Relación entre ortorexia, práctica deportiva, depresión y ansiedad

La Ortorexia Nerviosa (ON) es la excesiva preocupación por la alimentación saludable, generando malestar, culpa y aislamiento social, entre otros, en quienes la padecen. A pesar de no haber sido reconocida aún como un Trastorno de la Conducta Alimentaria (TCA) dentro del DSM-5 o la CIE-11, es cada vez mayor la presión a la que se ve sometida la población en el seguimiento de una dieta “sana” y estricta, ejercida en su mayoría por los medios de comunicación y movimientos como el Realfooding, e industrias como la moda o el gimnasio; siendo los deportistas uno de los colectivos más vulnerables a desarrollar este cuadro restrictivo y obsesivo. Es por ello, que el presente estudio tiene como objetivo conocer la relación entre ortorexia y práctica deportiva, así como la relación entre ortorexia, ansiedad y depresión. La muestra estuvo compuesta por 190 participantes entre 15 y 69 años, de los que 103 eran deportistas. Para hallar esta relación, se realizaron tres Análisis de Varianza (ANOVAS) y un Análisis de Correlación de Pearson. No obstante, los resultados no arrojaron diferencias significativas entre la población general y la población de deportistas, tampoco entre el propio grupo de deportistas; aunque se observaron diferencias significativas entre los grupos en ansiedad y depresión.Orthorexia Nervosa (ON) is the excessive preoccupation with healthy eating, generating discomfort, guilt and social isolation, among others, in those who suffer from it. Although it has not yet been recognized as an Eating Behavior Disorder (ED) within the DSM-5 or ICD-11, the pressure to which the population is subjected to follow a "healthy" and strict diet is increasing, mostly exerted by the media and movements such as Realfooding, and industries such as fashion or the gym; athletes being one of the most vulnerable groups to develop this restrictive and obsessive condition. For this reason, the present study aims to determine the relationship between orthorexia and sports practice, as well as the relationship between orthorexia, anxiety and depression. The sample consisted of 190 participants between 15 and 69 years of age, 103 of whom were athletes. To find this relationship, three Analyses of Variance (ANOVAS) and a Pearson Correlation Analysis were performed. However, the results show no significant differences between the general population and the population of athletes, nor between the group of athletes; although significant differences were observed between the groups in anxiety and depression

Recovering actives in multi-antitarget and target design of analogs of the myosin II inhibitor blebbistatin

In multitarget drug design, it is critical to identify active and inactive compounds against a variety of targets and antitargets. Multitarget strategies thus test the limits of available technology, be that in screening large databases of compounds vs a large number of targets, or in using in silica methods for understanding and reliably predicting these pharmacological outcomes In this paper, we have evaluated the potential of several in silica approaches to predict the target, antitarget and physicochemical profile of (S)-blebbistatin, the best-known myosin II ATPase inhibitor, and a series of analogs thereof Standard and augmented structure-based design techniques could not recover the observed activity profiles A ligand-based method using molecular fingerprints was, however, able to select actives for myosin II inhibition Using further ligand- and structure-based methods, we also evaluated toxicity through androgen receptor binding, affinity for an array of antitargets and the ADME profile (including assay-interfering compounds) of the series In conclusion, in the search for (S)-blebbistatin analogs, the dissimilarity distance of molecular fingerprints to known actives and the computed antitarget and physicochemical profile of the molecules can be used for compound design for molecules with potential as tools for modulating myosin II and motility-related diseases

Diseño editorial como herramienta de enseñanza y aprendizaje de lenguas indígenas

"Las poblaciones indígenas son aquellas que estaban viviendo en sus tierras antes de que llegaran los colonizadores de otros lugares, los cuales, al convertirse en el grupo dominante mediante la conquista, la ocupación, la colonización o por otros medios, segregan o discriminan a los pobladores originarios. Cada vez que los pueblos vecinos han ampliado sus territorios o llegan colonizadores de tierras lejanas, las culturas y el sustento de los indígenas han estado en peligro.

Determination of the optimum amount of superplasticizer additive for self-compacting concrete

ABSTRACT: Self-compacting concrete modifies its workability with small variations in the amount of superplasticizer additive. For this reason, large number of tests are required to monitor its workability. In order to determine the appropriate amount of additive for a single mix, the evolution of the power consumption of the concrete mixer during the addition of small amounts of additive to the concrete was analyzed. These results were compared both with typical workability characterization for self-compacting concrete and with the saturation point results, determined by the Marsh cone method. After this comparison, a good correlation was obtained between the results from the traditional tests and the proposed ?concrete mixer method?Funding: This research was funded by Spanish Ministry of Economy and Competitiveness of Spain, grant number MAT2014-57544-R”

Análisis del comportamiento a fatiga de morteros con árido reciclado procedentes de vía mediante tomografía axial computarizada

Para la mejora de la calidad de las infraestructuras ferroviarias y la reducción de los costes de mantenimiento se plantea la sustitución de la vía tradicional por vía en placa. Debido al gran coste que supone esta nueva sustitución se plantea el empleo de árido reciclado proveniente de componentes ferroviarios fuera de uso, concretamente de las traviesas y el balasto. En una primera etapa, se analizará el comportamiento a fatiga de morteros fabricados con las arenas recicladas tanto de las traviesas como del balasto. Para ello se han fabricado probetas cilíndricas miniatura de 40 mm de altura y 20 mm de diámetro para las que se han empleado tres arenas de diferentes procedencias, pero con la misma granulometría: arena de traviesa, de balasto y de sílice normalizada. El método empleado para la caracterización en fatiga es el método acelerado de LOCATI. Para la evaluación del daño ocasionado por la fatiga se ha utilizado la técnica de Tomografía Axial Computarizada que permitirá entre cada bloque de fatiga aplicado evaluar la evolución del tamaño y forma de los poros de mayor tamaño, numero de poros, así como detectar la aparición de fisuras y la evolución de las mismas.Nowadays railway infrastructure is becoming obsolete, due to evolution of the trains. For this reason, it is fundamental to improve railroad superstructures, as well as to find a way to recycle the superstructures already obsolete. As a solution, the use of ballast and sleepers out of use as aggregates for the manufacture of slab track is proposed. A validation of this material as an aggregate for the manufacture of slab track is proposed, it is focused on comparing its fatigue strength with that of a standardized aggregate. For this, a series of LOCATI fatigue tests mixed with CT analyses, to see the evolution of the damage suffered by the sample, is carried out.Los autores agradecen la financiación recibida para la realización de este trabajo al Programa Estatal de Investigación, Desarrollo e Innovación orientada a los Retos de la Sociedad en el marco del acuerdo de subvención MAT2014-57544-R, financiado por el Gobierno de España, Ministerio de Economía y Competitividad

Activity to Breast Cancer Cell Lines of Different Malignancy and Predicted Interaction with Protein Kinase C Isoforms of Royleanones

Plants have been used for centuries to treat several illnesses. The Plectranthus genus has a vast variety of species that has allowed the isolation of cytotoxic compounds with notable activities. The abietane diterpenes 6, 7-dehydroroyleanone (DeRoy, 1), 7α-acetoxy-6β-hydroxyroyleanone (Roy, 2), and Parvifloron D (ParvD, 3) were obtained from Plectranthus spp. and showed promising biological activities, such as cytotoxicity. The inhibitory effects of the different natural abietanes (1-3) were compared in MFC7, SkBr3, and SUM159 cell lines, as well as SUM159 grown in cancer stem cell-inducing conditions. Based on the royleanones’ bioactivity, the derivatives RoyBz (4), RoyBzCl (5), RoyPr2 (6), and DihydroxyRoy (7), previously obtained from 2, were selected for further studies. Protein kinases C (PKCs) are involved in several carcinogenic processes. Thus, PKCs are potential targets for cancer therapy. To date, the portfolio of available PKC modulators remains very limited due to the difficulty of designing isozyme-selective PKC modulators. As such, molecular docking was used to evaluate royleanones 1-6 as predicted isozyme-selective PKC binders. Subtle changes in the binding site of each PKC isoform change the predicted interaction profiles of the ligands. Subtle changes in royleanone substitution patterns, such as a double substitution only with non-substituted phenyls, or hydroxybenzoate at position four that flips the binding mode of ParvD (3), can increase the predicted interactions in certain PKC subtype

The effect of tightly-bound water molecules on scaffold diversity in computer-aided de novo ligand design of CDK2 inhibitors

We have determined the effects that tightly bound water molecules have on the de novo design of cyclin-dependent kinase-2 (CDK2) ligands. In particular, we have analyzed the impact of a specific structural water molecule on the chemical diversity and binding mode of ligands generated through a de novo structure-based ligand generation method in the binding site of CDK2. The tightly bound water molecule modifies the size and shape of the binding site and we have found that it also imposed constraints on the observed binding modes of the generated ligands. This in turn had the indirect effect of reducing the chemical diversity of the underlying molecular scaffolds that were able to bind to the enzyme satisfactorily

Predictors of Response to Exclusive Enteral Nutrition in Newly Diagnosed Crohn´s Disease in Children: PRESENCE Study from SEGHNP

Exclusive enteral nutrition (EEN) has been shown to be more effective than corticosteroids in achieving mucosal healing in children with Crohn´s disease (CD) without the adverse effects of these drugs. The aims of this study were to determine the efficacy of EEN in terms of inducing clinical remission in children newly diagnosed with CD, to describe the predictive factors of response to EEN and the need for treatment with biological agents during the first 12 months of the disease. We conducted an observational retrospective multicentre study that included paediatric patients newly diagnosed with CD between 2014–2016 who underwent EEN. Two hundred and twenty-two patients (140 males) from 35 paediatric centres were included, with a mean age at diagnosis of 11.6 ± 2.5 years. The median EEN duration was 8 weeks (IQR 6.6–8.5), and 184 of the patients (83%) achieved clinical remission (weighted paediatric Crohn’s Disease activity index [wPCDAI] 15 mg/L and ileal involvement tended to respond better to EEN. EEN administered for 6–8 weeks is effective for inducing clinical remission. Due to the high response rate in our series, EEN should be used as the first-line therapy in luminal paediatric Crohn’s disease regardless of the location of disease and disease activityS

Lo glocal y el turismo. Nuevos paradigmas de interpretación.

El estudio del turismo se realiza desde múltiples escalas y enfoques, este libro aborda muchos temas que es necesario discutir desde diversas perspectivas; es el caso de la reflexión sobre la propia disciplina y sus conceptos, así como los asuntos específicos referidos al impacto territorial, los tipos de turismo, las cuestiones ambientales, el tema de la pobreza, la competitividad, las políticas públicas, el papel de las universidades, las áreas naturales protegidas, la sustentabilidad, la cultura, el desarrollo, la seguridad, todos temas centrales documentados y expuestos con originalidad y dominio del asunto. Lo multiescalar es básico para la comprensión del sistema turístico, sistema formado de procesos globales, regionales y locales. El eje de discusión del libro es lo glocal, esa interacción entre lo nacional y local con lo global