Exploring Alternative Writing Styles: A Journey into Free-Writing and Bilingualism

This digital media composition explores two alternative writing styles: free-writing, a term coined by Peter Elbow, and translanguaging, the practice in which writers incorporate different languages into their writing. This project’s significance lies in helping college writers become more comfortable with the writing process and expressing their ideas more clearly. Doing so will promote inclusivity in bilingual education by creating an environment where students don’t have to limit which language they use for their writing. Traditional writing practices emphasize writing in a structured and formal manner, often discouraging individuals from exploring their thoughts and ideas freely. Additionally, bilingual education often prioritizes one language over the other, neglecting the benefits of incorporating multiple languages into writing. There is a lack of research exploring alternative writing styles, such as free-writing and translanguaging, as well as their potential benefits for college writers; while some research exists, there is a need to explore these topics further and to promote the benefits of incorporating alternative writing styles in education and daily life. This project aims to fill the gap by providing firsthand experiences with free-writing in both creative and academic contexts and exploring the potential benefits of incorporating different languages into writing. Through personal reflections, examples of free-writing in Spanish, and scholarly articles, this project aims to encourage writers to try new writing techniques, promote inclusivity in bilingual education, and bring awareness to the many unique ways of engaging with translanguaging in the classroom

Analysis of viability to promote a hub Ro/Ro terminal in Palma de Mallorca (Spain) Port

The presented paper is going to analyze the opportunity to develop a Ro/Ro hub in the Port of Palma de Mallorca. In order to get introduced in the study, the state of art related to geographical, economic tra c and human; conditions, will be reviewed; together with an in deep analysis of the port future capacities and main shipping lines crossing the western Mediterranean. At a first glance is it easy to understand that the competition with other container hub ports in Mediterranean does not a ord Palma de Mallorca to be positioned in this market. But the chance to become a hub in rolled tra c will be studied. The final results of this paper are going to identify the main particulars to be enforced to attract the main shipping companies that are providing transport services between the North and South coasts of the Mediterranean and the tra c between Italy and Spain

Inspecting the potential physiological and biomedical value of 44 conserved uncharacterised proteins of Streptococcus pneumoniae

BACKGROUND: The major Gram-positive coccoid pathogens cause similar invasive diseases and show high rates of antimicrobial resistance. Uncharacterised proteins shared by these organisms may be involved in virulence or be targets for antimicrobial therapy. RESULTS: Forty four uncharacterised proteins from Streptococcus pneumoniae with homologues in Enterococcus faecalis and/or Staphylococcus aureus were selected for analysis. These proteins showed differences in terms of sequence conservation and number of interacting partners. Twenty eight of these proteins were monodomain proteins and 16 were modular, involving domain combinations and, in many cases, predicted unstructured regions. The genes coding for four of these 44 proteins were essential. Genomic and structural studies showed one of the four essential genes to code for a promising antibacterial target. The strongest impact of gene removal was on monodomain proteins showing high sequence conservation and/or interactions with many other proteins. Eleven out of 40 knockouts (one for each gene) showed growth delay and 10 knockouts presented a chaining phenotype. Five of these chaining mutants showed a lack of putative DNA-binding proteins. This suggest this phenotype results from a loss of overall transcription regulation. Five knockouts showed defective autolysis in response to penicillin and vancomycin, and attenuated virulence in an animal model of sepsis. CONCLUSIONS: Uncharacterised proteins make up a reservoir of polypeptides of different physiological importance and biomedical potential. A promising antibacterial target was identified. Five of the 44 examined proteins seemed to be virulence factors.This work was supported by a Miguel Servet Research contract funded by the Fondo de Investigación Sanitaria (Ministerio de Economía y Competitividad de España) to Antonio J. Martin-Galiano, a Plan Nacional de I + D + I of Ministerio de Ciencia e Innovación grant (BIO2011-25343) to Adela G. de la Campa, and funds from the CIBER Enfermedades Respiratorias group (an initiative of the Instituto de Salud Carlos III).S

Alicante Coastal Management for Sustainable Development

Human intervention on the coast has been intense, due to the source of wealth that the coastal areas represent, especially in the form of tourism, which has resulted in a rapid erosion of its beaches. This paper discusses the current state of beach management in the various competent public administrations on the Costa Blanca (SE Spanish-Mediterranean), in relation to urban development and regression on the waterfront. To this end, an analysis has been carried out of the responses to a survey of those responsible for managing each of the 19 coastal municipalities of the Alicante coast, covering 244 km of coastline, 91 beaches and their personnel. Also, an investigation has been conducted as to whether this management’s aim is to protect the coastline and maintain the flora and fauna or just to manage recreation as the main economic activity is tourism. The analysis shows that the beach is simply regarded as a product or service offered to the user thereof. However, local authorities have not detected problems, possibly for two reasons: they do not have sufficient knowledge and this is understandable, given their lack of responsibilities in this area. This causes many beaches to have a high occupancy rate and there is a shift of users towards natural beaches. The study gives us information about the complex administrative process in the coastal system that often proves ineffective on this narrow strip of land

Automated HIV screening in the emergency department –earlier diagnosis, improved clinical outcomes

info:eu-repo/semantics/publishedVersio

Novel sulfonylurea derivatives as H3 receptor antagonists. Preliminary SAR studies

The combination of antagonism at histamine H3 receptor and the stimulation of insulin secretion have been proposed as an approach to new dual therapeutic agents for the treatment of type 2 diabetes mellitus associated with obesity. We have designed and synthesized a new series of non-imidazole derivatives, based on a basic amine ring connected through an alkyl spacer of variable length to a phenoxysulfonylurea moiety. These compounds were initially evaluated for histamine H3 receptor binding affinities, suggesting that a propoxy chain linker between the amine and the core ring could be essential for optimal binding affinity. Compound 56, 1-(naphthalen-1-yl)-3-[(p-(3-pyrrolidin-1-ylpropoxy)benzene)]sulfonylurea exhibited the best H3 antagonism affinity. However, since all these derivatives failed to block KATP channels, the link of these two related moieties should not be considered a good pharmacophore for obtaining new dual H3 antagonists with insulinotropic activity, suggesting the necessity to propose a new chemical hybrid prototype

Sustainable development city-beach in Alicante

[EN] Tourism development in recent decades has involved a large urban development in coastal areas, with different anthropogenic structural interventions on the coast such as the construction of commercial buildings and marinas, which has led to intense erosion and large imbalances in the last century. This situation also affects the city of Alicante, with the area between the port of Alicante and the Huertas Cape, one of the most depressed areas of the city, due to various actions carried out since the 70s, for anthropic example fillers for building marinas, jetties and broken in poor condition because they are made of sandstone, and a bad connection between the two parts of the city. In this work the creation of a new promenade that communicates both zones is proposed, creating new beaches eliminating anthro- pogenic fillings and the remains of breakwaters along the coast, the union of diverse marine area in one marina, and the insertion of an artificial reef multipurpose. With all this it is to improve the attraction of the area, and increase the mobility of the city on the coast.Aragonés, L.; García-Barba, J.; Villacampa, Y.; López, I.; Gómez Martín, ME.; Pagán, J. (2017). Sustainable development city-beach in Alicante. International Journal of Sustainable Development and Planning. 12(4):704-712. doi:10.2495/SDP-V12-N4-704-712S70471212

Plasticity of Fine-Root Traits Under Long-Term Irrigation of a Water-Limited Scots Pine Forest

CH va estar becat per la Swiss National Science Foundation (SNF), Grant number SNF 31003A_149507. LG va rebre suport d'una beca postdoctoral de la Alexander von Humboldt-Foundation (AvH).Trait-based approaches are increasingly used to investigate plant strategies for resource acquisition, growth, or competition between individual organisms or across species. However, the characterization of responses to environmental stimuli by fine-root systems of trees at the trait level is rather limited, particularly regarding the timing and degree of plasticity of the traits involved. These aspects become especially relevant under current climate-driven shifts in environmental conditions. In the present study, we examined the responses of the fine roots of Scots pines to increased soil water availability from long-term irrigation starting in the year 2003. The Scots pine forest is situated in a water-limited region in the central European Alps where increased tree mortality has been observed over the last two decades. The fine-root traits investigated include root system traits, root dynamic traits, architectural traits, and morphological traits. A first survey of fine-root traits in 2005 using ingrowth cores did not reveal any trait-based responses resulting from the irrigation treatment over a three-year period. Fine-root biomass, as periodically recorded by coring the topsoil from 2003 to 2016, showed a significant increase compared to the non-irrigated controls between three and nine years after the start of treatment. Overall, a maximum biomass increase due to the irrigation treatment was recorded in 2016 with about 80% higher biomass compared to controls. The analysis of fine-root traits revealed that irrigation significantly increased biomass, length, and production, but did not alter morphological and architectural traits, such as diameter, frequency of tips, specific root length (SRL), and root tissue density (RTD). In contrast, clear significant differences were found for all traits except for length when comparing the two root sampling methods, namely, ingrowth cores and soil coring. However, there were no interactions between the irrigation treatment and the sampling methods used and, therefore, the methods used did not affect the documented patterns, just the actual measured trait values

Expression of miR159 is altered in tomato plants undergoing drought stress

In a scenario of global climate change,water scarcity is amajor threat for agriculture, severely limiting crop yields. Therefore, alternatives are urgently needed for improving plant adaptation to drought stress. Among them, gene expression reprogramming by microRNAs (miRNAs) might offer a biotechnologically sound strategy. Drought-responsive miRNAs have been reported in manyplant species, and some of them are known to participate in complex regulatory networks via their regulation of transcription factors involved in water stress signaling. We explored the role of miR159 in the response of Solanum lycopersicum Mill. plants to drought stress by analyzing the expression of sly-miR159 and its target SlMYB transcription factor genes in tomato plants of cv. Ailsa Craig grown in deprived water conditions or in response to mechanical damage caused by the Colorado potato beetle, a devastating insect pest of Solanaceae plants. Results showed that sly-miR159 regulatory function in the tomato plants response to distinct stresses might be mediated by differential stress-specific MYB transcription factor targeting. sly-miR159 targeting of SlMYB33 transcription factor transcript correlated with accumulation of the osmoprotective compounds proline and putrescine, which promote drought tolerance. This highlights the potential role of sly-miR159 in tomato plants' adaptation to water deficit conditions

New quinoxaline derivatives as potential MT₁ and MT₂ receptor ligands.

Ever since the idea arose that melatonin might promote sleep and resynchronize circadian rhythms, many research groups have centered their efforts on obtaining new melatonin receptor ligands whose pharmacophores include an aliphatic chain of variable length united to an N-alkylamide and a methoxy group (or a bioisostere), linked to a central ring. Substitution of the indole ring found in melatonin with a naphthalene or quinoline ring leads to compounds of similar affinity. The next step in this structural approximation is to introduce a quinoxaline ring (a bioisostere of the quinoline and naphthalene rings) as the central nucleus of future melatoninergic ligand