La pericial psicológica en los procesos de nulidad matrimonial canónica.

The canonical annulment is one that declares that a marriage has never existed because according to the Code of Canon Law (CDC) it actually fell short of at least one of the essential elements required for a binding union. There are three main grounds of invalid marriages: the operation of a lead impediment, the defect or vice of consent and the defect of form. At present, 85% of causes that promote the onset of the process are of psychological nature. These are gathered in Can. 1095: insufficient use of reason, severe defect of discretion of judgement concerning the essential matrimonial rights and duties and inability to assume the essential obligations of marriage due to causes of psychic nature. The canonical expert witness evaluation share much of the methodology used in other fields of forensic practice, such as the study of means, a psychobiographical interview and complementary information obtained through the administration of psychometric tests. Finally, main psychological abnormalities that are known to incapacitate to canonical marriage will be describedLa nulidad canónica es aquella que declara que nunca existió un matrimonio porque desde el inicio estaba incurso en una de las causas de nulidad tal y como recoge el Código de Derecho Canónico (CDC). Principalmente existen tres causas de invalidez: la operación de un impedimento dirimente, el defecto o vicio de consentimiento y el defecto de forma. Actualmente, casi 9 de cada 10 causas que inician el proceso se refieren a incapacidad psicopatológica. Éstas vienen recogidas en el canon 1095: carencia de suficiente uso de razón, grave defecto de discreción de juicio acerca de los derechos y deberes esenciales del matrimonio e incapacidad para asumir las obligaciones esenciales del matrimonio por causas de naturaleza psíquica. La evaluación pericial canónica comparte gran parte de la metodología empleada en otros campos de actuación forense, como el estudio de los Autos, la entrevista psicobiográfica y la información complementaria obtenida mediante la administración de pruebas psicométricas. Sin embargo, existe un tipo de informe, el Voto sobre los autos, que es una figura legal que se contempla exclusivamente en el Derecho Procesal Canónico

Desarrollo de una plataforma computacional para el modelado matabólico de microorganismos

Synthetic biology focuses on the design and construction of artificial genetic systems that are capable of carrying out a specific function after being inserted into a living system. With the development of synthetic biology a new generation of bioengineers has appeared who develop complex, highly integrated genetic biological pathways. The improvement of this scientific discipline aims to establish a computational and conceptual framework that will support the development of modular artificial biological systems based on an engineering and systematic methodology. To achieve this, it will be necessary to provide new integrated computational tools in a common environment for the analysis of metabolic phenotypes, the design of new complex genetic pathways and the visualisation of metabolic maps to the next generation of designers in synthetic biology and future biotechnologists and biological engineers. A result of this research is the Hydra platform (Hybrid Draw and Routes Analysis) that integrates various tools for the design, analysis, and visualisation of metabolic networks.La Biología Sintética (BS) se centra en el diseño y la construcción de sistemas genéticos artificiales, capaces de desarrollar una función específica después de haber sido introducidos en un sistema vivo. Con el desarrollo de la BS, se observa una nueva generación de bioingenieros que desarrollan complejos circuitos biológicos genéticos con un alto nivel de integración. La mejora de esta disciplina científica tiene por objeto establecer un marco computacional y conceptual que dé asistencia al desarrollo de sistemas biológicos artificiales modulares basándose en una metodología ingenieril y sistemática, para lo que se necesita proveer a la próxima generación de diseñadores en Biología Sintética y a los futuros biotecnólogos e ingenieros biológicos de nuevas herramientas computacionales integradas en un entorno común para el análisis de fenotipos metabólicos, el diseño de nuevos circuitos genéticos complejos y la visualización de mapas metabólicos. Como resultado de esta investigación se obtiene la plataforma Hydra (Hybrid Draw and Routes Analysis), que integra diversas herramientas para el diseño, análisis y visualización de las redes metabólicas

Noninvasive imaging estimation of myocardial iron repletion following administration of intravenous iron: the myocardial-IRON Trial

Background Intravenous ferric carboxymaltose (FCM) improves symptoms, functional capacity, and quality of life in heart failure and iron deficiency. The mechanisms underlying these effects are not fully understood. The aim of this study was to examine changes in myocardial iron content after FCM administration in patients with heart failure and iron deficiency using cardiac magnetic resonance. Methods and Results Fifty-three stable heart failure and iron deficiency patients were randomly assigned 1:1 to receive intravenous FCM or placebo in a multicenter, double-blind study. T2* and T1 mapping cardiac magnetic resonance sequences, noninvasive surrogates of intramyocardial iron, were evaluated before and 7 and 30 days after randomization using linear mixed regression analysis. Results are presented as least-square means with 95% CI. The primary end point was the change in T2* and T1 mapping at 7 and 30 days. Median age was 73 (65-78) years, with N-terminal pro-B-type natriuretic peptide, ferritin, and transferrin saturation medians of 1690 pg/mL (1010-2828), 63 ng/mL (22-114), and 15.7% (11.0-19.2), respectively. Baseline T2* and T1 mapping values did not significantly differ across treatment arms. On day 7, both T2* and T1 mapping (ms) were significantly lower in the FCM arm (36.6 [34.6-38.7] versus 40 [38-42.1], P=0.025; 1061 [1051-1072] versus 1085 [1074-1095], P=0.001, respectively). A similar reduction was found at 30 days for T2* (36.3 [34.1-38.5] versus 41.1 [38.9-43.4], P=0.003), but not for T1 mapping (1075 [1065-1085] versus 1079 [1069-1089], P=0.577). Conclusions In patients with heart failure and iron deficiency, FCM administration was associated with changes in the T2* and T1 mapping cardiac magnetic resonance sequences, indicative of myocardial iron repletion. Clinical Trial Registration URL: http://www.clinicaltrials.gov. Unique identifier: NCT03398681