Historia postal de Cataluña (Breves datos sobre Camprodon)

De los Itinerarios Romanos de Antonino del Siglo IV, correspondientes a Cataluña, permiten suponer el trazado de la "Vía Augusta" que, atravesando las provincias de Tarragona y Barcelona, se dirigía a los Pirineos por Gerona; de esta vía se sabe que salían arterias secundarias que enlazaban con caminos, uniendo otras poblaciones; hago mención especial de una que pasaba por "Julia Libica" (Llívia) y antes de llegar a "Ausa" (Vic), tenía un ramal en dirección a "Gerunda" que entre otras, enlazaba con "Egosa" (CAMPRODON) para terminar con la "Vía Augusta"

Engineering protein self-assembling in protein-based nanomedicines for drug delivery and gene therapy

Altres ajuts: FISS/PS09-00165Altres ajuts: FISS/PI12-00327Lack of targeting and improper biodistribution are major flaws in current drug-based therapies that prevent reaching high local concentrations of the therapeutic agent. Such weaknesses impose the administration of high drug doses, resulting in undesired side effects, limited efficacy and enhanced production costs. Currently, missing nanosized containers, functionalized for specific cell targeting will be then highly convenient for the controlled delivery of both conventional and innovative drugs. In an attempt to fill this gap, health-focused nanotechnologies have put under screening a growing spectrum of materials as potential components of nanocages, whose properties can be tuned during fabrication. However, most of these materials pose severe biocompatibility concerns. We review in this study how proteins, the most versatile functional macromolecules, can be conveniently exploited and adapted by conventional genetic engineering as efficient building blocks of fully compatible nanoparticles for drug delivery and how selected biological activities can be recruited to mimic viral behavior during infection. Although engineering of protein self-assembling is still excluded from fully rational approaches, the exploitation of protein nano-assemblies occurring in nature and the direct manipulation of protein-protein contacts in bioinspired constructs open intriguing possibilities for further development. These methodologies empower the construction of new and potent vehicles that offer promise as true artificial viruses for efficient and safe nanomedical applications

Biocatalytic synthesis of oxygenated biofuels through the technologies of ionic liquids and supercritical carbon dioxide

Póster presentado en el Congreso Nacional de Biotecnologia (BIOTEC 2019), celebrado en Vigo (España) entre los días 10 y 13 de junio de 2019.The increase in the production of biofuels has generated in the market an excess of glycerol as a byproduct. Some glycerol derivatives, such as solketal (1,2-isopropylidene glycerol), have been used successfully to synthesize new oxygenated fuels, such as fatty acid solketal esters (FASE), in order to increase the octane number of the gasolines. Biodiesel exhibits an excellent suitability as a liquid fuel (adiabatic flame temperature, viscosity, etc.), blending up to 20% volume fraction of ASE

Total Oxidation of Propane Using CeO2 and CuO-CeO2 Catalysts Prepared Using Templates of Different Nature

[EN] Several CeO2 and CuO-CeO2 catalysts were prepared using different methods, i.e., a homogeneous precipitation with urea, a nanocasting route using CMK-3 carbon as a hard template and a sol¿gel process using Poly(methyl methacrylate) (PMMA) polymer as a soft template, and tested in the total oxidation of propane. The catalysts were characterized by a number of physicochemical techniques (XRD, N2 adsorption, TPR, XPS, Raman spectroscopy) showing distinct characteristics. For each series, Cu-Ce-O catalysts with low Cu-loadings (5 wt % CuO) showed the highest activity, higher than those samples either without copper or with high Cu-loading (13 wt % CuO). The incorporation of copper leads to an increase of the concentration of bulk defects but if the Cu-loading is too high the surface area drastically falls. The highest activity in the total oxidation of propane was achieved by Cu-containing ceria catalysts synthesized using a polymer as a template, as this method yields high surface area materials. The surface area and the number of bulk/sub-surface defects of the ceria seem to be the main properties determining the catalytic activityThe authors would like to acknowledge the DGICYT in Spain CTQ2012-37925-C03-2, CTQ2015-68951-C3-1-R, CTQ2015-68951-C3-3-R. Authors from ITQ also thank Project SEV-2012-0267 for financial support. B.S, R.S and A.M.D also thank UV-INV-AE16-484416.Solsona, B.; Sanchis, R.; Dejoz, AM.; Garcia, T.; Ruiz-Rodríguez, L.; López Nieto, JM.; Cecilia, JA.... (2017). Total Oxidation of Propane Using CeO2 and CuO-CeO2 Catalysts Prepared Using Templates of Different Nature. Catalysts. 7(4):96-110. https://doi.org/10.3390/catal7040096S961107

TITAN: A knowledge-based platform for Big Data workflow management

Modern applications of Big Data are transcending from being scalable solutions of data processing and analysis, to now provide advanced functionalities with the ability to exploit and understand the underpinning knowledge. This change is promoting the development of tools in the intersection of data processing, data analysis, knowledge extraction and management. In this paper, we propose TITAN, a software platform for managing all the life cycle of science workflows from deployment to execution in the context of Big Data applications. This platform is characterised by a design and operation mode driven by semantics at different levels: data sources, problem domain and workflow components. The proposed platform is developed upon an ontological framework of meta-data consistently managing processes and models and taking advantage of domain knowledge. TITAN comprises a well-grounded stack of Big Data technologies including Apache Kafka for inter-component communication, Apache Avro for data serialisation and Apache Spark for data analytics. A series of use cases are conducted for validation, which comprises workflow composition and semantic meta-data management in academic and real-world fields of human activity recognition and land use monitoring from satellite images.Universidad de Málaga. Andalucía TECH

Injecting domain knowledge in multi-objective optimization problems: A semantic approach

In the field of complex problem optimization with me-taheuristics, semantics has been used for modeling different aspects, such as: problem characterization, parameters, decision-maker's preferences, or algorithms. However, there is a lack of approaches where ontologies are ap-plied in a direct way into the optimization process, with the aim of enhancing it by allowing the systematic incorporation of additional domain knowledge. This is due to the high level of abstraction of ontologies, which makes them difficult to be mapped into the code implementing the problems and/or the specific operators of metaheuristics. In this paper, we present a strategy to inject domain knowledge (by reusing existing ontologies or creating a new one) into a problem implementation that will be optimized using a metaheu-ristic. Thus, this approach based on accepted ontologies enables building and exploiting complex computing systems in optimization problems. We describe a methodology to automatically induce user choices (taken from the ontology) into the problem implementations provided by the jMetal op-timization framework. With the aim of illustrating our proposal, we focus on the urban domain. Concretely, We start from defining an ontology repre-senting the domain semantics for a city (e.g., building, bridges, point of inte-rest, routes, etc.) that allows defining a-priori preferences by a decision ma-ker in a standard, reusable, and formal (logic-based) way. We validate our proposal with several instances of two use cases, consisting in bi-objective formulations of the Traveling Salesman Problem (TSP) and the Radio Net-work Design problem (RND), both in the context of an urban scenario. The results of the experiments conducted show how the semantic specification of domain constraints are effectively mapped into feasible solutions of the tackled TSP and RND scenarios. TUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Coordinación de casos prácticos en asignaturas del área de conocimiento “Gestión de la Información” según modelo curricular de informática de la ACM/IEEE 2013

Este artículo presenta el estado de desarrollo y resultados preliminares del proyecto de innovación docente de la Universidad de Málaga (PIE15-183): Coor-dinación de casos prácticos en asignaturas del área de conocimiento “Gestión de la Información” según modelo curricular de informática de la ACM/IEEE 2013.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Personality Disorders and Health Problems Distinguish Suicide Attempters from Completers in a Direct Comparison

Background Whether suicide attempters and completers represent the same population evaluated at different points along a progression towards suicide death, overlapping populations, or completely different populations is a problem still unresolved. Methods 446 Adult suicide attempters and knowledgeable collateral informants for 190 adult suicide probands were interviewed. Sociodemographic and clinical data was collected for both groups using semi-structured interviews and structured assessments. Univariate analyses and logistic regression models were conducted to explore the similarities and differences between suicide attempters and completers. Results Univariate analyses yielded significant differences in sociodemographics, recent life events, impulsivity, suicide intent, and distribution of Axis I and II disorders. A logistic regression model aimed at distinguishing suicide completers from attempters properly classified 90% of subjects. The most significant variables that distinguished suicide from attempted suicide were the presence of narcissistic personality disorder (OR=21.4; 95% CI=6.8–67.7), health problems (OR=20.6; 95% CI=5.6–75.9), male sex (OR=9.6; 95% CI=4.42–20.9), and alcohol abuse (OR=5.5; 95% CI=2.3–14.2). Limitations Our study shares the limitations of studies comparing suicide attempters and completers, namely that information from attempters can be obtained from the subject himself, whereas the assessment of completers depends on information from close family or friends. Furthermore, different semi-structured instruments assessed Axis I and Axis II disorders in suicide attempters and completers. Finally, we have no data on inter-rater reliability data. Conclusions Suicide completers are more likely to be male and suffer from alcohol abuse, health problems (e.g. somatic illness), and narcissistic personality disorder. The findings emphasize the importance of implementing suicide prevention programs tailored to suicide attempters and completers