179 research outputs found
Novel sources of Flavor Changed Neutral Currents in the model
Sources of Flavor Changed Neutral Currents (FCNC) naturally emerge from a
well motivated framework called 3-3-1 with right-handed neutrinos model,
for short, mediated by an extra neutral gauge boson .
Following previous works we calculate these sources and in addition we derive
new ones coming from CP-even and -odd neutral scalars which appear due to their
non-diagonal interactions with the physical standard quarks. Furthermore we
show that bounds related to the neutral mesons systems and may be significantly strengthened in the presence of these new
interactions allowing us to infer stronger constraints on the parameter space
of the model.Comment: Published version. 10 pages, 6 figure
Structure and reactivity of Trypanosoma brucei pteridine reductase: inhibition by the archetypal antifolate methotrexate
The protozoan Trypanosoma brucei has a functional pteridine reductase (TbPTR1), an NADPH-dependent short-chain reductase that participates in the salvage of pterins, which are essential for parasite growth. PTR1 displays broad-spectrum activity with pterins and folates, provides a metabolic bypass for inhibition of the trypanosomatid dihydrofolate reductase and therefore compromises the use of antifolates for treatment of trypanosomiasis. Catalytic properties of recombinant TbPTR1 and inhibition by the archetypal antifolate methotrexate have been characterized and the crystal structure of the ternary complex with cofactor NADP(+) and the inhibitor determined at 2.2 Å resolution. This enzyme shares 50% amino acid sequence identity with Leishmania major PTR1 (LmPTR1) and comparisons show that the architecture of the cofactor binding site, and the catalytic centre are highly conserved, as are most interactions with the inhibitor. However, specific amino acid differences, in particular the placement of Trp221 at the side of the active site, and adjustment of the β6-α6 loop and α6 helix at one side of the substrate-binding cleft significantly reduce the size of the substrate binding site of TbPTR1 and alter the chemical properties compared with LmPTR1. A reactive Cys168, within the active site cleft, in conjunction with the C-terminus carboxyl group and His267 of a partner subunit forms a triad similar to the catalytic component of cysteine proteases. TbPTR1 therefore offers novel structural features to exploit in the search for inhibitors of therapeutic value against African trypanosomiasis
Relativistically invariant analysis of --isobar production in deuteron electrodisintegration: general analysis of polarization effects
The differential cross section and the polarization observables for --isobar production in the deuteron electrodisintegration process, , are calculated in a general formalism based on structure
functions. The obtained expressions have a general nature, hold for
one--photon--exchange, assuming P--invariance of the electromagnetic
interaction and the conservation of the hadron electromagnetic current. The
dependence of the differential cross section of the
reaction on the vector and tensor polarizations of the deuteron target with
unpolarized and longitudinally polarized electrons is considered. The general
dependence of the asymmetries on two of five kinematic variables, the azimuthal
angle and (linear polarization of the virtual photon) is
calculated. A similar analysis is performed for the polarization of the nucleon
produced in reaction provided the electron beam is
unpolarized or longitudinally polarized. Polarization effects, which are due to
the strong interaction in the final state are calculated. The
photoproduction of the --isobar on the deuteron target has been
considered in detail, as a particular case. The differential cross section and
various polarization observables have been derived in terms of the reaction
amplitudes. The polarization observables due to the linear and circular
polarizations of the photon, when the deuteron target is arbitrarily polarized
have been derived in terms of the reaction amplitudes. The polarization of the
final nucleon is also considered.Comment: 52 page
Seismology of the Sun : Inference of Thermal, Dynamic and Magnetic Field Structures of the Interior
Recent overwhelming evidences show that the sun strongly influences the
Earth's climate and environment. Moreover existence of life on this Earth
mainly depends upon the sun's energy. Hence, understanding of physics of the
sun, especially the thermal, dynamic and magnetic field structures of its
interior, is very important. Recently, from the ground and space based
observations, it is discovered that sun oscillates near 5 min periodicity in
millions of modes. This discovery heralded a new era in solar physics and a
separate branch called helioseismology or seismology of the sun has started.
Before the advent of helioseismology, sun's thermal structure of the interior
was understood from the evolutionary solution of stellar structure equations
that mimicked the present age, mass and radius of the sun. Whereas solution of
MHD equations yielded internal dynamics and magnetic field structure of the
sun's interior. In this presentation, I review the thermal, dynamic and
magnetic field structures of the sun's interior as inferred by the
helioseismology.Comment: To be published in the proceedings of the meeting "3rd International
Conference on Current Developments in Atomic, Molecular, Optical and Nano
Physics with Applications", December 14-16, 2011, New Delhi, Indi
New measurement of the rare decay with CMD-2
A new measurement of the rare decay \phi \to \eta' \gamma performed with the
CMD-2 detector at Novosibirsk is described. Of the data sample corresponding to
the integrated luminosity of 14.5 pb^{-1}, twenty one events have been selected
in the mode \eta'\to\pi^+\pi^-\eta, \eta\to\gamma\gamma. The following
branching ratio was obtained: B(\phi \to \eta' \gamma) = (8.2^{+2.1}_{-1.9} \pm
1.1) 10^{-5}.Comment: 12 pages, 4 figures, LaTe
Perspectives in Global Helioseismology, and the Road Ahead
We review the impact of global helioseismology on key questions concerning
the internal structure and dynamics of the Sun, and consider the exciting
challenges the field faces as it enters a fourth decade of science
exploitation. We do so with an eye on the past, looking at the perspectives
global helioseismology offered in its earlier phases, in particular the
mid-to-late 1970s and the 1980s. We look at how modern, higher-quality, longer
datasets coupled with new developments in analysis, have altered, refined, and
changed some of those perspectives, and opened others that were not previously
available for study. We finish by discussing outstanding challenges and
questions for the field.Comment: Invited review; to appear in Solar Physics (24 pages, 6 figures
Deep inelastic inclusive and diffractive scattering at values from 25 to 320 GeV with the ZEUS forward plug calorimeter
Deep inelastic scattering and its diffractive component, , have been studied at HERA with the ZEUS
detector using an integrated luminosity of 52.4 pb. The method has
been used to extract the diffractive contribution. A wide range in the
centre-of-mass energy (37 -- 245 GeV), photon virtuality (20 -- 450
GeV) and mass (0.28 -- 35 GeV) is covered. The diffractive cross
section for GeV rises strongly with , the rise becoming
steeper as increases. The data are also presented in terms of the
diffractive structure function, , of the proton. For fixed
and fixed , \xpom F^{\rm D(3)}_2 shows a strong rise as \xpom \to
0, where \xpom is the fraction of the proton momentum carried by the
Pomeron. For Bjorken-, \xpom F^{\rm D(3)}_2 shows
positive scaling violations, while for
negative scaling violations are observed. The diffractive structure function is
compatible with being leading twist. The data show that Regge factorisation is
broken.Comment: 89 pages, 27 figure
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