Assessment of physical vulnerability of buildings and analysis of landslide risk at the municipal scale: application to the Loures municipality, Portugal

This study offers a semi-quantitative assessment of the physical vulnerability of buildings to landslides in a Portuguese municipality (Loures), as well as the quantitative landslide risk analysis computed as the product of the landslide hazard by the vulnerability and the economic value of the buildings. The hazard was assessed by combining the spatiotemporal probability and the frequency–magnitude relationship of the landslides. The physical vulnerability assessment was based on an inquiry of a pool of European landslide experts and a sub-pool of landslide experts who know the study area, and the answers’ variability was assessed with standard deviation. The average vulnerability of the basic geographic entities was compared by changing the map unit and applying the vulnerability to all the buildings of a test site, the inventory of which was listed on the field. The economic value was calculated using an adaptation of the Portuguese Tax Services approach, and the risk was computed for different landslide magnitudes and different spatiotemporal probabilities. As a rule, the vulnerability values given by the sub-pool of experts who know the study area are higher than those given by the European experts, namely for the high-magnitude landslides. The obtained vulnerabilities vary from 0.2 to 1 as a function of the structural building types and the landslide magnitude, and are maximal for 10 and 20m landslide depths. However, the highest risk was found for the landslides that are 3m deep, because these landslides combine a relatively high frequency in the Loures municipality with a substantial potential damage.info:eu-repo/semantics/publishedVersio

Trehalose alleviates the phenotype of Machado–Joseph disease mouse models

Machado-Joseph disease (MJD), also known as spinocerebellar ataxia type 3, is the most common of the dominantly inherited ataxias worldwide and is characterized by mutant ataxin-3 aggregation and neuronal degeneration. There is no treatment available to block or delay disease progression. In this work we investigated whether trehalose, a natural occurring disaccharide widely used in food and cosmetic industry, would rescue biochemical, behavioral and neuropathological features of an in vitro and of a severe MJD transgenic mouse model.This work was funded by BioBlast Pharma, the ERDF through the Regional Operational Program Center 2020, Competitiveness Factors Operational Program (COMPETE 2020) and National Funds through FCT (Foundation for Science and Technology) - SFRH/BD/87404/2012, BrainHealth2020 projects (CENTRO-01-0145-FEDER-000008), ViraVector (CENTRO-01-0145FEDER-022095), CortaCAGs (POCI-01-0145-FEDER-016719), SpreadSilenc‑ing POCI-01-0145-FEDER-029716 and POCI-01-0145-FEDER-007440, as well as the SynSpread, ESMI and ModelPolyQ under the EU Joint ProgramNeurodegenerative Disease Research (JPND), the last two co-funded bythe European Union H2020 program, GA No. 643417; by National Ataxia Foundation (USA), the American Portuguese Biomedical Research Fund (APBRF) and the Richard Chin and Lily Lock Machado–Joseph Disease Research Fund.info:eu-repo/semantics/publishedVersio

Reflexões e conhecimentos evidenciados por professores que estudam área de figuras planas

Apresenta-se, neste artigo, um estudo cujo objetivo é discutir e compreender o processo de (re)significação dos conhecimentos profissionais dos seus participantes concernente às discussões e às reflexões explicitadas por um grupo de professores que leciona matemática para os anos iniciais do ensino fundamental. Os professores estudaram o cálculo de área de figuras planas por meio da utilização de quadriculados. Fundamenta-se nos estudos de Zeichner e serrazina para discutir a reflexão sobre a prática e, em Ball, Thames e Phelps, para analisar a (re)significação dos conhecimentos dos profissionais envolvidos. Os dados analisados foram coletados durante os encontros do grupo na própria escola na qual os participantes lecionavam. Por meio das análises das discussões ocorridas, foi possível observar que os professores ampliaram o conhecimento comum e especializado do conteúdo, especialmente em relação às estratégias de cálculo da área, e ainda passaram a utilizar reconfiguração das figuras e as fórmulas de área com maior facilidade. O apoio mútuo permitiu que eles identificassem suas próprias necessidades e, então, modificassem suas análises acerca das estratégias para o cálculo de área a serem adotadas

Spatial and temporal changes in urban fabric exposure to sea level rise, from 1995 to 2018, in mainland Portugal

To project HighWaters (EXPL/GES-AMB/1246/2021). Pedro P. Santos is financed by FCT I.P. (CEECIND/00268/2017). This work was financed by the Research Unit UIDB/00295/2020 and UIDP/00295/2020.info:eu-repo/semantics/publishedVersio

Reflexões e conhecimentos evidenciados por professores que estudam área de figuras planas

This study aims to discuss and understand the process of (re)significance of teachers’ professional knowledge based on discussions and reflections carried out by a group of teachers who teach mathematics for the initial years of the elementary education. The teachers studied how to calculate the area of plane figures using squared arrays. This study is based on Zeichner’s and Serrazina’s research to discuss the reflection on the practice and, in Ball, Thames, and Phelps, to analyse the (re) significance of the knowledge of the professionals involved. The data analysed were collected during the group meetings at the school where the participants taught. Through the analyses of the discussions held, we could observe that the teachers expanded their common and specialised content knowledge, mainly in relation to the strategies to calculate area, and started using reconfiguration of the figures and formulas of area more assertively. Mutual support allowed them to identify their own needs and then modify their analyses of the strategies for area calculation to be adopted

Human Excellence: The Contribution of Personality

Este estudo teve por objetivo analisar, sob o enfoque da Psicologia Positiva, as explicações dos pesquisadores da excelência humana sobre o que a promove e a mantém nos mais variados domínios de atuação. Constatou-se que fatores pessoais e contextuais são mencionados, destacando-se as habilidades cognitivas e a prática deliberada no desempenho superior, sendo também as variáveis de personalidade decisivas para o desenvolvimento e a manifestação da excelência. Neste estudo, como na literatura na área, destaca-se a importância da persistência, controle emocional e abertura à experiência.El objetivo de este estudo fue analizar, desde el punto de vista de la Psicología Positiva, las explicaciones de los investigadores de la excelencia humana proponen para su desarrollo y manutencion en los mas variados campos de actividad. Se encontró que los factores personales y contextuales son mencionados, resaltándose las habilidades cognitivas y el rendimiento superior en la práctica deliberada, siendo las variables de personalidad fundamentales para el desarrollo y la demostración de la excelencia. Este estudo, basado en la literatura, destaca la importancia de la persistencia, el control emocional y apertura hacia la experiencia.This paper presents an analysis from the perspective of Positive Psychology of explanations from researchers concerning human excellence and what promotes and maintains it in the most varied domains. Personal and contextual factors are mentioned in the literature, while cognitive skills and intentional practice to achieve excellence stand out; personality variables are also critical to the development and demonstration of excellence. Based on the literature, this study suggests the importance of persistence, emotional control, and openness to experience

Sea level rise hazard in exposed coastal urban areas of Portugal mainland

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High status diet and health in Medieval Lisbon : a combined isotopic and osteological analysis of the Islamic population from São Jorge Castle, Portugal

This paper presents the first bioarchaeological study of Islamic diet and lifeways in medieval Portugal. Stable isotopes of δ13C and δ15N and osteological and paleopathological analyses are combined to explore the diet and health status of 27 humans buried within São Jorge Castle, Lisbon (eleventh to twelfth century), interpreted as a high status population. Human isotopic data are considered alongside an animal baseline comprised of 30 specimens sampled from nearby Praça da Figueira, including the main domesticates and fish. Isotopic data indicate an age- and sex-related difference in diet among the population, suggesting a difference in food access between females and children compared to males. Palaeopathological analysis indicates a low prevalence of non-specific stress indicators such as Harris lines (HL), linear enamel hypoplasia (LEH) and cribra orbitalia (CO) in this population in comparison to other medieval populations. LEH is only present in adults. These results suggest the presence of socio-cultural patterning relating to the organisation of the Islamic family, where women and men occupied different places in the household and society. This paper demonstrates the utility of a combined osteological and isotopic approach to understand the lifeways of Islamic populations in Medieval Iberia, as well as illuminates the lifeways of understudied segments of the population

Inequities in access to health care in different health systems: A study in municipalities of central Colombia and north-eastern Brazil

Introduction. Health system reforms are undertaken with the aim of improving equity of access to health care. Their impact is generally analyzed based on health care utilization, without distinguishing between levels of care. This study aims to analyze inequities in access to the continuum of care in municipalities of Brazil and Colombia. Methods. A cross-sectional study was conducted based on a survey of a multistage probability sample of people who had had at least one health problem in the prior three months (2,163 in Colombia and 2,167 in Brazil). The outcome variables were dichotomous variables on the utilization of curative and preventive services. The main independent variables were income, being the holder of a private health plan and, in Colombia, type of insurance scheme of the General System of Social Security in Health (SGSSS). For each country, the prevalence of the outcome variables was calculated overall and stratified by levels of per capita income, SGSSS insurance schemes and private health plan. Prevalence ratios were computed by means of Poisson regression models with robust variance, controlling for health care need. Results: There are inequities in favor of individuals of a higher socioeconomic status: in Colombia, in the three different care levels (primary, outpatient secondary and emergency care) and preventive activities; and in Brazil, in the use of outpatient secondary care services and preventive activities, whilst lower-income individuals make greater use of the primary care services. In both countries, inequity in the use of outpatient secondary care is more pronounced than in the other care levels. Income in both countries, insurance scheme enrollment in Colombia and holding a private health plan in Brazil all contribute to the presence of inequities in utilization. Conclusions: Twenty years after the introduction of reforms implemented to improve equity in access to health care, inequities, defined in terms of unequal use for equal need, are still present in both countries. The design of the health systems appears to determine access to the health services: two insurance schemes in Colombia with different benefits packages and a segmented system in Brazil, with a significant private component. © 2014 Garcia-Subirats et al.; licensee BioMed Central Ltd

Baroreflex Impairment Precedes Cardiometabolic Dysfunction in an Experimental Model of Metabolic Syndrome: Role of Inflammation and Oxidative Stress

This study analyzes whether autonomic dysfunction precedes cardiometabolic alterations in spontaneously hypertensive rats (SHR) with fructose overload. Animals were randomly distributed into three groups: control, hypertensive and hypertensive with fructose overload. Fructose overload (100 g/L) was initiated at 30 days old, and the animals (n = 6/group/time) were evaluated after 7, 15, 30 and 60 days of fructose consumption. Fructose consumption reduced baroreflex sensitivity by day 7, and still induced a progressive reduction in baroreflex sensitivity over the time. Fructose consumption also increased TNFα and IL-6 levels in the adipose tissue and IL-1β levels in the spleen at days 15 and 30. Fructose consumption also reduced plasmatic nitrites (day 15 and 30) and superoxide dismutase activity (day 15 and 60), but increased hydrogen peroxide (day 30 and 60), lipid peroxidation and protein oxidation (day 60). Fructose consumption increased arterial pressure at day 30 (8%) and 60 (11%). Fructose consumption also induced a late insulin resistance at day 60, but did not affect glucose levels. In conclusion, the results show that baroreflex sensitivity impairment precedes inflammatory and oxidative stress disorders, probably by inducing hemodynamic and metabolic dysfunctions observed in metabolic syndrome.Fil: Bernardes, Nathalia. Universidade de Sao Paulo; BrasilFil: Da Silva Dias, Danielle. Universidade Nove de Julho; BrasilFil: Fernandes Stoyell Conti, Filipe. Universidade de Sao Paulo; BrasilFil: De Oliveira Brito Monzani, Janaina. Universidade Nove de Julho; BrasilFil: Malfitano, Christiane. Universidade Nove de Julho; BrasilFil: Garcia Caldini, Elia. Universidade de Sao Paulo; BrasilFil: Ulloa, Luis. Universidade Nove de Julho; BrasilFil: Llesuy, Susana Francisca. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General e Inorgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; ArgentinaFil: Irigoyen, Maria Cláudia. Universidade de Sao Paulo; BrasilFil: De Angelis, Kátia. Universidade Nove de Julho; Brasi