Uso de benzodiacepinas por adictos a heroína a propósito de una revisión bibliográfica.

En este trabajo se aborda una revisión bibliográfica sobre la relación existente entre la dependencia a la heroína y el uso, abuso y dependencia a las benzodiacepinas (BZD). Se señala la amplia extensión del consumo de BZD por adictos en general y por los dependientes a heroína en particular, así como la posible naturaleza de tal consumo por este tipo de adictos. En nuestro medio las moléculas de BZD de las que más abusan los pacientes heroinómanos tratados son cloracepato dipotásico y flunitrazepam. Se analizan las posibles causas de esta preferencia en función de los resultados de los estudios revisados. Igualmente se señala la posible existencia de un patrón de uso y abuso particular para este tipo de adicto

Uso de benzodiacepinas por adictos a heroína a propósito de una revisión bibliográfica.

En este trabajo se aborda una revisión bibliográfica sobre la relación existente entre la dependencia a la heroína y el uso, abuso y dependencia a las benzodiacepinas (BZD). Se señala la amplia extensión del consumo de BZD por adictos en general y por los dependientes a heroína en particular, así como la posible naturaleza de tal consumo por este tipo de adictos. En nuestro medio las moléculas de BZD de las que más abusan los pacientes heroinómanos tratados son cloracepato dipotásico y flunitrazepam. Se analizan las posibles causas de esta preferencia en función de los resultados de los estudios revisados. Igualmente se señala la posible existencia de un patrón de uso y abuso particular para este tipo de adicto

Uso de benzodiacepinas por adictos a heroína a propósito de una revisión bibliográfica.

En este trabajo se aborda una revisión bibliográfica sobre la relación existente entre la dependencia a la heroína y el uso, abuso y dependencia a las benzodiacepinas (BZD). Se señala la amplia extensión del consumo de BZD por adictos en general y por los dependientes a heroína en particular, así como la posible naturaleza de tal consumo por este tipo de adictos. En nuestro medio las moléculas de BZD de las que más abusan los pacientes heroinómanos tratados son cloracepato dipotásico y flunitrazepam. Se analizan las posibles causas de esta preferencia en función de los resultados de los estudios revisados. Igualmente se señala la posible existencia de un patrón de uso y abuso particular para este tipo de adicto

An infiltration strategy to repair Carbon Fiber Reinforced Polymer (CFRP) parts

[EN] This paper presents a methodology to determine the damage levels of laminate carbon fibre reinforced plastics (CFRP) parts after controlled impacts. These techniques will be used to perform a re-infiltration technique to repair composite parts and to reduce maintenance costs. It will be included the manufacturing processes, material characterization and the application of the AITM-0010 standard. Also, it is propose the use of NUT Ultrasonic inspection to determine and characterized the degree of the damage measured. This NDT method uses an advanced pulse-echo technique that through allow exploration of different angles, shapes and positions of defects. (C) 2017 The Authors. Published by Elsevier B.V.The authors gratefully acknowledge the partial funding by the Federal Ministry of Education and Research of the German government under grant 03FH029AN4 and the Spanish government under DPI2013-44903-R-AR.Garcia-Girón, RE.; Linke, M.; Nesslinger, S.; García Manrique, JA. (2017). An infiltration strategy to repair Carbon Fiber Reinforced Polymer (CFRP) parts. Procedia Manufacturing. 13:380-387. https://doi.org/10.1016/j.promfg.2017.09.024S3803871

Isolation of entomopathogenic nematodes and control of Phyllophaga vetula Horn in Oaxaca, Mexico

This study aimed to isolate native entomopathogenic nematodes (EPN) in the Central Valleys of Oaxaca and to determine their potential for control of white grub (Phyllophaga vetula Horn). Fifty-five (55) soil samples were collected in 13 communities in the period August to October 2008 and 29.1% of these were found positive for EPN. Five isolates were selected for their apparent pathogenicity to third instar Galleria mellonella; two of the genus Steinernema and three Heterorhabditis. After evaluating these five isolates for control of white grubs, the Heterorhabditidae EPN presented the lowest values for both lethal dosages and lethal times. Using  polymerase chain reaction (PCR) procedures, the species Heterorhabditis mexicana, Steinernema  carpocapsae and Steinernema feltiae were identified. We concluded that H. mexicana was the most effective isolate for control of P. vetula larvae.Key words: Entomopathogenic nematodes, Steinernema, Heterorhabditis, bioassays, lethal dosages

Little evidence of range size conservatism in freshwater plants across two continents

Aim: Range size conservatism suggests that closely-related species maintain geographic ranges of similar extent. However, consensus regarding this suggestion has not been reached. To shed more light on this phenomenon, we studied freshwater plant range size conservatism, range overlap and environmental niche conservatism using congeneric species comparison in two continents. In addition, we investigated whether a phylogenetic signal is found in the range sizes of aquatic plants. Location: Europe and North America. Taxon: Freshwater plants. Methods: Across spatial resolutions (50 km2, 100 km2 and 200 km2), we applied Spearman correlations among 347 and 730 pairs of congeneric species in Europe and North America, respectively, and 63 pairs shared between them. In addition, Spearman correlations were used to evaluate how the degree of spatial overlap influences range sizes and which environmental variables explain variation in range sizes. Brownian evolutionary model was used to assess the phylogenetic signal in species range sizes. Results: We found no evidence of range size conservatism across spatial resolutions for any species and species shared between the continents. In addition, range sizes of more closely related species did not overlap geographically more than those of distantly related ones and no support for environmental niche conservatism was evidenced. Main conclusions: We found that aquatic plants show no range size conservatism in the Northern Hemisphere. This means that it is challenging to define different range sizes of freshwater plants through species traits. Furthermore, we are unable to predict unknown distributions of extant aquatic plant species based on known distributional attributes of closely related species. However, our findings suggest that the interpretations of previous investigations on the range sizes of aquatic plants remain valid due to lack of range size conservatism. These practical implications encourage studying range size conservatism across realms and regions, especially for understudied organismal groups

Revisiting the thiosemicarbazonecopper(II) reaction with glutathione. Activity against colorectal carcinoma cell lines

Thiosemicarbazones (TSCs), and their copper derivatives, have been extensively studied mainly due to the potential applications as antitumor compounds. A part of the biological activity of the TSC-CuII complexes rests on their reactivity against cell reductants, as glutathione (GSH). The present paper describes the structure of the [Cu(PTSC)(ONO2)]n compound (1) (HPTSC =pyridine-2-carbaldehyde thiosemicarbazone) and its spectroscopic and magnetic properties. ESI studies performed on the reaction of GSH with 1 and the analogous [{Cu (PTSC*)(ONO2)}2] derivative (2, HPTSC* =pyridine-2-carbaldehyde 4N-methylthiosemicarbazone) show the absence of peaks related with TSC-Cu-GSH species. However GSH-Cu ones are detected, in good agreement with the release of CuI ions after reduction in the experimental conditions. The reactivity of 1 and 2 with cytochrome c and myoglobin and their activities against HT-29 and SW-480 colon carcinoma cell lines are compared with those shown by the free HPTSC and HPTSC* ligands.Obra Social “la Caixa” (OSLC-2012-007), Ministerio de Economía y Competitividad and FEDER funds (CTQ2013-48937-C2-1-P, CTQ2015-70371-REDT, MAT2015-66441-P, BIO2015-67358-C2-2-P), Junta de Castilla y León (BU237U13), Gerencia Regional de Salud, Consejería de Sanidad, Junta de Castilla y León (GRS 1023/A/14), the Basque Government (project IT-779-13

Comprehensive cross-platform comparison of methods for non-invasive EGFR mutation testing : results of the RING observational trial.

Abstract Several platforms for noninvasive EGFR testing are currently used in the clinical setting with sensitivities ranging from 30% to 100%. Prospective studies evaluating agreement and sources for discordant results remain lacking. Herein, seven methodologies including two next-generation sequencing (NGS)-based methods, three high-sensitivity PCR-based platforms, and two FDA-approved methods were compared using 72 plasma samples, from EGFR-mutant non-small-cell lung cancer (NSCLC) patients progressing on a first-line tyrosine kinase inhibitor (TKI). NGS platforms as well as high-sensitivity PCR-based methodologies showed excellent agreement for EGFR-sensitizing mutations (K = 0.80-0.89) and substantial agreement for T790M testing (K = 0.77 and 0.68, respectively). Mutant allele frequencies (MAFs) obtained by different quantitative methods showed an excellent reproducibility (intraclass correlation coefficients 0.86-0.98). Among other technical factors, discordant calls mostly occurred at mutant allele frequencies (MAFs) ≤ 0.5%. Agreement significantly improved when discarding samples with MAF ≤ 0.5%. EGFR mutations were detected at significantly lower MAFs in patients with brain metastases, suggesting that these patients risk for a false-positive result. Our results support the use of liquid biopsies for noninvasive EGFR testing and highlight the need to systematically report MAFs. Keywords: NGS; circulating free DNA; epidermal growth factor receptor; non-small-cell lung cancer; osimertinib; tyrosine kinase inhibitor