488 research outputs found
Critical examination of cohesive-zone models in the theory of dynamic fracture
We have examined a class of cohesive-zone models of dynamic mode-I fracture,
looking both at steady-state crack propagation and its stability against
out-of-plane perturbations. Our work is an extension of that of Ching, Langer,
and Nakanishi (CLN) (Phys. Rev. E, vol. 53, no. 3, p. 2864 (1996)), who studied
a non-dissipative version of this model and reported strong instability at all
non-zero crack speeds. We have reformulated the CLN theory and have discovered,
surprisingly, that their model is mathematically ill-posed. In an attempt to
correct this difficulty and to construct models that might exhibit realistic
behavior, we have extended the CLN analysis to include dissipative mechanisms
within the cohesive zone. We have succeeded to some extent in finding
mathematically well posed systems; and we even have found a class of models for
which a transition from stability to instability may occur at a nonzero crack
speed via a Hopf bifurcation at a finite wavelength of the applied
perturbation. However, our general conclusion is that these cohesive-zone
models are inherently unsatisfactory for use in dynamical studies. They are
extremely difficult mathematically, and they seem to be highly sensitive to
details that ought to be physically unimportant.Comment: 19 pages, REVTeX 3.1, epsf.sty, also available at
http://itp.ucsb.edu/~lobkovs
Dynamic ductile to brittle transition in a one-dimensional model of viscoplasticity
We study two closely related, nonlinear models of a viscoplastic solid. These
models capture essential features of plasticity over a wide range of strain
rates and applied stresses. They exhibit inelastic strain relaxation and steady
flow above a well defined yield stress. In this paper, we describe a first step
in exploring the implications of these models for theories of fracture and
related phenomena. We consider a one dimensional problem of decohesion from a
substrate of a membrane that obeys the viscoplastic constitutive equations that
we have constructed. We find that, quite generally, when the yield stress
becomes smaller than some threshold value, the energy required for steady
decohesion becomes a non-monotonic function of the decohesion speed. As a
consequence, steady state decohesion at certain speeds becomes unstable. We
believe that these results are relevant to understanding the ductile to brittle
transition as well as fracture stability.Comment: 10 pages, REVTeX, 12 postscript figure
Understanding the stochastic partial differential equation approach to smoothing
DLM was funded by OPNAV N45 and the SURTASS LFA Settlement Agreement, being managed by the U.S. Navy's Living Marine Resources program under Contract No. N39430-17-C-1982.Correlation and smoothness are terms used to describe a wide variety of random quantities. In time, space, and many other domains, they both imply the same idea: quantities that occur closer together are more similar than those further apart. Two popular statistical models that represent this idea are basis-penalty smoothers (Wood in Texts in statistical science, CRC Press, Boca Raton, 2017) and stochastic partial differential equations (SPDEs) (Lindgren etĀ al. in J R Stat Soc Series B (Stat Methodol)Ā 73(4):423ā498, 2011). In this paper, we discuss how the SPDE can be interpreted as a smoothing penalty and can be fitted using the R package mgcv, allowing practitioners with existing knowledge of smoothing penalties to better understand the implementation and theory behind the SPDE approach.Publisher PDFPeer reviewe
Sociologyās missed opportunity: John Stuart-Glennieās lost theory of the moral revolution, also known as the axial age
In 1873, 75 years before Karl Jaspers published his theory of the Axial Age in 1949, unknown to Jaspers and to contemporary scholars today, Scottish folklorist John Stuart Stuart-Glennie elaborated the first fully developed and nuanced theory of what he termed āthe Moral Revolutionā to characterize the historical shift emerging roughly around 600 BCE in a variety of civilizations, most notably ancient China, India, Judaism, and Greece, as part of a broader critical philosophy of history. He continued to write on the idea over decades in books and articles and also presented his ideas to the fledgling Sociological Society of London in 1905, which were published the following year in the volume Sociological Papers, Volume 2. This article discusses Stuart-Glennieās ideas on the moral revolution in the context of his philosophy of history, including what he termed āpanzooinismā; ideas with implications for contemporary debates in theory, comparative history, and sociology of religion. It shows why he should be acknowledged as the originator of the theory now known as the axial age, and also now be included as a significant sociologist in the movement toward the establishment of sociology
Crowdsourced earthquake early warning
Earthquake early warning (EEW) can reduce harm to people and infrastructure from earthquakes and tsunamis, but it has not been implemented in most high earthquake-risk regions because of prohibitive cost. Common consumer devices such as smartphones contain low-cost versions of the sensors used in EEW. Although less accurate than scientific-grade instruments, these sensors are globally ubiquitous. Through controlled tests of consumer devices, simulation of an M_w (moment magnitude) 7 earthquake on Californiaās Hayward fault, and real data from the M_w 9 Tohoku-oki earthquake, we demonstrate that EEW could be achieved via crowdsourcing
Synārift sediment gravity flow deposition on a Late Jurassic faultāterraced slope, northern North Sea
Structurally controlled bathymetry in rifts has a significant influence on sediment routing pathways and depositional architecture of sediment gravity flow deposits. In contrast to rift segments characterized by crustal-scale half-grabens, the tectono-stratigraphic evolution of deep-water rift domains characterised by distributed faulting on narrow fault terraces has received little attention. We use 3D broadband seismic data, calibrated by boreholes, from the Lomre and Uer terraces in the northern North Sea rift to investigate Late Jurassic syn-rift sediment gravity flow systems on fault-terraced slopes. The sediment gravity flow fairways were sourced from hinterland drainages via basin margin deltaic systems on the Horda Platform to the southeast. The deep-water sedimentary systems evolve from initial, widespread submarine channelized lobe complexes, through submarine channels, to incised submarine canyons. This progressive confinement of the sediment gravity flow system was concomitant with progressive localization of strain onto the main terrace-bounding faults. Although the normal fault network on the terraces has local impact on deep-water sediment transport and the architecture of gravity flow deposits, it is the regional basin margin to rift axis gradient that dominantly controls deep-water sediment routing. Furthermore, the gravity flow deposits on the Lomre and Uer terraces were predominantly sourced by rift margin deltaic systems, not from erosion of local uplifted footwall crests, emphasising the significance of hinterland catchments in the development of volumetrically significant deep-water syn-rift depositional systems
Analysis of the interaction of monoclonal antibodies with surface IgM on neoplastic B-cells
In vitro studies identified three Burkitts lymphoma cell lines, Ramos, MUTU-I and Daudi, that were growth inhibited by anti-IgM antibody. However, only Ramos and MUTU-I were sensitive to monoclonal antibodies (mAb) recognizing the Fc region of surface IgM (anti-FcĪ¼). Experiments using anti-FcĪ¼ mAb (single or non-crossblocking pairs), polyclonal anti-Ī¼ Ab, and hyper-crosslinking with a secondary layer of Ab, showed that growth inhibition of B-cell lines was highly dependent on the extent of IgM crosslinking. This was confirmed by using Fabā², F(abā²)2and F(abā²)3derivatives from anti-FcĪ¼ mAb, where increasing valency caused corresponding increases in growth arrest and apoptosis, presumably as a result of more efficient BCR-crosslinking on the cell surface. The ability of a single mAb to induce growth arrest was highly dependent on epitope specificity, with mAb specific for the Fc region (CĪ¼2āCĪ¼4 domains) being much more effective than those recognizing the Fab region (anti-L chain, anti-Id and anti-FdĪ¼, or CĪ¼1). Only when hyper-crosslinked with polyclonal anti-mouse IgG did the latter result in appreciable growth inhibition. Binding studies showed that these differences in function were not related to differences in the affinity, but probably related to intrinsic crosslinking capacity of mAb. Ā© 1999 Cancer Research Campaig
Naturally-Acquired Influenza-Specific CD4+ T-Cell Proliferative Responses Are Impaired in HIV-Infected African Adults
BACKGROUND
Seasonal influenza has been associated with greater morbidity and mortality in AIDS patients. Highly-active antiretroviral therapy (HAART) has led to some reduction in influenza-related complications but the nature of naturally-acquired T-cell immunity to influenza virus in an African setting, and how this changes with immune reconstitution following HAART is unknown. We measured influenza-specific CD4(+) T-cell immunity in unimmunized HIV-infected Malawian adults and then investigated immune reconstitution following HAART.
METHODS
Peripheral blood mononuclear cells were isolated from HIV-infected and HIV-uninfected Malawian adults. CFSE proliferation and CD154 expression flow cytometry-based assays were used to measure influenza-specific CD4(+) T-cell immunity.
RESULTS
We found lower naturally-acquired proliferative influenza-specific CD4(+) T-cell responses in AIDS patients that was also present in asymptomatic HIV-infected adults with relatively high CD4 counts (>350 cells/Āµl). Influenza-specific CD4(+) T-cell immune reconstitution in HIV-infected patients on HAART for 12 months was poor despite a marked reduction in viral load and an increase in CD4 count. This poor immune reconstitution was characterised by a low influenza-specific proliferative CD4(+) T-cell response and reduced proportions of CD154-expressing influenza-specific CD4(+) T-cells in peripheral blood.
CONCLUSION
Our data suggest that asymptomatic HIV-infected adults may also be at risk of influenza-related complications and that HAART alone may not circumvent this risk in AIDS patients. This study highlights the need to identify possible interventions early in HIV infection to reduce the risk of influenza and to intensify influenza surveillance in these susceptible African populations
Water
Meta-analysis can be a powerful tool for demonstrating the applicability of a concept beyond the context of individual clinical trials and observational studies, including exploration of effects across different subgroups. Meta-analysis avoids Simpson's paradox, in which a consistent effect in constituent trials is reversed when results are simply pooled. Meta-analysis in critical care medicine is made more complicated, however, by the heterogeneous nature of critically ill patients and the contexts within which they are treated. Failure to properly adjust for this heterogeneity risks missing important subgroup effects in, for example, the interaction of treatment with varying levels of baseline risk. When subgroups are defined by characteristics that vary within constituent trials (such as age) rather than features constant within each trial (such as drug dose), there is the additional risk of incorrect conclusions due to the ecological fallacy. The present review explains these problems and the strategies by which they are overcome
Evaluation of high-throughput genomic assays for the Fc gamma receptor locus
Cancer immunotherapy has been revolutionised by the use of monoclonal antibodies (mAb) that function through their interaction with Fc gamma receptors (FcĪ³Rs). The low-affinity FcĪ³R genes are highly homologous, map to a complex locus at 1p23 and harbour single nucleotide polymorphisms (SNPs) and copy number variation (CNV) that can impact on receptor function and response to therapeutic mAbs. This complexity can hinder accurate characterisation of the locus. We therefore evaluated and optimised a suite of assays for the genomic analysis of the FcĪ³R locus amenable to peripheral blood mononuclear cells and formalin-fixed paraffin-embedded (FFPE) material that can be employed in a high-throughput manner. Assessment of TaqMan genotyping for FCGR2A-131H/R, FCGR3A-158F/V and FCGR2B-232I/T SNPs demonstrated the need for additional methods to discriminate genotypes for the FCGR3A-158F/V and FCGR2B-232I/T SNPs due to sequence homology and CNV in the region. A multiplex ligation-dependent probe amplification assay provided high quality SNP and CNV data in PBMC cases, but there was greater data variability in FFPE material in a manner that was predicted by the BIOMED-2 multiplex PCR protocol. In conclusion, we have evaluated a suite of assays for the genomic analysis of the FcĪ³R locus that are scalable for application in large clinical trials of mAb therapy. These assays will ultimately help establish the importance of FcĪ³R genetics in predicting response to antibody therapeutics
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