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Evolution of model proteins on a foldability landscape
Authors
Allaart
Arevalo
+124 more
Azzi
Baker
Bally
Beauchamp
Beck
Bernstein
Bertina
Bertina
Bertina
Bocchinfuso
Bocchinfuso
Borgel
Branden
Castaman
Chang
Chang
Chu
Comp
Comp
Dahlbäck
Dahlbäck
Dahlbäck
Dahlbäck
Dahlbäck
Dahlbäck
Dahlbäck
Dayhoff
DiScipio
Duchemin
Duchemin
Dunkel
Ehrig
Faioni
Fair
Fernández
Fernández
Formstone
Fortunati
Fujiwara
Gandrille
García de Frutos
Garrison
Gershagen
Gershagen
Ghosh
Girolami
Goruppi
Gray
Greengard
Griffin
Gómez
Hammond
Hammond
Hammond
He
He
Heeb
Hennessey
Higgins
Hildebrand
Hillarp
Hillarp
Härdig
Härdig
Jackson
Joseph
Joseph
Joseph
Kabsch
Kahn
Koppelman
Kusche-Gullberg
Levitt
Lijnzaad
Linse
Lundwall
Malm
Manfioletti
Martin
Matthews
Mustafa
Nakano
Needleman
Nelson
Nisker
Nomizu
Ohashi
Olsen
Patthy
Petra
Petra
Poch
Power
Rost
Rost
Rost
Rost
Sasaki
Schmidel
Scholtz
Schwarz
Selander-Sunnerhagen
Simmonds
Simmonds
Soriano-Garcia
Sreerama
Stitt
Sui
Sui
Thompson
Varnum
Villoutreix
Villoutreix
Vrielink
Walker
Walker
Yamazaki
Yang
Yasuda
Yurchenco
Zhu
Zöller
Zöller
Zöller
Publication date
1 January 1997
Publisher
'Wiley'
Doi
Abstract
We model the evolution of simple lattice proteins as a random walk in a fitness landscape, where the fitness represents the ability of the protein to fold. At higher selective pressure, the evolutionary trajectories are confined to neutral networks where the native structure is conserved and the dynamics are non self-averaging and nonexponential. The optimizability of the corresponding native structure has a strong effect on the size of these neutral networks and thus on the nature of the evolutionary process. Proteins 29:461–466, 1997. © 1997 Wiley-Liss, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/38527/1/6_ftp.pd
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