The bldC developmental locus of Streptomyces coelicolor encodes a member of a family of small DNA-binding proteins related to the DNA-binding domains of the MerR family.

The bldC locus, required for formation of aerial hyphae in Streptomyces coelicolor, was localized by map-based cloning to the overlap between cosmids D17 and D25 of a minimal ordered library. Subcloning and sequencing showed that bldC encodes a member of a previously unrecognized family of small (58- to 78-residue) DNA-binding proteins, related to the DNA-binding domains of the MerR family of transcriptional activators. BldC family members are found in a wide range of gram-positive and gram-negative bacteria. Constructed {Delta}bldC mutants were defective in differentiation and antibiotic production. They failed to form an aerial mycelium on minimal medium and showed severe delays in aerial mycelium formation on rich medium. In addition, they failed to produce the polyketide antibiotic actinorhodin, and bldC was shown to be required for normal and sustained transcription of the pathway-specific activator gene actII-orf4. Although {Delta}bldC mutants produced the tripyrrole antibiotic undecylprodigiosin, transcripts of the pathway-specific activator gene (redD) were reduced to almost undetectable levels after 48 h in the bldC mutant, in contrast to the bldC+ parent strain in which redD transcription continued during aerial mycelium formation and sporulation. This suggests that bldC may be required for maintenance of redD transcription during differentiation. bldC is expressed from a single promoter. S1 nuclease protection assays and immunoblotting showed that bldC is constitutively expressed and that transcription of bldC does not depend on any of the other known bld genes. The bldC18 mutation that originally defined the locus causes a Y49C substitution that results in instability of the protein

Pancreatic cysts suspected to be branch duct intraductal papillary mucinous neoplasm without concerning features have low risk for development of pancreatic cancer.

BackgroundThe risk of developing pancreatic cancer is uncertain in patients with clinically suspected branch duct intraductal papillary mucinous neoplasm (BD-IPMN) based on the "high-risk stigmata" or "worrisome features" criteria proposed in the 2012 international consensus guidelines ("Fukuoka criteria").MethodsRetrospective case series involving patients referred for endoscopic ultrasound (EUS) of indeterminate pancreatic cysts with clinical and EUS features consistent with BD-IPMN. Rates of pancreatic cancer occurring at any location in the pancreas were compared between groups of patients with one or more Fukuoka criteria ("Highest-Risk Group", HRG) and those without these criteria ("Lowest-Risk Group", LRG).ResultsAfter exclusions, 661 patients comprised the final cohort (250 HRG and 411 LRG patients), 62% female with an average age of 67 years and 4 years of follow up. Pancreatic cancer, primarily adenocarcinoma, occurred in 60 patients (59 HRG, 1 LRG). Prevalent cancers diagnosed during EUS, immediate surgery, or first year of follow up were found in 48/661 (7.3%) of cohort and exclusively in HRG (33/77, 42.3%). Using Kaplan-Meier method, the cumulative incidence of cancer at 7 years was 28% in HRG and 1.2% in LRG patients (P<0.001).ConclusionsThis study supports using Fukuoka criteria to stratify the immediate and long-term risks of pancreatic cancer in presumptive BD-IPMN. The risk of pancreatic cancer was highest during the first year and occurred exclusively in those with "high-risk stigmata" or "worrisome features" criteria. After the first year all BD-IPMN continued to have a low but persistent cancer risk

The LMT Galaxies' 3 mm Spectroscopic Survey: First Results

The molecular phase of the interstellar medium (ISM) in galaxies offers fundamental insight for understanding star-formation processes and how stellar feedback affects the nuclear activity of certain galaxies. We present here Large Millimeter Telescope spectra obtained with the Redshift Search Receiver, a spectrograph that cover simultaneously the 3 mm band from 74 to 111 GHz with a spectral resolution of around 100 km/s. The observed galaxies that have been detected previously in HCN, have different degrees of nuclear activity, one normal galaxy (NGC 6946), the starburst prototype (M 82) and two ultraluminous infrared galaxies (ULIRGs, IRAS 17208-0014 and Mrk 231). We plotted our data in the HCO+/HCN vs. HCN/13CO diagnostic diagram finding that NGC 6946 and M 82 are located close to other normal galaxies; and that both IRAS 17208-0014 and Mrk 231 are close to the position of the well known ULIRG Arp 220 reported by Snell et al. (2011). We found that in Mrk 231 -- a galaxy with a well known active galactic nucleus -- the HCO+/HCN ratio is similar to the ratio observed in other normal galaxies.Comment: Proceedings to appear in "Massive Young Star Clusters Near and Far: From the Milky Way to Reionization", 2013 Guillermo Haro Conference. Eds. Y. D. Mayya, D. Rosa-Gonzalez, & E. Terlevich, INAOE and AMC. 5 pages, 1 figur

Stellar disks of Collisional Ring Galaxies I. New multiband images, Radial intensity and color profiles, and confrontation with N-body simulations

We present new multi-band imaging data in the optical (BVRI and Halpha) and near infrared bands (JHK) of 15 candidate ring galaxies from the sample of Appleton & Marston (1997). We use these data to obtain color composite images, global magnitudes and colors of both the ring galaxy and its companion(s), and radial profiles of intensity and colors. We find that only nine of the observed galaxies have multi-band morphologies expected for the classical collisional scenario of ring formation, indicating the high degree of contamination of the ring galaxy sample by galaxies without a clear ring morphology. The radial intensity profiles, obtained by masking the off-centered nucleus, peak at the position of the ring, with the profiles in the continuum bands broader than that in the Halpha line. The images as well as the radial intensity and color profiles clearly demonstrate the existence of the pre-collisional stellar disk outside the star-forming ring, which is in general bluer than the disk internal to the ring. The stellar disk seems to have retained its size, with the disk outside the ring having a shorter exponential scale length as compared to the values expected in normal spiral galaxies of comparable masses. The rings in our sample of galaxies are found to be located preferentially at around half-way through the stellar disk. The most likely reason for this preference is bias against detecting rings when they are close to the center (they would be confused with the resonant rings), and at the edge of the disk the gas surface density may be below the critical density required for star formation. Most of the observed characteristics point to relatively recent collisions (<80 Myr ago) according to the N-body simulations of Gerber et al. (1996).Comment: To appear in AJ issue of September 2008. High resolution color image of Figure 2 and other supplementary images are available at http://www.inaoep.mx/~ydm/rings

Ongoing Star Formation In AGN Host Galaxy Disks: A View From Core-collapse Supernovae

The normalized radial distribution of young stellar populations (and cold gas) in nearby galactic disks is compared between AGN host galaxies and starforming galaxies (both with Hubble types between S0/a and Scd) by using type II supernovae (SNe) as tracers. A subset of 140 SNe\,II with available supernova position measurements are selected from the SAI-SDSS image catalog by requiring available SDSS spectroscopy data of their host galaxies. Our sample is finally composed of 46 AGNs and 94 starforming galaxies. Both directly measured number distributions and inferred surface density distributions indicate that a) the SNe detected in starforming galaxies follow an exponential law well; b) by contrast, the SNe detected in AGN host galaxies significantly deviate from an exponential law, which is independent of both morphological type and redshift. Specifically, we find a detection deficit around $R_{\mathrm{SN}}/R_{25,\mathrm{cor}}\sim0.5$ and an over-detection at outer region $R_{\mathrm{SN}}/R_{25,\mathrm{cor}}\sim0.6-0.8$. This finding provides a piece of evidence supporting that there is a link between ongoing star formation (and cold gas reservoir) taking place in the extended disk and central AGN activity.Comment: 5 pages, 4 figures, accepted by MNRA

Insights into the Therapeutic Potential of Glucocorticoid Receptor Modulators for Neurodegenerative Diseases

Glucocorticoids are crucial for stress-coping, resilience, and adaptation. However, if the stress hormones become dysregulated, the vulnerability to stress-related diseases is enhanced. In this brief review, we discuss the role of glucocorticoids in the pathogenesis of neurodegenerative disorders in both human and animal models, and focus in particular on amyotrophic lateral sclerosis (ALS). For this purpose, we used the Wobbler animal model, which mimics much of the pathology of ALS including a dysfunctional hypothalamic–pituitary–adrenal axis. We discuss recent studies that demonstrated that the pathological cascade characteristic for motoneuron degeneration of ALS is mimicked in the genetically selected Wobbler mouse and can be attenuated by treatment with the selective glucocorticoid receptor antagonist (GRA) CORT113176. In long-term treatment (3 weeks) GRA attenuated progression of the behavioral, inflammatory, excitatory, and cell-death-signaling pathways while increasing the survival signal of serine–threonine kinase (pAkt). The action mechanism of the GRA may be either by interfering with GR deactivation or by restoring the balance between pro- and anti-inflammatory signaling pathways driven by the complementary mineralocorticoid receptor (MR)- and GR-mediated actions of corticosterone. Accordingly, GR antagonism may have clinical relevance for the treatment of neurodegenerative diseases.Fil: de Nicola, Alejandro Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; ArgentinaFil: Meyer, Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Guennoun, Rachida. Inserm; Francia. Université Paris Sud; Francia. Université Paris Saclay; FranciaFil: Schumacher, Michael. Inserm; Francia. Université Paris Sud; Francia. Université Paris Saclay; FranciaFil: Hunt, Hazel. Corcepts Therapeutics; Estados UnidosFil: Belanoff, Joseph. Corcepts Therapeutics; Estados UnidosFil: de Kloet, E. Ronald. Leiden University. Leiden University Medical Center.; Países BajosFil: Gonzalez Deniselle, Maria Claudia. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentin

Curves on Heisenberg invariant quartic surfaces in projective 3-space

This paper is about the family of smooth quartic surfaces $X \subset \mathbb{P}^3$ that are invariant under the Heisenberg group $H_{2,2}$. For a very general such surface $X$, we show that the Picard number of $X$ is 16 and determine its Picard group. It turns out that the general Heisenberg invariant quartic contains 320 smooth conics and that in the very general case, this collection of conics generates the Picard group.Comment: Updated references, corrected typo

Concert recording 2017-11-27

[Track 1]. Concert prelude / Derek Bourgeois -- [Track 2]. Tuba concerto / Edward Gregson -- [Track 3]. Cyberspace / Peter Graham -- [Track 4]. Concert piece no. 1 / Rodger Vaughan -- [Track 5]. Rhapsody for euphonium / Jerry Brubaker -- [Track 6]. Concerto, K. 191. I. Allegro / W.A. Mozart -- [Track 7]. The green hill / Bert Appermont -- [Track 8]. Suite / Vaclav Nelhybel -- [Track 9]. Brides of the waves / Herbert L. Clarke -- [Track 10]. Fantasy / Philip Sparke -- [Track 11]. Concerto for euphonium. I. Allegro moderato / Philip Wilby

3D spectroscopy of merger Seyfert galaxy Mrk 334: nuclear starburst, superwind and the circumnuclear cavern

We are presenting new results on kinematics and structure of the Mrk 334 Seyfert galaxy. Panoramic (3D) spectroscopy is performed at the 6-m telescope of the Special Astrophysical Observatory of the Russian Academy of Sciences using the MPFS integral-field spectrograph and scanning Fabry--Perot interferometer. The deep images have revealed that Mrk 334 is observed during the final stage of its merging with a massive companion. A possible mass ratio ranges from 1/5 to 1/3. The merger has triggered mass redistribution in the disk resulting in an intensification of nuclear activity and in a burst of star formation in the inner region of the galaxy. The circumnuclear starburst is so intense that its contribution to the gas ionization exceeds that contribution of the AGN. We interpret the nuclear gas outflow with velocities of ~200 km/s as a galactic superwind that accompanies the violent star formation. This suggestion is consistent with the asymmetric X-ray brightness distribution in Mrk 334. The trajectory of the fragments of the disrupted satellite in the vicinity of the main galaxy nucleus can be traced. In the galaxy disk a cavern is found that is filled with a low-density ionized gas. We consider this region to be the place where the remnants of the companion have recently penetrated through the gaseous disk of the main galaxy.Comment: 13 pages, 13 figures, 2 table; accepted for publication by MNRA

Concert recording 2018-02-19

[Track 1]. The barber of Seville overture / Gioachino Rossini arranged by Hutchison -- [Track 2]. Capriccio for tuba and marimba / William Penn -- [Track 3]. Galgenlieder, op. 129. I. Das Geburtslied [Track 4]. II. Das Hemmed [Track 5]. III. Die zwei Wurzeln IV. Die Luft [Track 6]. V. Fisches Nachtgesang (tuba solo) [Track 7]. VI. Igel und Agel [Track 8]. VII. Die beiden Esel [Track 9]. VIII. Das Gebet / Jan Koetsier -- [Track 10]. Concerto per tuba e 4 corni. I. Introduction - allegro [Track 11]. II. Adagio [Track 12]. III. Allegro con spirito / Corrado Maria Saglietti -- [Track 13]. David and Goliath / Mike Forbes