Luminescence Sensors Applied to Water Analysis of Organic Pollutants—An Update

The development of chemical sensors for environmental analysis based on fluorescence, phosphorescence and chemiluminescence signals continues to be a dynamic topic within the sensor field. This review covers the fundamentals of this type of sensors, and an update on recent works devoted to quantifying organic pollutants in environmental waters, focusing on advances since about 2005. Among the wide variety of these contaminants, special attention has been paid polycyclic aromatic hydrocarbons, pesticides, explosives and emerging organic pollutants. The potential of coupling optical sensors with multivariate calibration methods in order to improve the selectivity is also discussed

La renovación de la palabra en el bicentenario de la Argentina : los colores de la mirada lingüística

El libro reúne trabajos en los que se exponen resultados de investigaciones presentadas por investigadores de Argentina, Chile, Brasil, España, Italia y Alemania en el XII Congreso de la Sociedad Argentina de Lingüística (SAL), Bicentenario: la renovación de la palabra, realizado en Mendoza, Argentina, entre el 6 y el 9 de abril de 2010. Las temáticas abordadas en los 167 capítulos muestran las grandes líneas de investigación que se desarrollan fundamentalmente en nuestro país, pero también en los otros países mencionados arriba, y señalan además las áreas que recién se inician, con poca tradición en nuestro país y que deberían fomentarse. Los trabajos aquí publicados se enmarcan dentro de las siguientes disciplinas y/o campos de investigación: Fonología, Sintaxis, Semántica y Pragmática, Lingüística Cognitiva, Análisis del Discurso, Psicolingüística, Adquisición de la Lengua, Sociolingüística y Dialectología, Didáctica de la lengua, Lingüística Aplicada, Lingüística Computacional, Historia de la Lengua y la Lingüística, Lenguas Aborígenes, Filosofía del Lenguaje, Lexicología y Terminología

Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials

Aims: The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials. Methods and Results: Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure < 100 mmHg (n = 1127), estimated glomerular filtration rate < 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594). Conclusions: GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation

Luminescence Sensors Applied to Water Analysis of Organic Pollutants—An Update

The development of chemical sensors for environmental analysis based on fluorescence, phosphorescence and chemiluminescence signals continues to be a dynamic topic within the sensor field. This review covers the fundamentals of this type of sensors, and an update on recent works devoted to quantifying organic pollutants in environmental waters, focusing on advances since about 2005. Among the wide variety of these contaminants, special attention has been paid polycyclic aromatic hydrocarbons, pesticides, explosives and emerging organic pollutants. The potential of coupling optical sensors with multivariate calibration methods in order to improve the selectivity is also discussed

Online third-order liquid chromatographic data with native and photoinduced fluorescence detection for the quantitation of organic pollutants in environmental water

Third-order liquid chromatographic data were generated online for the simultaneous quantitation of six organic environmental pollutants. The employed strategy consists in reducing the linear flow rate at the column outlet. A postcolumn UV reactor and a fluorimetric detector allowed to properly record both photoinduced and native excitation–emission fluorescence matrices (EEPIFMs and EEFMs, respectively). The obtained third-order liquid chromatography data were chemometrically processed with the multivariate curve resolution–alternating least-squares model. The sensitivity of the overall analytical method was enhanced by a very simple solid-phase extraction with C18 membranes, to be able to successfully apply it to natural water samples tested as real matrices. Favorable detection limits for the investigated pollutants, ranging from 0.02 to 0.27 ng mL–1, were attained, with relative prediction errors between 2 and 7%. Since the studied samples contain uncalibrated interferents, the applied strategy achieves the second-order advantage. Implications regarding the potential achievement of the third-order advantage are discussed.Fil: Pellegrino Vidal, Rocío Belén. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario (IQUIR-CONICET); Argentina.Fil: Olivieri, Alejandro César. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario (IQUIR-CONICET); Argentina.Fil: Ibañez, Gabriela A. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario (IQUIR-CONICET); Argentina.Fil: Escandar, Graciela Mónica. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario (IQUIR-CONICET); Argentina

Data from: Zoogeographic patterns of pelagic oceanic cephalopods along the eastern Pacific Ocean

Aim: To analyse the diversity and distribution of oceanic pelagic cephalopods along the Eastern Pacific Ocean, assessing the existence of biogeographic structuring, and the role of physical variables in generating geographical patterns. We hypothesized that the control by environmental factors, and the effect of geometric constraints, determine the range size and limits of distribution of oceanic cephalopods along the eastern Pacific Ocean, generating a latitudinal gradient in species richness. Location: Eastern Pacific Ocean (60°N – 60°S), from the Gulf of Alaska to the Southern Ocean. Methods: Based on a literature review and >5,000 records obtained from collections, we constructed a presence-absence matrix including 61 latitudinal bands (2° each) along the Eastern Pacific, and estimated species richness and range endpoints at each band. Biogeographic units were determined by means of multivariate analyses. Species richness was compared with null model predictions in order to test for the existence of geometric constraints using the Mid-Domain Null model. The effects on species richness of environmental variables (temperature, salinity and oxygen) were evaluated separately for surface and depth (0-1,000 m) data, by means of ordinary least squares regression and simultaneous autoregressive models. Rapoport’s pattern was assessed by applying the Stevens’ method and the range midpoint method. Results: Species richness was high across the tropics and decreased towards the both poles. We identified five biogeographic units, highlighting two major distribution breaks at 40°N and 42°S. Species richness was strongly related with environmental variables, although the combined variables accounted for a large fraction of the variance between 0-1,000 m (R2 = 0.99), while temperature was the best single predictor at the surface (R2 = 0.98). Species richness curves showed a mid-domain effect (MDE), and the mean latitudinal range was higher in the tropics and at warm latitudes, generating an inverse Rapoport’s pattern. Main conclusions: Along the Eastern Pacific Ocean, oceanic cephalopods exhibit both a clear biogeographic patterning and an interhemispheric (poleward decreasing) diversity gradient, which appear strongly related with physical factors and external forcing, as well as with a MDE as a seemingly consequence of the naturally bounded domain of the Eastern Pacific

Data from: Zoogeographic patterns of pelagic oceanic cephalopods along the eastern Pacific Ocean

Aim: To analyse the diversity and distribution of oceanic pelagic cephalopods along the Eastern Pacific Ocean, assessing the existence of biogeographic structuring, and the role of physical variables in generating geographical patterns. We hypothesized that the control by environmental factors, and the effect of geometric constraints, determine the range size and limits of distribution of oceanic cephalopods along the eastern Pacific Ocean, generating a latitudinal gradient in species richness. Location: Eastern Pacific Ocean (60°N – 60°S), from the Gulf of Alaska to the Southern Ocean. Methods: Based on a literature review and >5,000 records obtained from collections, we constructed a presence-absence matrix including 61 latitudinal bands (2° each) along the Eastern Pacific, and estimated species richness and range endpoints at each band. Biogeographic units were determined by means of multivariate analyses. Species richness was compared with null model predictions in order to test for the existence of geometric constraints using the Mid-Domain Null model. The effects on species richness of environmental variables (temperature, salinity and oxygen) were evaluated separately for surface and depth (0-1,000 m) data, by means of ordinary least squares regression and simultaneous autoregressive models. Rapoport’s pattern was assessed by applying the Stevens’ method and the range midpoint method. Results: Species richness was high across the tropics and decreased towards the both poles. We identified five biogeographic units, highlighting two major distribution breaks at 40°N and 42°S. Species richness was strongly related with environmental variables, although the combined variables accounted for a large fraction of the variance between 0-1,000 m (R2 = 0.99), while temperature was the best single predictor at the surface (R2 = 0.98). Species richness curves showed a mid-domain effect (MDE), and the mean latitudinal range was higher in the tropics and at warm latitudes, generating an inverse Rapoport’s pattern. Main conclusions: Along the Eastern Pacific Ocean, oceanic cephalopods exhibit both a clear biogeographic patterning and an interhemispheric (poleward decreasing) diversity gradient, which appear strongly related with physical factors and external forcing, as well as with a MDE as a seemingly consequence of the naturally bounded domain of the Eastern Pacific

Cuerpo(s), Subjetividad(es) y Conflicto(s) : hacia una sociología de los cuerpos y las emociones desde Latinoamérica

El libro reúne una serie de trabajos que contribuyen significativamente al debate interdisciplinario desde múltiples estrategias para indagar los vínculos entre cuerpo(s), subjetividad(es) y conflicto(s), presentando las voces de algunos sujetos actuantes, analizando las acciones que producen resistiendo (o no), sus experiencias. A partir de la convicción de que todo lo que sabemos del mundo lo interpretamos por y a través de nuestros cuerpos, la obra compila diferentes reflexiones al respecto desde América Latina: * Análisis de modos de sensibilidades, prácticas y representaciones que ponen en palabras la dominación. * La programación televisiva aparentemente banal en formatos como Cuestión de peso y Policías en acción donde se imponen paradigmas que discuten desde la estética hasta el horror y la crueldad. * Los carreros y cirujas de Córdoba y las políticas estatales destinadas a focalizar y atender sus necesidades inmediatas, como mecanismos para contener posibles alteraciones del sistema. * El discurso mediático referido al cuerpo enfermo (sida/cáncer). * Las emociones de lo abyecto: repugnancia e indignación. Estos son algunos de los estudios aquí presentados con la intención de conformar una sociología que construya el disfrute, la felicidad y la esperanza como temas teóricos y como acto descolonizador.Estudio preliminar: De los estudios de acción colectiva a la sociología del cuerpo. Un itinerario a través de las transformaciones de la estructuración social en el capitalismo de Latinoamérica Por María Eugenia Boito y Marcelo DAmico 9 Cuerpo y subjetividades en las sociedades de la incertidumbre Por Flavio Borghi 23 Conflicto y emociones. Un retrato de la vergüenza en Simmel, Elías y Giddens como excusa para interpretar prácticas en contextos de expulsión Por Gabriela Vergara 35 Imágenes crudas y mirada cruel sobre el otro de clase en Policías en Acción. Construcciones ideológicas sobre la alteridad de clase en la escena mediática contemporánea Por María Eugenia Boito 53 Trama(s) hecha(s) cuerpo(s): una estrategia de lectura de las vivencias de niños/as y jóvenes que habitan Ciudad de Mis Sueños Por María Belén Espoz Dalmasso e Ileana Desirée Ibañez 69 Los surcos de las experiencias placenteras en la vida escolarizada y no escolarizada Por Graciela Magallanes 83 Cuerpos Recuperados / Cuerpos en Custodia. Una lectura sintomal de la acción colectiva de la Cooperativa Junín de Salud Limitada Por Pedro Lisdero 101 Enfermedad, cuerpo, discursos: tres relatos sobre la experiencia Por Alicia Vaggione 119 Las emociones de lo abyecto: repugnancia e indignación Por Carlos Euardo Figari 131 A modo de Epílogo ¿Por qué una mirada sociológica de los cuerpos y las emociones? Por Adrián Scribano 141 Los Autores 15

Unlipidated Outer Membrane Protein Omp16 (U-Omp16) from Brucella spp. as Nasal Adjuvant Induces a Th1 Immune Response and Modulates the Th2 Allergic Response to Cow’s Milk Proteins

The discovery of novel mucosal adjuvants will help to develop new formulations to control infectious and allergic diseases. In this work we demonstrate that U-Omp16 from Brucella spp. delivered by the nasal route (i.n.) induced an inflammatory immune response in bronchoalveolar lavage (BAL) and lung tissues. Nasal co-administration of U-Omp16 with the model antigen (Ag) ovalbumin (OVA) increased the amount of Ag in lung tissues and induced OVA-specific systemic IgG and T helper (Th) 1 immune responses. The usefulness of U-Omp16 was also assessed in a mouse model of food allergy. U-Omp16 i.n. administration during sensitization ameliorated the hypersensitivity responses of sensitized mice upon oral exposure to Cow’s Milk Protein (CMP), decreased clinical signs, reduced anti-CMP IgE serum antibodies and modulated the Th2 response in favor of Th1 immunity. Thus, U-Omp16 could b