1,978 research outputs found
Perceptual Context in Cognitive Hierarchies
Cognition does not only depend on bottom-up sensor feature abstraction, but
also relies on contextual information being passed top-down. Context is higher
level information that helps to predict belief states at lower levels. The main
contribution of this paper is to provide a formalisation of perceptual context
and its integration into a new process model for cognitive hierarchies. Several
simple instantiations of a cognitive hierarchy are used to illustrate the role
of context. Notably, we demonstrate the use context in a novel approach to
visually track the pose of rigid objects with just a 2D camera
Minimal flavour violation extensions of the seesaw
We analyze the most natural formulations of the minimal lepton flavour
violation hypothesis compatible with a type-I seesaw structure with three heavy
singlet neutrinos N, and satisfying the requirement of being predictive, in the
sense that all LFV effects can be expressed in terms of low energy observables.
We find a new interesting realization based on the flavour group (being and respectively the SU(2) singlet and
doublet leptons). An intriguing feature of this realization is that, in the
normal hierarchy scenario for neutrino masses, it allows for sizeable
enhancements of transitions with respect to LFV processes involving
the lepton. We also discuss how the symmetries of the type-I seesaw
allow for a strong suppression of the N mass scale with respect to the scale of
lepton number breaking, without implying a similar suppression for possible
mechanisms of N productionComment: 14 pages, 6 figure
A review of RCTs in four medical journals to assess the use of imputation to overcome missing data in quality of life outcomes
Background: Randomised controlled trials (RCTs) are perceived as the gold-standard method for evaluating healthcare interventions, and increasingly include quality of life (QoL) measures. The observed results are susceptible to bias if a substantial proportion of outcome data are missing. The review aimed to determine whether imputation was used to deal with missing QoL outcomes. Methods: A random selection of 285 RCTs published during 2005/6 in the British Medical Journal, Lancet, New England Journal of Medicine and Journal of American Medical Association were identified. Results: QoL outcomes were reported in 61 (21%) trials. Six (10%) reported having no missing data, 20 (33%) reported ≤ 10% missing, eleven (18%) 11%–20% missing, and eleven (18%) reported >20% missing. Missingness was unclear in 13 (21%). Missing data were imputed in 19 (31%) of the 61 trials. Imputation was part of the primary analysis in 13 trials, but a sensitivity analysis in six. Last value carried forward was used in 12 trials and multiple imputation in two. Following imputation, the most common analysis method was analysis of covariance (10 trials). Conclusion: The majority of studies did not impute missing data and carried out a complete-case analysis. For those studies that did impute missing data, researchers tended to prefer simpler methods of imputation, despite more sophisticated methods being available.The Health Services Research Unit is funded by the Chief Scientist Office of the Scottish Government Health Directorate. Shona Fielding is also currently funded by the Chief Scientist Office on a Research Training Fellowship (CZF/1/31)
A review of RCTs in four medical journals to assess the use of imputation to overcome missing data in quality of life outcomes
Peer reviewedPublisher PD
Systematic review of factors affecting transition readiness skills in patients with inflammatory bowel disease.
BACKGROUND AND AIMS: The incidence of inflammatory bowel disease (IBD) diagnosed before adulthood is increasing worldwide. Transition from paediatric to adult healthcare requires certain skills. The aim of this study was to identify factors affecting these skills. METHODS: This review was registered on the PROSPERO database (CRD42019152272). Inclusion criteria: 1) studies of factors affecting transition readiness skills in patients with IBD 2) written in English 3) published since 1999. MEDLINE, CINAHL and PsychINFO databases were searched between 1999-2019. Quality was assessed using the Joanna Briggs Institute critical appraisal tools. RESULTS: Searches identified 822 papers. Sixteen papers were included. Age was positively associated with skills including disease knowledge and performing self-management behaviours (14 studies). Improvement often occurs at 18, however, skill deficiency may still remain. Increased self-efficacy (confidence) was associated with greater disease knowledge and performing self-management behaviours (3 studies). Self-efficacy was positively correlated with transition duration (2 studies) and health-related quality of life (r=0.57, p<0.001) (1 study), negatively correlated with depression (r=-0.57, p<0.001) and anxiety (r=-0.23, p=0.03) (1 study), and associated with higher education level (2 studies) and a family history of IBD (1 study). Females had higher self-management scores (3 studies), and greater healthcare satisfaction was significantly associated with higher knowledge (1 study). Greater transition communication improved knowledge, self-management, and overall transition readiness (2 studies). CONCLUSIONS: Potentially modifiable factors have been identified that could be supported in the transitioning IBD population to improve transition readiness. Identification of those with non-modifiable characteristics associated with poor readiness may aid targeted support
Identification of Maize Genes Associated with Host Plant Resistance or Susceptibility to Aspergillus flavus Infection and Aflatoxin Accumulation
infection and aflatoxin accumulation. inoculation were compared in two resistant maize inbred lines (Mp313E and Mp04∶86) in contrast to two susceptible maize inbred lines (Va35 and B73) by microarray analysis. Principal component analysis (PCA) was used to find genes contributing to the larger variances associated with the resistant or susceptible maize inbred lines. The significance levels of gene expression were determined by using SAS and LIMMA programs. Fifty candidate genes were selected and further investigated by quantitative RT-PCR (qRT-PCR) in a time-course study on Mp313E and Va35. Sixteen of the candidate genes were found to be highly expressed in Mp313E and fifteen in Va35. Out of the 31 highly expressed genes, eight were mapped to seven previously identified quantitative trait locus (QTL) regions. A gene encoding glycine-rich RNA binding protein 2 was found to be associated with the host hypersensitivity and susceptibility in Va35. A nuclear pore complex protein YUP85-like gene was found to be involved in the host resistance in Mp313E. infection and aflatoxin accumulation. These findings will be important in identification of DNA markers for breeding maize lines resistant to aflatoxin accumulation
The mu - e Conversion in Nuclei, mu --> e gamma, mu --> 3e Decays and TeV Scale See-Saw Scenarios of Neutrino Mass Generation
We perform a detailed analysis of lepton flavour violation (LFV) within
minimal see-saw type extensions of the Standard Model (SM), which give a viable
mechanism of neutrino mass generation and provide new particle content at the
electroweak scale. We focus, mainly, on predictions and constraints set on each
scenario from mu --> e gamma, mu --> 3e and mu - e conversion in the nuclei. In
this class of models, the flavour structure of the Yukawa couplings between the
additional scalar and fermion representations and the SM leptons is highly
constrained by neutrino oscillation measurements. In particular, we show that
in some regions of the parameters space of type I and type II see-saw models,
the Dirac and Majorana phases of the neutrino mixing matrix, the ordering and
hierarchy of the active neutrino mass spectrum as well as the value of the
reactor mixing angle theta_{13} may considerably affect the size of the LFV
observables. The interplay of the latter clearly allows to discriminate among
the different low energy see-saw possibilities.Comment: Expressions for the factors |C_{me}|^2 and |C_{mu3e}|^2 in the mu-e
conversion and mu-->3e decay rates, eqs. (36) and (49), respectively,
corrected; results in subsections 2.2 and 2.3 quantitatively changed,
qualitatively remain the same; figures 2, 3, 4 and 5 replace
Hybridization in parasites: consequences for adaptive evolution, pathogenesis and public health in a changing world
[No abstract available
Interplay of LFV and slepton mass splittings at the LHC as a probe of the SUSY seesaw
We study the impact of a type-I SUSY seesaw concerning lepton flavour
violation (LFV) both at low-energies and at the LHC. The study of the di-lepton
invariant mass distribution at the LHC allows to reconstruct some of the masses
of the different sparticles involved in a decay chain. In particular, the
combination with other observables renders feasible the reconstruction of the
masses of the intermediate sleptons involved in decays. Slepton mass splittings can be either
interpreted as a signal of non-universality in the SUSY soft breaking-terms
(signalling a deviation from constrained scenarios as the cMSSM) or as being
due to the violation of lepton flavour. In the latter case, in addition to
these high-energy processes, one expects further low-energy manifestations of
LFV such as radiative and three-body lepton decays. Under the assumption of a
type-I seesaw as the source of neutrino masses and mixings, all these LFV
observables are related. Working in the framework of the cMSSM extended by
three right-handed neutrino superfields, we conduct a systematic analysis
addressing the simultaneous implications of the SUSY seesaw for both high- and
low-energy lepton flavour violation. We discuss how the confrontation of
slepton mass splittings as observed at the LHC and low-energy LFV observables
may provide important information about the underlying mechanism of LFV.Comment: 50 pages, 42 eps Figures, typos correcte
Mdm2-SNP309 polymorphism in prostate cancer: no evidence for association with increased risk or histopathological tumour characteristics
The search for inherited cancer susceptibility factors is a major focus of epidemiologic cancer studies. Analyses of single-nucleotide polymorphisms (SNP) in a variety of genes revealed a correlation between a specific allele variant and cancer predisposition. Human mouse double-minute 2 protein (Mdm2) is a cellular E3 ligase capable of ubiquitination and degradation of p53. Therefore, Mdm2 is a crucial factor of cell cycle control and cell survival. The Mdm2 promoter SNP309 was shown to increase Mdm2 expression and can, thereby, inhibit the p53 pathway. This SNP was found to be associated with increased risk and early onset of various malignancies. For prostate cancer no studies are reported to date. In a case–control study we determined the distribution of the Mdm2 SNP309 in 145 male subjects with prostate cancer and in 124 male controls without any malignancy using RFLP analysis. Cases and controls showed a similar distribution of the SNP (P=0.299). Genotype distribution showed neither an association with histopathological characteristics of the tumours nor with prognosis. Age at disease onset was also not modified by the SNP. This first study of the Mdm2 SNP309 in prostate cancer patients suggests no correlation between a certain allelic variant and an increased cancer risk
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