Caracterización litogeoquímica de los batolitos de Las Lomas y Noque en el departamento de Piura y su comparación con los batolitos de la Cordillera Blanca y Challaviento

[ESP] Las variedades litológicas predominantes de los dos batolitos son tonalita y granodiorita, provenientes de magmas félsicos. La relación SiO2 vs. Sm/Yb permite determinar que ambos son de la misma edad. Las rocas son de naturaleza subalcalina de las series calcoalcalinas de medio y alto potasio, con un carácter metaluminoso. Los diagramas de discriminación tectonomagmática indican que son granitos de arco volcánico. Los elementos traza y tierras raras también muestran características típicas de rocas asociadas a subducción. La profundidad de la fuente magmática es menor de 20 km y la ausencia de granate indica que no hay contaminación mantélica. Ambos provienen de magmas húmedos, el batolito Las Lomas es del tipo “I” y de la serie de la magnetita, asociado a elementos calcófilos y a la mineralización de Cu-Mo, el batolito Noque del tipo “S” y de la serie de la Ilmenita, asociado a elementos litófilos, y no cae en ningún campo de mineralización específica. Comparando a los batolitos, los del norte son calcoalcalinos de medio K, los del centro y sur son calcoalcalinos de alto K, presencia de granate en el centro y sur, y todos los granitoides son de naturaleza de arco volcánico. Los batolitos del norte caen en el campo de los anorogénicos y los del centro y sur de los campos de tipo “I” y “S”. Los granitos del norte la profundidad de su fuente magmática alcanza menos de 20 km, la Cordillera Blanca 60 km y Challaviento 40 km. Las edades varían desde las más antiguas Las Lomas, Noque, Challaviento y la más joven la Cordillera Blanca coincidiendo con las dataciones radiométricas.[ENG] The predominant lithological varieties of the two Batholiths are tonalite, granodiorite from felsic magmas. The SiO2 vs. Sm / Yb to determine that both are of the same age. The rocks are nature of subalkaline and calc-alkaline series of medium and high potassium with metaluminous character. Tectonomagmatic diagrams indicate that they are of volcanic arc granites. Trace elements and rare earth rocks also they show typical features associated with subduction. The depth of the magma source is less than 20 km and the absence of garnet mantle indicate no contamination mantle. Both come from wet magmas, the batholith Las Lomas is of the type “I” and the of magnetite series, associated with chalcophile elements and Cu-Mo mineralization, the Batholith Noque type “S” and the ilmenite series associatedlithophile elements, and does not fall into any specific field of mineralization. Comparing the batholith, the North are medium-K, calc-alkaline, the center and south are high-K calc-alkaline, the presence of garnet in the center and south, and all are nature of volcanic arc granitoids. North Batholiths fall into the field of anorogenic and the central and southern batholiths of type “I” and “S”. North granites depth of its source magma reaches less than 20 kilometers, the Cordillera Blanca Challaviento 60 Km and 40Km. The ages range from the oldest Las Lomas, Noque, Challaviento and the younger the Cordillera Blanca coinciding with radiometric dating

Plan de negocio para implementar una plataforma virtual que facilite la ejecuci?n de clases acad?micas complementarias en los distritos de Trujillo y V?ctor Larco Herrera, en la provincia de Trujillo, en el departamento de La Libertad

La presente tesis tiene como objetivo, evaluar la viabilidad econ?mica de un modelo de negocio multilateral entre los demandantes y ofertantes de clases acad?micas complementarias de reforzamiento. El plan de negocio busca implementar la plataforma virtual T-ense?o que facilite la ejecuci?n de clases acad?micas complementarias a estudiantes de primaria y secundaria que pertenecen a los NSE A, B y C de los distritos de Trujillo y V?ctor Larco Herrera, en la Provincia de Trujillo, Departamento de La Libertad. Dentro de su propuesta de valor, contribuye con los tutores que son los padres o representantes de los estudiantes (tutorados), a encontrar asesores acad?micos calificados para el reforzamiento de las clases, buscando mejorar su nivel educativo; y, por el otro, contribuye con los asesores acad?micos a contactar a los tutores antes indicados y obtener ingresos adicionales. Los atributos m?s importantes de la propuesta de valor para los tutores son: el acceso a profesionales calificados, brindando un pool de asesores acad?micos, la seguridad por el buen historial civil de ?stos; y, el logro de mejores calificaciones de los tutorados. Y, para los asesores acad?micos son: generar ingresos extras, desarrollo de sus competencias t?cnicas y digitales, y, luego de un uso recurrente, obtendr?n incentivos

Low-value care practice in headache: a Spanish mixed methods research study

Background Headache is one of the most prevalent diseases. The Global Burden of Disease Study ranks it as the seventh most common disease overall and the second largest neurological cause of disability in the world. The "Do Not Do" recommendations are a strategy for increasing the quality of care and reducing the cost of care for headache. This study aimed to identify specific low-value practices in headache care, determine their frequency, and estimate the cost overrun that they represent, in order to establish "Do not Do" recommendations specifically for headache by consensus and according to scientific evidence. Methods This was a mixed methods research study that combined qualitative consensus-building techniques, involving a multidisciplinary panel of experts to define the "Do Not Do" recommendations in headache care, and a retrospective observational study with review of a randomized set of patient records from the past 6 months in four hospitals, to quantify the frequency of these "Do Not Do" practices. We calculated the sum of direct costs of medical consultations, medicines, and unnecessary diagnostic tests. Results Seven "Do Not Do" recommendations were established for headache. In total, 3507 medical records were randomly reviewed. Low-value practices had a highly variable occurrence, depending on the hospital and type of headache. Overall, 34.1% of low-value practices were related to treatment, 21% were related to overuse of imaging in consultation, and 19% were related to emergency care. The estimated cost of low-value practices in the four hospitals was 203,520.47 euros per 1000 patients. Conclusions This study identified low-value headache practices that need to be eradicated and provided data on their frequency and cost overruns

Scheme dependence of NLO corrections to exclusive processes

We apply the so-called conformal subtraction scheme to predict perturbatively exclusive processes beyond leading order. Taking into account evolution effects, we study the scheme dependence for the photon-to-pion transition form factor and the electromagnetic pion form factor at next-to-leading order for different pion distribution amplitudes. Relying on the conformally covariant operator product expansion and using the known higher order results for polarized deep inelastic scattering, we are able to predict perturbative corrections to the hard-scattering amplitude of the photon-to-pion transition form factor beyond next-to-leading order in the conformal scheme restricted to the conformal limit of the theory.Comment: RevTeX, 25 pages, 2 figures, 5 tables, minor changes, to be published in Phys. Rev.

Monoubiquitination of syntaxin 3 leads to retrieval from the basolateral plasma membrane and facilitates cargo recruitment to exosomes

Syntaxin 3 (Stx3), a SNARE protein located and functioning at the apical plasma membrane of epithelial cells, is required for epithelial polarity. A fraction of Stx3 is localized to late endosomes/lysosomes, although how it traffics there and its function in these organelles is unknown. Here we report that Stx3 undergoes monoubiquitination in a conserved polybasic domain. Stx3 present at the basolateral—but not the apical—plasma membrane is rapidly endocytosed, targeted to endosomes, internalized into intraluminal vesicles (ILVs), and excreted in exosomes. A nonubiquitinatable mutant of Stx3 (Stx3-5R) fails to enter this pathway and leads to the inability of the apical exosomal cargo protein GPRC5B to enter the ILV/exosomal pathway. This suggests that ubiquitination of Stx3 leads to removal from the basolateral membrane to achieve apical polarity, that Stx3 plays a role in the recruitment of cargo to exosomes, and that the Stx3-5R mutant acts as a dominant-negative inhibitor. Human cytomegalovirus (HCMV) acquires its membrane in an intracellular compartment and we show that Stx3-5R strongly reduces the number of excreted infectious viral particles. Altogether these results suggest that Stx3 functions in the transport of specific proteins to apical exosomes and that HCMV exploits this pathway for virion excretion

Long-term (trophic) purinergic signalling: purinoceptors control cell proliferation, differentiation and death

The purinergic signalling system, which uses purines and pyrimidines as chemical transmitters, and purinoceptors as effectors, is deeply rooted in evolution and development and is a pivotal factor in cell communication. The ATP and its derivatives function as a 'danger signal' in the most primitive forms of life. Purinoceptors are extraordinarily widely distributed in all cell types and tissues and they are involved in the regulation of an even more extraordinary number of biological processes. In addition to fast purinergic signalling in neurotransmission, neuromodulation and secretion, there is long-term (trophic) purinergic signalling involving cell proliferation, differentiation, motility and death in the development and regeneration of most systems of the body. In this article, we focus on the latter in the immune/defence system, in stratified epithelia in visceral organs and skin, embryological development, bone formation and resorption, as well as in cancer. Cell Death and Disease (2010) 1, e9; doi:10.1038/cddis.2009.11; published online 14 January 201

Soft tissue damage after minimally invasive THA: A comparison of 5 approaches

Methods 5 surgeons each performed a total hip arthroplasty on 5 fresh frozen cadaver hips, using either a MIS anterior, MIS anterolateral, MIS 2-incision, MIS posterior, or lateral transgluteal approach. Postoperatively, the hips were dissected and muscle damage color-stained. We measured proportional muscle damage relative to the midsubstance cross-sectional surface area (MCSA) using computerized color detection. The integrity of external rotator muscles, nerves, and ligaments was assessed by direct observation. Results None of the other MIS approaches resulted in less gluteus medius muscle damage than the lateral transgluteal approach. However, the MIS anterior approach completely preserved the gluteus medius muscle in 4 cases while partial damage occurred in 1 case. Furthermore, the superior gluteal nerve was transected in 4 cases after a MIS anterolateral approach and in 1 after the lateral transgluteal approach. The lateral femoral cutaneous nerve was transected once after both the MIS anterior approach and the MIS 2-incision approach. Interpretation The MIS anterior approach may preserve the gluteus medius muscle during total hip arthroplasty, but with a risk of damaging the lateral femoral cutaneous nerv

Competition and habitat quality influence age and sex distribution in wintering rusty blackbirds.

Bird habitat quality is often inferred from species abundance measures during the breeding and non-breeding season and used for conservation management decisions. However, during the non-breeding season age and sex classes often occupy different habitats which suggest a need for more habitat-specific data. Rusty Blackbird (Euphagus carolinus) is a forested wetland specialist wintering in bottomland hardwood forests in the south-eastern U. S. and belongs to the most steeply declining songbirds in the U.S. Little information is available to support priority birds such as the Rusty Blackbird wintering in this threatened habitat. We assessed age and sex distribution and body condition of Rusty Blackbirds among the three major habitats used by this species in the Lower Mississippi Alluvial Valley and also measured food availability. Overall, pecan groves had the highest biomass mainly driven by the amount of nuts. Invertebrate biomass was highest in forests but contributed only a small percentage to overall biomass. Age and sex classes were unevenly distributed among habitats with adult males primarily occupying pecan groves containing the highest nut biomass, females being found in forests which had the lowest nut biomass and young males primarily staying in forest fragments along creeks which had intermediate nut biomass. Males were in better body condition than females and were in slightly better condition in pecan groves. The results suggest that adult males occupy the highest quality habitat and may competitively exclude the other age and sex classes