Adaptation autonomique d'applications pervasives dirigée par les architectures

The autonomic adaptation of software application is becoming increasingly important in many domains, including pervasive field. Indeed, the integration fo different application resources (physical devices, services and third party applications) often needs to be dynamic and should adapt rapidly and automatically to changes in the execution context. To that end, service-oriented components offer support for adaptation at the architectural level. However, they do not allow the formalisation of all the design constraints that must be guaranteed during the execution of the system. To overcome this limitation, this thesis modeled the design, deployment and runtime architectures. Also, it proposes to establish links between them and has developed algorithms to check the validity of an execution architecture with respect to its architectural design. This led us to consider the entire life cycle of components and to define a set of concepts to be included in architectures supporting variability. This formalisation can be exploited both by a human administrator and by an autonomic manager that has its knowledge base increased and structured. The implementation resulted in the realization of a knowledge base, providing a studio (Cilia IDE) for the design, deployment and supervision of dynamic applications, as well as an autonomic manager that can update the structure of pervasive applications. This thesis has been validated using a pervasive application called “Actimetry”, developed in the FUI~MEDICAL project.La problématique d'adaptation autonomique prend de plus en plus d'importance dans l'administration des applications modernes, notamment pervasives. En effet, la composition entre les différentes ressources de l'application (dispositifs physiques, services et applications tierces) doit souvent être dynamique, et s'adapter automatiquement et rapidement aux évolutions du contexte d'exécution. Pour cela, les composants orientés services offrent un support à l'adaptation au niveau architectural. Cependant, ils ne permettent pas d'exprimer l'ensemble des contraintes de conception qui doivent être garanties lors de l'exécution du système. Pour lever cette limite, cette thèse a modélisé les architectures de conception, de déploiement et de l'exécution. De plus, elle a établi des liens entre celle-ci et proposé des algorithmes afin de vérifier la validité d'une architecture de l'exécution par rapport à son architecture de conception. Cela nous a conduits à considérer de près le cycle de vie des composants et à définir un ensemble de concepts afin de les faire participer à des architectures supportant la variabilité. Notons que cette formalisation peut être exploitée aussi bien par un administrateur humain, que par un gestionnaire autonomique qui voit ainsi sa base de connaissances augmentée et structurée. L'implantation a donné lieu à la réalisation d'une base de connaissance, mise à disposition d'un atelier (Cilia IDE) de conception, déploiement et supervision d'applications dynamiques, ainsi que d'un gestionnaire autonomique capable de modifier la structure d'une application pervasive. Cette thèse a été validée à l'aide d'une application pervasive nommée >, développée dans le cadre du projet FUI~MEDICAL

Advancing experimentation-as-a-service through urban IoT experiments

Smart cities are becoming a vibrant application domain for a number of science fields. As such, service providers and stakeholders are beginning to integrate co-creation aspects into current implementations to shape the future smart city solutions. In this context, holistic solutions are required to test such aspects in real city-scale Internet of Things (IoT) deployments, considering the complex city ecosystems. In this paper, we discuss OrganiCity's implementation of an experimentation-as-a-service (EaaS) framework, presenting a toolset that allows developing, deploying, and evaluating smart city solutions in a one-stop shop manner. This is the first time such an integrated toolset is offered in the context of a large-scale IoT infrastructure, which spans across multiple European cities. We discuss the design and implementation of the toolset, presenting our view on what EaaS should provide, and how it is implemented. We present initial feedback from 25 experimenter teams that have utilized this toolset in the OrganiCity project, along with a discussion on two detailed actual use cases to validate our approach. Learnings from all experiments are discussed as well as architectural considerations for platform scaling. Our feedback from experimenters indicates that EaaS is a viable and useful approach.The authors would like to thank the experimenter teams and volunteers who participated in OrganiCit

Assessment of the interplay between blood and skin vascular abnormalities in adult purpura fulminans

RATIONALE: Purpura fulminans in adults is a rare but devastating disease. Its pathophysiology is not well known. OBJECTIVES: To understand the pathophysiology of skin lesions in purpura fulminans, the interplay between circulating blood and vascular alterations was assessed. METHODS: Prospective multicenter study in four intensive care units. Patients with severe sepsis without skin lesions were recruited as control subjects. MEASUREMENTS AND MAIN RESULTS: Twenty patients with severe sepsis and purpura fulminans were recruited for blood sampling, and skin biopsy was performed in deceased patients. High severity of disease and mortality rates (80%) was observed. Skin biopsies in purpura fulminans lesions revealed thrombosis and extensive vascular damage: vascular congestion and dilation, endothelial necrosis, alteration of markers of endothelial integrity (CD31) and of the protein C pathway receptors (endothelial protein C receptor, thrombomodulin). Elevated plasminogen activating inhibitor-1 mRNA was also observed. Comparison with control patients showed that these lesions were specific to purpura fulminans. By contrast, no difference was observed for blood hemostasis parameters, including soluble thrombomodulin, activated protein C, and disseminated intravascular coagulation markers. Bacterial presence at the vascular wall was observed specifically in areas of vascular damage in eight of nine patients tested (including patients with Streptococcus pneumoniae, Neisseria meningitidis, Escherichia coli, and Pseudomonas aeruginosa infection). CONCLUSIONS: Thrombi and extensive vascular damage with multifaceted prothrombotic local imbalance are characteristics of purpura fulminans. A "vascular wall infection" hypothesis, responsible for endothelial damage and subsequent skin lesions, can be put forward

SocIoTal - The development and architecture of a social IoT framework

In this paper the development and architecture of the SocIoTal platform is presented. SocIoTal is a European FP7 project which aims to create a socially-aware citizen-centric Internet of Things infrastructure. The aim of the project is to put trust, user-control and transparency at the heart of the system in order to gain the confidence of everyday users and developers. By providing adequate tools and mechanisms that simplify complexity and lower the barriers of entry, it will encourage citizen participation in the Internet of Things. This adds a novel and rich dimension to the emerging IoT ecosystem, providing a wealth of opportunities for the creation of new services and applications. These services and applications will be able to address the needs of society therefore improving the quality of life in cities and communities. In addition to technological innovation, the SocIoTal project sought to innovate the way in which users and developers interact and shape the direction of the project. The project worked on new formats in obtaining data, information and knowledge. The first step consisted of gaining input, feedback and information on IoT as a reality in business. This led to a validated iterative methodology which formed part of the SocIoTal toolkit.This work was supported by the SocIoTal project under grant agreement No 609112

A Genome-Wide Association Study of the Protein C Anticoagulant Pathway

The Protein C anticoagulant pathway regulates blood coagulation by preventing the inadequate formation of thrombi. It has two main plasma components: protein C and protein S. Individuals with protein C or protein S deficiency present a dramatically increased incidence of thromboembolic disorders. Here, we present the results of a genome-wide association study (GWAS) for protein C and protein S plasma levels in a set of extended pedigrees from the Genetic Analysis of Idiopathic Thrombophilia (GAIT) Project. A total number of 397 individuals from 21 families were typed for 307,984 SNPs using the Infinium® 317 k Beadchip (Illumina). Protein C and protein S (free, functional and total) plasma levels were determined with biochemical assays for all participants. Association with phenotypes was investigated through variance component analysis. After correcting for multiple testing, two SNPs for protein C plasma levels (rs867186 and rs8119351) and another two for free protein S plasma levels (rs1413885 and rs1570868) remained significant on a genome-wide level, located in and around the PROCR and the DNAJC6 genomic regions respectively. No SNPs were significantly associated with functional or total protein S plasma levels, although rs1413885 from DNAJC6 showed suggestive association with the functional protein S phenotype, possibly indicating that this locus plays an important role in protein S metabolism. Our results provide evidence that PROCR and DNAJC6 might play a role in protein C and free protein S plasma levels in the population studied, warranting further investigation on the role of these loci in the etiology of venous thromboembolism and other thrombotic diseases

Genetic Background Analysis of Protein C Deficiency Demonstrates a Recurrent Mutation Associated with Venous Thrombosis in Chinese Population

Background: Protein C (PC) is one of the most important physiological inhibitors of coagulation proteases. Hereditary PC deficiency causes a predisposition to venous thrombosis (VT). The genetic characteristics of PC deficiency in the Chinese population remain unknown. Methods: Thirty-four unrelated probands diagnosed with hereditary PC deficiency were investigated. PC activity and antigen levels were measured. Mutation analysis was performed by sequencing the PROC gene. In silico analyses, including PolyPhen-2, SIFT, multiple sequence alignment, splicing prediction, and protein molecular modeling were performed to predict the consequences of each variant identified. One recurrent mutation and its relative risk for thrombosis in relatives were analyzed in 11 families. The recurrent mutation was subsequently detected in a case (VT patients)-control study, and the adjusted odds ratio (OR) for VT risk was calculated by logistic regression analysis. Results: A total of 18 different mutations, including 12 novel variants, were identified. One common mutation, PROC c.565C.T (rs146922325:C.T), was found in 17 of the 34 probands. The family study showed that first-degree relatives bearing this variant had an 8.8-fold (95%CI = 1.1–71.6) increased risk of venous thrombosis. The case-control (1003 vs. 1031) study identified this mutation in 5.88 % patients and in 0.87 % controls, respectively. The mutant allele conferred a high predisposition to venous thrombosis (adjusted OR = 7.34, 95%CI = 3.61–14.94). The plasma PC activity and antigen levels i

Evolution of model proteins on a foldability landscape

We model the evolution of simple lattice proteins as a random walk in a fitness landscape, where the fitness represents the ability of the protein to fold. At higher selective pressure, the evolutionary trajectories are confined to neutral networks where the native structure is conserved and the dynamics are non self-averaging and nonexponential. The optimizability of the corresponding native structure has a strong effect on the size of these neutral networks and thus on the nature of the evolutionary process. Proteins 29:461–466, 1997. © 1997 Wiley-Liss, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/38527/1/6_ftp.pd

Endothelial cell protein C receptor and the risk of venous thrombosis.

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