The entry of established electronics companies into the early computer industry in the UK and USA.

This thesis studies the efforts of a number of large electronics firms to enter and survive in the computer industries of the USA and Britain, from the Second World War to the early 1970s. It contrasts the relative failure of these firms with the greater ability to survive in this sector displayed by single product business machine companies and a number of new, start up, computer firms. The potential advantages that the multi-product electronics enterprise should have had in the new computer market are seen to have been outweighed by these firms being over burdened by the very scope of their operations. Their efforts to cover the whole electronics industry, rather than concentrating on a few sectors, mitigated the potential that they had. A number of case studies of such firms, both British and American, form the heart of this study. The main studies are:- UK: Ferranti, Electrical and Musical Industries and English Electric. US: Radio Corporation of America, and General Electric. To contrast the strategies and structures of the electronics combines, a number of short studies are made of British and American business machines and start-up companies: UK: International Computers and Tabulators. US: International Business Machines, and shorter studies on Burroughs, Control Data Corp., Digital Equipment Corp., Honeywell, National Cash Register, and Sperry-Rand. Study of the electronics firms in the computer industry sheds light on the overall weakness of the broad-based, multi-product, British and American electronics company in the electronics industry as a whole. There is also some comment on the roles of the two governments in shaping the computer industry

Critical Conversations around Hiring Equity and Anti-Racist Search Processes

When the COVID-19 pandemic shut down institutions in March 2020, many academic programs faced budget cuts and hiring freezes (Friga, 2020). The impact of budget cuts most severely impacted HBCU’s and rural colleges (Kelchen et al., 2021). Yet, as the pandemic restrictions eased and some schools found ways to begin hiring again; however, things were different this time. Many schools conducted their searches entirely virtually (Banks et al., 2020). As many social work educators can attest, a switch from in-person to virtual methods presented unique challenges (Paceley et al., 2021). This 4-person panel included a successful job candidate and three members of search committees. The panel shared tips and tricks that helped the searches run smoothly in the virtual environment. Additionally, there was a focus on making the virtual environment as welcoming and attractive as possible. The panel presented perspectives from rural and urban teaching-focused and research-focused institutions ranging in Carnegie Classifications from “R1: Doctoral Universities – Very high research activity” to “Master\u27s College and University”. These perspectives encompassed both PWI and HBCU. Critical conversations around hiring equity and antiracist search processes are an important part of higher education leadership. As social workers, we must act to eliminate racist hiring trends in higher education and bring equity to the front of the table in hiring conversations (Gates et al., 2021). Participants in this panel confronted their own biases related to antiracist search practices and learned new strategies for faculty searches in the landscape of an ongoing pandemic (Fariña et al., 2021)

Mosquito diversity and abundance in English wetlands – empirical evidence to guide predictions for wetland suitability for mosquitoes (Diptera: Culicidae)

The absence of habitat-based guidance for wetland managers on the British mosquito assemblages has in recent years prevented development of the ecological aspect of medical entomology in the UK. This has been particularly relevant in the context of emerging mosquito-borne disease and the creation of wetlands for biodiversity and flood-alleviation goals. This study aimed to provide empirically derived habitat-based predictions in order to assess the suitability of English wetland habitats for mosquitoes. Entomological field data on mosquito density and diversity were collected at 12 English wetlands in 2017 and 2018 using immature and adult mosquito surveys. Wetlands were chosen representing a number of wetland categories that included coastal, urban, wet woodland and established freshwater wetlands to identify key species and functional groups to inform predictions of mosquitoes by aquatic habitat type. Nineteen species were recorded from eight functional groups, totalling 38,577 adult female (19 mosquito species groups) and ~2,000 immature mosquitoes in 13 aquatic habitat types. Approximately 90% of all trapped mosquitoes were attributed to one of five species groups. The most common species were: Aedes (Och.) caspius (Pallas, 1771) (~35% of all mosquitoes), associated with coastal estuarine and flooded grassland sites, Ae. cantans/annulipes (19.7%) in wet woodland field sites, Anopheles claviger (16.2%) and Coquillettidia richiardii (12.6%) with the widest occurrence, found in nearly all field sites, and Ae. detritus (6.9%) in brackish field sites. Across the study, adult mosquito activity increased from week 21 with wet woodland Aedes mosquitoes, until week 40 with open-flood water species, with greatest diversity of species during weeks 23–30. The resulting data inform efforts towards developing predictive tools for non-entomologists to accurately predict the presence and abundance of British mosquitoes in a given habitat, using local knowledge of seasonal aquatic habitats

Association of Alleles Carried at TNFA -850 and BAT1 -22 with Alzheimer\u27s Disease

Background: Inflammatory changes are a prominent feature of brains affected by Alzheimer\u27s disease (AD). Activated glial cells release inflammatory cytokines which modulate the neurodegenerative process. These cytokines are encoded by genes representing several interleukins and TNFA, which are associated with AD. The gene coding for HLA-B associated transcript 1 (BAT1) lies adjacent to TNFA in the central major histocompatibility complex (MHC). BAT1, a member of the DEAD-box family of RNA helicases, appears to regulate the production of inflammatory cytokines associated with AD pathology. In the current study TNFA and BAT1 promoter polymorphisms were analysed in AD and control cases and BAT1 mRNA levels were investigated in brain tissue from AD and control cases. Methods: Genotyping was performed for polymorphisms at positions -850 and -308 in the proximal promoter of TNFA and position -22 in the promoter of BAT1. These were investigated singly or in haplotypic association in a cohort of Australian AD patients with AD stratified on the basis of their APOE ε4 genotype. Semi-quantitative RT-PCR was also performed for BAT1 from RNA isolated from brain tissue from AD and control cases. Results: APOE ε4 was associated with an independent increase in risk for AD in individuals with TNFA -850*2, while carriage of BAT1 -22*2 reduced the risk for AD, independent of APOE ε4 genotype. Semi-quantitative mRNA analysis in human brain tissue showed elevated levels of BAT1 mRNA in frontal cortex of AD cases. Conclusion: These findings lend support to the application of TNFA and BAT1 polymorphisms in early diagnosis or risk assessment strategies for AD and suggest a potential role for BAT1 in the regulation of inflammatory reactions in AD pathology

Transformation of Cs-IONSIV® into a ceramic wasteform by hot isostatic pressing

A simple method to directly convert Cs-exchanged IONSIV® IE-911 into a ceramic wasteform by hot isostatic pressing (1100 °C/190 MPa/2 hr) is presented. Two major Cs-containing phases, Cs2TiNb6O18 and Cs2ZrSi6O15, and a series of mixed oxides form. The microstructure and phase assemblage of the samples as a function of Cs content were examined using XRD, XRF, SEM and TEM/EDX. The chemical aqueous durability of the materials was investigated using the MCC-1 and PCT-B standard test methods. For HIPed Cs-IONSIV® samples, the MCC-1 normalised release rates of Cs were <1.57 × 10−1 g m−2 d−1 at 0–28 days, and <3.78 × 10−2 g m−2 d−1 for PCT-B at 7 days. The low rates are indicative of a safe long-term immobilisation matrix for Cs formed directly from spent IONSIV®. It was also demonstrated that the phase formation can be altered by adding Ti metal due to a controlled redox environment

Concrete stories, decomposing fictions: Body parts and body politics in Ahmed Saadawi’s Frankenstein in Baghdad

This essay reads the English translation of Ahmed Saadawi’s novel Frankenstein in Baghdad (2018) to explore the “concrete stories” and “infrastructural narratives” devised by the US military in support of its occupation of Baghdad. By stitching together a city and society littered with composing and decomposing fictions, Saadawi’s novel reveals how biopolitical governance produces, contra the hegemonic US war story of security consolidation and societal stabilization, pervasive insecurity instead. Saadawi’s “decomposing fictions”, as I call them, operate on three homologous terrains: the (de)composition of the city; the (de)composition of the body; and the (de)composition of the narrative itself. Through this three-tired conflation, Saadawi shows how body parts are biopolitical, and how narratives actively and materially reshape human bodies and urban infrastructures. The essay therefore argues that the novel aligns with a critical posthumanist perspective, one that allows for a more rigorous consideration of narrative systems (including fictions) as constitutive of and impactful upon human and non-human bodies and urban infrastructures than other concepts, such as “planned violence”, have so far allowed. By theorizing a more complex relationship between narrative form and the built environment in the contexts of militarized colonial and biopolitical urban governance, the essay shows how Saadawi’s novel not only challenges the “imaginative geographies” of the colonial present, but its material infrastructures as well

Evaluation of equity in informal land development systems in two Nigerian cities

The informal land development system in Sub-Saharan Africa (SSA) is perceived to promote equity and could be leveraged to support sustainable urban development and management. However, scanty empirical evidence exists on the extent of the system’s provision of equity to support policy formulation and practice in the region. Based on stakeholder workshops, focus group discussions and questionnaire surveys, this study analyses the system’s provision of equity in Nigeria. The study finds all categories of people undertake informal developments. Consistent with literature, this finding reflects wide patronage of the informal land development system and its relevance. Nevertheless, contrary to the existing perception, the system’s provision of equity is low. The study recommends for the institution of pro-poor and gender sensitive land development and management policies and programmes to increase the levels of equity to support the achievement of the country’s sustainable urban development and management agenda

Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial

Background: Glucagon-like peptide 1 receptor agonists differ in chemical structure, duration of action, and in their effects on clinical outcomes. The cardiovascular effects of once-weekly albiglutide in type 2 diabetes are unknown. We aimed to determine the safety and efficacy of albiglutide in preventing cardiovascular death, myocardial infarction, or stroke. Methods: We did a double-blind, randomised, placebo-controlled trial in 610 sites across 28 countries. We randomly assigned patients aged 40 years and older with type 2 diabetes and cardiovascular disease (at a 1:1 ratio) to groups that either received a subcutaneous injection of albiglutide (30–50 mg, based on glycaemic response and tolerability) or of a matched volume of placebo once a week, in addition to their standard care. Investigators used an interactive voice or web response system to obtain treatment assignment, and patients and all study investigators were masked to their treatment allocation. We hypothesised that albiglutide would be non-inferior to placebo for the primary outcome of the first occurrence of cardiovascular death, myocardial infarction, or stroke, which was assessed in the intention-to-treat population. If non-inferiority was confirmed by an upper limit of the 95% CI for a hazard ratio of less than 1·30, closed testing for superiority was prespecified. This study is registered with ClinicalTrials.gov, number NCT02465515. Findings: Patients were screened between July 1, 2015, and Nov 24, 2016. 10 793 patients were screened and 9463 participants were enrolled and randomly assigned to groups: 4731 patients were assigned to receive albiglutide and 4732 patients to receive placebo. On Nov 8, 2017, it was determined that 611 primary endpoints and a median follow-up of at least 1·5 years had accrued, and participants returned for a final visit and discontinuation from study treatment; the last patient visit was on March 12, 2018. These 9463 patients, the intention-to-treat population, were evaluated for a median duration of 1·6 years and were assessed for the primary outcome. The primary composite outcome occurred in 338 (7%) of 4731 patients at an incidence rate of 4·6 events per 100 person-years in the albiglutide group and in 428 (9%) of 4732 patients at an incidence rate of 5·9 events per 100 person-years in the placebo group (hazard ratio 0·78, 95% CI 0·68–0·90), which indicated that albiglutide was superior to placebo (p&lt;0·0001 for non-inferiority; p=0·0006 for superiority). The incidence of acute pancreatitis (ten patients in the albiglutide group and seven patients in the placebo group), pancreatic cancer (six patients in the albiglutide group and five patients in the placebo group), medullary thyroid carcinoma (zero patients in both groups), and other serious adverse events did not differ between the two groups. There were three (&lt;1%) deaths in the placebo group that were assessed by investigators, who were masked to study drug assignment, to be treatment-related and two (&lt;1%) deaths in the albiglutide group. Interpretation: In patients with type 2 diabetes and cardiovascular disease, albiglutide was superior to placebo with respect to major adverse cardiovascular events. Evidence-based glucagon-like peptide 1 receptor agonists should therefore be considered as part of a comprehensive strategy to reduce the risk of cardiovascular events in patients with type 2 diabetes. Funding: GlaxoSmithKline