Direct Magnetic Evidence, Functionalization, and Low-Temperature Magneto-Electron Transport in Liquid-Phase Exfoliated FePS3

Magnetism and the existence of magnetic order in a material is determined by its dimensionality. In this regard, the recent emergence of magnetic layered van der Waals (vdW) materials provides a wide playground to explore the exotic magnetism arising in the two-dimensional (2D) limit. The magnetism of 2D flakes, especially antiferromagnetic ones, however, cannot be easily probed by conventional magnetometry techniques, being often replaced by indirect methods like Raman spectroscopy. Here, we make use of an alternative approach to provide direct magnetic evidence of few-layer vdW materials, including antiferromagnets. We take advantage of a surfactant-free, liquid-phase exfoliation (LPE) method to obtain thousands of few-layer FePS3 flakes that can be quenched in a solvent and measured in a conventional SQUID magnetometer. We show a direct magnetic evidence of the antiferromagnetic transition in FePS3 few-layer flakes, concomitant with a clear reduction of the Néel temperature with the flake thickness, in contrast with previous Raman reports. The quality of the LPE FePS3 flakes allows the study of electron transport down to cryogenic temperatures. The significant through-flake conductance is sensitive to the antiferromagnetic order transition. Besides, an additional rich spectra of electron transport excitations, including secondary magnetic transitions and potentially magnon-phonon hybrid states, appear at low temperatures. Finally, we show that the LPE is additionally a good starting point for the mass covalent functionalization of 2D magnetic materials with functional molecules. This technique is extensible to any vdW magnetic familyE.B. acknowledges funds from Ministerio de Ciencia e Innovación in Spain (RTI2018-096075-A-C22, RYC2019- 028429-I). E.M.P. thanks the Spanish Ministerio de Ciencia e Innovación (PID2020-116661RB-I00) and Comunidad de Madrid (P2018/NMT-4367). M.G.H. and A.C.-G. acknowledge funds from European Union Horizon 2020 research and innovation program (Graphene Core3-Grant agreement no. 881603 Graphene-based disruptive technologies), EU FLAGERA through the project To2Dox (JTC-2019-009), and Comunidad de Madrid through the project CAIRO-CM project (Y2020/NMT-6661). A.C.-G. also acknowledges funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement no. 755655, ERC-StG 2017 project 2D-TOPSENSE) and the Ministry of Science and Innovation (Spain) through the project PID2020-115566RB-I00. M.L.R.G. acknowledges support by the Spanish Ministry of Science and Innovation through Research Project PID 2020- 113753RB-100. The National Centre for Electron Microscopy (ELECMI National Singular Scientific Facility) is also acknowledge for provision of access to corrected aberration microscopy facilities. CzechNanoLab Research Infrastructure supported by MEYS CR (LM2018110) is acknowledge

Vigilancia tecnológica en el aglomerado productivo del té de Misiones.

El trabajo presenta los avances de la investigación que se desarrolla en la Facultad de Ingeniería de la Universidad Nacional de Misiones contextualizado en el Aglomerado Productivo del té de Misiones. El objetivo es diseñar una metodología que facilite la realización de vigilancia tecnológica para el Aglomerado Productivo del Té de Misiones (AP), que sea útil para los empresarios y técnicos del AP y que optimice el tiempo invertido en esta tarea. El desarrollo se enfoca hacia la industria metalúrgica de la construcción de máquinas para la cosecha y el mantenimiento de los cultivos de té. El trabajo contempla las fases de caracterización de la información tecnológica, la selección de las bases de datos de interés y el desarrollo de criterios para el análisis de la información y la elaboración de los mapas tecnológicos. Los avances en la ejecución del proyecto han posibilitado iniciar un proceso de sistematización de información tecnológica contenida en documentos de patentes que resulta de interés estratégico para los empresarios del sector tealero de Misiones.publishedVersio

Formulation and characterisation of wheat bran oil-in-water nanoemulsions

Wheat bran oil (WBO) has been reported to have an important content of bioactive compounds, such as tocopherols, alkylresorcinols, steryl ferulates and other phenolic compounds; however, its poor solubility in water systems restricts its applications in the food industry. This study is focussed on the formulation of oil-in-water (O/W) nanoemulsions of WBO in order to improve the bioaccessibility of its active compounds. The influences of oil concentration, surfactant type and concentration, and emulsification method, on the droplet size and stability of the nanoemulsions were investigated. Response surface methodology was used to optimise the conditions for preparing stable nanoemulsions with the minimum droplet size. The optimal nanoemulsion was obtained when 1% of WBO and 7.3% of a surfactant mixture of Span 80 (37.4%) and Tween 80 (62.6%) were emulsified in water by high intensity ultrasonication for 50 s after pre-emulsification with a high speed blender during 5 min. The optimal nanoemulsion showed good stability over time and antioxidant and tyrosinase inhibitory activities, which make it suitable for use in food applications.This work is part of the GALANG project (Ref.: ITC-20113029) financed by the Spanish Government through CDTI

Investigación en color y calidad de alimentos

En esta ponencia se pretende presentar a los alumnos de la Escuela Politécnica Superior, las líneas de investigación del grupo Color y Calidad de Alimentos de la Universidad de Sevilla (AGR225, PAIDI) y las posibilidades de realizar Trabajos postdoctorales o continuar las salidas profesionales en el campo de industrias alimentarias.This paper tries to introduce to the student of Polytechnic School, the research lines of Color and Food Quality Group of the University of Seville (AGR225, PAIDI), and the possibilities of carrying out postdoctoral works or continuing the career in the field of food industries

Dialogue between Higher Education, Cooperation Development and Economics through Information Technologies; an imperative need for the success of the XXIth Century Society

Este proyecto es atemporal por lo que se continuará a través de otros proyectos de innovación docente, cooperación al desarrollo y TFG y Tesis de DoctoradoEl proyecto de Innovación Docente surge, en línea con los objetivos de "Erasmus Key Action 2", con el propósito de acercar la Educación Superior en Economía y Administración de Empresas de países desarrollados a la formación de micro-empresarios en países en desarrollo de África y Latinoamérica. Este acercamiento sería a través de las Tecnologías de la Información y Comunicación (TICs) que serán el vehículo de apoyo, en línea con los objetivos de esta convocatoria. Así se definirán nuevas metodologías docentes, más dinámicas e innovadoras en enseñanza presencial para los profesores. Se diseñaran herramientas de aprendizaje para las nuevas generaciones de estudiantes y de micro-empresarios en el tercer mundo. Finalmente, se diseñaran herramientas para la evaluación de la satisfacción de los estudiantes (micro-empresarios en países en desarrollo) junto con la promoción de solidaridad entre los alumnos de los grados de ADE y Economía en España al conocer el proyecto hacia la mejora de países en desarrollo por medio de la educación superior. Uno de los valores añadidos del proyecto es que ha conseguido reunir a 14 profesores de las áreas de Contabilidad, Finanzas, Marketing y Trabajo Social que son docentes de amplia experiencia en Universidades públicas y privadas de España pero que también han formado parte de equipos investigadores y docentes en Cooperación al Desarrollo en países como Etiopía, República Democrática del Congo, Malawi, Perú y Colombia. La experiencia de formar a micro-empresarios en países en desarrollo no es fácil y el coste de oportunidad de ir a clases de formación, aun en áreas importantes para ellos como la contabilidad, las micro-finanzas o las técnicas de ventas, es muy alto. Por ello hay que pensar en tecnologías que se acerquen a ellos y les motiven a la formación continua. Los Apps como recurso didáctico en las aulas en España empiezan a dejar de ser una novedad para ser un recurso más. Por ello, en este proyecto se propone programar/usar un App propio ajustado a los contenidos de Contabilidad, Finanzas y Marketing que se rodaría en los seminarios de las distintas asignaturas de los 14 profesores con cuestionario de motivación y satisfacción y test de aprendizaje para medir el éxito docente de este recurso.This teaching Innovation project emerges, in line with the objectives of "Erasmus Key Action 2", with the purpose of linking Higher Education with development cooperation and economics and business administration. This link will be between developed countries and developing countries of Africa and Latin America through the economics training of micro-entrepreneurs. This approach would be through the Information and Communication Technologies (ICTs) that will be the analytic tool, in line with the objectives of this call. ITs will define new teaching methods, more dynamic and innovative than face-to-face teaching for teachers. Learning tools will be designed for the new generations of students and micro-entrepreneurs in the third world. Finally, interactive tools for the evaluation of students' satisfaction (micro-entrepreneurs in developing countries) will be designed together with solidarity fostering among the students of the Economics and Business degrees in Spain when they learn about the project towards the improvement of countries in development through higher education. One of the added values of the project is that it has connected 14 teachers and researchers from the areas of Accounting, Finance, Marketing and Social Work who have extensive experience in public and private universities in Spain, but who have also been part of research teams in Development Cooperation in countries such as Ethiopia, Democratic Republic of the Congo, Malawi, Peru and Colombia. The experience of training micro-entrepreneurs in developing countries is not easy and the opportunity cost of going to training classes, even in areas important to them such as accounting, micro-finance or sales techniques, is very high . Therefore it is necessary to think about technologies that can approach them more easily and motivate them to the continuous formation (ITs). Apps as a didactic resource in classrooms in Spain are starting to stop being a novelty to be a usual resource. Therefore, in this project an own App programmed is proposed adjusted to the contents of Accounting, Finance and Marketing that would be applied and trialed in the seminars of the different subjects of the 14 teachers with motivation, satisfaction and learning questionnaires and test to measure the teaching success of this resource.Depto. de Administración Financiera y ContabilidadFac. de Ciencias Económicas y EmpresarialesFALSEsubmitte

Effectiveness, safety/tolerability of OBV/PTV/r ± DSV in patients with HCV genotype 1 or 4 with/without HIV-1 co-infection, chronic kidney disease (CKD) stage IIIb-V and dialysis in Spanish clinical practice - Vie-KinD study

Limited data are available on the effectiveness and tolerability of direct-acting antivirals (DAAs) therapies in the real world for HCV-infected patients with comorbidities. This study aimed to describe the effectiveness of OBV/PTV/r ± DSV (3D/2D regimen) with or without ribavirin (RBV) in HCV or HCV/HIV co-infected patients with GT1/GT4 and CKD (IIIb-V stages), including those under hemodialysis and peritoneal dialysis in routine clinical practice in Spain in 2015.Non-interventional, retrospective, multicenter data collection study in 31 Spanish sites. Socio-demographic, clinical variables, study treatment characteristics, effectiveness and tolerability data were collected from medical records.Data from 135 patients with a mean age (SD) of 58.3 (11.4) years were analyzed: 92.6% GT1 (81.6% GT1b and 17.6% GT1a) and 7.4% GT4, 14 (10.4%) HIV/HCV co-infected, 19.0% with fibrosis F3 and 28.1% F4 by FibroScan®, 52.6% were previously treated with pegIFN and RBV. 11.1%, 14.8% and 74.1% of patients had CKD stage IIIb, IV and V respectively. 68.9% of patients were on hemodialysis; 8.9% on peritoneal dialysis and 38.5% had history of renal transplant. A total of 125 (96.2%) of 135 patients were treated with 3D, 10 (7.4%) with 2D and 30.4% received RBV. The overall intention-to-treat (ITT) sustained virologic response at week 12 (SVR12) was 92.6% (125/135) and the overall modified-ITT (mITT) SVR12 was 99.2% (125/126). The SVR12 rates (ITT) per sub-groups were: HCV mono-infected (91.7%), HCV/HIV co-infected (100%), GT1 (92.0%), GT4 (100%), CKD stage IIIb (86.7%), stage IV (95%) and stage V (93%). Among the 10 non-SVR there was only 1 virologic failure (0.7%); 4 patients had missing data due lost to follow up (3.0%) and 5 patients discontinued 3D/2D regimen (3.7%): 4 due to severe adverse events (including 3 deaths) and 1 patient´s decision.These results have shown that 3D/2D regimens are effective and tolerable in patients with advanced CKD including those in dialysis with GT 1 or 4 chronic HCV mono-infection and HIV/HCV coinfection in a real-life cohort. The overall SVR12 rates were 92.6% (ITT) and 99.2% (mITT) without clinically relevant changes in eGFR until 12 weeks post-treatment. These results are consistent with those reported in clinical trials

Tipología de narrativas didácticas para YouTube: formatos didácticos audiovisuales realizados por el alumnado para innovar en el aprendizaje a través de las plataformas de streaming

Realización de contenidos audiovisuales para la enseñanza virtual en plataformas de vídeo. El alumnado de Ciencias de la Información crea y difunde materiales narrativos educativos diseñados para cursos online innovadores en YouTube

Immigrant IBD Patients in Spain Are Younger, Have More Extraintestinal Manifestations and Use More Biologics Than Native Patients

BackgroundPrevious studies comparing immigrant ethnic groups and native patients with IBD have yielded clinical and phenotypic differences. To date, no study has focused on the immigrant IBD population in Spain. MethodsProspective, observational, multicenter study comparing cohorts of IBD patients from ENEIDA-registry who were born outside Spain with a cohort of native patients. ResultsWe included 13,524 patients (1,864 immigrant and 11,660 native). The immigrants were younger (45 +/- 12 vs. 54 +/- 16 years, p < 0.001), had been diagnosed younger (31 +/- 12 vs. 36 +/- 15 years, p < 0.001), and had a shorter disease duration (14 +/- 7 vs. 18 +/- 8 years, p < 0.001) than native patients. Family history of IBD (9 vs. 14%, p < 0.001) and smoking (30 vs. 40%, p < 0.001) were more frequent among native patients. The most prevalent ethnic groups among immigrants were Caucasian (41.5%), followed by Latin American (30.8%), Arab (18.3%), and Asian (6.7%). Extraintestinal manifestations, mainly musculoskeletal affections, were more frequent in immigrants (19 vs. 11%, p < 0.001). Use of biologics, mainly anti-TNF, was greater in immigrants (36 vs. 29%, p < 0.001). The risk of having extraintestinal manifestations [OR: 2.23 (1.92-2.58, p < 0.001)] and using biologics [OR: 1.13 (1.0-1.26, p = 0.042)] was independently associated with immigrant status in the multivariate analyses. ConclusionsCompared with native-born patients, first-generation-immigrant IBD patients in Spain were younger at disease onset and showed an increased risk of having extraintestinal manifestations and using biologics. Our study suggests a featured phenotype of immigrant IBD patients in Spain, and constitutes a new landmark in the epidemiological characterization of immigrant IBD populations in Southern Europe