Sobreentrenamiento: análisis en atletas de alto rendimiento = Overtraining: analysis on high performance athletes

El objetivo del presente trabajo fue determinar el nivel de estrés-recuperación en deportistas de alto rendimiento según Momento de la temporada, género. Participaron 15 atletas de una edad comprendida entre los 18 a los 22 años (20,73±1,437), diferenciados en cinco disciplinas (velocidad, pértiga, altura, combinadas y lanzamientos), a los que se administró la versión española del Cuestionario de Estrés-Recuperación RESTQ Sport, para conocer el nivel de estos deportistas durante cuatro momentos de la temporada de pista cubierta. Este estudio longitudinal nos muestra que los niveles de estrés son inferiores a los de la recuperación. No se encontraron diferencias entre los distintos momentos de recogida de datos debido a los objetivos de los deportistas. Sí aparecen entre el género en factores de primer y segundo orden referentes a la recuperación, así como entre las distintas disciplinas analizadas aparece en EED y RED. Estos resultados los podemos ver en otros estudios realizados en las tomas no aparece significación por el periodo de la temporada (Molinero, 2009), entre el género existe un estrés similar y la diferencia aparece en que las mujeres tardan más en recuperar (Molinero, De la Vega, Salguero y Márquez, 2012

Alteraciones de la succión en prematuros y su implicación en Logopedia

Introducción: Los prematuros se caracterizan principalmente por un desarrollo inmaduro que repercute en su capacidad para alimentarse por vía oral. El papel del logopeda se centra en favorecer una alimentación segura y eficaz a través de la estimulación oral de la succión. Objetivos: Se pretenden exponer las razones por las que conviene estimular la succión en recién nacidos prematuros, comprobar los efectos de la misma a través del análisis de ensayos clínicos y explorar el papel que desempeña el logopeda en este proceso. Metodología: Se ha seleccionado 39 publicaciones para elaborar la revisión. Del total, 21 son ensayos clínicos centrados en la estimulación de la succión en prematuros a través de diferentes técnicas. Resultados: Los estudios mostraron que la estimulación de la succión produce beneficios a corto y a largo plazo, aunque no todos los autores coinciden en este supuesto. El logopeda es el profesional que estimula la succión en tan solo 4 ensayos, por lo que no suele ser el encargado de realizar esta labor en las UCIN. Conclusiones: La estimulación precoz de la succión en prematuros se debe aplicar para mejorar la alimentación y fomentar un adecuado desarrollo neurológico. Se requieren estudios futuros que empleen protocolos estandarizados y que incluyan al logopeda para aumentar la fiabilidad de los resultados.Grado en Logopedi

ARTUALLITY. Hablar de Arte contemporáneo en youtube

El proyecto Artuallity consiste en la producción de un programa seriado para youtube de contenido cultural y artístico destinado a un público joven, no experto. El objetivo de ARTUALLITY es el de acercar y difundir el arte contemporáneo con videos amenos, fáciles de entender para todo el mundo, accesibles y lúdicos.[EN] The Project consists in the production of a cultural and contemporary art YouTube programme for a young and non‐expert audience. Artuallity’s aim is to approach contemporary art through entretaining videos, easy to understand for everybody, accessible and diverting.López Gago, S. (2018). ARTUALLITY. Hablar de Arte contemporáneo en youtube. http://hdl.handle.net/10251/108941TFG

A mathematical model of thyroid disease response to radiotherapy

We present a mechanistic biomathematical model of molecular radiotherapy of thyroid disease. The general model consists of a set of differential equations describing the dynamics of different populations of thyroid cells with varying degrees of damage caused by radiotherapy (undamaged cells, sub-lethally damaged cells, doomed cells, and dead cells), as well as the dynamics of thyroglobulin and antithyroglobulin autoantibodies, which are important surrogates of treatment response. The model is presented in two flavours: on the one hand, as a deterministic continuous model, which is useful to fit populational data, and on the other hand, as a stochastic Markov model, which is particularly useful to investigate tumor control probabilities and treatment individualization. The model was used to fit the response dynamics (tumor/thyroid volumes, thyroglobulin and antithyroglobulin autoantibodies) observed in experimental studies of thyroid cancer and Graves’ disease treated with 131I-radiotherapy. A qualitative adequate fitting of the model to the experimental data was achieved. We also used the model to investigate treatment individualization strategies for differentiated thyroid cancer, aiming to improve the tumor control probability. We found that simple individualization strategies based on the absorbed dose in the tumor and tumor radiosensitivity (which are both magnitudes that can potentially be individually determined for every patient) can lead to an important raise of tumor control probabilities.This project has received funding from the Instituto de Salud Carlos III (PI17/01428 grant, FEDER co-funding). This project has received funding from the European Unions Horizon 2020 research and innovation programme under the Marie Skodowska-Curie grant agreement No 839135. This project has received funding from FEDER/Ministerio de Ciencia, Innovación y Universidades;Agencia Estatal de Investigación, under grant MTM2017-84446-C2-2-R

Down-regulation of a pectin acetylesterase gene modifies strawberry fruit cell wall pectin stracture and increases fruit firmness

Antisense-mediated down-regulation of several fruit-specific genes has previously demonstrated how the cell wall disassembly in strawberry fruit is mediated by a series of enzymes that act sequentially (Posé et al. 2011). An interesting example, the silencing of the polygalacturonase gene FaPG1, was also related with a significant increase of the post-harvest strawberry fruit firmness (Posé et al. 2013). Our research group has isolated a pectin acetylesterase gene, FaPAE1, which expression is enhanced during strawberry ripening. The main goal of this work was to elucidate the role of the degree of acetylation in cell wall integrity and fruit firmness through the antisense-mediated down-regulation of FaPAE1 in strawberry plants. Several transgenics lines were generated and 5 of them produced fruits 5-15% firmer than controls. Cell wall from ripe fruits was isolated from two independent transgenic lines and a control line, and sequentially extracted with different solvents (PAW, H2O, CDTA, Na2CO3). Modifications in fraction yield, its sugar composition and the degree of acetylation in each fraction were determined. Higher amounts of CDTA and Na2CO3 fractions were obtained in transgenic fruits, suggesting a decreased pectin solubilization as results of FaPAE1 silencing. Accordingly, the degree of acetylation of the Na2CO3-soluble pectins was greater in the transgenic lines than the control, but the opposite result was found in pectins from the CDTA fraction. These results suggest that PAE is preferentially active in pectis that are tightly bound to the cellulose-hemicellulose network and its activity could reduce the complexity of the cell wall structure, allowing that other hydrolytic enzymes could access the pectin chains. Thus, the increased fruit firmness observed in the transgenic FaPAE1 lines could be attributed to the direct effect of the silencing of the PAE enzyme and also to the indirect effect that the increase of the degree of acetylation of pectins has on the activity of other enzymes involved in the cell wall degradation. * Posé et al. (2011). Genes, Genomes and Genomics, 5 (Special Issue 1):40-48 * Posé et al. (2013). Plant Physiology, 150: 1022-1032 We acknowledge support from the Spanish Ministry of Economy and competitivity and Feder EU Funds (grant reference AGL2011-24814), FPI fellowships support for SP (BES-2006-13626) and CP (BES-2009027985), and grant "Ramón y Cajal" support for AJMA (RYC-2011-08839).Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Lectura en las emociones familiares en los estudiantes del IV ciclo de primaria del distrito el porvenir, 2021

The objective of this research is to determine what is the effect of reading on family emotions in students of the IV primary cycle of the El Porvenir district, 2021. The research belongs to the basic type, causal correlational level, used the scientific and descriptive method , with a descriptive-correlational design, for the sample 125 students of the fourth cycle of primary school, El Porvenir 2020, were taken probabilistically. Finally, it is concluded that with a significance level of 5%, and a correlation coefficient equal to 0.790 and a p-value: (0.000 <0.010) that there is a strong direct and significant correlation between Reading and family emotionsLa presente investigación tiene como objetivo determinar cuál es el efecto de la lectura en las emociones familiares en estudiantes del IV ciclo de primaria del distrito El Porvenir, 2021. La investigación, pertenece al tipo básica, nivel correlacional causal, utilizó el método científico y descriptivo, con un diseño descriptivo – correlacional, para la muestra se tomó probabilísticamente a 125 estudiantes de IV ciclo de primaria, El Porvenir 2021. Finalmente se concluye que con un nivel de significancia del 5%, y un coeficiente de correlación igual a 0,790 y un p-valor: (0,000<0,010) existe una correlación directa y significativa fuerte entre la Lectura y las emociones familiares

Antimicrobial activity of different nanocellulose films embedded with thyme, cinnamon, and oregano essential oils for active packaging application on raspberries

The study focuses on the antimicrobial activity of nanocellulose films (NFC) embedded with thyme, cinnamon, and oregano essential oils for active packaging application. The activity against model pathogenic bacteria was first tested to obtain each oil's minimum inhibitory concentration (MIC). The tests showed that the surface area of the films and the quantity of essential oil strongly influenced the antimicrobial effect. Then, the different active packaging systems were tested directly on packed raspberries to study their actual commercial packaging conditions. Through 12 days of storage at 1 & DEG;C, it was observed that thyme and oregano essential oils were more effective in maintaining the firmness and reducing the weight loss of the fruits compared to cinnamon essential oil or the control; no significant effect was observed on the other quality parameters that were considered. The essential oils independently proved effective in preventing fungal growth. However, the combined impact of thyme+oregano (NAP_TO) demonstrated the best performance.COST ACTION 19124 CIRCULA-BILITYinfo:eu-repo/semantics/publishedVersio

3'-[4-Aryl-(1,2,3-triazol-1-yl)]-3'-deoxythymidine analogues as potent and selective inhibitors of human mitochondrial thymidine kinase

In an effort to increase the potency and selectivity of earlier identified substrate-based inhibitors of mitochondrial thymidine kinase 2 (TK-2), we now describe the synthesis of new thymidine analogues containing a 4- or 5-substituted 1,2,3-triazol-1-yl substituent at the 3'-position of the 2'-deoxyribofuranosyl ring. These analogues were prepared by Cu- and Ru-catalyzed cycloadditions of 3'-azido-3'-deoxythymidine and the appropriate alkynes, which produced the 1,4- and 1,5-triazoles, respectively. Selected analogues showed nanomolar inhibitory activity for TK-2, while virtually not affecting the TK-1 counterpart. Enzyme kinetics indicated a competitive and uncompetitive inhibition profile against thymidine and the cosubstrate ATP, respectively. This behavior is rationalized by suggesting that the inhibitors occupy the substrate-binding site in a TK-2 ATP complex that maintains the enzyme's active site in a closed conformation through the stabilization of a small lid domain

La colección local, construyendo memoria colectiva. El caso de la biblioteca municipal de Ermua

Sara Gago Pascua