Seismic scattering and absorption parameters in the W-Bohemia/Vogtland region from elastic and acoustic radiative transfer theory

In this study, frequency-dependent seismic scattering and intrinsic attenuation parameters for the crustal structure beneath the W-Bohemia/Vogtland swarm earthquake region close to the border of Czech Republic and Germany are estimated. Synthetic seismogram envelopes are modelled using elastic and acoustic radiative transfer theory. Scattering and absorption parameters are determined by fitting these synthetic envelopes to observed seismogram envelopes from 14 shallow local events from the October 2008 W-Bohemia/Vogtland earthquake swarm. The two different simulation approaches yield similar results for the estimated crustal parameters and show a comparable frequency dependence of both transport mean free path and intrinsic absorption path length. Both methods suggest that intrinsic attenuation is dominant over scattering attenuation in the W-Bohemia/Vogtland region for the investigated epicentral distance range and frequency bands from 3 to 24 Hz. Elastic simulations of seismogram envelopes suggest that forward scattering is required to explain the data, however, the degree of forward scattering is not resolvable. Errors in the parameter estimation are smaller in the elastic case compared to results from the acoustic simulations. The frequency decay of the transport mean free path suggests a random medium described by a nearly exponential autocorrelation function. The fluctuation strength and correlation length of the random medium cannot be estimated independently, but only a combination of the parameters related to the transport mean free path of the medium can be computed. Furthermore, our elastic simulations show, that using our numerical method, it is not possible to resolve the value of the mean free path of the random medium

A multi-technology analysis of the 2017 North Korean nuclear test

On 3 September 2017 official channels of the Democratic People's Republic of Korea announced the successful test of a thermonuclear device. Only seconds to minutes after the alleged nuclear explosion at the Punggye-ri nuclear test site in the mountainous region in the country's northeast at 03:30:02 (UTC), hundreds of seismic stations distributed all around the globe picked up strong and distinct signals associated with an explosion. Different seismological agencies reported body wave magnitudes of well above 6.0, consequently estimating the explosive yield of the device on the order of hundreds of kT TNT equivalent. The 2017 event can therefore be assessed as being multiple times larger in energy than the two preceding North Korean events in January and September 2016. This study provides a multi-technology analysis of the 2017 North Korean event and its aftermath using a wide array of geophysical methods. Seismological investigations locate the event within the test site at a depth of approximately 0.6&thinsp;km below the surface. The radiation and generation of P- and S-wave energy in the source region are significantly influenced by the topography of the Mt. Mantap massif. Inversions for the full moment tensor of the main event reveal a dominant isotropic component accompanied by significant amounts of double couple and compensated linear vector dipole terms, confirming the explosive character of the event. The analysis of the source mechanism of an aftershock that occurred around 8&thinsp;min after the test in the direct vicinity suggest a cavity collapse. Measurements at seismic stations of the International Monitoring System result in a body wave magnitude of 6.2, which translates to an yield estimate of around 400&thinsp;kT TNT equivalent. The explosive yield is possibly overestimated, since topography and depth phases both tend to enhance the peak amplitudes of teleseismic P waves. Interferometric synthetic aperture radar analysis using data from the ALOS-2 satellite reveal strong surface deformations in the epicenter region. Additional multispectral optical data from the Pleiades satellite show clear landslide activity at the test site. The strong surface deformations generated large acoustic pressure peaks, which were observed as infrasound signals with distinctive waveforms even at distances of 401&thinsp;km. In the aftermath of the 2017 event, atmospheric traces of the fission product 133Xe were detected at various locations in the wider region. While for 133Xe measurements in September 2017, the Punggye-ri test site is disfavored as a source by means of atmospheric transport modeling, detections in October 2017 at the International Monitoring System station RN58 in Russia indicate a potential delayed leakage of 133Xe at the test site from the 2017 North Korean nuclear test.</p

Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization

Broadly neutralizing antibodies (bNAbs) to HIV-1 can prevent infection and are therefore of great importance for HIV-1 vaccine design. Notably, bNAbs are highly somatically mutated and generated by a fraction of HIV-1-infected individuals several years after infection. Antibodies typically accumulate mutations in the complementarity determining region (CDR) loops, which usually contact the antigen. The CDR loops are scaffolded by canonical framework regions (FWRs) that are both resistant to and less tolerant of mutations. Here, we report that in contrast to most antibodies, including those with limited HIV-1 neutralizing activity, most bNAbs require somatic mutations in their FWRs. Structural and functional analyses reveal that somatic mutations in FWR residues enhance breadth and potency by providing increased flexibility and/or direct antigen contact. Thus, in bNAbs, FWRs play an essential role beyond scaffolding the CDR loops and their unusual contribution to potency and breadth should be considered in HIV-1 vaccine design

Cortical thickness and resting-state cardiac function across the lifespan: a cross-sectional pooled mega analysis

Understanding the association between autonomic nervous system [ANS] function and brain morphology across the lifespan provides important insights into neurovisceral mechanisms underlying health and disease. Resting state ANS activity, indexed by measures of heart rate [HR] and its variability [HRV] has been associated with brain morphology, particularly cortical thickness [CT]. While findings have been mixed regarding the anatomical distribution and direction of the associations, these inconsistencies may be due to sex and age differences in HR/HRV and CT. Previous studies have been limited by small sample sizes, which impede the assessment of sex differences and aging effects on the association between ANS function and CT. To overcome these limitations, 20 groups worldwide contributed data collected under similar protocols of CT assessment and HR/HRV recording to be pooled in a mega-analysis (N = 1,218 (50.5% female), mean age 36.7 years (range: 12-87)). Findings suggest a decline in HRV as well as CT with increasing age. CT, particularly in the orbitofrontal cortex, explained additional variance in HRV, beyond the effects of aging. This pattern of results may suggest that the decline in HRV with increasing age is related to a decline in orbitofrontal CT. These effects were independent of sex and specific to HRV; with no significant association between CT and HR. Greater CT across the adult lifespan may be vital for the maintenance of healthy cardiac regulation via the ANS – or greater cardiac vagal activity as indirectly reflected in HRV may slow brain atrophy. Findings reveal an important association between cortical thickness and cardiac parasympathetic activity with implications for healthy aging and longevity that should be studied further in longitudinal research

Performance of the International Monitoring System Seismic Network Based on Ambient Seismic Noise Measurements

All nuclear explosions are banned by the Comprehensive Nuclear-Test-Ban Treaty. In the context of the treaty a verification regime was put into place to detect, locate, and characterize nuclear explosions at any time, by anyone and everywhere on the Earth. The International Monitoring System, which plays a key role in the verification regime, was set up by the Preparatory Commission of the Comprehensive Nuclear-Test-Ban Treaty Organization. Out of the several different monitoring techniques applied in the International Monitoring System the seismic waveform approach is the most effective and reliable technology for monitoring nuclear explosions underground. This study introduces a deterministic method of threshold monitoring that allows to asses a lower body wave magnitude limit of a potential seismic event in a certain geographical region, that can be detected by those seismic stations being part of the International Monitoring System network. The method is based on measurements of ambient seismic noise levels at the individual seismic stations along with global distance corrections terms for the body wave magnitude. The results suggest that an average global detection capability of approximately body wave magnitude 4.0 can be achieved using only stations from the primary seismic network of the International Monitoring System. The incorporation of seismic stations from the auxiliary seismic network leads to a slight improvement of the detection capability, while the use and analysis of wave arrivals from distances greater than 120∘ results in a significant improvement of the detection capability. Temporal variations in terms of hourly and monthly changes of the global detection capability can not be observed. Overall, comparisons between detection capability and manually retrieved body wave magnitudes from the Reviewed Event Bulletin suggest, that our method yields a more conservative estimation of the detection capability and that in reality detection thresholds might be even lower than estimated.Bundesanstalt für Geowissenschaften und Rohstoffe (BGR) (4230

Functional connectivity signatures of NMDAR dysfunction in schizophrenia—integrating findings from imaging genetics and pharmaco-fMRI

Both, pharmacological and genome-wide association studies suggest N-methyl-D-aspartate receptor (NMDAR) dysfunction and excitatory/inhibitory (E/I)-imbalance as a major pathophysiological mechanism of schizophrenia. The identification of shared fMRI brain signatures of genetically and pharmacologically induced NMDAR dysfunction may help to define biomarkers for patient stratification. NMDAR-related genetic and pharmacological effects on functional connectivity were investigated by integrating three different datasets: (A) resting state fMRI data from 146 patients with schizophrenia genotyped for the disease-associated genetic variant rs7191183 of GRIN2A (encoding the NMDAR 2 A subunit) as well as 142 healthy controls. (B) Pharmacological effects of the NMDAR antagonist ketamine and the GABA-A receptor agonist midazolam were obtained from a double-blind, crossover pharmaco-fMRI study in 28 healthy participants. (C) Regional gene expression profiles were estimated using a postmortem whole-brain microarray dataset from six healthy donors. A strong resemblance was observed between the effect of the genetic variant in schizophrenia and the ketamine versus midazolam contrast of connectivity suggestive for an associated E/I-imbalance. This similarity became more pronounced for regions with high density of NMDARs, glutamatergic neurons, and parvalbumin-positive interneurons. From a functional perspective, increased connectivity emerged between striato-pallido-thalamic regions and cortical regions of the auditory-sensory-motor network, while decreased connectivity was observed between auditory (superior temporal gyrus) and visual processing regions (lateral occipital cortex, fusiform gyrus, cuneus). Importantly, these imaging phenotypes were associated with the genetic variant, the differential effect of ketamine versus midazolam and schizophrenia (as compared to healthy controls). Moreover, the genetic variant was associated with language-related negative symptomatology which correlated with disturbed connectivity between the left posterior superior temporal gyrus and the superior lateral occipital cortex. Shared genetic and pharmacological functional connectivity profiles were suggestive of E/I-imbalance and associated with schizophrenia. The identified brain signatures may help to stratify patients with a common molecular disease pathway providing a basis for personalized psychiatry

Timing of thoracic and lumbar fracture fixation in spinal injuries: a systematic review of neurological and clinical outcome

A systematic review of all available evidence on the timing of surgical fixation for thoracic and lumbar fractures with respect to clinical and neurological outcome was designed. The purpose of this review is to clarify some of the controversy about the timing of surgical fracture fixation in spinal trauma. Better neurological outcome, shorter hospital stay and fewer complications have been reported after early fracture fixation. But there are also studies showing no difference in neurological outcome when compared to late treatment. Mortality is another controversial point since a recent report of higher mortality in early treated patients. A systematic review of the literature was preformed. Ten articles were included. Early fracture fixation is associated with less complications, shorter hospital and ICU stay. The effect of early treatment on the neurological outcome remains unclear due to the contradictory results of the included studies. Early thoracic and lumbar fracture fixation results in improvement of clinical outcome, but the effect on neurological outcome remains controversial

Cortical thickness and resting-state cardiac function across the lifespan: A cross-sectional pooled mega-analysis

Understanding the association between autonomic nervous system [ANS] function and brain morphology across the lifespan provides important insights into neurovisceral mechanisms underlying health and disease. Resting-state ANS activity, indexed by measures of heart rate [HR] and its variability [HRV] has been associated with brain morphology, particularly cortical thickness [CT]. While findings have been mixed regarding the anatomical distribution and direction of the associations, these inconsistencies may be due to sex and age differences in HR/HRV and CT. Previous studies have been limited by small sample sizes, which impede the assessment of sex differences and aging effects on the association between ANS function and CT. To overcome these limitations, 20 groups worldwide contributed data collected under similar protocols of CT assessment and HR/HRV recording to be pooled in a mega-analysis (N = 1,218 (50.5% female), mean age 36.7 years (range: 12–87)). Findings suggest a decline in HRV as well as CT with increasing age. CT, particularly in the orbitofrontal cortex, explained additional variance in HRV, beyond the effects of aging. This pattern of results may suggest that the decline in HRV with increasing age is related to a decline in orbitofrontal CT. These effects were independent of sex and specific to HRV; with no significant association between CT and HR. Greater CT across the adult lifespan may be vital for the maintenance of healthy cardiac regulation via the ANS—or greater cardiac vagal activity as indirectly reflected in HRV may slow brain atrophy. Findings reveal an important association between CT and cardiac parasympathetic activity with implications for healthy aging and longevity that should be studied further in longitudinal research