917 research outputs found
Vowel-onset detection by vowel-strength measurement, cochlear-nucleus simulation, and multilayer perceptrons
The burden of proof: the current state of atrial fibrillation prevention and treatment trials
Atrial fibrillation (AF) is an age-related arrhythmia of enormous socioeconomic significance. In recent years, our understanding of the basic mechanisms that initiate and perpetuate AF has evolved rapidly, catheter ablation of AF has progressed from concept to reality, and recent studies suggest lifestyle modification may help prevent AF recurrence. Emerging developments in genetics, imaging, and informatics also present new opportunities for personalized care. However, considerable challenges remain. These include a paucity of studies examining AF prevention, modest efficacy of existing antiarrhythmic therapies, diverse ablation technologies and practice, and limited evidence to guide management of high-risk patients with multiple comorbidities. Studies examining the long-term effects of AF catheter ablation on morbidity and mortality outcomes are not yet completed. In many ways, further progress in the field is heavily contingent on the feasibility, capacity, and efficiency of clinical trials to incorporate the rapidly evolving knowledge base and to provide substantive evidence for novel AF therapeutic strategies. This review outlines the current state of AF prevention and treatment trials, including the foreseeable challenges, as discussed by a unique forum of clinical trialists, scientists, and regulatory representatives in a session endorsed by the Heart Rhythm Society at the 12th Global CardioVascular Clinical Trialists Forum in Washington, DC, December 3–5, 2015
A Lanczos algorithm for linear response
An iterative algorithm is presented for solving the RPA equations of linear
response. The method optimally computes the energy-weighted moments of the
strength function, allowing one to match the computational effort to the
intrinsic accuracy of the basic mean-field approximation, avoiding the problem
of solving very large matrices. For local interactions, the computational
effort for the method scales with the number of particles N_p as O(N_p^3).Comment: 12 pages including 3 figures; Late
Effects of rapid prey evolution on predator-prey cycles
We study the qualitative properties of population cycles in a predator-prey
system where genetic variability allows contemporary rapid evolution of the
prey. Previous numerical studies have found that prey evolution in response to
changing predation risk can have major quantitative and qualitative effects on
predator-prey cycles, including: (i) large increases in cycle period, (ii)
changes in phase relations (so that predator and prey are cycling exactly out
of phase, rather than the classical quarter-period phase lag), and (iii)
"cryptic" cycles in which total prey density remains nearly constant while
predator density and prey traits cycle. Here we focus on a chemostat model
motivated by our experimental system [Fussmann et al. 2000,Yoshida et al. 2003]
with algae (prey) and rotifers (predators), in which the prey exhibit rapid
evolution in their level of defense against predation. We show that the effects
of rapid prey evolution are robust and general, and furthermore that they occur
in a specific but biologically relevant region of parameter space: when traits
that greatly reduce predation risk are relatively cheap (in terms of reductions
in other fitness components), when there is coexistence between the two prey
types and the predator, and when the interaction between predators and
undefended prey alone would produce cycles. Because defense has been shown to
be inexpensive, even cost-free, in a number of systems [Andersson and Levin
1999, Gagneux et al. 2006,Yoshida et al. 2004], our discoveries may well be
reproduced in other model systems, and in nature. Finally, some of our key
results are extended to a general model in which functional forms for the
predation rate and prey birth rate are not specified.Comment: 35 pages, 8 figure
The Primordial Inflation Explorer (PIXIE): A Nulling Polarimeter for Cosmic Microwave Background Observations
The Primordial Inflation Explorer (PIXIE) is an Explorer-class mission to
measure the gravity-wave signature of primordial inflation through its
distinctive imprint on the linear polarization of the cosmic microwave
background. The instrument consists of a polarizing Michelson interferometer
configured as a nulling polarimeter to measure the difference spectrum between
orthogonal linear polarizations from two co-aligned beams. Either input can
view the sky or a temperature-controlled absolute reference blackbody
calibrator. PIXIE will map the absolute intensity and linear polarization
(Stokes I, Q, and U parameters) over the full sky in 400 spectral channels
spanning 2.5 decades in frequency from 30 GHz to 6 THz (1 cm to 50 um
wavelength). Multi-moded optics provide background-limited sensitivity using
only 4 detectors, while the highly symmetric design and multiple signal
modulations provide robust rejection of potential systematic errors. The
principal science goal is the detection and characterization of linear
polarization from an inflationary epoch in the early universe, with
tensor-to-scalar ratio r < 10^{-3} at 5 standard deviations. The rich PIXIE
data set will also constrain physical processes ranging from Big Bang cosmology
to the nature of the first stars to physical conditions within the interstellar
medium of the Galaxy.Comment: 37 pages including 17 figures. Submitted to the Journal of Cosmology
and Astroparticle Physic
Understanding hadronic gamma-ray emission from supernova remnants
We aim to test the plausibility of a theoretical framework in which the
gamma-ray emission detected from supernova remnants may be of hadronic origin,
i.e., due to the decay of neutral pions produced in nuclear collisions
involving relativistic nuclei. In particular, we investigate the effects
induced by magnetic field amplification on the expected particle spectra,
outlining a phenomenological scenario consistent with both the underlying
Physics and the larger and larger amount of observational data provided by the
present generation of gamma experiments, which seem to indicate rather steep
spectra for the accelerated particles. In addition, in order to study to study
how pre-supernova winds might affect the expected emission in this class of
sources, the time-dependent gamma-ray luminosity of a remnant with a massive
progenitor is worked out. Solid points and limitations of the proposed scenario
are finally discussed in a critical way.Comment: 30 pages, 5 figures; Several comments, references and a figure added.
Some typos correcte
Energy Linearity and Resolution of the ATLAS Electromagnetic Barrel Calorimeter in an Electron Test-Beam
A module of the ATLAS electromagnetic barrel liquid argon calorimeter was
exposed to the CERN electron test-beam at the H8 beam line upgraded for
precision momentum measurement. The available energies of the electron beam
ranged from 10 to 245 GeV. The electron beam impinged at one point
corresponding to a pseudo-rapidity of eta=0.687 and an azimuthal angle of
phi=0.28 in the ATLAS coordinate system. A detailed study of several effects
biasing the electron energy measurement allowed an energy reconstruction
procedure to be developed that ensures a good linearity and a good resolution.
Use is made of detailed Monte Carlo simulations based on Geant which describe
the longitudinal and transverse shower profiles as well as the energy
distributions. For electron energies between 15 GeV and 180 GeV the deviation
of the measured incident electron energy over the beam energy is within 0.1%.
The systematic uncertainty of the measurement is about 0.1% at low energies and
negligible at high energies. The energy resolution is found to be about 10%
sqrt(E) for the sampling term and about 0.2% for the local constant term
Functional diversity of chemokines and chemokine receptors in response to viral infection of the central nervous system.
Encounters with neurotropic viruses result in varied outcomes ranging from encephalitis, paralytic poliomyelitis or other serious consequences to relatively benign infection. One of the principal factors that control the outcome of infection is the localized tissue response and subsequent immune response directed against the invading toxic agent. It is the role of the immune system to contain and control the spread of virus infection in the central nervous system (CNS), and paradoxically, this response may also be pathologic. Chemokines are potent proinflammatory molecules whose expression within virally infected tissues is often associated with protection and/or pathology which correlates with migration and accumulation of immune cells. Indeed, studies with a neurotropic murine coronavirus, mouse hepatitis virus (MHV), have provided important insight into the functional roles of chemokines and chemokine receptors in participating in various aspects of host defense as well as disease development within the CNS. This chapter will highlight recent discoveries that have provided insight into the diverse biologic roles of chemokines and their receptors in coordinating immune responses following viral infection of the CNS
Position resolution and particle identification with the ATLAS EM calorimeter
In the years between 2000 and 2002 several pre-series and series modules of
the ATLAS EM barrel and end-cap calorimeter were exposed to electron, photon
and pion beams. The performance of the calorimeter with respect to its finely
segmented first sampling has been studied. The polar angle resolution has been
found to be in the range 50-60 mrad/sqrt(E (GeV)). The neutral pion rejection
has been measured to be about 3.5 for 90% photon selection efficiency at pT=50
GeV/c. Electron-pion separation studies have indicated that a pion fake rate of
(0.07-0.5)% can be achieved while maintaining 90% electron identification
efficiency for energies up to 40 GeV.Comment: 32 pages, 22 figures, to be published in NIM
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