Defining a methodology to design and implement business process models in BPMN according to the standard ANSI/ISA-95 in a manufacturing enterprise

Nowadays, extended enterprise requires flexible and adaptable platforms which enable technology and internal integration between ERP and MES levels of manufacturing industry. Under the EAI perspective, it is proposed the use of ESB and BPMS technologies to improve integration between business and manufacturing layers. In order to enable this integration, it should be considered standard ANSI/ISA-95 Enterprise/Control System Integration due to it defines an effective model for business integration/manufacturing. In this paper, in order to develop applications that allow the orchestration of information exchanges between ERP/MES, a methodology is defined to design BPMN process models according to the standard ANSI/ISA-95 because it enables B2M integration projects development

Evaluation of the smooth muscle cell component and apoptosis in the varicose vein wall

This study was designed to evaluate the role of the smooth muscle cell and the apoptosis in the pathogenesis of the varicose vein. Segments of saphenous vein were obtained from healthy subjects and from those with varicose veins. The vein specimens were subdivided according to subject age (younger or older than 50 years) and according to the varicose vein source (distal or proximal). Morphological, ultrastructural, cell proliferation (anti-PCNA method) and cell death (TUNEL method) analysis were performed. The walls of healthy, control vein specimens acquired a more collagenous and papillomatous appearance with age. A slight increase in the number of TUNEL-positive cells was also observed in specimens from older subjects. The proportion of apoptotic cells was much greater in the varicose veins than in control specimens. Most cellular alterations were seen in proximal varicose segments obtained from young subjects. These specimens showed hypertrophic areas with a high degree of cellularity (both in the media and in the thickened intima). The highest proportion of apoptotic cells and collagenisation were also observed in these areas. The enhanced number of apoptotic cells in varicose veins observed mainly in proximal/young vein specimens could be responsible, at least in part, for the acceleration of the final fibrosclerotic process characteristic of the varicose vein wall

Meditenanean rainfull space-time variabili| and its relation with runoff modelling

[ES] El objetivo de esta investigación es estudiar el efecto de la variabilidad espacio-temporal de la lluvia en la respuesta hidrológica de la cuenca (caudal pico y volumen del hidrograma de crecida). Para ello se generaron 100 episodios sintéticos con el modelo estocástico multidimensional de lluvia RAINGEN, que sirvieron como entrada al modelo distribuido lluvia-escorrentía TETIS. La aplicación se llevó a cabo en la cuenca de la Rambla del Poyo, ubicada en la costa mediterránea de España. Se consideraron densidades de medición equivalentes a 1, 4, 16 y 64 Km2/pluviómetro e intervalo temporal de 10 minutos, para áreas entre 2 km2 y 421 km2. Se estudió también la respuesta de las cuencas considerando como entraba el hietograma medio de precipitación[EN] The aim of this paper is to study the effecto of the space-time rainfall variability in runoff modelling, specially the peak flow and the runoff volume. The distributed rain-fall-runoff model TETIS has been used for the discharge simulation, while the rainfall input consisted on a family of one hundred synthetics events, generated with the multidimentional stochastic rainfall model RAINGEN. teh study area is the Rambla del Poyo basin, located in the mediterranean coast in Spain. Rain gauge densities of 1, 4, 16 and 64 km2/gauge were considered, and time level of aggregation of 10 minutes considering basins between 2 km2 and 421 km2. The cahtchment's response to the average precipitation hyetograph was also compuetd and compared to the others.Guichard Romero, D.; García Bartual, RL.; Francés, F.; Domínguez Mora, R. (2006). La variabilidad espacio-temporal de la lluvia mediterránea y su influencia en la respuesta hidrológica. Quehacer cientifico en Chiapas. 1(1):9-21. http://hdl.handle.net/10251/99489S9211

Hemodynamic performance of different stent strategies for coronary bifurcations. Evaluation with a mathematical model

Purpose: Best percutaneous treatment strategy for lesions in coronary bifurcations is an ongoing subject of debate. There is limited data that analyses the effect of the different bifurcation strategies on coronary flow. Our aim is to evaluate the influence of different bifurcation stenting strategies on hemodynamic parameters, both in the main vessel (MV) and side branch (SB)

Responsabilidad social. Una propuesta desde la contabilidad social y ambiental para empresas clave de la región

En el Partido de General Pueyrredon existen empresas que se destacan por sus acciones de responsabilidad social, conformando un objeto de análisis relevante desde el punto de vista de la contabilidad social y ambiental debido a su impacto positivo en la comunidad. Por ello, mediante este proyecto se propuso relevar las políticas de responsabilidad social asumidas por dichas empresas, analizar el impacto en sus destinatarios y proponer sistemas de información contable que reflejen estas políticas y satisfagan las necesidades de los usuarios interesados. Se parte del hecho de que los usuarios del sistema contable asignan cada vez mayor relevancia a la información referida al desempeño social, ético y medioambiental de las empresas. En este sentido, las investigaciones que desde la disciplina contable y afines abordan esta temática, realizan aportes valiosos para el ejercicio de la profesión, y adicionalmente, permiten que las empresas que asumen una actitud responsable frente a diferentes problemáticas sociales puedan adecuar los informes de sus sistemas contables y dar cuenta de sus acciones a múltiples usuarios. Metodológicamente proponemos triangular nuestro objeto de investigación en base a un nutrido cuerpo teórico, información primaria relevada a través de entrevistas en profundidad e información secundaria proporcionada por las empresas seleccionadas para el estudio. Nos valemos de la teoría de los stakeholders para el marco analítico general de la investigación, y los desarrollos de la contabilidad social y ambiental para la propuesta de mejora de los informes empresariales.Fil: D'Onofrio, Paula. Universidad de Buenos Aires. Facultad de Ciencias Económicas; Argentina.Fil: Rodrigues, J. A. Universidade de São Paulo; Brasil.Fil: Iacono, C. Universidad Nacional de Mar del Plata. Facultad de Ciencias Económicas y Sociales; Argentina.Fil: Dominguez Marzano, Facundo. Universidad Nacional de Mar del Plata. Facultad de Ciencias Económicas y Sociales; Argentina.Fil: Hernández, R. Universidad Nacional de Mar del Plata. Facultad de Ciencias Económicas y Sociales; Argentina.Fil: Gorosito, Silvina Marcela. Universidad Nacional de Mar del Plata. Facultad de Ciencias Económicas y Sociales; Argentina.Fil: García, F. Universidad Nacional de Mar del Plata. Facultad de Ciencias Económicas y Sociales; Argentina

Predictive factors and early biomarkers of response in multiple sclerosis patients treated with natalizumab

There are an increasing number of treatments available for multiple sclerosis (MS). The early identification of optimal responders to individual treatments is important to achieve individualized therapy. With this aim, we performed a multicenter retrospective longitudinal study including 186 MS patients treated with natalizumab who were followed for 2 years. We analyzed the following variables at recruitment: sex, current age, age at disease onset, disease duration, EDSS, number of T2 and Gd + lesions, IgG and IgM oligoclonal bands, HLA class II (DR, DRB, DQA, DQB, and DRB1*15:01), IgG and IgM antibody titers against human herpesvirus 6 (HHV-6) and the antibody response to Epstein–Barr virus (EBV) through the measurement of the anti-EBNA-1 and anti-VCA IgG titers, in relation to clinical response (no relapses or disability progression), and to NEDA-3 (no evidence of disease activity in terms of clinical response and no changes in MRI scans either) after 2-years follow-up. Baseline EDSS score, baseline EBNA-1 IgG titers and percentage change of HHV6 IgG titers between baseline and 6 month visits were significantly different in clinical responders and in NEDA-3 status (all of them remained significant in the multivariate analysis). We identified three variables for the early identification of natalizumab optimal responders in a rapid and cost-effective approach

Persistent HIV-controllers are more prone to spontaneously clear HCV: a retrospective cohort study.

HIV-controllers have the ability to spontaneously maintain viraemia at low or undetectable levels in the absence of antiretroviral treatment. Furthermore, HIV-controllers seem to have a superior capacity to spontaneously clear hepatitis C virus (HCV) compared to non HIV-controllers. Some of these subjects eventually lose HIV-controller status (transient controllers), whereas some HIV-controllers show a persistent natural HIV control (persistent controllers). We aimed to analyse whether persistent controllers have superior capacity to spontaneously clear HCV compared to transient controllers. We recruited HIV-controllers from January 1981 up to October 2016 with available antibodies to HCV (anti-HCV) data (n = 744). Factors associated with HIV spontaneous control in relation to HCV status were analysed in persistent and transient HIV-controllers with anti-HCV positive (n = 202 and n = 138 respectively) in comparison with 1700 HCV positive non HIV-controllers recruited from January 1981 up to March 2018, bivariate and multivariate analyses, following a logistic regression model, were applied. In addition, the factors related to the loss and time to lose HIV-controller status were explored (n = 744) using Log rank test and Kaplan-Meier curves, in this case the multivariate analysis consisted in a Cox regression model. A higher frequency of HCV spontaneous clearance was found in persistent HIV-controllers (25.5%) compared to non-controllers (10.2%). After adjusting for potential confounders, as sex, age, HIV transmission risk, CD4+ T-cell nadir and time of follow-up, HCV clearance was independently associated with persistent HIV spontaneous control (p = 0.002; OR (95% CI) = 2.573 (1.428 to 4.633)), but not with transient spontaneous control (p = 0.119; 1.589 (0.888 to 2.845)). Furthermore, persistent HIV-controllers were more likely to spontaneously clear the HCV in comparison with transient controllers (p = 0.027; 0.377 (0.159 to 0.893). Finally, not to lose or lengthen the time of losing this control was independently associated with HCV spontaneous clearance (p = 0.010; 0.503 (0.297 to 0.850). This study shows an association between spontaneous persistent HIV-control and HCV spontaneous clearance. The study findings support the idea of preserved immune mechanisms in persistent HIV control implicated in HCV spontaneous clearance. These results highlight persistent HIV-controllers but not transient controllers as a good model of functional HIV cure.This work was supported by the Instituto de Salud Carlos III (research contracts CPII014/00025 to E.R.‐M., and FI14/00431 to L.T.‐D. and research projects PI12/02283, PI16/00684, PI19/01127 to E.R.‐M.) and Red Temática de Investigación Cooperativa en SIDA (Projects RD12/0017/0029, RD12/0017/0031, and RD16/0025/0020 and RD16/0025/0013), which is included in the Acción Estratégica en Salud, Plan Nacional de Investigación Científica, Desarrollo e Innovación Tecnológica 2008 to 2011 and 2013 to 2016, Instituto de Salud Carlos III, Fondos FEDER. E.R.‐M. was supported by Consejería de Salud y Bienestar Social of Junta de Andalucía through the Nicolás Monardes program (C‐0032/17), N Rallón is a Miguel Servet investigator from the Spanish Carlos III Institute of Health (ISCIII), grant CP14/00198, Madrid, Spain and B.D.M. received a grant from The Spanish Ministry of Education (FPU13/02451). Work in CL‐G’s laboratory was supported by grants SAF (2010 to 17226) and (2016‐77894‐R) from MINECO (Spain) and FIS (PI 13/02269, ISCIII) and in part by the RIS‐RETIC grants RD06/006/0036 and RD12/0017/0028 funded by the ISC III‐FEDER. MP has a contract of RIS‐RETIC RD12/0017/0036.S

VHMPID: a new detector for the ALICE experiment at LHC

This article presents the basic idea of VHMPID, an upgrade detector for the ALICE experiment at LHC, CERN. The main goal of this detector is to extend the particle identification capabilities of ALICE to give more insight into the evolution of the hot and dense matter created in Pb-Pb collisions. Starting from the physics motivations and working principles the challenges and current status of development is detailed.Comment: 4 pages, 6 figures. To be published in EPJ Web of Conference

Herschel FIR counterparts of selected Ly-alpha emitters at z~2.2. Fast evolution since z~3 or missed obscured AGNs?

Ly-alpha emitters (LAEs) are seen everywhere in the redshift domain from local to z~7. Far-infrared (FIR) counterparts of LAEs at different epochs could provide direct clues on dust content, extinction, and spectral energy distribution (SED) for these galaxies. We search for FIR counterparts of LAEs that are optically detected in the GOODS-North field at redshift z~2.2 using data from the Herschel Space Telescope with the Photodetector Array Camera and Spectrometer (PACS). The LAE candidates were isolated via color-magnitude diagram using the medium-band photometry from the ALHAMBRA Survey, ancillary data on GOODS-North, and stellar population models. According to the fitting of these spectral synthesis models and FIR/optical diagnostics, most of them seem to be obscured galaxies whose spectra are AGN-dominated. From the analysis of the optical data, we have observed a fraction of AGN or composite over source total number of ~0.75 in the LAE population at z~2.2, which is marginally consistent with the fraction previously observed at z=2.25 and even at low redshift (0.2<z<0.45), but significantly different from the one observed at redshift ~3, which could be compatible either with a scenario of rapid change in the AGN fraction between the epochs involved or with a non detection of obscured AGN in other z=2-3 LAE samples due to lack of deep FIR observations. We found three robust FIR (PACS) counterparts at z~2.2 in GOODS-North. This demonstrates the possibility of finding dust emission in LAEs even at higher redshifts.Comment: 11 pages (including Appendices), 6 figures. Accepted for publication in Astronomy & Astrophysics Letters (two references added