Girona, ciudad semilla de ciencia : educación científica para la sostenibilidad

Las ciudades ‘semilla de ciencia’ son el caballo de batalla del proyecto europeo Pollen, seed cities for science: a community approach for a sustainable growth of science education in Europe dirigido principalmente a las etapas de educación infantil y primaria. En la presente comunicación se analiza el proyecto ‘Girona, ciudad semilla de ciencia’ bajo el prisma de la educación para la sostenibilidad. Tomando como marco de referencia las características de la educación ambiental se analizan cualitativamente los diferentes componentes del proyecto. Como conclusión, se identifican debilidades y fortalezas del proyecto y se apuntan propuestas de mejoría para avanzar en la educación para la sostenibilidad, desde la educación científica y en el contexto de una ciudad semilla de ciencia. Finalmente, se proponen posibles nuevas líneas de investigación

Microevents produced by gas migration and expulsion at the seabed: A study based on sea bottom recordings from the Sea of Marmara

International audienceDifferent types of 4-component ocean bottom seismometers (OBS) were deployed for variable durations ranging from 1 week to about 4 months in 2007, over soft sediments covering the seafloor of the Tekirdag Basin (western part of the Sea of Marmara, Turkey). Non-seismic microevents were recorded by the geophones, but generally not by the hydrophones, except when the hydrophone is located less than a few tens of centimetres above the seafloor. The microevents are characterized by short durations of less than 0.8 s, by frequencies ranging between 4 and 30 Hz, and by highly variable amplitudes. In addition, no correlation between OBSs was observed, except for two OBSs, located 10 m apart. Interestingly, a swarm of ∼400 very similar microevents (based on principal component analysis) was recorded in less than one day by an OBS located in the close vicinity of an active, gas-prone fault cutting through the upper sedimentary layers. The presence of gas in superficial sediments, together with analogies with laboratory experiments, suggest that gas migration followed by the collapse of fluid-filled cavities or conduits could be the source of the observed microevents. This work shows that OBSs may provide valuable information to improve our understanding of natural degassing processes from the seafloor

Overview of the design of the ITER heating neutral beam injectors

The heating neutral beam injectors (HNBs) of ITER are designed to deliver 16.7MWof 1 MeVD0 or 0.87 MeVH0 to the ITER plasma for up to 3600 s. They will be the most powerful neutral beam\uf0a0(NB) injectors ever, delivering higher energy NBs to the plasma in a tokamak for longer than any previous systems have done. The design of the HNBs is based on the acceleration and neutralisation of negative ions as the efficiency of conversion of accelerated positive ions is so low at the required energy that a realistic design is not possible, whereas the neutralisation ofH 12 andD 12 remains acceptable ( 4856%). The design of a long pulse negative ion based injector is inherently more complicated than that of short pulse positive ion based injectors because: \u2022 negative ions are harder to create so that they can be extracted and accelerated from the ion source; \u2022 electrons can be co-extracted from the ion source along with the negative ions, and their acceleration must be minimised to maintain an acceptable overall accelerator efficiency; \u2022 negative ions are easily lost by collisions with the background gas in the accelerator; \u2022 electrons created in the extractor and accelerator can impinge on the extraction and acceleration grids, leading to high power loads on the grids; \u2022 positive ions are created in the accelerator by ionisation of the background gas by the accelerated negative ions and the positive ions are back-accelerated into the ion source creating a massive power load to the ion source; \u2022 electrons that are co-accelerated with the negative ions can exit the accelerator and deposit power on various downstream beamline components. The design of the ITER HNBs is further complicated because ITER is a nuclear installation which will generate very large fluxes of neutrons and gamma rays. Consequently all the injector components have to survive in that harsh environment. Additionally the beamline components and theNBcell, where the beams are housed, will be activated and all maintenance will have to be performed remotely. This paper describes the design of theHNBinjectors, but not the associated power supplies, cooling system, cryogenic system etc, or the high voltage bushingwhich separates the vacuum of the beamline fromthehighpressureSF6 of the high voltage (1MV) transmission line, through which the power, gas and coolingwater are supplied to the beam source. Also themagnetic field reduction system is not described

ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents

Establishing the interactome of the cancer-associated stress protein Nuclear Protein 1 (NUPR1), we found that it binds to several hundreds of proteins, including proteins involved in nuclear translocation, DNA repair, and key factors of the SUMO pathway. We demonstrated that the NUPR1 inhibitor ZZW-115, an organic synthetic molecule, competes with importins for the binding to the NLS region of NUPR1, thereby inhibiting its nuclear translocation. We hypothesized, and then proved, that inhibition of NUPR1 by ZZW-115 sensitizes cancer cells to DNA damage induced by several genotoxic agents. Strikingly, we found that treatment with ZZW-115 reduced SUMOylation of several proteins involved in DNA damage response (DDR). We further report that the presence of recombinant NUPR1 improved the SUMOylation in a cell-free system, indicating that NUPR1 directly stimulates the SUMOylation machinery. We propose that ZZW-115 sensitizes cancer cells to genotoxic agents by inhibiting the nuclear translocation of NUPR1 and thereby decreasing the SUMOylation-dependent functions of key proteins involved in the DDR

UFMylation of MRE11 is essential for telomere length maintenance and hematopoietic stem cell survival

International audienc

Measurement of the neutron flux at the Canfranc Underground Laboratory with HENSA

We have performed a long-term measurement of the neutron flux with the High Efficiency Neutron Spectrometry Array HENSA in the Hall A of the Canfranc Underground Laboratory. The Hall A measurement campaign lasted from October 2019 to March 2021, demonstrating an excellent stability of the HENSA setup. Preliminary results on the neutron flux from this campaign are presented for the first time. In Phase 1 (113 live days) a total neutron flux of 1.66(2) $\times$10$^{-5}$ cm$^{-2}$ s$^{-1}$ is obtained. Our results are in good agreement with those from our previous shorter measurement where a reduced experimental setup was employed.Comment: Proceedings of the 17th International Conference on Topics in Astroparticle and Underground Physics (TAUP 2021

Cephalosporin-resistant Pneumococci and Sickle Cell Disease

Increasingly resistant bacteria in sickle cell disease patients indicate need to evaluate extendedspectrum cephalosporin therapy