325 research outputs found
Adorno?s Grey, Taussig?s Blue: Colour, Organization and Critical Affect
In this article we seek to open up the study of affect and organization to colour. Often simply taken for granted in organizational life and usually neglected in organizational thought, colour is an affective force by default. Deploying and interweaving the languages of affect theory, critical theory, and organization studies, we discuss colour as a primary phenomenon for the study of ?critical affect?. We then trace colour?s affect in conditioning the unfolding of organization in two particular ?colour/spaces? ? Adorno?s grey and Taussig?s blue of our title ? and discuss both its ambiguity and critical potential. Finally, we ponder what colour might do to the style of an organizational scholarship attuned to affect, where sentences blur with things and forces more than they seek to represent them
Redes Sociais e Comportamento Sexual: para uma visão relacional da sexualidade, do risco e da prevenção
Com base num inquérito representativo da população
portuguesa entre 18 e 65 anos, realizado em
2007, este estudo investiga o impacto de fatores de
rede social sobre os comportamentos sexuais dos
indivĂduos. AtravĂ©s da percepção normativa dos
inquiridos sobre a moral sexual dos seus amigos e familiares
e de indicadores relativos à caracterização
da rede de confidĂȘncia sexual, tais como o nĂșmero, a
identidade, o gĂȘnero, a idade e o comportamento dos
confidentes em matéria de sexualidade e prevenção
face ao risco de infecção por DSTs, obtivemos um
retrato multidimensional das redes sociais dos
indivĂduos. A realização de anĂĄlises de regressĂŁo
linear e logĂstica permitiu avaliar o impacto preditivo
da rede sobre o nĂșmero de parceiros sexuais,
as relaçÔes sexuais ocasionais e o uso do preservativo.
Os dados mostram que os fatores de rede sĂŁo
importantes para explicar o comportamento sexual
dos indivĂduos. Redes constituĂdas por amigos e
mais liberais em termos de moral sexual tendem a
influenciar o comportamento sexual, levando a um
maior experimentalismo, sobretudo no caso das mulheres.
Por outro lado, a homologia entre o comportamento
sexual dos confidentes e o dos inquiridos
Ă© relevante para explicar o recurso ao preservativo
nas relaçÔes sexuais ocasionais, especialmente no
caso dos homens. Tanto numa perspectiva relacional
da sexualidade como numa Ăłptica epidemiolĂłgica,
a anĂĄlise das redes sociais dos indivĂduos constitui
um aspecto importante para a compreensĂŁo e
explicação da variedade de experiĂȘncias sexuais, mais restritas ou mais plurais, e para os riscos de
infecção que daà podem advir
Persistence and compliance to antidepressant treatment in patients with depression: A chart review
<p>Abstract</p> <p>Background</p> <p>Adherence has recently been suggested to be divided into these two components: persistence (i.e., whether patients continue treatment or not) and compliance (i.e., whether patients take doses as instructed). However, no study has yet assessed these two clinically relevant components at the same time in adherence to antidepressant treatment in the clinical outpatient setting.</p> <p>Methods</p> <p>In this retrospective chart-review, 6-month adherence to antidepressants was examined in 367 outpatients with a major depressive disorder (ICD-10) (170 males; mean ± SD age 37.6 ± 13.9 years), who started antidepressant treatment from April 2006 through March 2007. Additionally, we evaluated Medication Possession Rate (MPR), defined as the total days a medication was dispensed to patients divided by the treatment period.</p> <p>Results</p> <p>Only 161 patients (44.3%) continued antidepressant treatment for 6 months. Among 252 patients who discontinued their initial antidepressant, 63.1% of these patients did so without consulting their physicians. Sertraline use was associated with a higher persistence rate at month 6 (odds ratio 2.59 in comparison with sulpiride), and the use of anxiolytic benzodiazepines had a positive effect on persistence to antidepressant treatment only at month 1 (odds ratio 2.14). An overall MPR was 0.77; 55.6% of patients were considered compliant (i.e., a MPR of ℠0.8).</p> <p>Conclusion</p> <p>Given a high rate of antidepressant discontinuation without consulting their physicians, closer communication between patients and their physicians should be encouraged. Although the use of anxiolytic benzodiazepines was associated with a higher persistence to antidepressant treatment at month 1, the use of these drugs should be avoided as a rule, given their well-known serious adverse effects.</p
Viewing scenes of the history of chemistry through the opera glass
Artistic creation has always reflected the spirit of the moment and opera has not been an exception. There are several examples of operas which appeared at key moments of the development of science, portraying them. Additionally there are also operas that emerged after scientific events or the lifetime of the scientists they were inspired on. In what concerns chemistry, the first category could be exemplified by the apothecary operas (already discussed by the author in a previous paper of this journal) while the others could be illustrated by recent operas such as Dr. Atomic or Madame Curie.
Continuing our endeavor of establishing relations between opera and chemistry, and considering that history of science plays an important role in the process of teaching and learning sciences, some milestones of the history of chemistry are here revisited through the opera glass. The operas analyzed have been grouped in the following categories: Operas of Fire and Metallurgy, Operas of the Philosophers of Antiquity, Operas of Alchemy, Operas of the Age of Enlightenment, Operas of the Revolutions and Operas of Entropy.Thanks are due to the Foundation for Science and Technology (FCTâPortugal) and FEDER (European Fund for Regional Development)-COMPETE/QREN/EU for financial support through the research unity PEst-C/QUI/UI686/2013.
Neuer Kopf, alte Ideen? : "Normalisierung" des Front National unter Marine Le Pen
In this article, it is investigated
whether vibrational entropy
(VE) is an important contribution to the free energy of globular proteins
at ambient conditions. VE represents the major configurational-entropy
contribution of these proteins. By definition, it is an average of
the configurational entropies of the protein within single minima
of the energy landscape, weighted by their occupation probabilities.
Its large part originates from thermal motion of flexible torsion
angles giving rise to the finite peak widths observed in torsion angle
distributions. While VE may affect the equilibrium properties of proteins,
it is usually neglected in numerical calculations as its consideration
is difficult. Moreover, it is sometimes believed that all well-packed
conformations of a globular protein have similar VE anyway. Here, we measure explicitly the VE for six different conformations from simulation data of a test protein. Estimates
are obtained using the quasi-harmonic approximation for three coordinate
sets, Cartesian, bond-angle-torsion (BAT), and a new set termed rotamer-degeneracy
lifted BAT coordinates by us. The new set gives improved estimates
as it overcomes a known shortcoming of the quasi-harmonic approximation
caused by multiply populated rotamer states, and it may serve for
VE estimation of macromolecules in a very general context. The obtained
VE values depend considerably on the type of coordinates used. However,
for all coordinate sets we find large entropy differences between
the conformations, of the order of the overall stability of the protein.
This result may have important implications on the choice of free
energy expressions used in software for protein structure prediction,
protein design, and NMR refinement
How to think about informal proofs
This document is the Accepted Manuscript version of the following article: Brendan Larvor, âHow to think about informal proofsâ, Synthese, Vol. 187(2): 715-730, first published online 9 September 2011. The final publication is available at Springer via doi:10.1007/s11229-011-0007-5It is argued in this study that (i) progress in the philosophy of mathematical practice requires a general positive account of informal proof; (ii) the best candidate is to think of informal proofs as arguments that depend on their matter as well as their logical form; (iii) articulating the dependency of informal inferences on their content requires a redefinition of logic as the general study of inferential actions; (iv) it is a decisive advantage of this conception of logic that it accommodates the many mathematical proofs that include actions on objects other than propositions; (v) this conception of logic permits the articulation of project-sized tasks for the philosophy of mathematical practice, thereby supplying a partial characterisation of normal research in the fieldPeer reviewedFinal Accepted Versio
The Consensus from the Mycobacterium avium ssp. paratuberculosis (MAP) Conference 2017.
On March 24 and 25, 2017 researchers and clinicians from around the world met at Temple University in Philadelphia to discuss the current knowledge of Mycobacterium avium ssp. paratuberculosis (MAP) and its relationship to human disease. The conference was held because of shared concern that MAP is a zoonotic bacterium that poses a threat not only to animal health but also human health. In order to further study this problem, the conferees discussed ways to improve MAP diagnostic tests and discussed potential future anti-MAP clinical trials. The conference proceedings may be viewed on the www.Humanpara.org website. A summary of the salient work in this field is followed by recommendations from a majority of the conferees
Transcriptomics of Haemophilus (GlÀsserella) parasuis serovar 5 subjected to culture conditions partially mimetic to natural infection for the search of new vaccine antigens
11 p.Haemophilus (GlĂ€sserella) parasuis is the etiological agent of GlĂ€sserâs disease in pigs. Control of this disorder has been traditionally based on bacterins. The search for alternative vaccines has focused mainly on the study of outer membrane proteins. This study investigates the transcriptome of H. (G.) parasuis serovar 5 subjected to in vitro conditions mimicking to those existing during an infection (high temperature and iron-restriction), with the aim of detecting the overexpression of genes coding proteins exposed on bacterial surface, which could represent good targets as vaccine candidates.
The transcriptomic approach identified 13 upregulated genes coding surface proteins: TbpA, TbpB, HxuA, HxuB, HxuC, FhuA, FimD, TolC, an autotransporter, a protein with immunoglobulin folding domains, another large protein with a tetratricopeptide repeat and two small proteins that did not contain any known domains. Of these, the first six genes coded proteins being related to iron extraction.
Six of the proteins have already been tested as vaccine antigens in murine and/or porcine infection models and showed protection against H. (G.) parasuis. However, the remaining seven have not yet been tested and, consequently, they could become useful as putative antigens in the prevention of GlĂ€sserâs disease. Anyway, the expression of this seven novel vaccine candidates should be shown in other serovars different from serovar 5.S
Late style and speaking out: J A Symonds's In the Key of Blue
This article examines In the Key of Blue (1893)âan essay collection by John Addington Symondsâas a case study in queer public utterance during the early 1890s. Viewed through the critical lens of late style, as theorised by Edward Said, the evolution of this project, from compilation through to reader reception, reveals Symonds's determination to âspeak outâ on the subject of homosexuality. Paradoxically, In the Key of Blue was thus a timely and untimely work: it belonged to a brief period of increased visibility and expressiveness when dealing with male same-sex desire, spearheaded by a younger generation of Decadent writers, but it also cut against the grain of nineteenth-century social taboo and legal repression. Symonds's essay collection brought together new and previously unpublished work with examples of his writing for the periodical press. These new combinations, appearing together for the first time, served to facilitate new readings and new inferences, bringing homosexual themes to the fore. This article traces the dialogic structure of In the Key of Blue , its strategies for articulating homosexual desire, and examines the response of reviewers, from the hostile to celebratory
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