815 research outputs found
A Closed-Form Solution of the Multi-Period Portfolio Choice Problem for a Quadratic Utility Function
In the present paper, we derive a closed-form solution of the multi-period
portfolio choice problem for a quadratic utility function with and without a
riskless asset. All results are derived under weak conditions on the asset
returns. No assumption on the correlation structure between different time
points is needed and no assumption on the distribution is imposed. All
expressions are presented in terms of the conditional mean vectors and the
conditional covariance matrices. If the multivariate process of the asset
returns is independent it is shown that in the case without a riskless asset
the solution is presented as a sequence of optimal portfolio weights obtained
by solving the single-period Markowitz optimization problem. The process
dynamics are included only in the shape parameter of the utility function. If a
riskless asset is present then the multi-period optimal portfolio weights are
proportional to the single-period solutions multiplied by time-varying
constants which are depending on the process dynamics. Remarkably, in the case
of a portfolio selection with the tangency portfolio the multi-period solution
coincides with the sequence of the simple-period solutions. Finally, we compare
the suggested strategies with existing multi-period portfolio allocation
methods for real data.Comment: 38 pages, 9 figures, 3 tables, changes: VAR(1)-CCC-GARCH(1,1) process
dynamics and the analysis of increasing horizon are included in the
simulation study, under revision in Annals of Operations Researc
Winner-take-all selection in a neural system with delayed feedback
We consider the effects of temporal delay in a neural feedback system with
excitation and inhibition. The topology of our model system reflects the
anatomy of the avian isthmic circuitry, a feedback structure found in all
classes of vertebrates. We show that the system is capable of performing a
`winner-take-all' selection rule for certain combinations of excitatory and
inhibitory feedback. In particular, we show that when the time delays are
sufficiently large a system with local inhibition and global excitation can
function as a `winner-take-all' network and exhibit oscillatory dynamics. We
demonstrate how the origin of the oscillations can be attributed to the finite
delays through a linear stability analysis.Comment: 8 pages, 6 figure
Isolated and dynamical horizons and their applications
Over the past three decades, black holes have played an important role in
quantum gravity, mathematical physics, numerical relativity and gravitational
wave phenomenology. However, conceptual settings and mathematical models used
to discuss them have varied considerably from one area to another. Over the
last five years a new, quasi-local framework was introduced to analyze diverse
facets of black holes in a unified manner. In this framework, evolving black
holes are modeled by dynamical horizons and black holes in equilibrium by
isolated horizons. We review basic properties of these horizons and summarize
applications to mathematical physics, numerical relativity and quantum gravity.
This paradigm has led to significant generalizations of several results in
black hole physics. Specifically, it has introduced a more physical setting for
black hole thermodynamics and for black hole entropy calculations in quantum
gravity; suggested a phenomenological model for hairy black holes; provided
novel techniques to extract physics from numerical simulations; and led to new
laws governing the dynamics of black holes in exact general relativity.Comment: 77 pages, 12 figures. Typos and references correcte
Core components for effective infection prevention and control programmes: new WHO evidence-based recommendations
Abstract
Health care-associated infections (HAI) are a major public health problem with a significant impact on morbidity, mortality and quality of life. They represent also an important economic burden to health systems worldwide. However, a large proportion of HAI are preventable through effective infection prevention and control (IPC) measures. Improvements in IPC at the national and facility level are critical for the successful containment of antimicrobial resistance and the prevention of HAI, including outbreaks of highly transmissible diseases through high quality care within the context of universal health coverage. Given the limited availability of IPC evidence-based guidance and standards, the World Health Organization (WHO) decided to prioritize the development of global recommendations on the core components of effective IPC programmes both at the national and acute health care facility level, based on systematic literature reviews and expert consensus. The aim of the guideline development process was to identify the evidence and evaluate its quality, consider patient values and preferences, resource implications, and the feasibility and acceptability of the recommendations. As a result, 11 recommendations and three good practice statements are presented here, including a summary of the supporting evidence, and form the substance of a new WHO IPC guideline
NuStar observations of WISE J1036+0449, a galaxy at z ∼ 1 obscured by hot dust
Hot dust-obscured galaxies (hot DOGs), selected from Wide-Field Infrared Survey Explorer’s all-sky infrared survey, host some of the most powerful active galactic nuclei known and may represent an important stage in the evolution of galaxies. Most known hot DOGs are located at z> 1.5, due in part to a strong bias against identifying them at lower redshift related to the selection criteria. We present a new selection method that identifies 153 hot DOG candidates at z˜ 1, where they are significantly brighter and easier to study. We validate this approach by measuring a redshift z = 1.009 and finding a spectral energy distribution similar to that of higher-redshift hot DOGs for one of these objects, WISE J1036+0449 ({L}{Bol}≃ 8× {10}46 {erg} {{{s}}}-1). We find evidence of a broadened component in Mg II, which would imply a black hole mass of {M}{BH}≃ 2× {10}8 {M}⊙ and an Eddington ratio of {λ }{Edd}≃ 2.7. WISE J1036+0449 is the first hot DOG detected by the Nuclear Spectroscopic Telescope Array, and observations show that the source is heavily obscured, with a column density of {N}{{H}}≃ (2{--}15)× {10}23 {{cm}}-2. The source has an intrinsic 2-10 keV luminosity of ˜ 6× {10}44 {erg} {{{s}}}-1, a value significantly lower than that expected from the mid-infrared/X-ray correlation. We also find that other hot DOGs observed by X-ray facilities show a similar deficiency of X-ray flux. We discuss the origin of the X-ray weakness and the absorption properties of hot DOGs. Hot DOGs at z≲ 1 could be excellent laboratories to probe the characteristics of the accretion flow and of the X-ray emitting plasma at extreme values of the Eddington ratio
Solar Spectroscopy and (Pseudo-)Diagnostics of the Solar Chromosphere
I first review trends in current solar spectrometry and then concentrate on
comparing various spectroscopic diagnostics of the solar chromosphere. Some are
actually not at all chromospheric but just photospheric or clapotispheric and
do not convey information on chromospheric heating, even though this is often
assumed. Balmer Halpha is the principal displayer of the closed-field
chromosphere, but it is unclear how chromospheric fibrils gain their large
Halpha opacity. The open-field chromosphere seems to harbor most if not all
coronal heating and solar wind driving, but is hardly seen in optical
diagnostics.Comment: To appear in "Recent Advances in Spectroscopy: Astrophysical,
Theoretical and Experimental Perspectives", eds. R.K. Chaudhuri, M.V.
Mekkaden, A.V. Raveendran and A. Satya Narayanan, Astrophysics and Space
Science Proceedings, Springer, Heidelberg, 2009. Revision: references
corrected, new references added, minor text correction
Search for rare quark-annihilation decays, B --> Ds(*) Phi
We report on searches for B- --> Ds- Phi and B- --> Ds*- Phi. In the context
of the Standard Model, these decays are expected to be highly suppressed since
they proceed through annihilation of the b and u-bar quarks in the B- meson.
Our results are based on 234 million Upsilon(4S) --> B Bbar decays collected
with the BABAR detector at SLAC. We find no evidence for these decays, and we
set Bayesian 90% confidence level upper limits on the branching fractions BF(B-
--> Ds- Phi) Ds*- Phi)<1.2x10^(-5). These results
are consistent with Standard Model expectations.Comment: 8 pages, 3 postscript figues, submitted to Phys. Rev. D (Rapid
Communications
Protective Efficacy of BCG Overexpressing an L,D-Transpeptidase against M. tuberculosis Infection
Background: M. bovis Bacille Calmette-Guérin (BCG), currently the only available vaccine against tuberculosis (TB), fails to adequately protect individuals from active and latent TB infection. New vaccines are desperately needed to decrease the worldwide burden of TB. Methods and Findings: We created a recombinant strain of BCG that overproduces an L,D-transpeptidase in order to alter the bacterial peptidoglycan layer and consequently increase the ability of this immunogen to protect against virulent M. tuberculosis (Mtb). We demonstrate that this novel recombinant BCG protects mice against virulent Mtb at least as well as control BCG, as measured by its ability to reduce bacterial burden in lungs and spleen, reduce lung histopathology, and prolong survival. A nutrient starved recombinant BCG preparation, while offering comparable protection, elicited a response characterized by elevated levels of select Th1 cytokines. Conclusions: Recombinant BCG overexpressing a L,D-transpeptidase that is nutrient starved elicits a stronger Th1 type response and is at least as protective as parent BCG. Results from this study suggest that nutrient starvation treatment of live BCG vaccines should be further investigated as a way to increase host induction of Th-1 related cytokines in the development of experimental anti-TB vaccines
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