Administrative management and organizational commitment in educational institutions

The present study focused on determining the relationship between administrative management and organizational commitment in workers in the education sector. It has been developed according to the positivist paradigm of quantitative approach, basic research, non-experimental design, cross-sectional, correlational type, applying the hypothetical deductive method. The population was made up of 88 workers from the education sector such as teachers, administrative personnel and managers. Two questionnaires were used, one for administrative management and the other for Organizational Commitment, which were subjected to expert criteria; These instruments obtained 0.885 and 0.801 reliability by Cronbach's alpha. The evaluation of the results was made by Rho de Spearman, obtaining a value of for Administrative management and of for Organizational commitment. It was concluded that there was a positive and significant relationship between both variables, establishing that as long as there is good management, the commitment of the workers increases progressively.El presente estudio se enfocó en determinar la relación de la gestión administrativa con el compromiso organizacional en trabajadores del sector educación. Se ha desarrollado según el paradigma positivista de enfoque cuantitativo, investigación básica, diseño no experimental, corte transversal, tipo correlacional, aplicando el método hipotético deductivo. La población estuvo conformada por 88 trabajadores del sector educación tales como docentes, personal administrativo y directivos. Se emplearon dos cuestionarios uno de gestión administrativa y otro de Compromiso organizacional, los que fueron sometidos a criterios de expertos; dichos instrumentos obtuvieron 0.885 y 0.801 de fiabilidad por alfa de Cronbach. La evaluación de los resultados fue hecha por Rho de Spearman, obteniéndose un valor de para Gestión administrativa y de para Compromiso organizacional. Se concluyó que existió una relación positiva y significativa entre ambas variables, estableciéndose que mientras exista una buena gestión, el compromiso de los trabajadores se incrementa progresivamente

“From bricks to Click": Metacognitive Reading Skills of Students in the Pre and During Pandemic Era

This paper addressed the emerging gap on the quality of reading instruction before and during the COVID 19 Pandemic onslaught. This study generally aimed to determine how EFL university students utilized metacognitive online reading methods before and after the Covid-19 outbreak. A study was conducted to investigate whether EFL university students' use of metacognitive reading methods had changed before and after the Covid-19 pandemic, and if so, what had changed. This study employed mixed-methods research utilizing quantitively and qualitative research designs.  Testing the significant difference on the reading strategies of the students using t-test, the result revealed there is a significant difference on the reading strategies of the students. This indicates that during COVID 19 the students were able to attain a very high level of reading strategies compared during the pre-pandemic era which is attributed to the adoption of online learning where the mode of instruction is taken virtually and reading references among the students were mostly taken thru online access. On the qualitative context utilizing exploratory sequential design, revealed that EFL students were able to better their metacognitive online reading strategies during the COVID 19 as reflected in four themes: easier access of reading materials, flexibility of time and space, characteristics of e-books, and issues on the disruption of reading concentration brought by online reading activities. As a result, there is a perceived need to improve EFL students' metacognitive understanding of online reading techniques and help them become better online English readers. Helping students develop their metacognitive awareness of online reading methods and helping them master their metacognitive reading strategy usage are two approaches to help EFL students better comprehend online texts

How big data is used as a key element for hybrid university education

Hybrid learning in universities is the blending and mixing of the learning environments, this includes both face-to-face (FTF) which implies classroom instruction and online environment (E-learning)  as well. According to De Mauro, Greco and Grimaldi (2016), Ellis’ study shows that hybrid learning provides the students with the opportunity to understand and explore the real world at the same time through various authentic experiences. Authentic experience as cited by De Mauro, Greco and Grimaldi (2016) can be facilitated in the online learning environment through coming up with sufficient online learning or by blending learning to combine both online and FTF learning. The main objective of hybrid learning is to enhance effective and efficient experience through a more improved delivery model. This study is based on the review of previous articles using PRISMA methodology, it focuses on the big data as key element in hybrid learning in university education. The main objective of this study is to review 40 articles published in Scopus within 2010 to 2022 subject to big data in education, hybrid learning in universities or higher learning institutions and based on their findings the study come up with a conclusion  as discussed below

TVI - Arquitectura y Construcción - AR323 - 202101

Descripción: El curso TVI-Arquitectura y construcción introduce al estudiante en el conocimiento de las necesidades constructivas del proyecto arquitectónico y en la aplicación de los sistema estructurales; en la coordinación de sistemas estructurales para hacer posible que los sótanos de estacionamiento calcen sobre plantas de desarrollo habitacional, que los ductos de instalaciones eléctricas y sanitarias tengan continuidad, etc. Se diseñan pequeños edificios de oficinas, fábricas, centros comerciales, clínicas, complejos deportivos, etc. Propósito: Desarrollar propuestas arquitectónicas cuya concepción involucre la necesidad de pensar en sistemas estructurales adecuados, un correcto dimensionamiento para las necesidades materiales del proyecto (tales como estacionamiento, traslado de muebles, y seguridad) La construcción implica decidir una lógica estructural, por el comportamiento del material, y la expresión arquitectónica en coherencia con el tema ¿organización y funcionamiento- y el lugar. La asignatura contribuye al desarrollo de las competencias específicas de la carrera: Diseño Fundamentado, que corresponde a los criterios NAAB PC2, PC3, PC8, PC5, SC3, SC5, así como, Técnica y Construcción que corresponde a los criterios NAAB SC1, SC4, SC6; ambas en el nivel de logro 2. Tiene como requisito la asignatura de AR309 TV - Arquitectura y Medio Ambient

Efficacy and safety of the CVnCoV SARS-CoV-2 mRNA vaccine candidate in ten countries in Europe and Latin America (HERALD): a randomised, observer-blinded, placebo-controlled, phase 2b/3 trial

Background: Additional safe and efficacious vaccines are needed to control the COVID-19 pandemic. We aimed to analyse the efficacy and safety of the CVnCoV SARS-CoV-2 mRNA vaccine candidate. Methods: HERALD is a randomised, observer-blinded, placebo-controlled, phase 2b/3 clinical trial conducted in 47 centres in ten countries in Europe and Latin America. By use of an interactive web response system and stratification by country and age group (18–60 years and ≥61 years), adults with no history of virologically confirmed COVID-19 were randomly assigned (1:1) to receive intramuscularly either two 0·6 mL doses of CVnCoV containing 12 μg of mRNA or two 0·6 mL doses of 0·9% NaCl (placebo) on days 1 and 29. The primary efficacy endpoint was the occurrence of a first episode of virologically confirmed symptomatic COVID-19 of any severity and caused by any strain from 15 days after the second dose. For the primary endpoint, the trial was considered successful if the lower limit of the CI was greater than 30%. Key secondary endpoints were the occurrence of a first episode of virologically confirmed moderate-to-severe COVID-19, severe COVID-19, and COVID-19 of any severity by age group. Primary safety outcomes were solicited local and systemic adverse events within 7 days after each dose and unsolicited adverse events within 28 days after each dose in phase 2b participants, and serious adverse events and adverse events of special interest up to 1 year after the second dose in phase 2b and phase 3 participants. Here, we report data up to June 18, 2021. The study is registered at ClinicalTrials.gov, NCT04652102, and EudraCT, 2020–003998–22, and is ongoing. Findings: Between Dec 11, 2020, and April 12, 2021, 39 680 participants were enrolled and randomly assigned to receive either CVnCoV (n=19 846) or placebo (n=19 834), of whom 19 783 received at least one dose of CVnCoV and 19 746 received at least one dose of placebo. After a mean observation period of 48·2 days (SE 0·2), 83 cases of COVID-19 occurred in the CVnCoV group (n=12 851) in 1735·29 person-years and 145 cases occurred in the placebo group (n=12 211) in 1569·87 person-years, resulting in an overall vaccine efficacy against symptomatic COVID-19 of 48·2% (95·826% CI 31·0–61·4; p=0·016). Vaccine efficacy against moderate-to-severe COVID-19 was 70·7% (95% CI 42·5–86·1; CVnCoV 12 cases in 1735·29 person-years, placebo 37 cases in 1569·87 person-years). In participants aged 18–60 years, vaccine efficacy against symptomatic disease was 52·5% (95% CI 36·2–64·8; CVnCoV 71 cases in 1591·47 person-years, placebo, 136 cases in 1449·23 person-years). Too few cases occurred in participants aged 61 years or older (CVnCoV 12, placebo nine) to allow meaningful assessment of vaccine efficacy. Solicited adverse events, which were mostly systemic, were more common in CVnCoV recipients (1933 [96·5%] of 2003) than in placebo recipients (1344 [67·9%] of 1978), with 542 (27·1%) CVnCoV recipients and 61 (3·1%) placebo recipients reporting grade 3 solicited adverse events. The most frequently reported local reaction after any dose in the CVnCoV group was injection-site pain (1678 [83·6%] of 2007), with 22 grade 3 reactions, and the most frequently reported systematic reactions were fatigue (1603 [80·0%] of 2003) and headache (1541 [76·9%] of 2003). 82 (0·4%) of 19 783 CVnCoV recipients reported 100 serious adverse events and 66 (0·3%) of 19 746 placebo recipients reported 76 serious adverse events. Eight serious adverse events in five CVnCoV recipients and two serious adverse events in two placebo recipients were considered vaccination-related. None of the fatal serious adverse events reported (eight in the CVnCoV group and six in the placebo group) were considered to be related to study vaccination. Adverse events of special interest were reported for 38 (0·2%) participants in the CVnCoV group and 31 (0·2%) participants in the placebo group. These events were considered to be related to the trial vaccine for 14 (<0·1%) participants in the CVnCoV group and for five (<0·1%) participants in the placebo group. Interpretation: CVnCoV was efficacious in the prevention of COVID-19 of any severity and had an acceptable safety profile. Taking into account the changing environment, including the emergence of SARS-CoV-2 variants, and timelines for further development, the decision has been made to cease activities on the CVnCoV candidate and to focus efforts on the development of next-generation vaccine candidates. Funding: German Federal Ministry of Education and Research and CureVac

The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

International audienceSignificance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population

The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

International audienceSignificance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

BackgroundWe previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15-20% of cases of life-threatening COVID-19 in unvaccinated patients. Therefore, the determinants of life-threatening COVID-19 remain to be identified in similar to 80% of cases.MethodsWe report here a genome-wide rare variant burden association analysis in 3269 unvaccinated patients with life-threatening COVID-19, and 1373 unvaccinated SARS-CoV-2-infected individuals without pneumonia. Among the 928 patients tested for autoantibodies against type I IFN, a quarter (234) were positive and were excluded.ResultsNo gene reached genome-wide significance. Under a recessive model, the most significant gene with at-risk variants was TLR7, with an OR of 27.68 (95%CI 1.5-528.7, P=1.1x10(-4)) for biochemically loss-of-function (bLOF) variants. We replicated the enrichment in rare predicted LOF (pLOF) variants at 13 influenza susceptibility loci involved in TLR3-dependent type I IFN immunity (OR=3.70[95%CI 1.3-8.2], P=2.1x10(-4)). This enrichment was further strengthened by (1) adding the recently reported TYK2 and TLR7 COVID-19 loci, particularly under a recessive model (OR=19.65[95%CI 2.1-2635.4], P=3.4x10(-3)), and (2) considering as pLOF branchpoint variants with potentially strong impacts on splicing among the 15 loci (OR=4.40[9%CI 2.3-8.4], P=7.7x10(-8)). Finally, the patients with pLOF/bLOF variants at these 15 loci were significantly younger (mean age [SD]=43.3 [20.3] years) than the other patients (56.0 [17.3] years; P=1.68x10(-5)).ConclusionsRare variants of TLR3- and TLR7-dependent type I IFN immunity genes can underlie life-threatening COVID-19, particularly with recessive inheritance, in patients under 60 years old