Etwinning projects: In the distance learning

El artículo expone los resultados de la implantación de los proyectos eTwinning en los centros de primaria desde la perspectiva del profesorado. El estudio pretende conocer cómo se ha implantado, dificultades y limitaciones, qué aporta a profesores y alumnos, etc., para ello se ha entrevistado al profesorado responsable. Se concluye que es un elemento innovador para manejo TIC y para el aprendizaje de otras lenguas. Implica trabajo colaborativo, intercambio cultural y dimensión europea de la educaciónThe article presents the results of implementing eTwinning projects in primary schools from the perspective of teachers. The study aims to determine how you have implemented, difficulties and limitations, which provides teachers and students, etc., for it has interviewed the teacher responsible. We conclude that management is an innovative tool for ICT and learning other languages. Involves collaborative work, cultural exchange and the European dimension of educatio

Relación entre diabetes y cáncer de páncreas

La diabetes mellitus (DM) y el cáncer son afecciones crónicas y multifactoriales, siendo dos de las enfermedades con mayor prevalencia en la población a nivel mundial, afectando así a millones de personas. Numerosos estudios asocian la diabetes con distintas neoplasias, en especial, con el cáncer de páncreas (CP). No obstante, el papel que juega la diabetes en dicha relación es objeto de discusión, ya que se desconoce si debe tratarse la DM como un factor de riesgo que predispone a padecer cáncer de páncreas en un futuro, o, por el contrario, si es consecuencia directa de un previo diagnóstico de dicho tumor. Dado que el CP se caracteriza por un alto porcentaje de muertes, y suele diagnosticarse, en la mayoría de sus casos, en estadios avanzados debido a su escasa sintomatología al inicio de la enfermedad, el hecho de conocer qué papel juega la DM, podría ser de gran ayuda a la hora de elaborar programas para la salud que sirvan para reducir la incidencia de nuevos casos de CP. El objetivo de este trabajo, ha sido determinar la relación existente entre la DM y el CP, intentando responder así, cuál es el papel que juega cada patología en dicha asociación

Proyectos eTwinning: Aprendiendo en la distancia

El artículo expone los resultados de la implantación de los proyectos eTwinning en los centros de primaria desde la perspectiva del profesorado. El estudio pretende conocer cómo se ha implantado, dificultades y limitaciones, qué aporta a profesores y alumnos, etc., para ello se ha entrevistado al profesorado responsable. Se concluye que es un elemento innovador para manejo TIC y para el aprendizaje de otras lenguas. Implica trabajo colaborativo,  intercambio cultural y dimensión europea de la educación.

Gene-environment interaction analysis of redox-related metals and genetic variants with plasma metabolic patterns in a general population from Spain: The Hortega Study

Background: Limited studies have evaluated the joint influence of redox-related metals and genetic variation on metabolic pathways. We analyzed the association of 11 metals with metabolic patterns, and the interacting role of candidate genetic variants, in 1145 participants from the Hortega Study, a population-based sample from Spain. Methods: Urine antimony (Sb), arsenic, barium (Ba), cadmium (Cd), chromium (Cr), cobalt (Co), molybdenum (Mo) and vanadium (V), and plasma copper (Cu), selenium (Se) and zinc (Zn) were measured by ICP-MS and AAS, respectively. We summarized 54 plasma metabolites, measured with targeted NMR, by estimating metabolic principal components (mPC). Redox-related SNPs (N = 291) were measured by oligo-ligation assay. Results: In our study, the association with metabolic principal component (mPC) 1 (reflecting non-essential and essential amino acids, including branched chain, and bacterial co-metabolism versus fatty acids and VLDL subclasses) was positive for Se and Zn, but inverse for Cu, arsenobetaine-corrected arsenic (As) and Sb. The association with mPC2 (reflecting essential amino acids, including aromatic, and bacterial co-metabolism) was inverse for Se, Zn and Cd. The association with mPC3 (reflecting LDL subclasses) was positive for Cu, Se and Zn, but inverse for Co. The association for mPC4 (reflecting HDL subclasses) was positive for Sb, but inverse for plasma Zn. These associations were mainly driven by Cu and Sb for mPC1; Se, Zn and Cd for mPC2; Co, Se and Zn for mPC3; and Zn for mPC4. The most SNP-metal interacting genes were NOX1, GSR, GCLC, AGT and REN. Co and Zn showed the highest number of interactions with genetic variants associated to enriched endocrine, cardiovascular and neurological pathways. Conclusions: Exposures to Co, Cu, Se, Zn, As, Cd and Sb were associated with several metabolic patterns involved in chronic disease. Carriers of redox-related variants may have differential susceptibility to metabolic alterations associated to excessive exposure to metals.This work was supported by the Strategic Action for Research in Health sciences [CP12/03080, PI15/00071, PI10/0082, PI13/01848, PI14/00874, PI16/01402, PI21/00506 and PI11/00726], CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN) (CIBER-02-08-2009, CB06/03 and CB12/03/30,016), the State Agency for Research (PID2019-108973RB- C21 and C22), the Valencia Government (GRUPOS 03/101; PROM- ETEO/2009/029 and ACOMP/2013/039, IDIFEDER/ 2021/072 and GRISOLIAP/2021/119), the Castilla-Leon Government (GRS/279/A/08) and European Network of Excellence Ingenious Hypercare (EPSS- 037093) from the European Commission. The Strategic Action for Research in Health sciences, CIBERDEM and CIBEROBN are initiatives from Carlos III Health Institute Madrid and cofunded with European Funds for Regional Development (FEDER). The State Agency for Research and Carlos III Health Institute belong to the Spanish Ministry of Science and Innovation. ADR received the support of a fellowship from “la Caixa” Foundation (ID 100010434) (fellowship code “LCF/BQ/DR19/11740016”). MGP received the support of a fellowship from “la Caixa” Foundation (ID 100010434, fellowship code LCFLCF/BQ/DI18/11660001). The funding bodies had no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript

Technical and environmental improvement of the bleaching sequence of dissolving pulp for fibre production

Reactivity of dissolving pulp is one of the main parameters to determine its availability to be transformed into viscose. It is related to the use of carbon disulphide (CS2). An industrial sequential totally chlorine free bleaching process is used as case study. It is carried out in two stages: (1) Alkaline extraction (EOP) and (2) peroxide bleaching (PO). In order to assess how to decrease the use of carbon disulphide, several experiments were performed at laboratory scale for the two stages mentioned before by modifying the operating conditions: NaOH and H2O2 dosages, time and temperature. Reactivity using a modified Fock’s method and pentosan content was analysed along with quality pulp parameters: α-cellulose, viscosity and lignin content (kappa number). Results showed that reactivity increases through the bleaching process and varies with the chemical dosage in both stages. Pulp obtained at the best conditions had the following characteristics: reactivity, 95.3%; α-cellulose 91.17%; intrinsic viscosity, 448 mL/g; kappa number, 1.81 and pentosan content 2.86%, and as a result, CS2 usage was reduced by 11.88%. At the best conditions obtained in this work, NaOH dosage in PO stage was reduced to zero and temperature was slightly lower, when compared with industrial operating conditions

Use of metalloproteomics to access environmental stress in the free-living mice mus spretus

Comunicaciones a congreso

Intraarticular Administration Effect of Hydrogen Sulfide on an In Vivo Rat Model of Osteoarthritis

[Abstract] Osteoarthritis (OA) is the most common articular chronic disease. However, its current treatment is limited and mostly symptomatic. Hydrogen sulfide (H2S) is an endogenous gas with recognized physiological activities. The purpose here was to evaluate the effects of the intraarticular administration of a slow-releasing H2S compound (GYY-4137) on an OA experimental model. OA was induced in Wistar rats by the transection of medial collateral ligament and the removal of the medial meniscus of the left joint. The animals were randomized into three groups: non-treated and intraarticularly injected with saline or GYY-4137. Joint destabilization induced articular thickening (≈5% increment), the loss of joint mobility and flexion (≈12-degree angle), and increased levels of pain (≈1.5 points on a scale of 0 to 3). Animals treated with GYY-4137 presented improved motor function of the joint, as well as lower pain levels (≈75% recovery). We also observed that cartilage deterioration was attenuated in the GYY-4137 group (≈30% compared with the saline group). Likewise, these animals showed a reduced presence of pro-inflammatory mediators (cyclooxygenase-2, inducible nitric oxide synthase, and metalloproteinase-13) and lower oxidative damage in the cartilage. The increment of the nuclear factor-erythroid 2-related factor 2 (Nrf-2) levels and Nrf-2-regulated gene expression (≈30%) in the GYY-4137 group seem to be underlying its chondroprotective effects. Our results suggest the beneficial impact of the intraarticular administration of H2S on experimental OA, showing a reduced cartilage destruction and oxidative damage, and supporting the use of slow H2S-producing molecules as a complementary treatment in OA.Instituto de Salud Carlos III; PI16/02124Xunta de Galicia; AGRUP2015/05 CICA-INIBICXunta de Galicia; IN607A 2017/1

US “Development Assistance” to ALBA-TCP Countries (2017-2021), a Critical Radiography

El artículo presenta una radiografía de la “asistencia para el desarrollo” de EE.UU. a los países del ALBA-TCP en período 2017-2021, brindando una descripción detallada de las agencias y subagencias estadounidenses que financian e implementan la asistencia, las instituciones locales que canalizan la asistencia en los países de la Alianza y los sectores a los que es destinada. El análisis empírico se realiza a partir de las bases de datos oficiales del gobierno estadounidense, USAID Explorer y ForeingAssistance.gov, pero desde una perspectiva que critica la clasificación oficial de la asistencia. Los hallazgos ponen en evidencia que el modus operandi de la “asistencia” económica y para la seguridad está intrínsecamente articulado a una red institucional, extendida en el tiempo y en el territorio, que garantiza la reproducción de determinadas concepciones de desarrollo, democracia y seguridad, que trasciende a gobiernos demócratas y republicanos.The article presents an X-ray of US "development assistance" to ALBA-TCP countries in 2017-2021, providing a detailed description of US agencies and sub-agencies that fund and implement assistance, local institutions that channel assistance in the countries of the Alliance and the sectors to which it is directed. The empirical analysis is carried out from the official databases of the US government, USAID Explorer and ForeignAssistance.gov, but from a perspective that criticizes the official classification of assistance. The findings show that the modus operandi of economic and security assistance is intrinsically articulated to an institutional network, extended in time and territory, which guarantees the reproduction of certain conceptions of development, democracy and security that transcends Democrat and Republican governments.Fil: Lajtman Bereicoa, Tamara. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Sociales. Instituto de Estudios de América Latina y el Caribe; Argentina. Centro Estratégico Latinoamericano de Geopolítica; ArgentinaFil: García Fernández, Anibal. Universidad Nacional Autónoma de México; México. Centro Estratégico Latinoamericano de Geopolítica; ArgentinaFil: Romano, Silvina Maria. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Sociales. Instituto de Estudios de América Latina y el Caribe; Argentina. Centro Estratégico Latinoamericano de Geopolítica; Argentin

Estados Unidos y la diplomacia de la vacuna COVID19

El artículo expone datos interesantes y detallados sobre la diplomacia de la vacuna COVID-19 en América Latina y el Caribe (ALC), y el rol asumido por EE.UU. frente a la rivalidad con China y Rusia.Fil: Lajtman Bereicoa, Tamara. Universidad de Buenos Aires. Facultad de Ciencias Sociales. Instituto de Estudios de América Latina y el Caribe; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: García Fernández, Aníbal. Universidad Nacional Autónoma de México; MéxicoFil: Romano, Silvina Maria. Universidad de Buenos Aires. Facultad de Ciencias Sociales. Instituto de Estudios de América Latina y el Caribe; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

Magnocellular bias in exogenous attention to biologically salient stimuli as revealed by manipulating their luminosity and color

This is the author’s final version of the article, and that the article has been accepted for publication in Journal of Cognitive NeuroscienceExogenous attention is a set of mechanisms that allow us to detect and reorient toward salient events—such as appetitive or aversive—that appear out of the current focus of attention. The nature of these mechanisms, particularly the involvement of the parvocellular and magnocellular visual processing systems, was explored. Thirty-four participants performed a demanding digit categorization task while salient (spiders or S) and neutral (wheels or W) stimuli were presented as distractors under two figure–ground formats: heterochromatic/isoluminant (exclusively processed by the parvocellular system, Par trials) and isochromatic/heteroluminant (preferentially processed by the magnocellular system, Mag trials). This resulted in four conditions: SPar, SMag, WPar, and WMag. Behavioral (RTs and error rates in the task) and electrophysiological (ERPs) indices of exogenous attention were analyzed. Behavior showed greater attentional capture by SMag than by SPar distractors and enhanced modulation of SMag capture as fear of spiders reported by participants increased. ERPs reflected a sequence from magnocellular dominant (P1p, ≃120 msec) to both magnocellular and parvocellular processing (N2p and P2a, ≃200 msec). Importantly, amplitudes in one N2p subcomponent were greater to SMag than to SPar and WMag distractors, indicating greater magnocellular sensitivity to saliency. Taking together, results support a magnocellular bias in exogenous attention toward distractors of any nature during initial processing, a bias that remains in later stages when biologically salient distractors are presen