Clinicopathological And Immunohistochemical Evaluation Of Oral And Oropharyngeal Squamous Cell Carcinoma In Chilean Population

In oral and oropharyngeal squamous cell carcinoma (OCSCC and OPSCC) exist an association between clinical and histopathological parameters with cell proliferation, basal lamina, connective tissue degradation and surrounding stroma markers. We evaluated these associations in Chilean patients. A convenience sample of 37 cases of OCSCC (n=16) and OPSCC (n=21) was analyzed clinically (TNM, clinical stage) and histologically (WHO grade of differentiation, pattern of tumor invasion). We assessed the expression of p53, Ki67, HOXA1, HOXB7, type IV collagen (ColIV) and carcinoma-associated fibroblast (a-SMA-positive cells). Additionally we conducted a univariate/bivariate analysis to assess the relationship of these variables with survival rates. Males were mostly affected (56.2% OCSCC, 76.2% OPSCC). Patients were mainly diagnosed at III/IV clinical stages (68.8% OCSCC, 90.5% OPSCC) with a predominantly infiltrative pattern invasion (62.9% OCSCC, 57.1% OPSCC). Significant association between regional lymph nodes (N) and clinical stage with OCSCC-HOXB7 expression (Chi-Square test P < 0.05) was observed. In OPSCC a statistically significant association exists between p53, Ki67 with gender (Chi-Square test P < 0.05). In OCSCC and OPSCC was statistically significant association between ki67 with HOXA1, HOXB7, and between these last two antigens (Pearson's Correlation test P < 0.05). Furthermore OPSCC-p53 showed significant correlation when it was compared with a-SMA (Kendall's Tau-c test P < 0.05). Only OCSCC-pattern invasion and OPSCC-primary tumor (T) pattern resulted associated with survival at the end of the follow up period (Chi-Square Likelihood Ratio, P < 0.05). Clinical, histological and immunohistochemical features are similar to seen in other countries. Cancer proliferation markers were associated strongly from each other. Our sample highlights prognostic value of T and pattern of invasion, but the conclusions may be limited and should be considered with caution (small sample). Many cases were diagnosed in the advanced stages of the disease, which suggests that the diagnosis of OCSCC and OPSCC is made late.7959685977Wang, Q., Gao, P., Wang, X., Duan, Y., Investigation and identification of potential biomarkers in human saliva for the early diagnosis of oral squamous cell carcinoma (2013) Clin Chim Acta, 427 C, pp. 79-85Parkin, D., Bray, F., Ferlay, J., Pisani, P., Global cancer statistics, 2002 (2005) CA Cancer J Clin, 55, p. 74Dissanayaka, W.L., Pitiyage, G., Kumarasiri, P.V., Liyanage, R.L., Dias, K.D., Tilakaratne, W.M., Clinical and histopathologic parameters in survival of oral squamous cell carcinoma (2012) Oral Surg Oral Med Oral Pathol Oral Radiol, 113, pp. 518-525Koontongkaew, S., The tumor microenvironment contribution to development, growth, invasion and metastasis of head and neck squamous cell carcinomas (2013) J Cancer, 4, p. 66Dalianis, T., Human papillomavirus and oropharyngeal cancer, the epidemics, and significance of additional clinical 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Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Facial Pigmentation Associated With Amiodarone

Amiodarone is one of the most commonly used drugs for treatment of cardiac arrhythmia. Several undesirable effects are associated with its long-term use. This report describes the case of a 71-year-old female patient, with a diagnosis of cardiac arrhythmia, who presented with a stigmatizing blue-gray facial pigmentation and altered serum values of thyroid hormones associated with the intake of amiodarone. The patient was referred to her cardiologist. The aim of this report is to increase clinicians' awareness about the potential adverse effects of this drug.614e15e17Smith, W., Guidelines for the diagnosis and management of arrhythmogenic right ventricular cardiomyopathy (2011) Heart Lung Circ, 20 (12), pp. 757-760. , Members of CSANZ Cardiovascular Genetics Working GroupVan Herendael, H., Dorian, P., Amiodarone for the treatment and prevention of ventricular fibrillation and ventricular tachycardia (2010) Vasc Health Risk Manag, 6, pp. 465-472Harris, L., McKenna, W.J., Rowland, E., Holt, D.W., Storey, G.C., Krikler, D.M., Side effects of long-term amiodarone therapy (1983) Circulation, 67 (1), pp. 45-51Ioannides, M.A., Moutiris, J.A., Zambartas, C., A case of pseudocyanotic coloring of skin after prolonged use of amiodarone (2003) Int J Cardiol, 90 (2-3), pp. 345-346Sohns, C., Zabel, M., Current role of amiodarone in antiarrhythmic therapy (2010) [Article in German] Herzschrittmacherther Elektrophysiol, 21 (4), pp. 239-243Itoh, K., Kato, R., Hotta, N., A case report of myolysis during high-dose amiodarone therapy for uncontrolled ventricular tachycardia (1998) Jpn Circ J, 62 (4), pp. 305-308Bahadir, S., Apaydin, R., Cobanoilu, U., Amiodarone pigmentation, eye and thyroid alterations (2000) J Eur Acad Dermatol Venereol, 14 (3), pp. 194-195Raptis, L., Papathanasiou, H., Pappas, G., Akritidis, N., It's all in the face: Amiodarone-induced myxedema and skin pigmentation (2006) Eur J Dermatol, 16 (5), pp. 590-591Pawar, P.S., Woo, D.A., Extrapyramidal symptoms with concomitant use of amitriptyline and amiodarone in an elderly patient (2010) Am J Geriatr Pharmacother, 8 (6), pp. 595-598Scully, C., Bagan, J.V., Adverse drug reactions in the orofacial region (2004) Crit Rev Oral Biol Med, 15 (4), pp. 221-239Wiper, A., Roberts, D.H., Schmitt, M., Amiodarone-induced skin pigmentation: Q-switched laser therapy, an effective treatment option (2007) Heart, 93 (1), p. 15Enseleit, F., Wyss, C.A., Duru, F., Noll, G., Rischitzka, F., The blue man: Amiodarone-induced skin discoloration (2006) Circulation, 113 (5), pp. e63. , Images in cardiovascular medicineNikolidakis, S., Kyriakides, Z.S., Barbatis, C., Images in cardiology. Blue-grey cutaneous discolouration secondary to amiodarone treatment (2006) Heart, 92 (4), p. 436Monk, B., Amiodarone-induced photosensitivity and basal-cell carcinoma (1990) Clin Exp Dermatol, 15 (4), pp. 319-320Maoz, K.B., Dvash, S., Brenner, S., Brenner, S., Amiodaroneinduced skin pigmentation and multiple basal-cell carcinomas (2009) Int J Dermatol, 48 (12), pp. 1398-140

Segmental Odontomaxillary Dysplasia: Report Of 3 Cases And Literature Review

Segmental Odontomaxillary Dysplasia (SOD) is an uncommon developmental disorder of unknown etiology that causes a unilateral alteration of the maxilla associated with an abnormal growth and maturation of bone, lack of one or both premolars and delayed tooth eruption on the affected side, alteration of adjacent gingival tissue with or without facial cutaneous lesions. Radiographically is observed an irregular trabecular pattern and reduction of the maxillary sinus. There are 50 cases reported in the English-language literature. A literature review is herein presented emphasizing the clinical, radiographic, and histological features, and three additional cases of SOD affecting a 22 years-old woman, a 18 years-old man, and a 5 years-old boy, respectively are described. © 2011 Springer Science+Business Media, LLC.62171177Prusack, N., Segmental odontomaxillary dysplasia: a case report and review of the literature (2000) Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 90 (4), pp. 483-488Koenig, L.J., Lynch, D.P., Yancey, K.B., Segmental odontomaxillary dysplasia presenting with facial hypertrichosis, commissural lip clefting, and hyperlinear palms (2008) Pediatr Dermatol, 25 (4), pp. 491-492Yassin, O.M., Rihani, F.B., Combined cutaneous findings with segmental odontomaxillary dysplasia: review of the literature and proposal of a new clinical classification (2008) Int Med Case Rep J, 1, pp. 7-11Packota, G.V., Pharoah, M.J., Petrikowski, C.G., Radiographic features of segmental odontomaxillary dysplasia: a study of 12 cases (1996) Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 82 (5), pp. 577-584Miles, D.A., Lovas, J.L., Cohen Jr., M.M., Hemimaxillofacial dysplasia: a newly recognized disorder of facial asymmetry, hypertrichosis of the facial skin, unilateral enlargement of the maxilla, and hypoplastic teeth in two patients (1987) Oral Surg Oral Med Oral Pathol, 64 (4), pp. 445-448Danforth, R.A., Segmental odontomaxillary dysplasia. Report of eight cases and comparison with hemimaxillofacial dysplasia (1990) Oral Surg Oral Med Oral Pathol, 70 (1), pp. 81-85Welsch, M.J., Stein, S.L., A syndrome of hemimaxillary enlargement, asymmetry of the face, tooth abnormalities, and skin findings (HATS) (2004) Pediatr Dermatol, 21 (4), pp. 448-451Whitt, J.C., Segmental odontomaxillary dysplasia: report of a series of 5 cases with long-term follow-up (2011) Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 112 (2), pp. e29-e47Armstrong, C., Histopathology of the teeth in segmental odontomaxillary dysplasia: new findings (2004) J Oral Pathol Med, 33 (4), pp. 246-248Becktor, K.B., Segmental odontomaxillary dysplasia: clinical, radiological and histological aspects of four cases (2002) Oral Dis, 8 (2), pp. 106-110Kuklani, R.M., Nair, M.K., Segmental odontomaxillary dysplasia: review of the literature and case report (2010) Int J Dent., p. 837283Jones, A.C., Ford, M.J., Simultaneous occurrence of segmental odontomaxillary dysplasia and Becker's nevus (1999) J Oral Maxillofac Surg, 57 (10), pp. 1251-1254Paticoff, K., Hemimaxillofacial dysplasia: a report of two new cases and further delineation of the disorder (1997) Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 83 (4), pp. 484-488Desalvo, M.S., Segmental odontomaxillary dysplasia (hemimaxillofacial dysplasia): case report (1996) Pediatr Dent, 18 (2), pp. 154-156Velez, I., Segmental odontomaxillary dysplasia. Report of two cases and review of the literature (2002) Todays FDA, 14 (12), pp. 20-21Drake, D.L., Segmental odontomaxillary dysplasia: an unusual orthodontic challenge (2003) Am J Orthod Dentofac Orthop, 123 (1), pp. 84-86Gavalda, C., Segmental odontomaxillary dysplasia (2004) Med Oral, 9 (2), p. 181Bhatia, S.K., Case report: segmental odontomaxillary dysplasia-a rare disorder (2008) Eur Arch Paediatr Dent, 9 (4), pp. 245-248Ozpinar, B., Prosthetic rehabilitation of segmental odontomaxillary dysplasia: seven-year follow-up (2009) Cleft Palate Craniofac J, 46 (1), pp. 103-107Friedlander-Barenboim, S., Kamburoglu, K., Kaffe, I., Clinical and radiological presentation of hemimaxillofacial dysplasia/segmental odontomaxillary dysplasia: Critical analysis and report of a case (2011) Oral Surg Oral Med Oral Pathol Oral Radiol EndodMinett, C.P., Daley, T.D., Hemimaxillofacial Dysplasia (Segmental Odontomaxillary Dysplasia): Case Study With 11 Years of Follow-Up From Primary to Adult Dentition (2011) J Oral Maxillofac Surg.Porwal, R., Hemimaxillofacial dysplasia: a variable presentation (2008) J Craniofac Surg, 19 (6), pp. 1554-155

Potential role of nuclear magnetic resonance spectroscopy to identify salivary metabolite alterations in patients with head and neck cancer

The analysis of the salivary metabolomic profile may offer an early phase approach to assess the changes associated with a wide range of diseases including head and neck cancer. The aim of the present study was to investigate the potential of nuclear magn16567956800The authors acknowledge the contribution of NMR Metabolomics Laboratory at the University of Eastern Finland (Kuopio, Finland). Funding The present study was supported by the Finnish Funding Agency for Technology and Innovation (Tekes) project ‘Novel spe