Influence of the biomechanical variables of the gait cycle in running economy. [Influencia de variables biomecánicas del ciclo de paso en la economía de carrera].

<p algn="justify">The aim of this study was to investigate the relationships between biomechanical variables and running economy (RE). Eleven recreational (RR) and 14 well-trained runners (WT) completed 4 min stages on a treadmill at different speeds. During the test, biomechanical variables such as ground contact time (tc), swing time (tsw), stride length, frequency and angle and the length of the different subphases of ground contact were calculated using an optical measurement system. VO2 was measured in order to calculate RE. The WT runners were more economical than the RR at all speeds and presented lower tc, higher tsw, longer strides, lower stride frequencies and higher stride angles (P<0.05). Similarly, the WT runners experienced a later propulsion subphase than the RR runners (P<0.05). RE was positively related to tc, stride frequency and 10-km race pace, whereas it was negatively related to tsw, stride length, stride angle and the propulsive subphase. Our results suggest that running patterns characterized by longer stride lengths and higher stride angles, lower stride frequencies and tc, higher tsw and later propulsion suphases may enable an efficient energy use per stride. </p> Resumen <p align="justify">El objetivo de este estudio fue el investigar las relaciones entre diferentes variables biomecánicas y la economía de carrera (RE). Once atletas populares (RR) y 14 atletas altamente entrenados (WT) completaron estadios de 4 min en tapiz rodante a diferentes velocidades. Durante el test, el tiempo de contacto (tc) y de vuelo (tsw), la longitud, frecuencia y ángulo de zancada y la duración de las diferentes sub-fases del tiempo de contacto se calcularon usando un sistema óptico. Se midió el VO2 para calcular la RE. Los atletas WT fueron más económicos que los RR y presentaron menores tc, mayores tsw, zancadas más largas, frecuencias más bajas y ángulos mayores (P<0.05). Además, los atletas WT experimentaron la sub-fase propulsiva más tarde que los RR (P<0.05). La RE estuvo positivamente relacionada con el tc, la frecuencia de zancada y el ritmo de 10 km, mientras que estuvo negativamente relacionada con el tsw, longitud y ángulo de zancada y la sub-fase propulsiva. Estos resultados sugieren que una biomecánica caracterizada por zancadas más largas, ángulos de zancada y tsw mayores, menores frecuencias y tc, y sub-fases propulsivas más tardías pueden favorecer un uso energético más eficiente.</p

Características físicas y antropométricas, y análisis de juego en jugadores de pádel de elite

The goals of the present study were, on the one hand, to determine the anthropometric,strength (measured by jump and hand-grip tests) compared to other racquet sports,and on the other hand, to analyze the time-motion characteristics during the under-23Spanish Paddle championships. Thus, 14 men (20,38 ± 1,92 yr) and 12 women(19.73 ± 2,37 yr) participated in this study. Firstly, participants were assessed foranthropometric measurements; secondly, strength was measured by jump andhand-grip tests before and immediately after the match; finally, the time-motion ofmatches were quantified during the under-23 Spanish Championship in 2012. Theanthropometric characteristics of paddle players were slightly different in comparisonto players of other racket sports. In respect of strength parameters, there were notsignificant differences between pre-match and post-match measurements, indicatingno fatigue component after competition. In respect to time motion analyses, restingperiods were significantly longer compared to the effective playing time. Paddle seemsto have less time active than table-tennis and badminton, but more time active thantennis.&nbsp; &nbsp; &nbsp; Los objetivos de este estudio son, por un lado, determinar las características antropométricas y de fuerza (medida mediante test de hand-grip y salto vertical con brazos libres) comprándolo con otros deportes de raqueta, y por otro, analizar las características propias del juego durante el Campeonato de España de Pádel sub-23. Para ello 14 hombres (20,38 ± 1,92 años) y 12 mujeres (19,73 ± 2,37 años) participaron en este estudio. A todos ellos se les realizó unas mediciones antropométricas, y unos tests de fuerza de miembro superior (hand-grip) y de miembro inferior (salto vertical con brazos libres) antes y después de los partidos. Por último, se registraron los datos de analisis de juego durante dicho evento. Los resultados muestran que las características antropométricas de los jugadores de pádel difieren ligeramente de las de los jugadores de otros deportes de raqueta. Los valores de fuerza, no disminuyeron después del partido, no observándose ningún indicio de fatiga. Respecto al análisis de las características del juego, el pádel se caracteriza por tener menos tiempo activo que el tenis de mesa y el badminton, pero más tiempo activo que el tenis

multi level alignments as an extensible representation basis for textual entailment algorithms

A major problem in research on Textual Entailment (TE) is the high implementation effort for TE systems. Recently, interoperable standards for annotation and preprocessing have been proposed. In contrast, the algorithmic level remains unstandardized, which makes component re-use in this area very difficult in practice. In this paper, we introduce multi-level alignments as a central, powerful representation for TE algorithms that encourages modular, reusable, multilingual algorithm development. We demonstrate that a pilot open-source implementation of multi-level alignment with minimal features competes with state-of-theart open-source TE engines in three languages

Teasing apart the joint effect of demography and natural selection in the birth of a contact zone

Vast population movements induced by recurrent climatic cycles have shaped the genetic structure of plant species. During glacial periods species were confined to low-latitude refugia from which they recolonized higher latitudes as the climate improved. This multipronged recolonization led to many lineages that later met and formed large contact zones. We utilize genomic data from 5000 Picea abies trees to test for the presence of natural selection during recolonization and establishment of a contact zone in Scandinavia. Scandinavian P. abies is today made up of a southern genetic cluster originating from the Baltics, and a northern one originating from Northern Russia. The contact zone delineating them closely matches the limit between two major climatic regions. We show that natural selection contributed to its establishment and maintenance. First, an isolation-with-migration model with genome-wide linked selection fits the data better than a purely neutral one. Second, many loci show signatures of selection or are associated with environmental variables. These loci, regrouped in clusters on chromosomes, are often related to phenology. Altogether, our results illustrate how climatic cycles, recolonization and selection can establish strong local adaptation along contact zones and affect the genetic architecture of adaptive traits

An insight into racial bias in dermoscopy repositories: A HAM10000 data set analysis

ABSTRACT: Background Studies have revealed a lack of representation of skin of colour patients in academic sources of dermatologic diseases, including databases. This visual racism has consequently generated less comfort and confidence among the specialists in the care and attention of this ethnic group, including the opportunity of being correctly diagnosed. Objectives To investigate and uncover potential racial biases in the HAM10000 data set through an exploratory analysis of the dark skin tones representation, the identification of inaccuracies in its documentation, the recognition of relevant skin conditions absent for darker skin and the lack of ethnic diversity variables crucial for validating diagnosis across different skin tones. Methods An exploratory examination was conducted to investigate the occurrence of dark skin within the HAM10000 database (housed in a Harvard Dataverse repository), consisting of 10,015 dermoscopic images of skin lesions. A visual depiction encompassing the whole skin tones was generated by sampling four crucial data points from each image and applying the Gray World Algorithm for colour normalization. To confirm the accuracy of the graphical representation, dermatologists validated the pixel sampling process by analysing a randomly selected 10% of the images for each type of skin lesion. This visual representation was produced for the entire data set as well as for each skin lesion type. The study was further enhanced by comparing the skin lesion representation within the HAM10000 data set against documented prevalences of relevant conditions affecting dark skin. Results Less than 5% of the images came from dark-skinned patients. Nevertheless, in about 4.9% of cases, our pixel sampling method might inadvertently capture shadows or dark spots resulting from the imaging device or the lesion itself rather than the individual's actual skin tone. In addition, there are inaccuracies in the data set's claims of diversity and comprehensive coverage, notably the underrepresentation of conditions prevalent in darker skin and the absence of ethnic diversity variables. Conclusions Visual racism is an issue that needs to be addressed in medical sources of information and education. Image databases and artificial intelligence models need to be nourished with information, including all skin types, to guarantee equal access to opportunities. Furthermore, any instances where conditions affecting people of colour are underrepresented must be meticulously documented and reported to highlight and address these disparities effectively. This is particularly important in dermoscopy imaging, where solely relying on image-based racial bias analysis is limited. The alteration of the patient's actual skin tone by the dermatoscope's lighting complicates the accurate assessment of racial bias

Calpain Activator Dibucaine Induces Platelet Apoptosis

Calcium-dependent calpains are a family of cysteine proteases that have been demonstrated to play key roles in both platelet glycoprotein Ibα shedding and platelet activation and altered calpain activity is associated with thrombotic thrombocytopenic purpura. Calpain activators induce apoptosis in several types of nucleated cells. However, it is not clear whether calpain activators induce platelet apoptosis. Here we show that the calpain activator dibucaine induced several platelet apoptotic events including depolarization of the mitochondrial inner transmembrane potential, up-regulation of Bax and Bak, down-regulation of Bcl-2 and Bcl-XL, caspase-3 activation and phosphatidylserine exposure. Platelet apoptosis elicited by dibucaine was not affected by the broad spectrum metalloproteinase inhibitor GM6001. Furthermore, dibucaine did not induce platelet activation as detected by P-selectin expression and PAC-1 binding. However, platelet aggregation induced by ristocetin or α-thrombin, platelet adhesion and spreading on von Willebrand factor were significantly inhibited in platelets treated with dibucaine. Taken together, these data indicate that dibucaine induces platelet apoptosis and platelet dysfunction

Waste prevention for sustainable resource and waste management

Although the 2Rs (reduce and reuse) are considered high-priority approaches, there has not been enough quantitative research on effective 2R management. The purpose of this paper is to provide information obtained through the International Workshop in Kyoto, Japan, on 11–13 November 2015, which included invited experts and researchers in several countries who were in charge of 3R policies, and an additional review of 245 previous studies. It was found that, regarding policy development, the decoupling between environmental pressures and economy growth was recognized as an essential step towards a sustainable society. 3R and resource management policies, including waste prevention, will play a crucial role. Approaches using material/substance flow analyses have become sophisticated enough to describe the fate of resources and/or hazardous substances based on human activity and the environment, including the final sink. Life-cycle assessment has also been developed to evaluate waste prevention activities. Regarding target products for waste prevention, food loss is one of the waste fractions with the highest priority because its countermeasures have significant upstream and downstream effects. Persistent organic pollutants and hazardous compounds should also be taken into account in the situation where recycling activities are globally widespread for the promotion of a material-cycling society

What traits are carried on mobile genetic elements, and why?

Although similar to any other organism, prokaryotes can transfer genes vertically from mother cell to daughter cell, they can also exchange certain genes horizontally. Genes can move within and between genomes at fast rates because of mobile genetic elements (MGEs). Although mobile elements are fundamentally self-interested entities, and thus replicate for their own gain, they frequently carry genes beneficial for their hosts and/or the neighbours of their hosts. Many genes that are carried by mobile elements code for traits that are expressed outside of the cell. Such traits are involved in bacterial sociality, such as the production of public goods, which benefit a cell's neighbours, or the production of bacteriocins, which harm a cell's neighbours. In this study we review the patterns that are emerging in the types of genes carried by mobile elements, and discuss the evolutionary and ecological conditions under which mobile elements evolve to carry their peculiar mix of parasitic, beneficial and cooperative genes

Genome-wide analysis identifies 12 loci influencing human reproductive behavior.

The genetic architecture of human reproductive behavior-age at first birth (AFB) and number of children ever born (NEB)-has a strong relationship with fitness, human development, infertility and risk of neuropsychiatric disorders. However, very few genetic loci have been identified, and the underlying mechanisms of AFB and NEB are poorly understood. We report a large genome-wide association study of both sexes including 251,151 individuals for AFB and 343,072 individuals for NEB. We identified 12 independent loci that are significantly associated with AFB and/or NEB in a SNP-based genome-wide association study and 4 additional loci associated in a gene-based effort. These loci harbor genes that are likely to have a role, either directly or by affecting non-local gene expression, in human reproduction and infertility, thereby increasing understanding of these complex traits

The genetic architecture of type 2 diabetes

The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies have identified scores of common variants associated with type 2 diabetes, but in aggregate, these explain only a fraction of heritability. To test the hypothesis that lower-frequency variants explain much of the remainder, the GoT2D and T2D-GENES consortia performed whole genome sequencing in 2,657 Europeans with and without diabetes, and exome sequencing in a total of 12,940 subjects from five ancestral groups. To increase statistical power, we expanded sample size via genotyping and imputation in a further 111,548 subjects. Variants associated with type 2 diabetes after sequencing were overwhelmingly common and most fell within regions previously identified by genome-wide association studies. Comprehensive enumeration of sequence variation is necessary to identify functional alleles that provide important clues to disease pathophysiology, but large-scale sequencing does not support a major role for lower-frequency variants in predisposition to type 2 diabetes