Log canonical thresholds of Del Pezzo Surfaces in characteristic p

The global log canonical threshold of each non-singular complex del Pezzo surface was computed by Cheltsov. The proof used Koll\'ar-Shokurov's connectedness principle and other results relying on vanishing theorems of Kodaira type, not known to be true in finite characteristic. We compute the global log canonical threshold of non-singular del Pezzo surfaces over an algebraically closed field. We give algebraic proofs of results previously known only in characteristic $0$. Instead of using of the connectedness principle we introduce a new technique based on a classification of curves of low degree. As an application we conclude that non-singular del Pezzo surfaces in finite characteristic of degree lower or equal than $4$ are K-semistable.Comment: 21 pages. Thorough rewrite following referee's suggestions. To be published in Manuscripta Mathematic

Current distribution and giant magnetoimpedance in composite wires with helical magnetic anisotropy

The giant magnetoimpedance effect in composite wires consising of a non-magnetic inner core and soft magnetic shell is studied theoretically. It is assumed that the magnetic shell has a helical anisotropy. The current and field distributions in the composite wire are found by means of a simultaneous solution of Maxwell equations and the Landau-Lifshitz equation. The expressions for the diagonal and off-diagonal impedance are obtained for low and high frequencies. The dependences of the impedance on the anisotropy axis angle and the shell thickness are analyzed. Maximum field sensitivity is shown to correspond to the case of the circular anisotropy in the magnetic shell. It is demonstrated that the optimum shell thickness to obtain maximum impedance ratio is equal to the effective skin depth in the mahnetic material.Comment: 23 pages, 7 figure

Determination of barrier heights and prefactors from protein folding rate data

We determine both barrier heights and prefactors for protein folding by applying constraints determined from experimental rate measurements to a Kramers theory for folding rate. The theoretical values are required to match the experimental values at two conditions of temperature and denaturant that induce the same stability. Several expressions for the prefactor in the Kramers rate equation are examined: a random energy approximation, a correlated energy approximation, and an approximation using a single Arrhenius activation energy. Barriers and prefactors are generally found to be large as a result of implementing this recipe, i.e. the folding landscape is cooperative and smooth. Interestingly, a prefactor with a single Arrhenius activation energy admits no formal solution.Comment: 11 pages, 5 figures, 1 table, Accepted Biophys

Mechanical durability of hydrophobic surfaces fabricated by injection moulding of laser-induced textures

YesThe paper reports an investigation on the mechanical durability of textured thermoplastic surfaces together with their respective wetting properties. A range of laser-induced topographies with different aspect ratios from micro to nanoscale were fabricated on tool steel inserts using an ultrashort pulsed near infrared laser. Then, through micro-injection moulding the topographies were replicated onto polypropylene surfaces and their durability was studied systematically. In particular, the evolution of topographies on textured thermoplastic surfaces together with their wetting properties were investigated after undergoing a controlled mechanical abrasion, i.e. reciprocating dry and wet cleaning cycles. The obtained empirical data was used both to study the effects of cleaning cycles and also to identify cleaning procedures with a minimal impact on textured thermoplastic surfaces and their respective wetting properties. In addition, the use of 3D areal parameters that are standardised and could be obtained readily with any state-of-the-art surface characterisation system are discussed for monitoring the surfaces' functional response.European Commission H2020 ITN programme “European ESRs Network on Short Pulsed Laser Micro/Nanostructuring of Surfaces for Improved Functional Applications” (Laser4Fun) under the Marie Skłodowska-Curie grant agreement No. 675063 (www.laser4fun.eu) and the UKIERI DST programme “Surface functionalisation for food, packaging, and healthcare applications”. In addition, the work was supported by three other H2020 programmes, i.e. the projects on “Modular laser based additive manufacturing platform for large scale industrial applications” (MAESTRO), “High-Impact Injection Moulding Platform for mass-production of 3D and/or large micro-structured surfaces with Antimicrobial, Self-cleaning, Anti-scratch, Anti-squeak and Aesthetic functionalities” (HIMALAIA) and “Process Fingerprint for Zero-defect Net-shape Micromanufacturing” (MICROMAN)

Coherent two pion photoproduction on 12C

We develop the formalism for coherent two pion photoproduction in nuclei and perform actual calculations of cross sections for $\pi^-\pi^+$ and $\pi^0\pi^0$ photoproduction on $^{12}C$. We find that due to the isospin symmetry the cross section for $\pi^0\pi^0$ production is very small and has a maximum when the pions propagate together. However, the kinematical region where the energies and polar angles of the two $\pi^0$ mesons are equal and their relative azimuthal angle $\phi=180^0$ is forbidden. Conversely in the $\pi^-\pi^+$ production the pions prefer to have a relative azimuthal angle 180$^0$ and the production of the pions propagating together is suppressed. The dominant one-body mechanism in both channels is related to the excitation of the $\Delta$ isobar. Hence the reaction can serve as a source of information about $\Delta$'s properties in nucleus. We have found that the reaction is sensitive to effects of the pion and $\Delta$ renormalization in the nuclear medium, similar to those found in the coherent $(\gamma,\pi^0)$ reaction, but magnified because of the presence of the two pions.Comment: 17 pages LATEX and 11 postscript figure

República: Año III Número 387 - (14/11/33)

PURPOSE OF REVIEW: The purpose of this study was to investigate the association of 26 inflammatory biomarkers (acute phase proteins, cytokines, chemokines) and renal markers with coronary lipid core burden index (LCBI) assessed by near-infrared spectroscopy (NIRS) imaging, as well as the association of these biomarkers with long-term cardiovascular outcome. RECENT FINDINGS: NIRS-derived LCBI has recently been shown to be an independent predictor of major adverse cardiac events (MACE). However, studies on the association between circulating biomarkers and NIRS-derived characteristics have not yet been performed. Between 2008 and 2011, 581 patients underwent diagnostic coronary angiography or percutaneous coronary intervention for stable angina pectoris or acute coronary syndrome (ACS). NIRS of a non-culprit vessel was performed in a subset of 203 patients. In multivariable analyses, TNF-alpha tended to be associated with higher LCBI (beta 0.088 ln (pg/ml) increase per unit LCBI; 95% CI 0.000-0.177, p = 0.05) after adjustment for clinical characteristics. However, this association did not persist after Bonferroni correction (statistical threshold 0.0019). Major adverse cardiac events (MACE) were registered in 581 patients during a median follow-up time of 4.7 years (IQR: [4.2-5.6] years). After adjustment for clinical characteristics and Bonferroni correction, IL-8 (HR 1.60; 95% CI [1.18-2.17] per ln (pg/ml), p = 0.002) was borderline associated with MACE and significantly associated with all-cause mortality or ACS (HR 1.75; 95% CI [1.24-2.48] per ln (pg/ml), p = 0.0015). In conclusion, we found that IL-8 was independently associated with clinical outcome, but altogether, the multiplex panel we investigated here did not render a useful blood biomarker of high LCBI

Breaking the Glass Ceiling Philosophy and Reality: A Study of Gender Progress and Career Development in the Corporate World

With the evolving nature of the business world, it has become a modern necessity to have a diverse workforce. As such, human resources professionals and managers must be prepared for the redesign of their organizations to be more inclusive throughout their formal hierarchies. Although the overall attitudes have become generally more feminist, the unfortunate reality is that women continue to face internal and external barriers which act as a ceiling to their career development and advancement

Energy Transfer between Throats from a 10d Perspective

Strongly warped regions, also known as throats, are a common feature of the type IIB string theory landscape. If one of the throats is heated during cosmological evolution, the energy is subsequently transferred to other throats or to massless fields in the unwarped bulk of the Calabi-Yau orientifold. This energy transfer proceeds either by Hawking radiation from the black hole horizon in the heated throat or, at later times, by the decay of throat-localized Kaluza-Klein states. In both cases, we calculate in a 10d setup the energy transfer rate (respectively decay rate) as a function of the AdS scales of the throats and of their relative distance. Compared to existing results based on 5d models, we find a significant suppression of the energy transfer rates if the size of the embedding Calabi-Yau orientifold is much larger than the AdS radii of the throats. This effect can be partially compensated by a small distance between the throats. These results are relevant, e.g., for the analysis of reheating after brane inflation. Our calculation employs the dual gauge theory picture in which each throat is described by a strongly coupled 4d gauge theory, the degrees of freedom of which are localized at a certain position in the compact space.Comment: 25 pages; a comment adde

Beauty is Attractive: Moduli Trapping at Enhanced Symmetry Points

We study quantum effects on moduli dynamics arising from the production of particles which are light at special points in moduli space. The resulting forces trap the moduli at these points, which often exhibit enhanced symmetry. Moduli trapping occurs in time-dependent quantum field theory, as well as in systems of moving D-branes, where it leads the branes to combine into stacks. Trapping also occurs in an expanding universe, though the range over which the moduli can roll is limited by Hubble friction. We observe that a scalar field trapped on a steep potential can induce a stage of acceleration of the universe, which we call trapped inflation. Moduli trapping ameliorates the cosmological moduli problem and may affect vacuum selection. In particular, rolling moduli are most powerfully attracted to the points with the largest number of light particles, which are often the points of greatest symmetry. Given suitable assumptions about the dynamics of the very early universe, this effect might help to explain why among the plethora of possible vacuum states of string theory, we appear to live in one with a large number of light particles and (spontaneously broken) symmetries. In other words, some of the surprising properties of our world might arise not through pure chance or miraculous cancellations, but through a natural selection mechanism during dynamical evolution.Comment: 50 pages, 4 figures; v2: added references and an appendix describing a related classical proces

Attitudes and perceptions of next-of-kin/loved ones toward end-of-life HIV cure-related research: A qualitative focus group study in Southern California

As end-of-life (EOL) HIV cure-related research expands, understanding perspectives of participants’ next-of-kin (NOK) is critical to maintaining ethical study conduct. We conducted two small focus groups and two one-on-one interviews using focus group guides with the NOK of Last Gift study participants at the University of California, San Diego (UCSD). Participating NOK included six individuals (n = 5 male and n = 1 female), including a grandmother, grandfather, partner, spouse, and two close friends. Researchers double-coded the transcripts manually for overarching themes and sub-themes using an inductive approach. We identified six key themes: 1) NOK had an accurate, positive understanding of the Last Gift clinical study; 2) NOK felt the study was conducted ethically; 3) Perceived benefits for NOK included support navigating the dying/grieving process and personal growth; 4) Perceived drawbacks included increased sadness, emotional stress, conflicted wishes between NOK and study participants, and concerns around potential invasiveness of study procedures at the EOL; 5) NOK expressed pride in loved ones’ altruism; and 6) NOK provided suggestions to improve the Last Gift study, including better communication between staff and themselves. These findings provide a framework for ethical implementation of future EOL HIV cure-related research involving NOK