Branching of negative streamers in free flight

We recently have shown that a negative streamer in a sufficiently high homogeneous field can branch spontaneously due to a Laplacian instability, rather than approach a stationary mode of propagation with fixed radius. In our previous simulations, the streamer started from a wide initial ionization seed on the cathode. We here demonstrate in improved simulations that a streamer emerging from a single electron branches in the same way. In fact, though the evolving streamer is much more narrow, it branches after an even shorter propagation distance.Comment: 4 pages, 3 figure

Review of recent results on streamer discharges and discussion of their relevance for sprites and lightning

It is by now well understood that large sprite discharges at the low air densities of the mesosphere are physically similar to small streamer discharges in air at standard temperature and pressure. This similarity is based on Townsend scaling with air density. First the theoretical basis of Townsend scaling and a list of six possible corrections to scaling are discussed; then the experimental evidence for the similarity between streamers and sprites is reviewed. We then discuss how far present sprite and streamer theory has been developed, and we show how streamer experiments can be interpreted as sprite simulations. We review those results of recent streamer research that are relevant for sprites and other forms of atmospheric electricity and discuss their implications for sprite understanding. These include the large range of streamer diameters and velocities and the overall 3D morphology with branching, interaction and reconnection, the dependence on voltage and polarity, the electron energies in the streamer head and the consecutive chemical efficiency and hard radiation. New theoretical and experimental results concern measurements of streamer spectra in air, the density dependence of streamer heating (hot leaders are unlikely at 80 km altitude and cold streamers are unlikely in liquids), and a discussion of the influence of magnetic fields on thermal electrons or on energetic electrons in streamers or sprites.Comment: 38 pages, 4 figures, article accepted for publication in J. Geophys. Res. - Space Physic

A study of the possibility of sprites in the atmospheres of other planets

Sprites are a spectacular type of transient luminous events (TLE) which occur above thunderstorms immediately after lightning. They have shapes of giant jellyfish, carrots or columns and last tens of milliseconds. In Earth's atmosphere, sprites mostly emit in red and blue wavelengths from excited N2 and N2+ and span a vertical range between 50 and 90 km above the surface. The emission spectra, morphology and occurrence heights of sprites reflect the properties of the planetary atmosphere they inhabit and are related to the intensity of the initiating parent lightning.. This paper presents results of theoretical calculations of the expected occurrence heights of sprites above lightning discharges in the CO2 atmosphere of Venus, the N2 atmosphere of Titan and the H2-He atmosphere of Jupiter. The expected emission features are presented and the potential of detecting sprites in planetary atmospheres by orbiting spacecraft is discussed.Comment: 26 pages, 4 figures, to appear in J. Geophys. Res. - Planet

Integration und Willkommenskultur im ländlichen Raum

INTEGRATION UND WILLKOMMENSKULTUR IM LÄNDLICHEN RAUM Integration und Willkommenskultur im ländlichen Raum / Klimach, Cornelia (Rights reserved) ( -

Gesundheit fördern in vernetzten Strukturen

Kolip P, Gerken U, Schaefer I, Mühlbach A, Gebhardt B. Gesundheit fördern in vernetzten Strukturen. Weinheim: Beltz Juventa; 2013

Evaluation der Förderinitiative "Aktionsbündnisse Gesunde Lebensstile und Lebenswelten" - Instrumentarium und erste Ergebnisse zur Planungsqualität

Gerken U, Schaefer I, Mühlbach A, Morin Elias G, Gebhardt B, Kolip P. Evaluation der Förderinitiative "Aktionsbündnisse Gesunde Lebensstile und Lebenswelten" - Instrumentarium und erste Ergebnisse zur Planungsqualität. Das Gesundheitswesen. 2012;74(2):112-116

Treatment With Grazoprevir/Elbasvir for Renal Transplant Recipients With Chronic Hepatitis C Virus Infection and Impaired Allograft Function

Background. Direct-acing antiviral agents are highly efficient treatment options for chronic hepatitis C virus (HCV) infection after renal allograft transplantation. Treatment options for patients with impaired graft function remain limited. Therefore, we assessed the effectiveness and safety of grazoprevir/elbasvir therapy for patients with chronic HCV infection and impaired renal allograft function. Methods. Eleven renal allograft recipients with therapy-naïve HCV genotype (GT) 1a, 1b, or 4 were treated with the fixed-dose combination of elbasvir/grazoprevir without ribavirin for 12 weeks. All recipients exhibited impaired graft function with an average glomerular filtration rate lower than 30 mL/min per 1.73 m2. Clinical data were retrospectively reviewed for renal and liver function parameters. Patients were closely monitored for trough levels of immunosuppressive agents, viral load, laboratory values, and potential adverse effects. Results. Seven (64%) patients exhibited a rapid virologic response within 4 weeks (HCV GT1a, n = 2; HCV GT1b, n = 5). The other 4 patients exhibited a virologic response within 8 weeks (HCV GT1b, n = 3; HCV GT 4, n = 1). All patients exhibited a sustained virologic response at week 12 after the end of treatment. Clinical measures of liver function improved substantially for all patients. Few adverse effects were reported. Impaired renal allograft function and proteinuria remained stable. For most patients, only moderate adjustments to the tacrolimus dosage were necessary for maintaining sufficient trough levels. Conclusions. This treatment appears to be safe and effective for renal transplant recipients with impaired allograft function and is a promising treatment option for eradicating HCV infection in this patient population

Tumour stage distribution and survival of malignant melanoma in Germany 2002-2011

Background Over the past two decades, there has been a rising trend in malignant melanoma incidence worldwide. In 2008, Germany introduced a nationwide skin cancer screening program starting at age 35. The aims of this study were to analyse the distribution of malignant melanoma tumour stages over time, as well as demographic and regional differences in stage distribution and survival of melanoma patients. Methods Pooled data from 61 895 malignant melanoma patients diagnosed between 2002 and 2011 and documented in 28 German population-based and hospital-based clinical cancer registries were analysed using descriptive methods, joinpoint regression, logistic regression and relative survival. Results The number of annually documented cases increased by 53.2% between 2002 (N = 4 779) and 2011 (N = 7 320). There was a statistically significant continuous positive trend in the proportion of stage UICC I cases diagnosed between 2002 and 2011, compared to a negative trend for stage UICC II. No trends were found for stages UICC III and IV respectively. Age (OR 0.97, 95% CI 0.97–0.97), sex (OR 1.18, 95% CI 1.11–1.25), date of diagnosis (OR 1.05, 95% CI 1.04–1.06), ‘diagnosis during screening’ (OR 3.24, 95% CI 2.50–4.19) and place of residence (OR 1.23, 95% CI 1.16–1.30) had a statistically significant influence on the tumour stage at diagnosis. The overall 5-year relative survival for invasive cases was 83.4% (95% CI 82.8–83.9%). Conclusions No distinct changes in the distribution of malignant melanoma tumour stages among those aged 35 and older were seen that could be directly attributed to the introduction of skin cancer screening in 2008.

Emergence of sprite streamers from screening-ionization waves in the lower ionosphere

Sprite discharges above thunderclouds at altitudes of 40-90 km (refs1-5) are usually created by a strong positive cloud-to-ground lightning flash6. Sometimes these sprite discharges emerge from a visible halo 5,7-9, and during the first stage they always propagate downwards and branch on their way 5,7,9-11. Modelling efforts have been restricted to conditions of non-ionized air of constant density and show double-headed sprites12 or sprites starting from metal electrodes, but they do not explain why observations exclusively record sprites that propagate downwards. Here we present simulations with a numerical discharge model on a non-uniform, dynamically adapted computational grid13 to capture the wide range of emerging spatial scales, and we use realistic air and electron densities that vary with altitude. Our model shows a downward-propagating screening-ionization wave in the lower ionosphere that sharpens and collapses into a sprite streamer as it propagates farther down. Streamer velocity, diameter and length until branching agree with observations9 within measuring accuracy. We speculate that sprites generically emerge through the collapse of a wide screening-ionization wave into a sprite streamer, although this wave is only sometimes visible as a luminous halo. © 2009 Macmillan Publishers Limited. All rights reserved