marques Laura
- Martinot Alain
- Mate-Cano Irene
- Maton Pierre
- Matsinen Maire
- McCorry Ann
- McCullagh Bernadette
- McMaster Paddy
- Menson Esse
- Montagnani Carlotta
- Mougkou Katerina
- Mozgis Dzintars
- Murki Srinivas
- Najdenov Peter
- Nash Clare
- Nichols Kristen
- Nicolini Giangiacomo
- Nielsen Jens Peter
- Olivier Romain
- Omar Abeer
- Orbach Daniel
- Pagava Karaman
- Patel Mitul
- Petersen Jes Reinholdt
- Pluta Magdalena
- Poorisrisak Porntiva
- Pouladfar Gholamreza
- Prot-Labarthe Sonia
- Rajagopal Veena
- Raka Denis
- Raka Lul
- Raman Mala
- Rashed Asia N.
- Renner Lorna
- Robbrecht Dirk
- Rodrigues Fernanda
- Roilides Emmanuel
- Rojo Pablo
- Rubic Zana
- Rummukainen Maija-Liisa
- Russell Alison Bedford
- Saavedra-Lozano Jesus
- Sahu Suneeta
- Santiago Begona
- Satodia Prakash
- Schlag Stephanie A. A.
- Scorrer Tim
- Sharland Mike
- Sharpe David
- Sherland Mike
- Singh Sanjeev
- Singhal Tanu
- Soltani Jafar
- Soto Beatriz
- Spyridis Nikos
- Sviestina Inese
- Syridou Garyfallia
- Tagarro Alfredo
- Tamm Eda
- Tavchioska Gabriela
- Tenconi Rossana
- Terol Barrero Pedro
- Unuk Sibila
- Ureta Noelia
- Usonis Vytautas
- Van Rossom Paul
- Vandewal Wouter
- Versporten Ann
- Zaoutis Theoklis
- Zarate Castanon Patricia
- Zarb Peter
- Publication venue
- Publication date
- 01/01/2019
- Field of study
International Nosocomial Infection Control Consortiu (INICC) report, data summary of 43 countries for 2007-2012. Device-associated module
- Author
- Abdullah Mufareh Assiri
- Abeer Ahmed Mohmed
- Abeer Aly Omar
- Abhijeet Raha
- Abizer Nuruddin Manked
- Achilleas Gikas
- Adela Arguello Ruiz
- Adem Karbuz
- Adrian M. Puello Guerrero Glenny Mirabal
- Adriana Montanini
- Adriana Romani
- Afzal Azim
- Agamenon Alves Oliveira
- Agreta Gecaj-Gashi
- Ahmed Hakawi
- Ahmet Dilek
- Aisha Mubarak
- Ajoy Krishna Sarkar
- Alexander Molkov
- Alexander Tchekulaev
- Alfredo Lagares Guzman
- Alfredo Paucar
- Algirdas Dagys
- Ali Kaya
- Ali Metin Otkun
- Ali Omer Abdul Aziz
- Ali Pekcan Demiroz
- Aline Besen
- Aliye Yasayacak
- Alka Thool
- Alka Thool
- Alper Sener
- Altaf Ahmed
- Alysia Faye Giani
- Alzbeta Marcekova
- Amani Ali El-Kholy
- Amani Fouad Sayed
- Amaury Mielle Filho
- Ameurfina Curioso Silo
- Amine Ali Zeggwagh
- Amjad Mahboob
- Amna Mostafa Mohamed
- Amol Harshe
- Ana Lucía Bonilla Escudero
- Ana Marãa Perez Fernandez
- Ana Paula Fontes Pinheiro
- Ana Paula Vasconcelos Carneiro
- Ana Silvia Rearte
- Anahita Sanaei
- Analen Fabros Cabato
- Andrea Peña Padilla
- Andres Eduardo Mindiola Rochel
- Andres H. Corchuelo Martinez
- Andrzej Kubler
- Angel Gonzalez Vargas
- Angel Orlando Flores Alvarado
- Angelina Mendonca
- Anil Bilolikar
- Anil Karlekar
- Anirban Karmakar
- Anis Shiham Zainal Abidin
- Anju Mathew
- Anna Lesnakova
- Annalyn Amor Malificio
- Antigona Hasani
- Antonio Claudio do Amaral Baruzzi
- Antonio Martinez Mulia
- Antonio Solano Chinchilla
- Anu Kurian
- Anucha Apisarnthanarak
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- Masoud Alebouyeh
- Masoud Alebouyeh
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- Mohamad Ftouni
- Mohamed Hassan
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- Pravin Kumar Nair
- Preeti Rajeev Mehta
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- Prokopis Kithreotis
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- Purva Mathur
- R. Kelkar
- R. Sukanya
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- Ram Gopalakrishnan
- Ramesh Venkatraman
- Ramona Severino
- Rasha Hamed Elsherif
- Ravikumar Krupanandan
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- Regina Berba
- Reham Ali Dewdar
- Reham Hamed
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- Renata Amaral De Moraes
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- Rimantas Kevalas
- Rimita Dey
- Riya Thakkar
- Roaa Hasan Basri
- Roberto Carlos Mares Morales
- Roberto Espinoza Atarama
- Rodolfo Toomey
- Rodrigo Pires Dos Santos
- Rohini Dhawale
- Rosalia Fernández-Hidalgo
- Rosana Richtmann
- Rosita Gasmin Aromin
- Ruby Jose Ramapurath
- Rungratchanee Pimathai
- Rédouane Abouqal
- S. Muralidharan
- S. Sampat
- S. Saranya
- S.K. Biswas
- S.N. Myatra
- Saadet Arsan
- Saban Esen
- Saeed Ali Al Darani
- Salih Cesur
- Sameeh Salem Ghazal
- Samir Sahu
- Samir Sahu
- Sandra Liliana Romero Torres
- Sandra Milena Bonilla
- Sanghamitra Mishra
- Sanjay Bhattacharya
- Sanjay Singhal
- Sanjeev Singh
- Sanjeev Sood
- Sankar Sengupta
- Santosh Singh
- Sarika Juneja
- Saroj Kumar Patnaik
- Sasheela Sri La Sri Ponnampala
- Saswati Sinha
- Seelas Blessymole
- Sehnaz Kaya
- Selene Manga Chavez
- Selin Bardak
- Selvi Yener Erdogan
- Senthilkumar Rajagopal
- Sergey Puzanov
- Sergio Blecher
- Sergio Esparza-Ahumada
- Serhat Unal
- Sevim Karacorlu
- Shamsher Dalal
- Sheena Binu
- Sheena Mary Sibin
- Shefali Bhattacharya
- Shirley Tenorio López
- Shobhana Kumari Kadankunnel
- Shoeb Nizamuddin Kardekar
- Shufang Wang
- Shufang Zhuo
- Sibel Bolukcu
- Silom Jamulitrat
- Simasadat Seyedjavadi
- Simone Amorim
- Siva Kumar
- Sladjana Vasiljevic
- Sneha Mary George
- Snezana Tufekcievska Guroska
- Socorro Torres Zegarra
- Sohini Arora
- Solange Regina Oliveira Castro
- Somayeh Jahani-Sherafat
- Sona Hlinkova
- Sonali Khamkar
- Sonay Incesoy Ozdemir
- Song Liqiang
- Sonia Joseph
- Soniya Thorat
- Souha Sami Kanj
- Soumya Samal
- Srdjan Pasic
- Srinivas Samavedam
- Subhash Kumar Todi
- Subodh Kumar
- Sudhir Gupta
- Sudhiranjan Misra
- Suga Thomas Varghese
- Suha Sen
- Suhas Nirkhiwale
- Sujata Malik
- Sujith Sujith
- Sujoy Mukherjee
- Sukanya Rangaswamy
- Suman Singh
- Sumana Baidya
- Sumi Nandwani
- Summiya Nizamuddin
- Sumru Ozkan
- Suneeta Sahu
- Sunil Bhamare
- Sunil Sharma
- Suo Yao
- Supriya Chabukswar
- Suresh Kumar
- Susana Gutierrez-Martinez
- Susmita Basu
- Suthinee Wanitanukool
- Suvin Shetty
- Suwara Somabutr
- Suzan Sacar
- Suzette A. Bunsay
- Swarna Banergee
- Swathy Sathish
- Sweta Shah
- Syed Faisal Mahmood
- Syed Zahid Bukhari
- Tahsine Mahfouz
- Tala Kardas
- Tamiris Moreira
- Tanıl Kendirli
- Tanja Anguseva
- Tanu Singhal
- Tao Lili
- Tarek Dendane
- Tarquino Eristidesg Sanchez
- Tatiane T. Rodrigues
- Tenzin Zompa
- Teodora Atencio-Espinoza
- Tereza De Jesus Pinheiro Gomes Bandeira
- Thara Francis
- Thejas Vini
- Tomas Kondratas
- Tomasz Lazowski
- Tran Thi My Hanh
- Tran Thi Thuy Hang
- Trudell Mapp
- Truong Anh Thu
- Tânia Mara Lima De Barros Araújo
- Ufuk Cakir
- Umesh Gupta
- V. Raut
- V.R. Ramanan
- Vaibhavi R. Subhedar
- Vaidotas Gurskis
- Valentina Tulupova
- Valter Furlan
- Vanessa A. Marquez Mondalgo
- Vanessa Bermudez
- Vatsal Kothari
- Velmira Angelova Velinova
- Velu Pandi Suresh Kumar
- Vempati Venkateshwar
- Victor Dumitrascu
- Victoria D. Villanueva
- Vikram Padbidri
- Vineya Rai
- Violeta Jivkova Dicheva
- Visanu Thamlikitkul
- Vladimir Kretov
- Vladimir Shalapuda
- Vladislav Belskiy
- Vo Thi Hong Thoa
- Víctor Daniel Rosenthal
- Walter Enrique Prudencio Leon
- Walter Enrique Prudencio Leon
- Wan Nurbayah Wan Yusoff
- Wania Vasconcelos de Freitas
- Wieslawa Duszynska
- Wilmer Villamil-Gomez
- Wong Kang Kwong
- Wu Kangxiong
- Xihua Geng
- Xiuqin Guo
- Xu Ziqin
- Xuesong Yang
- Yasemin Gelebek
- Yassir Khidir Mohammed
- Yatin Mehta
- Yazmin Leon Vega
- Yiang Shumei
- Yuet-Meng Cheong
- Yuri Mariela Perez Hernandez
- Yvis Ruiz
- Zan Mitrev
- Zaneta Bogoevska-Miteva
- Zeina Kanafani
- Zeinab Salah Seliem
- Zenaida Durán Gil De Añez
- Zeynel Gokmen
- Zeynep Kaya
- Ziad Ahmed Memish
- Zoila Rosa Diaz Tavera
- Zoila Rosa Diaz Tavera
- Çağlar Ödek
- Publication venue
- Elsevier Inc
- Publication date
- 01/09/2014
- Field of study
We report the results of an International Nosocomial Infection Control Consortium (INICC) surveillance study from January 2007-December 2012 in 503 intensive care units (ICUs) in Latin America, Asia, Africa, and Europe. During the 6-year study using the Centers for Disease Control and Prevention's (CDC) U.S. National Healthcare Safety Network (NHSN) definitions for device-associated health care–associated infection (DA-HAI), we collected prospective data from 605,310 patients hospitalized in the INICC's ICUs for an aggregate of 3,338,396 days. Although device utilization in the INICC's ICUs was similar to that reported from ICUs in the U.S. in the CDC's NHSN, rates of device-associated nosocomial infection were higher in the ICUs of the INICC hospitals: the pooled rate of central line–associated bloodstream infection in the INICC's ICUs, 4.9 per 1,000 central line days, is nearly 5-fold higher than the 0.9 per 1,000 central line days reported from comparable U.S. ICUs. The overall rate of ventilator-associated pneumonia was also higher (16.8 vs 1.1 per 1,000 ventilator days) as was the rate of catheter-associated urinary tract infection (5.5 vs 1.3 per 1,000 catheter days). Frequencies of resistance of Pseudomonas isolates to amikacin (42.8% vs 10%) and imipenem (42.4% vs 26.1%) and Klebsiella pneumoniae isolates to ceftazidime (71.2% vs 28.8%) and imipenem (19.6% vs 12.8%) were also higher in the INICC's ICUs compared with the ICUs of the CDC's NHSN
An international observational study to assess the impact of the Omicron variant emergence on the clinical epidemiology of COVID-19 in hospitalised patients
- Author
- A M Udara Lakshan Attanyake
- Aasiyah Rashan
- Aasiyah Rashan
- Abby Hurd
- Abdulrahman Al-Fares
- Abhishek Dasgupta
- Abigail Beane
- Adrian Streinu-Cercel
- Adrienne Chan
- Aidan Burrell
- Alan Hartman
- Alberto Uribe
- Alejandro Martin-Quiros
- Alejandro Martín-Quiros
- Alejandro Martín-Quiros
- Aleksander Rygh Holten
- Alexander J Mentzer
- Alfredo Antonio Chetta
- Ali Abbas
- Alicia Gonzalez
- Alison M Meynert
- Alistair Nichol
- Allison McGeer
- Ama Kwakyewaa Bedu-Addo
- Amanda Corley
- Amanda Rojek
- Amanda Rojek
- Amar Bhatt
- Amna Faheem
- Amy Lester-Grant
- Ana Aroca
- Ana da Silva Filipe
- Ana Freitas Ribeiro
- Anais Rampello
- Anant Kataria
- Anca Streinu-Cercel
- Anca Streinu-Cercel
- Anders Benjamin Kildal
- Anders Kildal
- Anders Tveita
- Andra-Maris Post
- Andrea Angheben
- Andrea Ticinesi
- Andrea Villoldo
- Andreas Lind
- Andrew Dagens
- Andrew Letizia
- Andy Law
- Angela Alberti
- Anja Grosse Lordemann
- Anna Berenguera
- Anne Margarita Dyrhol-Riise
- Anne McCarthy
- Anne-Marie Guerguerian
- Annemarie B Docherty
- Antonia Ho
- Antonio Arcadipane
- Arabella Fahy
- Ardiyan Apriyana
- Arjen M Dondorp
- Asgar Rishu
- Asgar Rishu
- Astarini Hidayah
- Audrey Dubot-Pérès
- B P Sanka Ruwan Sri Darshana
- Barbara Wanjiru Citarella
- Barbara Wanjiru Citarella
- Beathe Kiland Granerud
- Beatrice Alex
- Benjamin Bach
- Bianca Boxma
- Birgitte Stiksrud
- Bounthavy Chaleunphon
- Bountoy Sibounheuang
- Brenda Molloy
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- Brigid Flynn
- Bronner P Gonçalves
- Bronner P Gonçalves
- Budha Charan Singh
- Cameron J Fairfield
- Carlo Ferrari
- Carlos Cañada Illana
- Carlotta Mutti
- Caroline Martins Rego
- Caroline Mudara
- Carrol Gamble
- Cassidy Codan
- Caterina Caminiti
- Catherine A Shaw
- Catherine Blier
- Catherine Marquis
- Cecilia Canepa
- Ceila Maria Sant Ana Malaque
- Chamira Kodippily
- Charlotte Summers
- Chiara Vitiello
- Chloe Donohue
- Chris Kandel
- Christel Arnold-Day
- Christiana Kartsonaki
- Christiana Kartsonaki
- Christl A Donnelly
- Christophe Fraser
- Christopher A Green
- Clare Jackson
- Clark D Russell
- Claudia Bianco
- Claudia Figueiredo-Mello
- Claudia Figueiredo-Mello
- Claudia Montes
- Colin McArthur
- Cornelius Rau
- Dafsah Juzar
- Dag Henrik Reikvam
- Dan Meyer
- Daniel Haber
- Daniel Marino
- Danoy Chommanam
- David Bellemare
- David L Robertson
- David Maslove
- David S Y Ong
- David S Y Ong
- David Stuart
- David Thomson
- Debby Bogaert
- Deepali Kumar
- Demetrios Kutsogiannis
- Derbrenn OConnor
- Diego Fernando Bautista Rincon
- Diego Franch-Llasat
- Diptesh Aryal
- Diptesh Aryal
- Dori-Ann Martin
- Dounia Bouhmani
- Edel Meaney
- Eder Caceres
- Efstathia Mihelis
- Egle Saviciute
- Elaine McPartlan
- Elena Molinos
- Elena Ranza
- Elizabeth A Ashley
- Ellen Shadowitz
- Else Quist-Paulsen
- Eman Al Qasim
- Emily Neumann
- Emma C Thomson
- Emmanuelle A Dankwa
- Emmanuelle Denis
- Enrico Adriano
- Esteban Garcia-Gallo
- Eva Miranda Marwali
- Evert-Jan Wils
- Evert-Jan Wils
- Ewen M Harrison
- Ewen M Harrison
- Federica Fogliazza
- Federica Garofalo
- Felwa Bin Humaid
- Ferran Roche-Campo
- Fiona Griffiths
- Francesca Carlacci
- Francesco Rausa
- Francisca Adewhajah
- Frank Manetta
- Frank Olav Pettersen
- Franklina Korkor Abebrese
- François Lamontagne
- François Martin Carrier
- François Martin Carrier
- Fredrik Müller
- Frédérick D'Aragon
- G Argin
- Gail Carson
- Gail Carson
- Gamage Dona Dilanthi Priyadarshani
- Gary Leeming
- Gary Schwartz
- Gayle Carney
- Gennaro Martucci
- Georgios Pollakis
- Geraldine Goco
- Gianluigi Li Bassi
- Giorgio Economopoulos
- Giovanna Occhipinti
- Giovanna Panarello
- Giuseppe Maglietta
- Gloria Crowl
- Graham S Cooke
- Gry Kloumann Bekken
- Gyan Sandhu
- Haixia Shi
- Hannah Habraken
- Hannah Keane
- Hannah Marrinan
- Hayley Hardwick
- Hazel Bergin
- Heidi Dalton
- Hem Paneru
- Henrique Mateus Fernandes
- Himasha Muvindi
- Himed Musaab
- Hubert Tessier-Grenier
- Husna Begum
- Iam Claire E Sarmiento
- Ignacio Martin-Loeches
- Ilaria Valzano
- Imrana Khalid
- Indrek Rätsep
- Ingrid G Bustos
- Inês Carqueja
- Irene Bandoh
- ISARIC Clinical Characterisation Group
- J Kenneth Baillie
- J Kenneth Baillie
- Jacky Y Suen
- Jake Dunning
- Jake Dunning
- James Joshua Douglas
- James Joshua Douglas
- James Lee
- James Scott-Brown
- James Vickers
- Jan Cato Holter
- Janet Diaz
- Janet Harrison
- Janet Liang
- Janet T Scott
- Janice Caoili
- Janice Caoili
- Jaques Sztajnbok
- Jeff Powis
- Jennifer Lee
- Jess Gibson
- Jia Wei
- Jillian Deacon
- Jo Dalton
- Joan Gómez-Junyent
- Joan Gómez-Junyent
- Joanne Downey
- Joaquín Baruch
- Joaquín Baruch
- John Beca
- John F Fraser
- John Marshall
- Johnny McKeown
- Jonathan Bitton
- Jordi Rello
- José Antonio Lepe
- José Ernesto Vidal
- João Camões
- Juan Fiorda
- Juan Pablo Horcajada
- Judit Villar
- Julia Garcia-Diaz
- Julian Chica
- Kalynn Kennon
- Kamal Abu Jabal
- Karl Erik Müller
- Karolina Krawczyk
- Kate Ainscough
- Kathy Brickell
- Katie O'Hearn
- Kenneth A McLean
- Kevin Katz
- Kizy Sanchez de Oliveira
- Kristian Tonby
- Kusum Menon
- Lance C W Turtle
- Lars Hegelund
- Lars Heggelund
- Latsaniphone Bountthasavong
- Laura Feeney
- Laura Marsh
- Laura Merson
- Laura Merson
- Laura Patrizi
- Laveena Munshi
- Leanne Hays
- Leonardo Salazar
- Leonardo Salazar
- Liadain Reid
- Lina Morales Cely
- Linda Gail Skeie
- Linda O'Shea
- Lisa Norman
- Lisa Patterson
- Liv Hesstvedt
- Lorinda Essuman
- Lorna Murphy
- Louise Sigfrid
- Luca Sacchelli
- Lucian Durham
- Lucille Blumberg
- Luis Felipe Reyes
- Luis Felipe Reyes
- Luis Periel
- Lukas Arenz
- Madiha Hashmi
- Madiha Hashmi
- Mahdad Noursadeghi
- Malcolm G Semple
- Malcolm G Semple
- Mangala Narasimhan
- Manivanh Vongsouvath
- Maram Zahran
- Marco Echeverria-Villalobos
- Mare Pejkovska
- Margarite Grable
- Maria Angelica Rivera Nuñez
- Maria Donnelly
- Maria Lawrensia Tampubolon
- Maria Majori
- Maria Zambon
- Marianne Fraher
- Mariano Esperatti
- Marie Connor
- Marina Aiello
- Marina Lanza
- Mark G Pritchard
- Mark Pritchard
- Marlene Santos
- Martina Escher
- Mary Copland
- Massimo Palmarini
- Matteo Puntoni
- Matteo Rossetti
- Matthew Hall
- Matthew Hall
- Matthew Nelder
- Mayfong Mayxay
- Meera Chand
- Melissa Parker
- Mical Paul
- Michael Edelstein
- Michael Varrone
- Michaela Barnikel
- Michele Petrovic
- Michelle E Kho
- Michelle Girvan
- Michelle Smyth
- Mohd Basri Mat Nor
- Mohiuddin Shiekh
- Moirangthem Bikram Singh
- Moritz U G Kraemer
- Moses Siaw-Frimpong
- Muge Cevik
- Murray Dryden
- Murray Wham
- Musharaf Sadat
- Nashat Abu Salah
- Nathaniel Christy
- Netta Beer
- Nick Daneman
- Nicola Latronico
- Nicole White
- Nidyanara Castanheira
- Nina Jamieson
- Nora Fuentes
- Oana Sandulescu
- Obada Yousif
- Oleksa Rewa
- Ooyanong Phonemixay
- P G Ishara Udayanga
- Paa Kobina Forson
- Paddy Mallon
- Paolo Parducci
- Pathik Dhanger
- Patricia Fontela
- Patricia Gordon
- Patrick Archambault
- Patrizia Bonelli
- Patrizia Mammi
- Paul Klenerman
- Paul Tierney
- Paula Custodio
- Perren J Cobb
- Peter Daley
- Peter Doran
- Peter Horby
- Peter Horby
- Peter Kiiza
- Peter Openshaw
- Phil Gallagher
- Philippe Jouvet
- Phoebe Ampaw
- Phouvieng Douangdala
- Piero L Olliaro
- Piero L Olliaro
- Piret Sillaots
- Pompini Agustina Sitompul
- Pooja Varghese
- Prasan Kumar Panda
- Rachael McConnochie
- Rachael Parke
- Rajavardhan Rangappa
- Rajavardhan Rangappa
- Rajesh Mohan Shetty
- Rakesh Arora
- Rashan Haniffa
- Renata Barbalho
- Richard S Tedder
- Riinu Pius
- Rima Song
- Rob Fowler
- Robert A Fowler
- Roberta Cavalin
- Roberta Pisi
- Roberto Roncon-Albuquerque
- Robin Kobbe
- Romans Matulevics
- Rosario Maria Torres Santos-Olmo
- Ross Hendry
- Rumaisah Satyawati
- Rupert Higgins
- Ruth Lyons
- Ryan S Thwaites
- Sabina Mason
- Sadie Kelly
- Sally Shrapnel
- Samreen Ijaz
- Samuel Hinton
- Sandra Rossi
- Sanne Wesselius
- Santi Dewayanti
- Saptadi Yuliarto
- Sara Clohisey
- Sarah E McDonald
- Sarah Moore
- Saye Khoo
- Scott Pharand
- Sebastian Vencken
- Seán Keating
- Shaikh Sharjeel
- Sharma Keshav
- Shaun Thompson
- Sheryl Ann Abdukahil
- Shiranee Sriskandan
- Shirley Sarfo-Mensah
- Shona C Moore
- Silvia Bertagnolio
- Silvia Castañeda
- Simon Forsyth
- Simone Piva
- Soe Soe Thwin
- Sophia Ankrah
- Sophie Halpin
- Soulichanya Phoutthavong
- Sree Satyapriya
- Srinivas Murthy
- Srinivas Murthy
- Stephanie Roberts
- Stephanie Yerkovich
- Stephanie-Susanne Stecher
- Stephen R Knight
- Steve Webb
- Sue Smith
- Summer Hamza
- Surya Otto Wijaya
- Susanne Dudman
- Synne Jenum
- Sérgio Gaião
- Sílvia Ferreira
- Teresa Lawrence
- Thalha Rashan
- Thipsavanh Bounphiengsy
- Thushan de Silva
- Timothy M Uyeki
- Tirupakuzhi Vijayaraghavan
- Tiziana Meschi
- Tom Drake
- Tom Fletcher
- Tom Solomon
- Touxiong Yiaye
- Trude Steinsvik
- Uluhan Sili
- Valeria Balan
- Valeria Balan
- Valla Sahraei
- Vanessa Sancho-Shimizu
- Vegard Skogen
- Victoria Shaw
- Viladeth Praphasiri
- Vilmaris Quinones-Cardona
- Volkan Korten
- Waasila Jassat
- Waasila Jassat
- Wei Shen Lim
- Wendy S Barclay
- William A Paxton
- William Dechert
- William Greenhalf
- Wilna Oosthuyzen
- Xin Ci Wong
- Xin Ci Wong
- Yael Dishon
- Yaseen Arabi
- Yaseen Arabi
- Yock Ping Chow
- Yock Ping Chow
- Yvelynne Kelly
- Zulfiqar Sandhu
- Publication venue
- 'eLife Sciences Publications, Ltd'
- Publication date
- 01/01/2022
- Field of study
Background: Whilst timely clinical characterisation of infections caused by novel SARS-CoV-2 variants is necessary for evidence-based policy response, individual-level data on infecting variants are typically only available for a minority of patients and settings.
Methods: Here, we propose an innovative approach to study changes in COVID-19 hospital presentation and outcomes after the Omicron variant emergence using publicly available population-level data on variant relative frequency to infer SARS-CoV-2 variants likely responsible for clinical cases. We apply this method to data collected by a large international clinical consortium before and after the emergence of the Omicron variant in different countries.
Results: Our analysis, that includes more than 100,000 patients from 28 countries, suggests that in many settings patients hospitalised with Omicron variant infection less often presented with commonly reported symptoms compared to patients infected with pre-Omicron variants. Patients with COVID-19 admitted to hospital after Omicron variant emergence had lower mortality compared to patients admitted during the period when Omicron variant was responsible for only a minority of infections (odds ratio in a mixed-effects logistic regression adjusted for likely confounders, 0.67 [95% confidence interval 0.61-0.75]). Qualitatively similar findings were observed in sensitivity analyses with different assumptions on population-level Omicron variant relative frequencies, and in analyses using available individual-level data on infecting variant for a subset of the study population.
Conclusions: Although clinical studies with matching viral genomic information should remain a priority, our approach combining publicly available data on variant frequency and a multi-country clinical characterisation dataset with more than 100,000 records allowed analysis of data from a wide range of settings and novel insights on real-world heterogeneity of COVID-19 presentation and clinical outcome
At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods
- Author
- Abdukahil Sheryl Ann
- Abdulkadir Nurul Najmee
- Abe Ryuzo
- Abel Laurent
- Abreu Julia Rodriguez
- Abrous Amal
- Absil Lara
- Acker Andrew
- Adachi Shingo
- Adam Elisabeth
- Adriano Enrico
- Adrião Diana
- Ageel Saleh Al
- Ahmed Shakeel
- Aiello Marina
- Ainscough Kate
- Airlangga Eka
- Aisa Tharwat
- Akimoto Takako
- Akmal Ernita
- Al-dabbous Tala
- Al-Fares Abdulrahman
- Alalqam Razi
- Alberti Angela
- Alegesan Senthilkumar
- Alegre Cynthia
- Alessi Marta
- Alex Beatrice
- Alexandre Kévin
- Alfoudri Huda
- Ali Adam
- Ali Imran
- Alidjnou Kazali Enagnon
- Aliudin Jeffrey
- Alkhafajee Qabas
- Allavena Clotilde
- Allou Nathalie
- Alves João
- Alves João Melo
- Alves Rita
- Amaral Maria
- Amira Nur
- Ammerlaan Heidi
- Ampaw Phoebe
- Andini Roberto
- Andréjak Claire
- Angheben Andrea
- Angoulvant François
- Ansart Séverine
- Anthonidass Sivanesen
- Antonelli Massimo
- Anwar Kazi Rubayet
- Apriyana Ardiyan
- Arabi Yaseen
- Aragao Irene
- Arancibia Francisco
- Araujo Carolline
- Arcadipane Antonio
- Archambault Patrick
- Arenz Lukas
- Arlet Jean-Benoît
- Arnold-Day Christel
- Arora Lovkesh
- Arora Rakesh
- Artaud-Macari Elise
- Aryal Diptesh
- Asaki Motohiro
- Asensio Angel
- Ashley Elizabeth A.
- Ashraf Muhammad
- Assie Jean Baptiste
- Asyraf Amirul
- Atique Anika
- Attanyake AM Udara Lakshan
- Auchabie Johann
- Auger Christelle Chantalat
- Aumaitre Hugues
- Auvet Adrien
- Azemar Laurène
- Azoulay Cecile
- Bach Benjamin
- Bachelet Delphine
- Badr Claudine
- Baig Nadia
- Baillie J. Kenneth
- Baird J Kevin
- Bak Erica
- Bakakos Agamemnon
- Bakar Nazreen Abu
- Bal Andriy
- Balakrishnan Mohanaprasanth
- Balan Valeria
- Banheiro Bruno Sarmento
- Bani-Sadr Firouzé
- Barbalho Renata
- Barbosa Nicholas Yuri
- Barclay Wendy S.
- Barnett Saef Umar
- Barnikel Michaela
- Barrasa Helena
- Barrelet Audrey
- Barrigoto Cleide
- Bartoli Marie
- Baruch Joaquín
- Basmaci Romain
- Basri Muhammad Fadhli Hassin
- Bassi Gianluigi Li
- Battaglini Denise
- Bauer Jules
- Beane Abigail
- Bedossa Alexandra
- Bee Ker Hong
- Begum Husna
- Behilill Sylvie
- Beishuizen Albertus
- Bekken Gry Kloumann
- Beljantsev Aleksandr
- Bellemare David
- Beltrame Anna
- Beltrão Beatriz Amorim
- Beluze Marine
- Benech Nicolas
- Benjiman Lionel Eric
- Benkerrou Dehbia
- Bennett Suzanne
- Bento Luís
- Berdal Jan-Erik
- Berge Marcel van den
- Bergeaud Delphine
- Bergin Hazel
- Bertoli Giulia
- Bertolino Lorenzo
- Bessis Simon
- Betz Adam
- Bevilcaqua Sybille
- Bezulier Karine
- Bhatt Amar
- Bhavsar Krishna
- Bianco Claudia
- Bidin Farah Nadiah
- Bihan Clément Le
- Bisoffi Zeno
- Bissuel François
- Biston Patrick
- Bitker Laurent
- Bitton Jonathan
- Blanco-Schweizer Pablo
- Blier Catherine
- Bloos Frank
- Blot Mathieu
- Blumberg Lucille
- Boccia Filomena
- Bodenes Laetitia
- Bogaert Debby
- Boivin Anne-Hélène
- Bolaños Isabela
- Bolze Pierre-Adrien
- Bompart François
- Bonelli Patrizia
- Bonfasius Aurelius
- Borges Diogo
- Borie Raphaël
- Bosse Hans Martin
- Botelho-Nevers Elisabeth
- Bouadma Lila
- Bouchaud Olivier
- Bouchez Sabelline
- Bouhmani Dounia
- Bouhour Damien
- Bouiller Kévin
- Bouillet Laurence
- Bouisse Camile
- Bounphiengsy Thipsavanh
- Bountthasavong Latsaniphone
- Boureau Anne-Sophie
- Bourke John
- Bouscambert Maude
- Bousquet Aurore
- Bouziotis Jason
- Boxma Bianca
- Boyer-Besseyre Marielle
- Boylan Maria
- Bozza Fernando Augusto
- Braconnier Axelle
- Braga Cynthia
- Brandenburger Timo
- Brazzi Luca
- Breen Dorothy
- Breen Patrick
- Brewster David
- Brickell Kathy
- Brien Fionnuala O
- Bris Cyril Le
- Browne Alex
- Browne Shaunagh
- Brozzi Nicolas
- Brusse-Keizer Marjolein
- Buchtele Nina
- Bugaeva Polina
- Buisson Marielle
- Buonsenso Danilo
- Burhan Erlina
- Burrell Aidan
- Bustos Ingrid G.
- Butnaru Denis
- Cabie André
- Cabral Susana
- Cabrita Joana Alves
- Caceres Eder
- Cadoz Cyril
- Callaghan Annmarie O
- Callahan Mia
- Calligy Kate
- Calvache Jose Andres
- Caminiti Caterina
- Camões João
- Campana Valentine
- Campbell Paul
- Campisi Josie
- Canepa Cecilia
- Cantero Mireia
- Caraux-Paz Pauline
- Cardellino Chiara Simona
- Cardoso Filipa
- Cardoso Filipe
- Cardoso Nelson
- Cardoso Sofia
- Carelli Simone
- Carlacci Francesca
- Carlier Nicolas
- Carmoi Thierry
- Carney Gayle
- Carqueja Inês
- Carret Marie-Christine
- Carrier François Martin
- Carroll Ida
- Carson Gail
- Carvalho Leonor
- Casanova Maire-Laure
- Cascão Mariana
- Casey Siobhan
- Casimiro José
- Cassandra Bailey
- Castanheira Nidyanara
- Castañeda Silvia
- Castor-Alexandre Guylaine
- Castro Ivo
- Catarino Ana
- Catherine François-Xavier
- Cattaneo Paolo
- Cavalin Roberta
- Cavalli Giulio Giovanni
- Cavayas Alexandros
- Cárcel Sheila
- Ceccato Adrian
- Cely Lina Morales
- Cerkovnik Shelby
- Cervantes-Gonzalez Minerva
- Chair Anissa
- Chakveatze Catherine
- Chaleunphon Bounthavy
- Chan Adrienne
- Chand Meera
- Chapplain Jean-Marc
- Charpentier Charlotte
- Chas Julie
- Chatterjee Allegra
- Chau Nguyen Van Vinh
- Chen Anjellica
- Chenard Léo
- Cheng Matthew Pellan
- Cheret Antoine
- Chetta Alfredo Antonio
- Chia Jack Song
- Chiarabini Thibault
- Chica Julian
- Chidambaram Suresh Kumar
- Chirouze Catherine
- Chiumello Davide
- Cho Hwa Jin
- Cho Sung-Min
- Choileain Orna Ni
- Cholley Bernard
- Chommanam Danoy
- Chopin Marie-Charlotte
- Chow Ting Soo
- Chow Yock Ping
- Christy Nathaniel
- Chua Hiu Jian
- Chua Jonathan
- Cidade Jose Pedro
- Citarella Barbara Wanjiru
- Citarella Barbara Wanjiru
- Ciullo Anna
- Clarke Emma
- Clarke Jennifer
- Clifton Lei
- Clohisey Sara
- Codan Cassidy
- Cody Caitriona
- Coelho Alexandra
- Coles Jennifer
- Coles Megan
- Colin Gwenhaël
- Collins Michael
- Colombo Sebastiano Maria
- Combs Pamela
- Connor Marie
- Conrad Anne
- Contreras Sofía
- Conway Elaine
- Cooke Graham S.
- Copland Mary
- Cordel Hugues
- Corley Amanda
- Cornelis Sabine
- Cornet Alexander Daniel
- Corpuz Arianne Joy
- Cortegiani Andrea
- Corvaisier Grégory
- Costigan Emma
- Couffignal Camille
- Couffin-Cadiergues Sandrine
- Courtois Roxane
- Cousse Stéphanie
- Cregan Rachel
- Cristella Cosimo
- Croonen Sabine
- Crowl Gloria
- Crump Jonathan
- Cruz Claudina
- Csete Marc
- Cullen Ailbhe
- Cummings Matthew
- Curley Ger
- Curlier Elodie
- Curran Colleen
- Curto Elena Gallego
- Custodio Paula
- D'Aragon Frédérick
- D'Orleans Charles Crepy
- D'Ortenzio Eric
- da Silva Filipe Ana
- Da Silva Fernanda Dias
- Da Silveira Charlene
- Dabaliz Al-Awwab
- Dagens Andrew
- Dahly Darren
- Dalton Heidi
- Dalton Jo
- Daly Seamus
- Damas Juliana
- Daneman Nick
- Daniel Corinne
- Dankwa Emmanuelle A
- Dantas Jorge
- Darshana B. P. Sanka Ruwan Sri
- de Brito Carlos Alexandre Antunes
- de Castro Maisa Guimarães
- de Jong Menno
- de Loughry Gillian
- de Mendoza Diego
- De Montmollin Etienne
- de Oliveira França Rafael Freitas
- de Piero Maria
- de Pinho Oliveira Ana Isabel
- De Rosa Rosanna
- De Rose Cristina
- de Silva Thushan
- de Velde Stijn Van
- de Vries Peter
- Deacon Jillian
- Dean David
- Debard Alexa
- Debray Marie-Pierre
- DeCastro Nathalie
- Dechert William
- Deconninck Lauren
- Decours Romain
- Defous Eve
- Delacroix Isabelle
- Delaveuve Eric
- Delavigne Karen
- Delfos Nathalie M.
- Deligiannis Ionna
- Dell'Amore Andrea
- Delmas Christelle
- Delobel Pierre
- Delsing Corine
- Demonchy Elisa
- Denis Emmanuelle
- Deplanque Dominique
- Depuydt Pieter
- Desai Mehul
- Descamps Diane
- Desvallées Mathilde
- Devouge Eglantine Ferrand
- Dewayanti Santi
- Dhanger Pathik
- Diallo Alpha
- Diamantis Sylvain
- Dias Andrea
- Dias André
- Diaz Juan Jose
- Diaz Priscila
- Diaz Rodrigo
- Didier Kévin
- Diehl Jean-Luc
- Dieperink Wim
- Dimet Jérôme
- Dinot Vincent
- Diop Fara
- Diouf Alphonsine
- Dishon Yael
- Djossou Félix
- Docherty Annemarie B.
- Doherty Helen
- Dominguez Carmen Infante
- Dondorp Arjen M
- Dong Andy
- Donnelly Christl A.
- Donnelly Maria
- Donohue Chloe
- Donohue Sean
- Donohue Yoann
- Doran Peter
- Dorival Céline
- Douangdala Phouvieng
- Douglas James Joshua
- Douma Renee
- Dournon Nathalie
- Dow Denisse Bazan
- Downer Triona
- Downey Joanne
- Downing Mark
- Drake Tom
- Driscoll Aoife
- Dryden Murray
- Dubee Vincent
- Dubos François
- Dubot-Pérès Audrey
- Ducancelle Alexandre
- Duculan Toni
- Dudman Susanne
- Duggal Abhijit
- Dunand Paul
- Dunning Jake
- Duplaix Mathilde
- Durante-Mangoni Emanuele
- Durham Lucian
- Dussol Bertrand
- Duthoit Juliette
- Duval Xavier
- Dyrhol-Riise Anne Margarita
- Ean Sim Choon
- Echeverria-Villalobos Marco
- Economopoulos Giorgio
- Egan Siobhan
- Eira Carla
- Elapavaluru Subbarao
- Elharrar Brigitte
- Ellerbroek Jacobien
- Eloy Philippine
- Elshazly Tarek
- Elyazar Iqbal
- Enderle Isabelle
- Endo Tomoyuki
- Eng Chan Chee
- Engelmann Ilka
- Enouf Vincent
- Epaulard Olivier
- Escher Martina
- Esperatti Mariano
- Esperou Hélène
- Esposito-Farese Marina
- Estevão João
- Etienne Manuel
- Ettalhaoui Nadia
- Everding Anna Greti
- Evers Mirjam
- Fabre Isabelle
- Fabre Marc
- Faheem Amna
- Fahy Arabella
- Fairfield Cameron J.
- Fakar Zul
- Falher Georges Le
- Faria Pedro
- Fateena Hanan
- Fatoni Arie Zainul
- Faure Karine
- Favory Raphaël
- Fayed Mohamed
- Feely Niamh
- Feeney Laura
- Feltz Machteld Van der
- Fernandes Jorge
- Fernandes Marília Andreia
- Fernandes Susana
- Ferrand François-Xavier
- Ferrari Carlo
- Ferraz Mário
- Ferrão Joana
- Ferreira Benigno
- Ferreira Bernardo
- Ferreira Isabel
- Ferreira Sílvia
- Ferrer-Roca Ricard
- Ferriere Nicolas
- Fevre Lucie Le
- Ficko Céline
- Figueiredo-Mello Claudia
- Finlayson William
- Fiorda Juan
- Flament Thomas
- Flateau Clara
- Fletcher Tom
- Florence Aline-Marie
- Florio Letizia Lucia
- Flynn Brigid
- Flynn Deirdre
- Fogliazza Federica
- Foley Claire
- Foley Jean
- Fomin Victor
- Fonseca Claudio Duarte
- Fonseca Tatiana
- Fontela Patricia
- Forsyth Simon
- Foster Denise
- Foti Giuseppe
- Fourn Erwan
- Fowler Robert A.
- Fraher Marianne
- Franch-Llasat Diego
- Fraser Christophe
- Fraser John F
- Freire Marcela Vieira
- Friedrich Caren
- Fritz Ricardo
- Fry Stéphanie
- Fuentes Nora
- Fukuda Masahiro
- G Argin
- Gaborieau Valérie
- Gaci Rostane
- Gagliardi Massimo
- Gagnard Jean-Charles
- Gagneux-Brunon Amandine
- Gaião Sérgio
- Gallagher Phil
- Gamble Carrol
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- Kobbe Robin
- Kodippily Chamira
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- Leeming Gary
- Lefebvre Bénédicte
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- Loschner Anthony L.
- Loubet Paul
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- Meynert Alison M.
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- null null
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- Ong David S. Y.
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- Peariasamy Kalaiarasu
- Peariasamy Kalaiarasu M.
- Peek Giles J.
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- Postma Douwe F.
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- Pritchard Mark G.
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- Rishu Asgar
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- Semple Malcolm G.
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- Taccone Fabio S.
- Tagherset Lysa
- Taib Shahdattul Mawarni
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- Taufik M Azhari
- Tawfik Hassan
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- Thomson Emma C.
- Thurai Surain Raaj Thanga
- Thuy Duong Bich
- Thwaites Ryan S.
- Ticinesi Andrea
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- Tieroshyn Vadim
- Timashev Peter S
- Timsit Jean-François
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- Turnier Paul Le
- Turtle Lance C. W.
- Tveita Anders
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- Uyeki Timothy M.
- Vajdovics Cristinava
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- Valk Paul van der
- Valran Amélie
- Valzano Ilaria
- van Someren Greve Frank
- Vanel Noémie
- Vanoverschelde Henk
- Varghese Pooja
- Varrone Michael
- Vasconcelos Malte Kohns
- Vasudayan Shoban Raj
- Vauchy Charline
- Vecham Pavan Kumar
- Veen Ilonka van
- Veeran Shaminee
- Veislinger Aurélie
- Vekens Nicky Van Der
- Vencken Sebastian
- Ventura Sara
- Verbon Annelies
- Vickers James
- Vidal José Ernesto
- Vieira César
- Villanueva Joy Ann
- Villar Judit
- Villeneuve Pierre-Marc
- Villoldo Andrea
- Vishwanathan Gayatri
- Visseaux Benoit
- Visser Hannah
- Vitiello Chiara
- Vongsouvath Manivanh
- Vonkeman Harald
- Voort Peter Van der
- Vuotto Fanny
- Wahab Noor Hidayu
- Wahab Suhaila Abdul
- Wahid Nadirah Abdul
- Wainstein Marina
- Webb Steve
- Wei Jia
- Weil Katharina
- Wen Tan Pei
- Werf Sylvie Van Der
- Wesselius Sanne
- West T. Eoin
- Wham Murray
- Whelan Bryan
- Wicky Paul Henri
- Wiedemann Aurélie
- Wijaya Surya Otto
- Wille Keith
- Willems Sue
- Williams Patricia J
- Williams Virginie
- Willigen Hugo Van
- Wils Evert-Jan
- Wong Calvin
- Wong Teck Fung
- Wong Xin Ci
- Wong Xin Ci
- Wong Yew Sing
- Wright Natalie
- Xian Gan Ee
- Xian Lim Saio
- Xuan Kuan Pei
- Xynogalas Ioannis
- Yacoub Sophie
- Yakop Siti Rohani Binti Mohd
- Yamazaki Masaki
- Yarad Elizabeth
- Yazdanpanah Yazdan
- Yelnik Cécile
- Yeoh Chian Hui
- Yerkovich Stephanie
- Yiaye Touxiong
- Yiu Ng Wing
- Yokoyama Toshiki
- Yonis Hodane
- Yousif Obada
- Yuliarto Saptadi
- Zaaqoq Akram
- Zabbe Marion
- Zabert Gustavo E
- Zacharowski Kai
- Zahid Masliza
- Zahran Maram
- Zaidan Nor Zaila Binti
- Zambon Maria
- Zambrano Miguel
- Zanella Alberto
- Zawadka Konrad
- Zaynah Nurul
- Zayyad Hiba
- Zoufaly Alexander
- Zucman David
- Publication venue
- Publication date
- 16/07/2024
- Field of study
By September 2022, more than 600 million cases of SARS-CoV-2 infection have been reported globally, resulting in over 6.5 million deaths. COVID-19 mortality risk estimators are often, however, developed with small unrepresentative samples and with methodological limitations. It is highly important to develop predictive tools for pulmonary embolism (PE) in COVID-19 patients as one of the most severe preventable complications of COVID-19. Early recognition can help provide life-saving targeted anti-coagulation therapy right at admission. Using a dataset of more than 800,000 COVID-19 patients from an international cohort, we propose a cost-sensitive gradient-boosted machine learning model that predicts occurrence of PE and death at admission. Logistic regression, Cox proportional hazards models, and Shapley values were used to identify key predictors for PE and death. Our prediction model had a test AUROC of 75.9% and 74.2%, and sensitivities of 67.5% and 72.7% for PE and all-cause mortality respectively on a highly diverse and held-out test set. The PE prediction model was also evaluated on patients in UK and Spain separately with test results of 74.5% AUROC, 63.5% sensitivity and 78.9% AUROC, 95.7% sensitivity. Age, sex, region of admission, comorbidities (chronic cardiac and pulmonary disease, dementia, diabetes, hypertension, cancer, obesity, smoking), and symptoms (any, confusion, chest pain, fatigue, headache, fever, muscle or joint pain, shortness of breath) were the most important clinical predictors at admission. Age, overall presence of symptoms, shortness of breath, and hypertension were found to be key predictors for PE using our extreme gradient boosted model. This analysis based on the, until now, largest global dataset for this set of problems can inform hospital prioritisation policy and guide long term clinical research and decision-making for COVID-19 patients globally. Our machine learning model developed from an international cohort can serve to better regulate hospital risk prioritisation of at-risk patients
Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study
- Author
- Abbas Ali
- Abdukahil Sheryl Ann
- Abe Ryuzo
- Abel Laurent
- Abreu Julia Rodriguez
- Absil Lara
- Acharya Subhash
- Acker Andrew
- Adrião Diana
- Ahmed Shakeel
- Ainscough Kate
- Aisa Tharwat
- Akimoto Takako
- Akmal Ernita
- Al Ageel Saleh
- Al Qasim Eman
- Al-dabbous Tala
- Al-Fares Abdulrahman
- Alalqam Razi
- Alegesan Senthilkumar
- Alegre Cynthia
- Alessi Marta
- Alex Beatrice
- Alexandre Kévin
- Alfoudri Huda
- Ali Imran
- Alidjnou Kazali Enagnon
- Aliudin Jeffrey
- Alkhafajee Qabas
- Allavena Clotilde
- Allou Nathalie
- Altaf Aneela
- Alves João
- Alves João Melo
- Alves Rita
- Amaral Maria
- Ampaw Phoebe
- Andini Roberto
- Andréjak Claire
- Angheben Andrea
- Angoulvant François
- Ansart Séverine
- Antonelli Massimo
- Apriyana Ardiyan
- Arabi Yaseen
- Aragao Irene
- Araujo Carolline
- Arcadipane Antonio
- Archambault Patrick
- Arenz Lukas
- Arlet Jean-Benoît
- Arnold-Day Christel
- Arora Lovkesh
- Arora Rakesh
- Artaud-Macari Elise
- Aryal Diptesh
- Aryal Diptesh
- Asensio Angel
- Asif Namra
- Asim Mohammad
- Assie Jean Baptiste
- Atif Minahel
- Atique Anika
- Attanyake A. M. Udara Lakshan
- Auchabie Johann
- Auger Christelle Chantalat
- Aumaitre Hugues
- Auvet Adrien
- Azemar Laurène
- Azoulay Cecile
- Bach Benjamin
- Bachelet Delphine
- Badr Claudine
- Baig Nadia
- Baillie J. Kenneth
- Bak Erica
- Bakakos Agamemnon
- Bal Andriy
- Balan Valeria
- Balazote Pablo Serrano
- Banheiro Bruno Sarmento
- Bani-Sadr Firouzé
- Barbalho Renata
- Barclay Wendy S.
- Barnikel Michaela
- Barrasa Helena
- Barrelet Audrey
- Barrigoto Cleide
- Barrio Noelia García
- Bartoli Marie
- Baruch Joaquín
- Basmaci Romain
- Bassi Gianluigi Li
- Battaglini Denise
- Bauer Jules
- Beane Abigail
- Bedossa Alexandra
- Begum Husna
- Behilill Sylvie
- Beishuizen Albertus
- Bekken Gry Kloumann
- Beljantsev Aleksandr
- Bellemare David
- Beltrame Anna
- Beluze Marine
- Benech Nicolas
- Benkerrou Dehbia
- Bennett Suzanne
- Bento Luís
- Berdal Jan-Erik
- Bergeaud Delphine
- Bergin Hazel
- Bermejo Carlos Lumbreras
- Bermúdez Juan Luis Cruz
- Bertoli Giulia
- Bertolino Lorenzo
- Bessis Simon
- Bevilcaqua Sybille
- Bezulier Karine
- Bhatt Amar
- Bhavsar Krishna
- Bianco Claudia
- Bissuel François
- Bitker Laurent
- Bitton Jonathan
- Blanco-Schweizer Pablo
- Blier Catherine
- Bloos Frank
- Blot Mathieu
- Boccia Filomena
- Bodenes Laetitia
- Bogaert Debby
- Boivin Anne-Hélène
- Bolze Pierre-Adrien
- Bompart François
- Borges Diogo
- Borie Raphaël
- Bosse Hans Martin
- Botelho-Nevers Elisabeth
- Bouadma Lila
- Bouchaud Olivier
- Bouchez Sabelline
- Bouhmani Dounia
- Bouhour Damien
- Bouiller Kévin
- Bouillet Laurence
- Bouisse Camile
- Boureau Anne-Sophie
- Bourke John
- Bouscambert Maude
- Bousquet Aurore
- Bouziotis Jason
- Boxma Bianca
- Boyer-Besseyre Marielle
- Boylan Maria
- Bozza Fernando
- Braconnier Axelle
- Braga Cynthia
- Brandenburger Timo
- Brazzi Luca
- Breen Dorothy
- Breen Patrick
- Brickell Kathy
- Brien Fionnuala O.
- Browne Alex
- Browne Shaunagh
- Brusse-Keizer Marjolein
- Buchtele Nina
- Buesaquillo Christian
- Bugaeva Polina
- Buisson Marielle
- Burhan Erlina
- Burrell Aidan
- Bustos Ingrid G.
- Butnaru Denis
- Cabie André
- Cabral Susana
- Cabrita Joana Alves
- Caceres Eder
- Cadoz Cyril
- Callaghan Annmarie O.
- Calligy Kate
- Calvache Jose Andres
- Campana Valentine
- Campbell Paul
- Camões João
- Canepa Cecilia
- Cantero Mireia
- Caraux-Paz Pauline
- Cardellino Chiara Simona
- Cardoso Filipa
- Cardoso Filipe
- Cardoso Nelson
- Cardoso Sofia
- Carelli Simone
- Carlier Nicolas
- Carmoi Thierry
- Carney Gayle
- Carqueja Inês
- Carret Marie-Christine
- Carrier François Martin
- Carroll Ida
- Carson Gail
- Casanova Maire-Laure
- Cascão Mariana
- Casey Siobhan
- Casimiro José
- Cassandra Bailey
- Castanheira Nidyanara
- Castañeda Silvia
- Castor-Alexandre Guylaine
- Castrillón Henry
- Castro Ivo
- Catarino Ana
- Catherine François-Xavier
- Cattaneo Paolo
- Cavalin Roberta
- Cavalli Giulio Giovanni
- Cavayas Alexandros
- Ceccato Adrian
- Cely Lina Morales
- Cervantes-Gonzalez Minerva
- Chair Anissa
- Chakveatze Catherine
- Chan Adrienne
- Chand Meera
- Chapplain Jean-Marc
- Chas Julie
- Chaudry Mobin
- Chen Anjellica
- Chen Yih-Sharng
- Cheng Matthew Pellan
- Cheret Antoine
- Chia Jack Song
- Chiarabini Thibault
- Chica Julian
- Chirouze Catherine
- Chiumello Davide
- Cho Sung-Min
- Choileain Orna Ni
- Cholley Bernard
- Chopin Marie-Charlotte
- Cidade Jose Pedro
- Citarella Barbara Wanjiru
- Ciullo Anna
- Clarke Emma
- Clarke Jennifer
- Clohisey Sara
- Cobb Perren J.
- Codan Cassidy
- Cody Caitriona
- Coelho Alexandra
- Coles Megan
- Colin Gwenhaël
- Collins Michael
- Colombo Sebastiano Maria
- Combs Pamela
- Connor Marie
- Conrad Anne
- Contreras Sofía
- Conway Elaine
- Cooke Graham S.
- Copland Mary
- Cordel Hugues
- Corley Amanda
- Cornelis Sabine
- Cornet Alexander Daniel
- Corpuz Arianne Joy
- Cortegiani Andrea
- Corvaisier Grégory
- Costigan Emma
- Couffignal Camille
- Couffin-Cadiergues Sandrine
- Courtois Roxane
- Cousse Stéphanie
- Cregan Rachel
- Croonen Sabine
- Crowl Gloria
- Crump Jonathan
- Cruz Claudina
- Csete Marc
- Cullen Ailbhe
- Cummings Matthew J.
- Curley Ger
- Curlier Elodie
- Curran Colleen
- Custodio Paula
- Cárcel Sheila
- da Silva Filipe Ana
- Da Silveira Charlene
- Dabaliz Al-Awwab
- Dagens Andrew
- Dahly Darren
- Dalton Heidi
- Dalton Jo
- Daly Seamus
- Damas Juliana
- Daneman Nick
- Daniel Corinne
- Dankwa Emmanuelle A.
- Dantas Jorge
- Darshana B. P. Sanka Ruwan Sri
- de Brito Carlos Alexandre Antunes
- de Castro Maisa Guimarães
- de la Calle Guillermo Maestro
- de Loughry Gillian
- de Mendoza Diego
- De Montmollin Etienne
- de Oliveira França Rafael Freitas
- de Pinho Oliveira Ana Isabel
- De Rosa Rosanna
- de Silva Thushan
- de Vries Peter
- Deacon Jillian
- Dean David
- Debard Alexa
- Debray Marie-Pierre
- DeCastro Nathalie
- Dechert William
- Deconninck Lauren
- Decours Romain
- Defous Eve
- Delacroix Isabelle
- Delaveuve Eric
- Delavigne Karen
- Dell’Amore Andrea
- Delmas Christelle
- Delobel Pierre
- Delsing Corine
- Demonchy Elisa
- Denis Emmanuelle
- Deplanque Dominique
- Depuydt Pieter
- Descamps Diane
- Desvallées Mathilde
- Devouge Eglantine Ferrand
- Dewayanti Santi
- Dhanger Pathik
- Diallo Alpha
- Diamantis Sylvain
- Dias André
- Diaz Juan Jose
- Diaz Priscila
- Diaz Rodrigo
- Didier Kévin
- Diehl Jean-Luc
- Dieperink Wim
- Dimet Jérôme
- Dinot Vincent
- Diop Fara
- Diouf Alphonsine
- Dishon Yael
- Djossou Félix
- Docherty Annemarie B.
- Doherty Helen
- Dominguez Carmen Infante
- Dondorp Arjen M.
- Donnelly Christl A.
- Donnelly Maria
- Donohue Chloe
- Donohue Sean
- Donohue Yoann
- Doran Peter
- Dorival Céline
- Douglas James Joshua
- Dournon Nathalie
- Dow Denisse Bazan
- Downer Triona
- Downey Joanne
- Downing Mark
- Drake Tom
- Driscoll Aoife
- Dubee Vincent
- Dubos François
- Ducancelle Alexandre
- Dudman Susanne
- Dunand Paul
- Dunning Jake
- Duplaix Mathilde
- Duque Sara
- Durante-Mangoni Emanuele
- Durham Lucian
- Dussol Bertrand
- Duthoit Juliette
- Duval Xavier
- Dyrhol-Riise Anne Margarita
- D’Aragon Frédérick
- D’Ortenzio Eric
- Echeverria-Villalobos Marco
- Egan Siobhan
- Eira Carla
- Elapavaluru Subbarao
- Elharrar Brigitte
- Ellerbroek Jacobien
- Eloy Philippine
- Elshazly Tarek
- Enderle Isabelle
- Endo Tomoyuki
- Engelmann Ilka
- Enouf Vincent
- Epaulard Olivier
- Escher Martina
- Esperatti Mariano
- Esperou Hélène
- Esposito-Farese Marina
- Estevão João
- Etienne Manuel
- Ettalhaoui Nadia
- Everding Anna Greti
- Evers Mirjam
- Fabre Isabelle
- Fabre Marc
- Faheem Amna
- Fahy Arabella
- Fairfield Cameron J.
- Fakar Zul
- Fareed Komal
- Faria Pedro
- Farooq Ahmed
- Fatoni Arie Zainul
- Faure Karine
- Favory Raphaël
- Fayed Mohamed
- Feely Niamh
- Feeney Laura
- Fernandes Jorge
- Fernandes Marília Andreia
- Fernandes Susana
- Ferrand François-Xavier
- Ferraz Mário
- Ferreira Benigno
- Ferreira Bernardo
- Ferreira Isabel
- Ferreira Sílvia
- Ferrer-Roca Ricard
- Ferriere Nicolas
- Ferrão Joana
- Ficko Céline
- Figueiredo-Mello Claudia
- Fiorda Juan
- Flament Thomas
- Flateau Clara
- Fletcher Tom
- Florio Letizia Lucia
- Flynn Deirdre
- Foley Claire
- Foley Jean
- Fomin Victor
- Fonseca Claudio Duarte
- Fonseca Tatiana
- Fontela Patricia
- Forsyth Simon
- Foster Denise
- Foti Giuseppe
- Fourn Erwan
- Fowler Robert A.
- Fraher Marianne
- Franch-Llasat Diego
- Fraser Christophe
- Fraser John F.
- Freire Marcela Vieira
- French Craig
- Friedrich Caren
- Fry Stéphanie
- Fuentes Nora
- Fuentes Yuli V.
- Fukuda Masahiro
- G Argin
- Gaborieau Valérie
- Gaci Rostane
- Gagliardi Massimo
- Gagnard Jean-Charles
- Gagneux-Brunon Amandine
- Gaião Sérgio
- Gallagher Phil
- Gamble Carrol
- Gandonniere Charlotte Salmon
- Garan Arthur
- Garcia Rebekha
- Garcia-Gallo Esteban
- Garcês Rui Caetano
- García Ruth N. Jorge
- Garimella Navya
- Garot Denis
- Garrait Valérie
- Gauli Basanta
- Gault Nathalie
- Gavin Aisling
- Gavrylov Anatoliy
- Gaymard Alexandre
- Gebauer Johannes
- Geraud Eva
- Germano Nuno
- Ghosn Jade
- Giani Marco
- Gibson Jess
- Gigante Tristan
- Gilg Morgane
- Gilroy Elaine
- Giordano Guillermo
- Girvan Michelle
- Gissot Valérie
- Glikman Daniel
- Glybochko Petr
- Gnall Eric
- Goco Geraldine
- Goehringer François
- Goepel Siri
- Goffard Jean-Christophe
- Golob Jonathan
- Gominet Marie
- Gonzalez Alicia
- González Víctor Quirós
- Gonçalves Bronner P.
- Gordon Patricia
- Gorenne Isabelle
- Goubert Laure
- Goujard Cécile
- Goulenok Tiphaine
- Grable Margarite
- Graf Jeronimo
- Grandin Edward Wilson
- Granerud Beathe Kiland
- Granier Pascal
- Grasselli Giacomo
- Green Christopher A.
- Greene Courtney
- Greenhalf William
- Greffe Segolène
- Grieco Domenico Luca
- Griffee Matthew
- Griffiths Fiona
- Groenendijk Albert
- Gruner Heidi
- Gu Yusing
- Guedj Jérémie
- Guego Martin
- Guellec Dewi
- Guerguerian Anne-Marie
- Guerreiro Daniela
- Guery Romain
- Guillaumot Anne
- Guilleminault Laurent
- Guimard Thomas
- Gómez-Junyent Joan
- Haalboom Marieke
- Haber Daniel
- Habraken Hannah
- Hachemi Ali
- Hadri Nadir
- Haidri Fakhir
- Hakak Sheeba
- Hall Adam
- Hall Matthew
- Halpin Sophie
- Hameed Jawad
- Hamer Ansley
- Hamidfar Rebecca
- Hammond Terese
- Haniffa Rashan
- Hardwick Hayley
- Harrison Ewen M.
- Harrison Janet
- Harrison Samuel Bernard Ekow
- Hasan Mohd Shahnaz
- Hashmi Junaid
- Hashmi Madiha
- Hayat Muhammad
- Hayes Ailbhe
- Hays Leanne
- Heerman Jan
- Heggelund Lars
- Hendry Ross
- Hennessy Martina
- Hentzien Maxime
- Herreros José Miguel Cisneros
- Hershey Andrew
- Hesstvedt Liv
- Hidayah Astarini
- Higgins Dawn
- Higgins Eibhilin
- Higgins Rupert
- Hinchion Rita
- Hinton Samuel
- Hitoto Hikombo
- Ho Antonia
- Hoctin Alexandre
- Hoffmann Isabelle
- Hoiting Oscar
- Holt Rebecca
- Holten Aleksander Rygh
- Holter Jan Cato
- Horby Peter
- Horcajada Juan Pablo
- Hoshino Koji
- Hoshino Kota
- Houas Ikram
- Hough Catherine L.
- Hssain Ali Ait
- Hsu Jimmy Ming-Yang
- Hulot Jean-Sébastien
- Humaid Felwa Bin
- Huo Stella
- Hurd Abby
- Hussain Iqbal
- Ibáñez-Prada Elsa D.
- Ijaz Samreen
- Ikram Arfan
- Illes Hajnal-Gabriela
- Imbert Patrick
- Imran Mohammad
- Imtiaz Aftab
- Inácio Hugo
- Ippolito Mariachiara
- Isgett Sarah
- Isidoro Tiago
- Isnard Margaux
- Ivulich Daniel
- Iñiguez Jonathan Samuel Chávez
- Jaafar Danielle
- Jaafoura Salma
- Jabot Julien
- Jackson Clare
- Jamieson Nina
- Jaquet Pierre
- Jaud-Fischer Coline
- Jaureguiberry Stéphane
- Jego Florence
- Jenum Synne
- Jiménez Miguel Pedrera
- Joseph Cédric
- Joseph Mark
- Joshi Swosti
- Jourdain Mercé
- Jouvet Philippe
- Jung Anna
- Juzar Dafsah
- Kafif Ouifiya
- Kaguelidou Florentia
- Kali Sabina
- Kalomoiri Smaragdi
- Kandamby Darshana Hewa
- Kandel Chris
- Kanwal Darakhshan
- Kartsonaki Christiana
- Kataria Anant
- Katz Kevin
- Kay Christy
- Keane Hannah
- Keating Seán
- Kelly Andrea
- Kelly Aoife
- Kelly Claire
- Kelly Niamh
- Kelly Sadie
- Kelly Yvelynne
- Kelsey Maeve
- Kennon Kalynn
- Kernan Maeve
- Kerroumi Younes
- Keshav Sharma
- Khalid Imrana
- Khalid Osama
- Khalil Antoine
- Khan Coralie
- Khan Irfan
- Khan Quratul Ain
- Khan Rashid Nasim
- Khanal Sushil
- Khatak Abid
- Khawaja Amin
- Kho Michelle E.
- Khoo Saye
- Khoso Nasir
- Kida Yuri
- Kiiza Peter
- Kildal Anders Benjamin
- Kimmoun Antoine
- Kindgen-Milles Detlef
- Kitamura Nobuya
- Klenerman Paul
- Klont Rob
- Knight Stephen R.
- Kobbe Robin
- Kodippily Chamira
- Koirala Sabin
- Kosgei Caroline
- Kpangon Arsène
- Krawczyk Karolina
- Kruglova Oksana
- Kumar Deepali
- Kumar Mukesh
- Kuriakose Dinesh
- Kurtzman Ethan
- Kutsogiannis Demetrios
- Kutsyna Galyna
- Kyriakoulis Konstantinos
- Lachatre Marie
- Lacoste Marie
- Laffey John G.
- Lagrange Marie
- Laine Fabrice
- Lairez Olivier
- Lakhey Sanjay
- Lalueza Antonio
- Lambert Marc
- Lamontagne François
- Langelot-Richard Marie
- Langlois Vincent
- Lantang Eka Yudha
- Lanza Marina
- Laouénan Cédric
- Laribi Samira
- Lariviere Delphine
- Lasry Stéphane
- Latif Naveed
- Launay Odile
- Laureillard Didier
- Lavie-Badie Yoan
- Law Andrew
- Lawrence Cassie
- Lawrence Teresa
- Le Bihan Clément
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- Le Falher Georges
- Le Fevre Lucie
- Le Hingrat Quentin
- Le Maréchal Marion
- Le Mestre Soizic
- Le Moal Gwenaël
- Le Moing Vincent
- Le Nagard Hervé
- Le Turnier Paul
- Le Minh
- Leal Ema
- Leathlobhair Niamh Ni
- Lee James
- Lee Jennifer
- Lee Su Hwan
- Lee Todd C.
- Leeming Gary
- Lefebvre Bénédicte
- Lefebvre Laurent
- Lefèvre Benjamin
- LeGac Sylvie
- Lelievre Jean-Daniel
- Lellouche François
- Lemaignen Adrien
- Lemee Véronique
- Lemeur Anthony
- Lemmink Gretchen
- Lennon Jenny
- Leone Marc
- Leone Michela
- Lescure François-Xavier
- Lesens Olivier
- Lesouhaitier Mathieu
- Lester-Grant Amy
- Levy Bruno
- Levy Yves
- Levy-Marchal Claire
- Lewandowska Katarzyna
- León Rafael
- Liaquat Ali
- Liegeon Geoffrey
- Lim Wei Shen
- Lima Chantre
- Lina Bruno
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- Lingas Guillaume
- Lion-Daolio Sylvie
- Liu Keibun
- Livrozet Marine
- Lizotte Patricia
- Loforte Antonio
- Lolong Navy
- Lopes Diogo
- Lordemann Anja Grosse
- Loschner Anthony L.
- Loubet Paul
- Loufti Bouchra
- Louis Guillame
- Lourenco Silvia
- Lovelace-Macon Lara
- Lowik Marije
- Lucet Jean Christophe
- Luna Carlos M.
- Luong Liem
- Luque Nestor
- Luton Dominique
- Lwin Nilar
- Lyons Ruth
- L’Her Erwan
- Maasikas Olavi
- Mabiala Oryane
- Machado Moïse
- Machado Sara
- Macheda Gabriel
- Madiha Hashmi
- Mahieu Rafael
- Mahy Sophie
- Maia Ana Raquel
- Maier Lars S.
- Maillet Mylène
- Maitre Thomas
- Malaque Ana
- Malfertheiner Maximilian
- Malik Nadia
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- Maltez Fernando
- Malvy Denis
- Manda Victoria
- Mandelbrot Laurent
- Mankikian Julie
- Manning Edmund
- Manuel Aldric
- Marino Daniel
- Marino Flávio
- Markowicz Samuel
- Marques Ana
- Marquis Catherine
- Marsh Brian
- Marsh Laura
- Marshal Megan
- Marshall John C.
- Martelli Celina Turchi
- Martin Emily
- Martin-Blondel Guillaume
- Martin-Loeches Ignacio
- Martinot Martin
- Martins Ana
- Martins João
- Martins Nuno
- Martucci Gennaro
- Martynenko Olga
- Marwali Eva Miranda
- Maslove David
- Mason Sabina
- Masood Sobia
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- Mathew Meghena
- Mathieu Daniel
- Mattei Mathieu
- Matulevics Romans
- Maulin Laurence
- Maxwell Michael
- Maynar Javier
- Mazzoni Thierry
- Mc Evoy Natalie
- Mc Sweeney Lisa
- McArthur Colin
- McArthur Colin
- McCarthy Aine
- McCarthy Anne
- McCloskey Colin
- McConnochie Rachael
- McDermott Sherry
- McDonald Sarah E.
- McElroy Aine
- McElwee Samuel
- McEneany Victoria
- McGeer Allison
- McKay Chris
- McKeown Johnny
- McLean Kenneth A.
- McNally Paul
- McNicholas Bairbre
- McPartlan Elaine
- Meaney Edel
- Mear-Passard Cécile
- Mechlin Maggie
- Meher Maqsood
- Mele Ferruccio
- Melo Luis
- Memon Kashif
- Mendes Joao Joao
- Menkiti Ogechukwu
- Menon Kusum
- Mentré France
- Mentzer Alexander J.
- Mercier Emmanuelle
- Mercier Noémie
- Merckx Antoine
- Mergeay-Fabre Mayka
- Mergler Blake
- Merson Laura
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- Meyer Dan
- Meynert Alison M.
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- Müller Fredrik
- Müller Karl Erik
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- Neto Raul
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- Ng Pauline Yeung
- Nghi Anthony
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- Ong David S. Y.
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- Opavsky Anne
- Openshaw Peter
- Orakzai Saijad
- Orozco-Chamorro Claudia Milena
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- Oziol Eric
- O’Callaghan Annmarie
- O’Donnell Max
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- O’Hearn Katie
- O’Shea Linda
- O’Sullivan Miriam
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- Palacios Mario
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- Payen Jean-François
- Peelman Florent
- Peiffer-Smadja Nathan
- Peigne Vincent
- Pejkovska Mare
- Pelosi Paolo
- Peltan Ithan D.
- Pereira Rui
- Perez Daniel
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- Pesenti Antonio
- Pestre Vincent
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- Petrovic Michele
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- Ponscarme Diane
- Post Andra-Maris
- Postma Douwe F.
- Povoa Pedro
- Powis Jeff
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- Preau Sébastien
- Prebensen Christian
- Preiser Jean-Charles
- Prinssen Anton
- Pritchard Mark G.
- Priyadarshani Gamage Dona Dilanthi
- Proença Lucia
- Pudota Sravya
- Pulicken Mathew
- Purcell Gregory
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- Póvoas Diana
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- Quist-Paulsen Else
- Quraishi Mohammed
- Rabaud Christian
- Rabindrarajan Ebenezer
- Rafael Aldo
- Rafiq Marie
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- Rainieri Fernando
- Ramachandran Pratheema
- Ramakrishnan Nagarajan
- Ramalho José
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- Rangappa Rajavardhan
- Ranjan Ritika
- Rapp Christophe
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- Rashan Thalha
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- Real Andre
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- Revest Matthieu
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- Tagherset Lysa
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- Teixeira João
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- Thompson Shaun
- Thomson David
- Thomson Emma C.
- Thwaites Ryan S.
- Tierney Paul
- Tieroshyn Vadim
- Timashev Peter S.
- Timsit Jean-François
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- Turmel Jean-Marie
- Turtle Lance C. W.
- Twardowski Pawel
- Téoulé François
- Uchiyama Makoto
- Udayanga P. G. Ishara
- Udy Andrew
- Ullrich Roman
- Uribe Alberto
- Usman Asad
- Uva Maria Sousa
- Uyeki Timothy M.
- Vajdovics Cristinava
- Val-Flores Luís
- Valran Amélie
- Van de Velde Stijn
- van den Berge Marcel
- van der Palen Job
- van der Valk Paul
- Van Der Vekens Nicky
- Van der Voort Peter
- Van Der Werf Sylvie
- van Gulik Laura
- Van Hattem Jarne
- van Netten Carolien
- van Veen Ilonka
- Vanel Noémie
- Vanoverschelde Henk
- Varghese Pooja
- Vasconcelos Malte Kohns
- Vauchy Charline
- Vecham Pavan Kumar
- Veislinger Aurélie
- Vencken Sebastian
- Ventura Sara
- Verbon Annelies
- Vickers James
- Vidal José Ernesto
- Vieira César
- Vijayan Deepak
- Vijayaraghavan Bharath Kumar Tirupakuzhi
- Vijayaraghavan Bharath Kumar Tirupakuzhi
- Villanueva Joy Ann
- Villar Judit
- Villeneuve Pierre-Marc
- Villoldo Andrea
- Visseaux Benoit
- Visser Hannah
- Vitiello Chiara
- Vonkeman Harald
- Vuotto Fanny
- Wang Chih-Hsien
- Webb Steve
- Wei Jia
- Weil Katharina
- Wesselius Sanne
- West T. Eoin
- Wham Murray
- Whelan Bryan
- White Nicole
- Wicky Paul Henri
- Wiedemann Aurélie
- Wijaya Surya Otto
- Wille Keith
- Willems Suzette
- Williams Virginie
- Wils Evert-Jan
- Wong Calvin
- Xynogalas Ioannis
- Yamazaki Masaki
- Yazdanpanah Yazdan
- Yelnik Cécile
- Yerkovich Stephanie
- Yiu Ng Wing
- Yokoyama Toshiki
- Yonis Hodane
- Yousif Obada
- Yuliarto Saptadi
- Zaaqoq Akram
- Zabbe Marion
- Zahran Maram
- Zambon Maria
- Zanella Alberto
- Zayyad Hiba
- Zoufaly Alexander
- Zucman David
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 13/09/2022
- Field of study
Background: Up to 30% of hospitalised patients with COVID-19 require advanced respiratory support, including high-flow nasal cannulas (HFNC), non-invasive mechanical ventilation (NIV), or invasive mechanical ventilation (IMV). We aimed to describe the clinical characteristics, outcomes and risk factors for failing non-invasive respiratory support in patients treated with severe COVID-19 during the first two years of the pandemic in high-income countries (HICs) and low middle-income countries (LMICs).
Methods: This is a multinational, multicentre, prospective cohort study embedded in the ISARIC-WHO COVID-19 Clinical Characterisation Protocol. Patients with laboratory-confirmed SARS-CoV-2 infection who required hospital admission were recruited prospectively. Patients treated with HFNC, NIV, or IMV within the first 24 h of hospital admission were included in this study. Descriptive statistics, random forest, and logistic regression analyses were used to describe clinical characteristics and compare clinical outcomes among patients treated with the different types of advanced respiratory support.
Results: A total of 66,565 patients were included in this study. Overall, 82.6% of patients were treated in HIC, and 40.6% were admitted to the hospital during the first pandemic wave. During the first 24 h after hospital admission, patients in HICs were more frequently treated with HFNC (48.0%), followed by NIV (38.6%) and IMV (13.4%). In contrast, patients admitted in lower- and middle-income countries (LMICs) were less frequently treated with HFNC (16.1%) and the majority received IMV (59.1%). The failure rate of non-invasive respiratory support (i.e. HFNC or NIV) was 15.5%, of which 71.2% were from HIC and 28.8% from LMIC. The variables most strongly associated with non-invasive ventilation failure, defined as progression to IMV, were high leukocyte counts at hospital admission (OR [95%CI]; 5.86 [4.83-7.10]), treatment in an LMIC (OR [95%CI]; 2.04 [1.97-2.11]), and tachypnoea at hospital admission (OR [95%CI]; 1.16 [1.14-1.18]). Patients who failed HFNC/NIV had a higher 28-day fatality ratio (OR [95%CI]; 1.27 [1.25-1.30]).
Conclusions: In the present international cohort, the most frequently used advanced respiratory support was the HFNC. However, IMV was used more often in LMIC. Higher leucocyte count, tachypnoea, and treatment in LMIC were risk factors for HFNC/NIV failure. HFNC/NIV failure was related to worse clinical outcomes, such as 28-day mortality. Trial registration This is a prospective observational study; therefore, no health care interventions were applied to participants, and trial registration is not applicable