Evaluación formativa y desempeño docente, en los maestros de comunicación de la Unidad de Gestión Educativa Local N°13 – Yauyos, 2020

La presente investigación titulada: Evaluación Formativa y Desempeño Docente, en los maestros de Comunicación de la Unidad de Gestión Educativa Local N°13 – Yauyos, 2020. Tiene el objetivo de determinar la relación entre Evaluación Formativa y Desempeño Docente aplicado por los maestros del área de comunicación en la UGEL Nº13 Yauyos 2020. La investigación desarrollada ha sido clasificada como cuantitativa, no-experimental, aplicativa, descriptiva, transversal y correlacional: ya que no se generan cambios entre las unidades de análisis, los datos se recopilan en un solo momento y se propone determinar el grado de relación entre las variables analizadas y que son aplicadas por los docentes del área de comunicación de la UGEL Nº13 que está ubicada en la provincia de Yauyos, la unidad de análisis fue cada docente que labora en el área de comunicación de la UGEL 13. Como resultado de la investigación se ha encontrado que se concluye que existe relación directa y significativa (Rho de Spearman= 0.564 y Sig. = 0,000), entre la variable Evaluación Formativa aplicada por los docentes y el Desempeño Docente que aplican en el área de comunicación de la UGEL Nº13 Yauyos 2020

Effect of Continuous Positive Airway Pressure on Inflammatory, Antioxidant, and Depression Biomarkers in Women With Obstructive Sleep Apnea: A Randomized Controlled Trial

Study objectives: The effect of continuous positive airway pressure (CPAP) on mediators of cardiovascular disease and depression in women with obstructive sleep apnea (OSA) is unknown. We aimed to assess the effect of CPAP therapy on a variety of biomarkers of inflammation, antioxidant activity, and depression in women with OSA. Methods: We conducted a multicenter, randomized controlled trial in 247 women diagnosed with moderate-to-severe OSA (apnea-hypopnea index [AHI] ? 15). Women were randomized to CPAP (n = 120) or conservative treatment (n = 127) for 12 weeks. Changes in tumor necrosis factor ? (TNF?), interleukin 6 (IL-6), C-reactive protein (CRP), intercellular adhesion molecule 1 (ICAM-1), catalase (CAT), superoxide dismutase (SOD), and brain-derived neurotrophic factor (BDNF) were assessed. Additional analyses were conducted in subgroups of clinical interest. Results: Women had a median (25th-75th percentiles) age of 58 (51-65) years, body mass index 33.5 (29.0-38.3) kg/m2, and AHI 33.3 (22.8-49.3). No differences were found between groups in the baseline levels of the biomarkers. After 12 weeks of follow-up, there were no changes between groups in any of the biomarkers assessed. These results did not change when the analyses were restricted to sleepy women or to those with severe OSA. In women with CPAP use at least 5 hours per night, only TNF? levels decreased compared to the control group (-0.29 ± 1.1 vs -0.06 ± 0.53, intergroup difference -0.23 [95% CI = -0.03 to -0.50]; p = 0.043). Conclusions: Twelve weeks of CPAP therapy does not improve biomarkers of inflammation, antioxidant activity, or depression compared to conservative treatment in women with moderate-to-severe OSA

Senegalese sole transcriptomic profiles in response to different betanodavirus RGNNV/SJNNV reassortant strains

Betanodaviruses are the causative agents of viral nervous necrosis (VNN), a disease that has been reported in more than 40 marine and freshwater fish species worldwide, including Senegalese sole (Solea senegalensis). Based on the variable region T4 (RNA2), betanodaviruses have been classified into 4 genotypes: striped jack nervous necrosis virus (SJNNV), tiger puffer nervous necrosis virus (TPNNV), redspotted grouper nervous necrosis virus (RGNNV), and barfin flounder nervous necrosis virus (BFNNV). Reassortant isolates combining genomic segments from the SJNNV and RGNNV genotypes have been obtained from farmed fish species. The reassortant SpSs-IAusc160.03 (wild type reassortant), with a genome consisting of RGNNV-type RNA1 and SJNNV-type RNA2 segments, is more suited for infecting sole than the parental genotypes, causing 100% mortality by bath challenges. Furthermore, compared with the parental SJNNV genotype, this reassortant strain presents two aminoacidic substitutions (positions 247 and 270) at the extreme C-terminal of the capsid protein, which are involved in host specificity. In the current study, the RNA-Seq technology has been used to determine changes in Senegalese sole transcriptome after infection with the wild type and a less virulent recombinant (rSs160.03247+270) with mutations at aminoacids 247 (serine to alanine) and 270 (serine to asparagine), provoking a 40% decreased mortality. Animals (5 g weight) were distributed into two groups to be intramuscularly injected with the above described viral strains (2x105 TCID50/fish). A negative control group (L15-injected) was also established. Head kidney and nervous tissues (eye+brain) were sampled at 48 post-inoculation. A total of 633 genes were differentially expressed (DEGs) in animals infected with the wild type isolate (358 up-regulated and 49 down-regulated in head kidney; 206 up-regulated and 20 down-regulated in eye+brain), whereas only 393 genes were differentially expressed in animals infected with the mutated isolate (129 up-regulated and 10 down-regulated in head-kidney; 28 up-regulated and 226 down-regulated in eye+brain). The results obtained indicate a 37.9% decrease in the number of DEGs after infection with the mutated reassortant, as well as an inversion in the proportion of genes up/down-regulated in nervous tissue of these animals. In addition, the expression patterns of genes coding for proteins involved in the IFN type I pathway were different in both group of animals. Thus, genes coding for proteins acting as mediators of IFN type I expression (MDA5, LGP2, IRF3, IRF7) and IFN-stimulated genes (ISG15, Mx, PKR, IFI6, IFI35, IFI44, IFIT-1, among others) were up-regulated in animals infected with the wild type reassortant, whereas no-differential expression of these genes was observed in animals infected with the mutated isolate. The different transcriptomic profiles obtained could help to better understand NNV pathogenesis in Senegalese sole, setting up the importance as virulence determinants of aminoacids at positions 247 and 270 within the RNA2 segment. Furthermore, the results obtained permit to identify DEGs that could be used to develop new strategies to control this infectious disease, which has reached high relevance in the aquaculture sector.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Efficacy and safety of robotic spine surgery: systematic review and meta-analysis

Background: Robotic surgery (RS) may offer benefits compared with freehand/conventional surgery (FS) in the treatment of patients with spinal disease. The aim of this study was to evaluate the efficacy and safety of RS versus FS in spinal fusion. Methods: A systematic review and meta-analysis was performed. Data analysis and risk of bias assessment were analysed using REVMAN V5.3. Results: We found 11 randomised clinical trials involving 817 patients (FS: 408, RS: 409). The main diagnosis was degenerative spine disease. SpineAssist, Renaissance (Mazor Robotics), Tianji Robot and TiRobot robots (TINAVI Medical Technologies) were used. Pedicle screw placement within the safety zone (grades A + B according to the Gertzbein and Robbins scale) ranged from 93% to 100% in FS versus 85-100% in RS (relative risk 1.01, 95% CI 1.00-1.03, p = 0.14). Regarding intervention time, the meta-analysis showed a mean difference (MD) of 6.45 min (95% CI -13.59 to 26.49, p = 0.53). Mean hospital stay was MD of -0.36 days (95% CI -1.03 to 0.31, p = 0.30) with no differences between groups. Contradictory results were found regarding fluoroscopy time, although there seems to be a lower radiation dose in RS versus FS (p < 0.05). Regarding safety, the studies included surgical revision frequency. Conclusions: No conclusive results were found suggesting that there are benefits in using RS over FS for spinal fusion. Further research with adequate patient selection, robot type and quality-of-life variables is needed.S

Urticarial lesions in a pregnant woman

No abstract available</p

Urticarial lesions in a pregnant woman

No abstract available</p

(Serie: Conservación y Manejo de Áreas Naturales Protegidas del Altiplano Mexicano)

El Programa de Manejo del Área Natural Protegida Parque Estatal Otomí – Mexica es un instrumento de planeación incluyente, dinámico, flexible y congruente con lo que establece el Código para la Biodiversidad del Estado de México (CBEM) y la Ley General del Equilibrio Ecológico y la Protección al Ambiente (LGEEPA), teniendo como propósito cumplir con los objetivos de su decreto.El Programa de Manejo del Área Natural Protegida Parque Estatal Otomí – Mexica es un instrumento de planeación incluyente, dinámico, flexible y congruente con lo que establece el Código para la Biodiversidad del Estado de México (CBEM) y la Ley General del Equilibrio Ecológico y la Protección al Ambiente (LGEEPA), teniendo como propósito cumplir con los objetivos de su decreto.Gobierno del Estado de México Universidad Autónoma del Estado de México Colegio de Ciencias Geográficas del Estado de México, A. C

Bioenergetic and Autophagic Characterization of Skin Fibroblasts from C9orf72 Patients.

The objective of this study is to describe the alterations occurring during the neurodegenerative process in skin fibroblast cultures from C9orf72 patients. We characterized the oxidative stress, autophagy flux, small ubiquitin-related protein SUMO2/3 levels as well as the mitochondrial function in skin fibroblast cultures from C9orf72 patients. All metabolic and bioenergetic findings were further correlated with gene expression data obtained from RNA sequencing analysis. Fibroblasts from C9orf72 patients showed a 30% reduced expression of C9orf72, ~3-fold increased levels of oxidative stress and impaired mitochondrial function obtained by measuring the enzymatic activities of mitochondrial respiratory chain complexes, specifically of complex III activity. Furthermore, the results also reveal that C9orf72 patients showed an accumulation of p62 protein levels, suggesting the alteration of the autophagy process, and significantly higher protein levels of SUMO2/3 (p = 0.03). Our results provide new data reinforcing that C9orf72 cells suffer from elevated oxidative damage to biomolecules and organelles and from increased protein loads, leading to insufficient autophagy and an increase in SUMOylation processes

Obtaining a Vodka-like Distillate from a Native Colombian Yam (Dioscorea Spp.)

Yam is currently an emblematic tuber from Colombian Caribbean Region. Its cultivation and consumption are linked to the arrival of slaves on the Caribbean Coast. Colombia’s yam has stood out worldwide for its technological advances in cultivation and it has been among the countries with the best performance indicators in tons per hectare planted. The 90% of the national production comes from Caribbean Region. However, the high perishability of the yam, and high temperatures, the lack of communication routes and the high transportation costs, increase the losses and limit the profitability of the product. There is an overproduction of yam and other tubers too. The impact has come to significantly impoverish both farmers and consumers, even affecting the presence of yam in local population diet. Under similar circumstances, in many cultures distilled alcoholic beverages have emerged from local foods, such as wheat, malt, potato, sugar cane, grapes, etc. The aim of this article is to show preliminary results about using yam as a raw material in an alternative way. It could contribute to increase yam’s value through developing a vodka-like distilled process. In this case, raw yam flour was hydrolyzed to obtain a worth to be fermented at 20°C with a commercial S. cerevisiae yeast. After fermentation a simple batch distillation in a copper distiller was made. During the process, it was measured temperature, fermentation time, pH, and Brix degree. All transformation process was done in a pilot plant (CE 640 Gunt, Hamburg). A first-order kinetics model was adjusted to sugars consumption, and a Gompertz model was used to ethanol production. It is concluded that an alcoholic beverage based on yam can be an alternative to yam overproduction. Keywords.Yam, fermented beverages, distilled beverages, physicochemical analysis, ki

Role of Gut Microbiota on Cardio-Metabolic Parameters and Immunity in Coronary Artery Disease Patients with and without Type-2 Diabetes Mellitus

Gut microbiota composition has been reported as a factor linking host metabolism with the development of cardiovascular diseases (CVD) and intestinal immunity. Such gut microbiota has been shown to aggravate CVD by contributing to the production of trimethylamine N-oxide (TMAO), which is a pro-atherogenic compound. Treg cells expressing the transcription factor Forkhead box protein P3 (FoxP3) play an essential role in the regulation of immune responses to commensal microbiota and have an atheroprotective role. However, the aim of this study was to analyze the role of gut microbiota on cardio-metabolic parameters and immunity in coronary artery disease (CAD) patients with and without type-2 diabetes mellitus (DM2). The study included 16 coronary CAD-DM2 patients, and 16 age, sex, and BMI matched CAD patients without DM2 (CAD-NDM2). Fecal bacterial DNA was extracted and analyzed by sequencing in a GS Junior 454 platform followed by a bioinformatic analysis (QIIME and PICRUSt). The present study indicated that the diversity and composition of gut microbiota were different between the CAD-DM2 and CAD-NDM2 patients. The abundance of phylum Bacteroidetes was lower, whereas the phyla Firmicutes and Proteobacteria were higher in CAD-DM2 patients than those in the CAD-NDM2 group. CAD-DM2 patients had significantly less beneficial or commensal bacteria (such as Faecalibacterium prausnitzii and Bacteroides fragilis) and more opportunistic pathogens (such as Enterobacteriaceae, Streptococcus, and Desulfovibrio). Additionally, CAD-DM2 patients had significantly higher levels of plasma zonulin, TMAO, and IL-1B and significantly lower levels of IL-10 and FOXP3 mRNA expression than CAD-NDM2. Moreover, in the CAD-MD2 group, the increase in Enterobacteriaceae and the decrease in Faecalibacterium prausnitzii were significantly associated with the increase in serum TMAO levels, while the decrease in the abundance of Bacteroides fragilis was associated with the reduction in the FOXP3 mRNA expression, implicated in the development and function of Treg cells. These results suggest that the presence of DM2 is related to an impaired regulation of the immune system in CAD patients, mediated in part by the gut microbiota composition and functionality and the production and effects of their gut microbiota derived molecules