Princípios e práticas ecológicas para o manejo de insetos-praga na agricultura.

bitstream/item/109190/1/1112-05-nco-folderPrincipiosPraticasEcologicas.pd

Field evaluation of Bt cotton crop impact on nontarget pests: cotton aphid and boll weevil.

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A Randomized, Double Blind, Placebo-Controlled Trial of Pioglitazone in Combination with Riluzole in Amyotrophic Lateral Sclerosis

BACKGROUND: Pioglitazone, an oral anti-diabetic that stimulates the PPAR-gamma transcription factor, increased survival of mice with amyotrophic lateral sclerosis (ALS). METHODS/PRINCIPAL FINDINGS: We performed a phase II, double blind, multicentre, placebo controlled trial of pioglitazone in ALS patients under riluzole. 219 patients were randomly assigned to receive 45 mg/day of pioglitazone or placebo (one: one allocation ratio). The primary endpoint was survival. Secondary endpoints included incidence of non-invasive ventilation and tracheotomy, and slopes of ALS-FRS, slow vital capacity, and quality of life as assessed using EUROQoL EQ-5D. The study was conducted under a two-stage group sequential test, allowing to stop for futility or superiority after interim analysis. Shortly after interim analysis, 30 patients under pioglitazone and 24 patients under placebo had died. The trial was stopped for futility; the hazard ratio for primary endpoint was 1.21 (95% CI: 0.71-2.07, p = 0.48). Secondary endpoints were not modified by pioglitazone treatment. Pioglitazone was well tolerated. CONCLUSION/SIGNIFICANCE: Pioglitazone has no beneficial effects on the survival of ALS patients as add-on therapy to riluzole. TRIAL REGISTRATION: Clinicaltrials.gov NCT00690118

Nanotechnology and the Treatment of HIV Infection

Suboptimal adherence, toxicity, drug resistance and viral reservoirs make the lifelong treatment of HIV infection challenging. The emerging field of nanotechnology may play an important role in addressing these challenges by creating drugs that possess pharmacological advantages arising out of unique phenomena that occur at the “nano” scale. At these dimensions, particles have physicochemical properties that are distinct from those of bulk materials or single molecules or atoms. In this review, basic concepts and terms in nanotechnology are defined, and examples are provided of how nanopharmaceuticals such as nanocrystals, nanocapsules, nanoparticles, solid lipid nanoparticles, nanocarriers, micelles, liposomes and dendrimers have been investigated as potential anti-HIV therapies. Such drugs may, for example, be used to optimize the pharmacological characteristics of known antiretrovirals, deliver anti-HIV nucleic acids into infected cells or achieve targeted delivery of antivirals to the immune system, brain or latent reservoirs. Also, nanopharmaceuticals themselves may possess anti-HIV activity. However several hurdles remain, including toxicity, unwanted biological interactions and the difficulty and cost of large-scale synthesis of nanopharmaceuticals

Programa de qualidade de vida em uma universidade pública : a percepção dos servidores

Monografia (especialização)—Universidade de Brasília, Faculdade de Economia, Administração, Contabilidade e Ciência da Informação e Documentação, 2009.Esta pesquisa teve como objetivo geral avaliar as contribuições do Projeto Viva Bem UnB na melhoria da qualidade no trabalho do servidor universitário. A metodologia utilizada foi a abordagem qualitativa, com a realização de seis entrevistas com alguns dos participantes do Projeto. Como resultado verificou-se que o Projeto Viva Bem UnB foi muito bem avaliado pelos servidores que dele participam. Relatos apontam mudanças positivas com relação à qualidade de vida do trabalhador como, por exemplo, melhoria na qualidade do sono, na disposição para o trabalho, entre outras. A pesquisa mostrou, contudo, que na percepção dos entrevistados, o envolvimento da Universidade de Brasília com a questão “Qualidade de Vida no Trabalho” ainda deixa muito a desejar. Os entrevistados relataram que o Projeto precisa de uma infra-estrutura física mais adequada, bem como de uma parceria mais efetiva com o Departamento de Educação Física da Instituição. O apoio das chefias aos que participam do Projeto não foi considerado essencial, uma vez que as atividades são desenvolvidas fora do horário normal de trabalho