Hacia un modelo teórico explicativo de la innovación en los distritos de turismo cultural

This paper presents a theoretical model that analyses the direct effect of social capital on innovation, as well as the mediating effect of acquisition of knowledge between both variables in firms in a cultural tourist district. We analyse the bidimensional nature of social capital —bonded capital and bridging capital—. It is an approach to the context and characteristics of cultural tourist districts. We point out several future investigation lines related to the differentiation between types of knowledge and innovation. We propose recommendations about the orientation of relations between companies and institutions of cultural tourist districts.En este trabajo se plantea un modelo teórico que analiza el efecto directo, y mediado por la adquisición de conocimiento, del capital social sobre la innovación desarrollada por las empresas pertenecientes a un distrito turístico cultural. Se analiza el carácter bidimensional del capital social —bonded capital y bridging capital—. Se realiza una aproximación al contexto y las caracteristicas de los distritos turísticos culturales. Se establecen diversas líneas futuras de trabajo vinculadas a la diferenciación entre tipos de conocimiento y de innovación. Se proponen recomendaciones sobre la orientación de las relaciones entre las empresas y con las instituciones de los distritos turísticos culturales

Entrepreneurial orientation and the threat of imitation: The influence of upstream and downstream capabilities

This paper uncovers the complexity between Entrepreneurial Orientation (EO) and performance. The paper explores the effect of the threat of imitation, which is a key external factor to explain competitive dynamics, and hence highlights effectiveness of EO. Also the paper accounts for the role of upstream (technical) and downstream (marketing) capabilities as they influence effectiveness of EO. Our results show that, under threat of imitation, downstream marketing capabilities facilitate taping into opportunities derived from EO, which positively affects performance. Conversely, available upstream technical capabilities do not aim at EO when imitation threats exist in the environment. Of importance is that we question the complexity between EO and performance can be better understood using a configurational approach

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Towards an explanatory model of innovation in the cultural tourism district

En este trabajo se plantea un modelo teórico que analiza el efecto directo, y mediado por la adquisición de conocimiento, del capital social sobre la innovación desarrollada por las empresas pertenecientes a un distrito turístico cultural. Se analiza el carácter bidimensional del capital social —bonded capital y bridging capital—. Se realiza una aproximación al contexto y las caracteristicas de los distritos turísticos culturales. Se establecen diversas líneas futuras de trabajo vinculadas a la diferenciación entre tipos de conocimiento y de innovación. Se proponen recomendaciones sobre la orientación de las relaciones entre las empresas y con las instituciones de los distritos turísticos culturales.ABSTRACT: This paper presents a theoretical model that analyses the direct effect of social capital on innovation, as well as the mediating effect of acquisition of knowledge between both variables in firms in a cultural tourist district. We analyse the bidimensional nature of social capital —bonded capital and bridging capital—. It is an approach to the context and characteristics of cultural tourist districts. We point out several future investigation lines related to the differentiation between types of knowledge and innovation. We propose recommendations about the orientation of relations between companies and institutions of cultural tourist districts

BONDING CAPITAL, EXPLOTACIÓN DE CONOCIMIENTO E INNOVACIÓN INCREMENTAL EN LOS CLUSTERS DE TURISMO CULTURAL: LAS CIUDADES PATRIMONIO DE LA HUMANIDAD EN ESPAÑA

En este trabajo analizamos el papel de la estrategia de conocimiento en explotación para explicar la relación entre capital social en su dimensión bonding y la innovación incremental en el ámbito de los clusters. Hemos aplicado un modelo estructural sobre una muestra de 215 empresas del sector de turismo cultural de las Ciudades Patrimonio de la Humanidad de Espana. Los resultados revelan la existencia de un efecto indirecto significativo del bonding capital sobre la innovación incremental a través del desarrollo de una estrategia de conocimiento en explotación. Estos resultados sugieren que si las empresas de un cluster de turismo cultural son capaces de aprovechar sus redes densas y vínculos fuertes para implantar estrategias de conocimiento en explotación, tenderán a desarrollar mayores innovaciones incrementales

Psychological and Biographical Determinants of Entrepreneurial Intention: Does the Learning Environment Act as a Mediator?

The aim of this research is to study the mediating role of the learning process in explaining the relationships between certain psychological and biographical characteristics and entrepreneurial intention. The findings suggest that the effect of psychological and biographical aspects on entrepreneurial intention depend on the extent to which students are able to take advantage of their personal capabilities in order to develop an effective learning process. Learning process factors (information about course guides, student effort and educational processes) mediate the relationships between specific psychological factors (achievement need, internal control and autonomy) and entrepreneurial intention. With regard to biographical factors, we find no mediating effect on entrepreneurial intention through the learning process. The present study provides a better understanding of the antecedents of entrepreneurial intention, helping to fill the gap in the literature