A survey of extended radio jets with Chandra and HST

We present the results from an X-ray and optical survey of a sample of 17 radio jets in AGN performed with Chandra and HST. The sample was selected from the radio and is unbiased toward detection at shorter wavelengths, but preferentially it includes beamed sources. We find that X-ray emission is common on kpc-scales, with over half radio jets exhibiting at least one X-ray knot on the Chandra images. The distributions of the radio-to-X-ray and radio-to-optical spectral indices for the detected jets are similar to the limits for the non-detections,suggesting all bright radio jets have X-ray counterparts which will be visible in longer observations. Comparing the radio and X-ray morphologies shows that the majority of the X-ray jets have structures that closely map the radio. Analysis of the SED of the jet knots suggest the knots in which the X-ray and radio morphologies track each other produce X-rays by IC scattering of the Cosmic Microwave Background. The remaining knots produce X-rays by the synchrotron process. Spectral changes are detected along the jets, with the ratio of the X-ray-to-radio and optical-to-radio flux densities decreasing from the inner to the outer regions. This suggests the presence of an additional contribution to the X-ray flux in the jet's inner part, either from synchrotron or IC of the stellar light. Alternatively, in a pure IC/CMB scenario, the plasma decelerates as it flows from the inner to the outer regions. Finally, the X-ray spectral indices for the brightest knots are flat, indicating that the bulk of the luminosity of the jets is emitted at GeV energies, and raising the interesting possibility of future detections with GLAST.Comment: 26 pages, 6 ps figures, 6 jpeg figures (1 replaced); accepted for publication in Ap

XMM-Newton spectroscopy of an X-ray selected sample of RL AGNs

This paper presents the X-ray spectroscopy of an X-ray selected sample of 25 radio-loud (RL) AGNs extracted from the XBSS sample. The main goal is to study the origin of the X-ray spectral differences usually observed between radio-loud and radio-quiet (RQ) AGNs. To this end, a comparison sample of 53 RQ AGNs has been also extracted from the same XBSS sample and studied together with the sample of RL AGNs. We have focused the analysis on the distribution of the X-ray spectral indices of the power-law component that models the large majority of the spectra in both samples. We find that the mean X-ray energy spectral index is very similar in the 2 samples and close to alpha_X~1. However, the intrinsic distribution of the spectral indices is significantly broader in the sample of RL AGNs. In order to investigate the origin of this difference, we have divided the RL AGNs into blazars and ``non-blazars'', on the basis of the available optical and radio information. We find strong evidence that the broad distribution observed in the RL AGN sample is mainly due to the presence of the blazars. Furthermore, within the blazar class we have found a link between the X-ray spectral index and the value of the radio-to-X-ray spectral index suggesting that the observed X-ray emission is directly connected to the emission of the relativistic jet. This trend is not observed among the ``non-blazars'' RL AGNs. This favours the hypothesis that, in these latter sources, the X-ray emission is not significantly influenced by the jet emission and it has probably an origin similar to the RQ AGNs. Overall, the results presented here indicate that the observed distribution of the X-ray spectral indices in a given sample of RL AGNs is strongly dependent on the amount of relativistic beaming present in the selected sources.Comment: 18 pages, 10 figures, accepted for publication in A&

Hsp70 in mitochondrial biogenesis

The family of hsp70 (70 kilodalton heat shock protein) molecular chaperones plays an essential and diverse role in cellular physiology, Hsp70 proteins appear to elicit their effects by interacting with polypeptides that present domains which exhibit non-native conformations at distinct stages during their life in the cell. In this paper we review work pertaining to the functions of hsp70 proteins in chaperoning mitochondrial protein biogenesis. Hsp70 proteins function in protein synthesis, protein translocation across mitochondrial membranes, protein folding and finally the delivery of misfolded proteins to proteolytic enzymes in the mitochondrial matrix

Report for the Urban Flooding Awareness Act

Illinois General AssemblyOpe

AGILE detection of intense gamma-ray emission from the blazar PKS 1510-089

We report the detection by the AGILE (Astro-rivelatore Gamma a Immagini LEggero) satellite of an intense gamma-ray flare from the source AGL J1511-0909, associated with the powerful quasar PKS 1510-089, during ten days of observations from 23 August to 1 September 2007. During the observation period, the source was in optical decrease following a flaring event monitored by the GLAST-AGILE Support Program (GASP) of the Whole Earth Blazar Telescope (WEBT). The simultaneous gamma-ray, optical, and radio coverage allows us to study the spectral energy distribution and the theoretical models based on the synchrotron and inverse Compton (IC) emission mechanisms. AGILE observed the source with its two co-aligned imagers, the Gamma-Ray Imaging Detector and the hard X-ray imager Super-AGILE sensitive in the 30 MeV - 50 GeV and 18 - 60 keV bands, respectively. Between 23 and 27 August 2007, AGILE detected gamma-ray emission from PKS 1510-089 when this source was located about 50 degrees off-axis, with an average flux of (270 +/- 65) x 10^{-8} photons cm^{-2} s^{-1} for photon energy above 100 MeV. In the following period, 28 August - 1 September, after a satellite re-pointing, AGILE detected the source at about 35 degrees off-axis, with an average flux (E > 100 MeV) of (195 +/- 30) x 10^{-8} photons cm^{-2} s^{-1}. No emission was detected by Super-AGILE, with a 3-sigma upper limit of 45 mCrab in 200 ksec. The spectral energy distribution is modelled with a homogeneous one-zone synchrotron self Compton (SSC) emission plus contributions by external photons: the SSC emission contributes primarily to the X-ray band, whereas the contribution of the IC from the external disc and the broad line region match the hard gamma-ray spectrum observed.Comment: 5 pages, 5 figures, accepted for publication in A&

Semaglutide and cardiovascular outcomes in patients with obesity and prevalent heart failure: a prespecified analysis of the SELECT trial

Background: Semaglutide, a GLP-1 receptor agonist, reduces the risk of major adverse cardiovascular events (MACE) in people with overweight or obesity, but the effects of this drug on outcomes in patients with atherosclerotic cardiovascular disease and heart failure are unknown. We report a prespecified analysis of the effect of once-weekly subcutaneous semaglutide 2·4 mg on ischaemic and heart failure cardiovascular outcomes. We aimed to investigate if semaglutide was beneficial in patients with atherosclerotic cardiovascular disease with a history of heart failure compared with placebo; if there was a difference in outcome in patients designated as having heart failure with preserved ejection fraction compared with heart failure with reduced ejection fraction; and if the efficacy and safety of semaglutide in patients with heart failure was related to baseline characteristics or subtype of heart failure. Methods: The SELECT trial was a randomised, double-blind, multicentre, placebo-controlled, event-driven phase 3 trial in 41 countries. Adults aged 45 years and older, with a BMI of 27 kg/m2 or greater and established cardiovascular disease were eligible for the study. Patients were randomly assigned (1:1) with a block size of four using an interactive web response system in a double-blind manner to escalating doses of once-weekly subcutaneous semaglutide over 16 weeks to a target dose of 2·4 mg, or placebo. In a prespecified analysis, we examined the effect of semaglutide compared with placebo in patients with and without a history of heart failure at enrolment, subclassified as heart failure with preserved ejection fraction, heart failure with reduced ejection fraction, or unclassified heart failure. Endpoints comprised MACE (a composite of non-fatal myocardial infarction, non-fatal stroke, and cardiovascular death); a composite heart failure outcome (cardiovascular death or hospitalisation or urgent hospital visit for heart failure); cardiovascular death; and all-cause death. The study is registered with ClinicalTrials.gov, NCT03574597. Findings: Between Oct 31, 2018, and March 31, 2021, 17 604 patients with a mean age of 61·6 years (SD 8·9) and a mean BMI of 33·4 kg/m2 (5·0) were randomly assigned to receive semaglutide (8803 [50·0%] patients) or placebo (8801 [50·0%] patients). 4286 (24·3%) of 17 604 patients had a history of investigator-defined heart failure at enrolment: 2273 (53·0%) of 4286 patients had heart failure with preserved ejection fraction, 1347 (31·4%) had heart failure with reduced ejection fraction, and 666 (15·5%) had unclassified heart failure. Baseline characteristics were similar between patients with and without heart failure. Patients with heart failure had a higher incidence of clinical events. Semaglutide improved all outcome measures in patients with heart failure at random assignment compared with those without heart failure (hazard ratio [HR] 0·72, 95% CI 0·60-0·87 for MACE; 0·79, 0·64-0·98 for the heart failure composite endpoint; 0·76, 0·59-0·97 for cardiovascular death; and 0·81, 0·66-1·00 for all-cause death; all pinteraction>0·19). Treatment with semaglutide resulted in improved outcomes in both the heart failure with reduced ejection fraction (HR 0·65, 95% CI 0·49-0·87 for MACE; 0·79, 0·58-1·08 for the composite heart failure endpoint) and heart failure with preserved ejection fraction groups (0·69, 0·51-0·91 for MACE; 0·75, 0·52-1·07 for the composite heart failure endpoint), although patients with heart failure with reduced ejection fraction had higher absolute event rates than those with heart failure with preserved ejection fraction. For MACE and the heart failure composite, there were no significant differences in benefits across baseline age, sex, BMI, New York Heart Association status, and diuretic use. Serious adverse events were less frequent with semaglutide versus placebo, regardless of heart failure subtype. Interpretation: In patients with atherosclerotic cardiovascular diease and overweight or obesity, treatment with semaglutide 2·4 mg reduced MACE and composite heart failure endpoints compared with placebo in those with and without clinical heart failure, regardless of heart failure subtype. Our findings could facilitate prescribing and result in improved clinical outcomes for this patient group. Funding: Novo Nordisk

Reduced Axial Scan Length Coronary Calcium Scoring Reduces Radiation Dose and Provides Adequate Clinical Decision-Making Before Coronary CT Angiography

Extensive coronary artery calcium (CAC) diminishes the accuracy of coronary computed tomography angiography (CCTA). Many imagers adjust CCTA acquisition parameters depending on a preCCTA Agatston CAC score to optimize diagnostic accuracy. Typical preCCTA CAC imaging adds considerably to radiation exposure, partially attributable to imaging beyond the area known for highest CAC, the proximal coronary arteries. We aimed to determine whether a z-axis reduced scan length (RSL) would identify the majority of CAC and provide adequate information to computed tomography angiography providers relative to a standard full-scan length (FSL) preCCTA noncontrast CT. We retrospectively examined 200 subjects. The mean CAC scores detected in RSL and FSL were 77.4 (95% CI 50.6 to 104.3) and 93.9 (95% CI 57.3 to 130.5), respectively. RSL detected 81% of the FSL CAC. Among false negatives, with no CAC detected in RSL, FSL CAC severity was minimal (mean score 2.8). There was high concordance, averaging 88%, between CCTA imaging parameter adjustment decisions made by 2 experienced imagers based on either RSL or FSL. CAC detected and decision concordance decreased with increasing CAC burden. CAC detected was lower, and false negatives were more common in the right coronary artery owing to its anatomic course, placing larger segments outside RSL. Axial scan length and effective dose decreased 59% from FSL (∼14.5 cm/∼1.1 mSv) to RSL (∼5.9 cm/∼0.45 mSv). This retrospective study suggests that RSL identifies most CAC, results in similar CCTA acquisition parameter modifications, and reduces radiation exposure. Our colleagues corroborated these results in a recently published prospective study