1,571 research outputs found
Prospects for intermediate mass black hole binary searches with advanced gravitational-wave detectors
We estimated the sensitivity of the upcoming advanced, ground-based
gravitational-wave observatories (the upgraded LIGO and Virgo and the KAGRA
interferometers) to coalescing intermediate mass black hole binaries (IMBHB).
We added waveforms modeling the gravitational radiation emitted by IMBHBs to
detectors' simulated data and searched for the injected signals with the
coherent WaveBurst algorithm. The tested binary's parameter space covers
non-spinning IMBHBs with source-frame total masses between 50 and 1050
and mass ratios between and 1. We found that
advanced detectors could be sensitive to these systems up to a range of a few
Gpc. A theoretical model was adopted to estimate the expected observation
rates, yielding up to a few tens of events per year. Thus, our results indicate
that advanced detectors will have a reasonable chance to collect the first
direct evidence for intermediate mass black holes and open a new, intriguing
channel for probing the Universe over cosmological scales.Comment: 9 pages, 4 figures, corrected the name of one author (previously
misspelled
The database BIOSCAT: a tool for structure research by scattering and hydrodynamic methods
The crystal structures of a large number of proteins and nucleic acids are known and the corresponding sets of coordinates are stored in the Brookhaven Protein Data Bank. For structure investigations of biological macromolecules in solution, scattering and hydrodynamical methods are powerful biophysical tools when starting the data interpretation on the basis of the crystal structure of the molecules. The database BIOSCAT covers the main structural parameters estimable by X-ray scattering, translation and rotation diffusion methods and the X-ray scattering intensities and low- and high-resolution real-space electron distance distribution functions of 70 biological macromolecules and of oligonucleotides in standard conformation. The parameters and the scattered intensities are calculated from the atomic coordinates using the improved cube method and the real-space functions are estimated via a termination-error-reduced Fourier sine transformation. The database access is organized by the program PASSDB, which can generally be used for 'readable' databases. A simple query language allows enquiries into the database without knowledge of a programming language. The program CONVSQL converts the database into normalized relations that can be handled by structured query languages (SQLs)
Unique Case of Anca-Negative Pauci-Immune Necrotizing Glomerulonephritis With Diffuse Alveolar Hemorrhage, Potentially Associated With Midostaurin
We present a 61-year-old male with FLT3-mutated acute myeloid leukemia treated with midostaurin who developed acute kidney injury requiring hemodialysis and pulmonary renal syndrome. Antibodies to proteinase-3, myeloperoxidase, and glomerular basement membrane were negative. Renal biopsy confirmed acute pauci-immune focal necrotizing glomerulonephritis (GN) with fibrin crescents indicating rapidly progressing glomerulonephritis. He improved with pulse methylprednisolone, intravenous cyclophosphamide, and plasma exchange with resolution of hemoptysis. This case highlights the importance of prompt renal biopsy to guide early initiation of life-saving therapies. To our knowledge, this is the first reported case of ANCA-negative pauci-immune necrotizing GN likely secondary to midostaurin
A burst search for gravitational waves from binary black holes
Compact binary coalescence (CBC) is one of the most promising sources of
gravitational waves. These sources are usually searched for with matched
filters which require accurate calculation of the GW waveforms and generation
of large template banks. We present a complementary search technique based on
algorithms used in un-modeled searches. Initially designed for detection of
un-modeled bursts, which can span a very large set of waveform morphologies,
the search algorithm presented here is constrained for targeted detection of
the smaller subset of CBC signals. The constraint is based on the assumption of
elliptical polarisation for signals received at the detector. We expect that
the algorithm is sensitive to CBC signals in a wide range of masses, mass
ratios, and spin parameters. In preparation for the analysis of data from the
fifth LIGO-Virgo science run (S5), we performed preliminary studies of the
algorithm on test data. We present the sensitivity of the search to different
types of simulated CBC waveforms. Also, we discuss how to extend the results of
the test run into a search over all of the current LIGO-Virgo data set.Comment: 12 pages, 4 figures, 2 tables, submitted for publication in CQG in
the special issue for the conference proceedings of GWDAW13; corrected some
typos, addressed some minor reviewer comments one section restructured and
references updated and correcte
Networks of gravitational wave detectors and three figures of merit
This paper develops a general framework for studying the effectiveness of
networks of interferometric gravitational wave detectors and then uses it to
show that enlarging the existing LIGO-VIRGO network with one or more planned or
proposed detectors in Japan (LCGT), Australia, and India brings major benefits,
including much larger detection rate increases than previously thought... I
show that there is a universal probability distribution function (pdf) for
detected SNR values, which implies that the most likely SNR value of the first
detected event will be 1.26 times the search threshold. For binary systems, I
also derive the universal pdf for detected values of the orbital inclination,
taking into account the Malmquist bias; this implies that the number of
gamma-ray bursts associated with detected binary coalescences should be 3.4
times larger than expected from just the beaming fraction of the gamma burst.
Using network antenna patterns, I propose three figures of merit that
characterize the relative performance of different networks... Adding {\em any}
new site to the planned LIGO-VIRGO network can dramatically increase, by
factors of 2 to 4, the detected event rate by allowing coherent data analysis
to reduce the spurious instrumental coincident background. Moving one of the
LIGO detectors to Australia additionally improves direction-finding by a factor
of 4 or more. Adding LCGT to the original LIGO-VIRGO network not only improves
direction-finding but will further increase the detection rate over the
extra-site gain by factors of almost 2, partly by improving the network duty
cycle... Enlarged advanced networks could look forward to detecting three to
four hundred neutron star binary coalescences per year.Comment: 38 pages, 7 figures, 2 tables. Accepted for publication in Classical
and Quantum Gravit
Experimental Investigation on the Deformation Response of Hybrid 3D Woven Composites
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/97059/1/AIAA2012-1572.pd
Recommended from our members
Skin Deep: Highlights of NREL Surface Analysis PV Research
The Surface Analysis project provides measurement support and leadership for collaborative research activities involving surface chemistry and physics in all areas of the PV program. Significant results from the past fiscal year include the following: i) in-situ XPS, UPS, and AES studies of chemical-bath exposure of CIGS surfaces demonstrated that Group-III elements are preferentially removed from the surface, that type conversion of the surface occurs, and that the addition of a surfactant improves CdS deposition and thus device performance; ii) XPS studies of polyethylene terephthalate (PET) candidate backsheet materials have shown that plasma exposure prior to oxide-barrier deposition results in the formation of low-molecular-weight fragments that result in the formation of a weak interfacial layer that fails during damp-heat exposure; iii) an empirical relation was derived for the source geometry that leads to optimal film-thickness uniformity in rotating-substrate physical-vapor deposition (PVD) systems; and iv) PVD flux-distribution calculations were performed to develop a novel method for combinatorial thin-film synthesis
Weak Lensing from Space I: Instrumentation and Survey Strategy
A wide field space-based imaging telescope is necessary to fully exploit the
technique of observing dark matter via weak gravitational lensing. This first
paper in a three part series outlines the survey strategies and relevant
instrumental parameters for such a mission. As a concrete example of hardware
design, we consider the proposed Supernova/Acceleration Probe (SNAP). Using
SNAP engineering models, we quantify the major contributions to this
telescope's Point Spread Function (PSF). These PSF contributions are relevant
to any similar wide field space telescope. We further show that the PSF of SNAP
or a similar telescope will be smaller than current ground-based PSFs, and more
isotropic and stable over time than the PSF of the Hubble Space Telescope. We
outline survey strategies for two different regimes - a ``wide'' 300 square
degree survey and a ``deep'' 15 square degree survey that will accomplish
various weak lensing goals including statistical studies and dark matter
mapping.Comment: 25 pages, 8 figures, 1 table, replaced with Published Versio
Supernova / Acceleration Probe: A Satellite Experiment to Study the Nature of the Dark Energy
The Supernova / Acceleration Probe (SNAP) is a proposed space-based
experiment designed to study the dark energy and alternative explanations of
the acceleration of the Universe's expansion by performing a series of
complementary systematics-controlled measurements. We describe a
self-consistent reference mission design for building a Type Ia supernova
Hubble diagram and for performing a wide-area weak gravitational lensing study.
A 2-m wide-field telescope feeds a focal plane consisting of a 0.7
square-degree imager tiled with equal areas of optical CCDs and near infrared
sensors, and a high-efficiency low-resolution integral field spectrograph. The
SNAP mission will obtain high-signal-to-noise calibrated light-curves and
spectra for several thousand supernovae at redshifts between z=0.1 and 1.7. A
wide-field survey covering one thousand square degrees resolves ~100 galaxies
per square arcminute. If we assume we live in a cosmological-constant-dominated
Universe, the matter density, dark energy density, and flatness of space can
all be measured with SNAP supernova and weak-lensing measurements to a
systematics-limited accuracy of 1%. For a flat universe, the
density-to-pressure ratio of dark energy can be similarly measured to 5% for
the present value w0 and ~0.1 for the time variation w'. The large survey area,
depth, spatial resolution, time-sampling, and nine-band optical to NIR
photometry will support additional independent and/or complementary dark-energy
measurement approaches as well as a broad range of auxiliary science programs.
(Abridged)Comment: 40 pages, 18 figures, submitted to PASP, http://snap.lbl.go
Inflammation, insulin resistance, and diabetes-mendelian randomization using CRP haplotypes points upstream
Background
Raised C-reactive protein (CRP) is a risk factor for type 2 diabetes. According to the Mendelian randomization method, the association is likely to be causal if genetic variants that affect CRP level are associated with markers of diabetes development and diabetes. Our objective was to examine the nature of the association between CRP phenotype and diabetes development using CRP haplotypes as instrumental variables.
Methods and Findings
We genotyped three tagging SNPs (CRP + 2302G > A; CRP + 1444T > C; CRP + 4899T > G) in the CRP gene and measured serum CRP in 5,274 men and women at mean ages 49 and 61 y (Whitehall II Study). Homeostasis model assessment-insulin resistance (HOMA-IR) and hemoglobin A1c (HbA1c) were measured at age 61 y. Diabetes was ascertained by glucose tolerance test and self-report. Common major haplotypes were strongly associated with serum CRP levels, but unrelated to obesity, blood pressure, and socioeconomic position, which may confound the association between CRP and diabetes risk. Serum CRP was associated with these potential confounding factors. After adjustment for age and sex, baseline serum CRP was associated with incident diabetes (hazard ratio = 1.39 [95% confidence interval 1.29-1.51], HOMA-IR, and HbA1c, but the associations were considerably attenuated on adjustment for potential confounding factors. In contrast, CRP haplotypes were not associated with HOMA-IR or HbA1c (p=0.52-0.92). The associations of CRP with HOMA-IR and HbA1c were all null when examined using instrumental variables analysis, with genetic variants as the instrument for serum CRP. Instrumental variables estimates differed from the directly observed associations (p=0.007-0.11). Pooled analysis of CRP haplotypes and diabetes in Whitehall II and Northwick Park Heart Study II produced null findings (p=0.25-0.88). Analyses based on the Wellcome Trust Case Control Consortium (1,923 diabetes cases, 2,932 controls) using three SNPs in tight linkage disequilibrium with our tagging SNPs also demonstrated null associations.
Conclusions
Observed associations between serum CRP and insulin resistance, glycemia, and diabetes are likely to be noncausal. Inflammation may play a causal role via upstream effectors rather than the downstream marker CRP
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