132 research outputs found
Asymmetric polarity reversals, bimodal field distribution, and coherence resonance in a spherically symmetric mean-field dynamo model
Using a mean-field dynamo model with a spherically symmetric helical
turbulence parameter alpha which is dynamically quenched and disturbed by
additional noise, the basic features of geomagnetic polarity reversals are
shown to be generic consequences of the dynamo action in the vicinity of
exceptional points of the spectrum. This simple paradigmatic model yields long
periods of constant polarity which are interrupted by self-accelerating field
decays leading to asymmetric polarity reversals. It shows the recently
discovered bimodal field distribution, and it gives a natural explanation of
the correlation between polarity persistence time and field strength. In
addition, we find typical features of coherence resonance in the dependence of
the persistence time on the noise.Comment: 5 pages, 7 figure
Transient downflows associated with the intensification of small-scale magnetic features and bright point formation
Small-scale magnetic features are present everywhere in the solar
photosphere. Theoretical models, numerical calculations, and simulations
describing the formation of these features have existed for a few decades, but
there are only a few observational studies in direct support of the
simulations. In this study we present the evolution of small-scale magnetic
features with a spatial resolution close to 0.15 arcsecond and compare these
observations with those predicted by numerical simulations and also with
previous observational work of a similar nature. We analyze a 40 min time
sequence of full Stokes spectropolarimetric 630.25 nm data from a plage region
near the Sun center. We use line-of-sight velocities and magnetic field
measurements obtained using Milne-Eddington inversion techniques with and
without stray-light compensation along with measured continuum and line minimum
intensities. We discuss the results in relation to earlier observations and
simulations. We present eight cases involving strong downflows and magnetic
field intensification. All cases studied are associated with the formation of a
bright point in the continuum. In three out of the eight cases we find the
presence of weak opposite polarity field in close proximity to the downflow.
Our data are consistent with earlier simulations describing flux tube collapse,
but the transition to a state with stronger field appears transient and
short-lived, rather than resulting in a permanent field intensification. Three
cases of weak opposite polarity field found adjacent to the downflows do not
appear related to reconnection but may be related to overturning convection
pulling down some field lines and leading to up/down "serpentine" field, as
seen in some simulations.Comment: Accepted for publication in Astronomy & Astrophysic
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Electron Capture, Collision-Induced, and Electron Capture-Collision Induced Dissociation in Q-TOF
Recently, we demonstrated that a radio-frequency-free electromagnetostatic (RF-free EMS) cell could be retrofitted into a triple quad mass spectrometer to allow electron-capture dissociation (ECD) without the aid of cooling gas or phase-specific electron injection into the cell [1-2]. Subsequently, we used our RF-free EMS cell in the same instrument platform to demonstrate ECD occurring in the same space and at the same time with collision-induced dissociation (CID) to produce golden pairs and even triplets from peptides [3]. In this report, we demonstrate that ECD and CID product-ion mass spectra can be recorded at high resolution with flexible control of fragmentation processes using a newly designed cell installed in a hybrid Q-TOF tandem mass spectrometer.This is an author's manuscript. The published article is copyrighted by Springer and can be found at: https://doi.org/10.1007/s13361-010-0072-xKeywords: A radio-frequency-free electromagnetostatic cell, Electron capture dissociationKeywords: A radio-frequency-free electromagnetostatic cell, Electron capture dissociatio
Why dynamos are prone to reversals
In a recent paper (Phys. Rev. Lett. 94 (2005), 184506; physics/0411050) it
was shown that a simple mean-field dynamo model with a spherically symmetric
helical turbulence parameter alpha can exhibit a number of features which are
typical for Earth's magnetic field reversals. In particular, the model produces
asymmetric reversals, a positive correlation of field strength and interval
length, and a bimodal field distribution. All these features are attributable
to the magnetic field dynamics in the vicinity of an exceptional point of the
spectrum of the non-selfadjoint dynamo operator. The negative slope of the
growth rate curve between the nearby local maximum and the exceptional point
makes the system unstable and drives it to the exceptional point and beyond
into the oscillatory branch where the sign change happens. A weakness of this
reversal model is the apparent necessity to fine-tune the magnetic Reynolds
number and/or the radial profile of alpha. In the present paper, it is shown
that this fine-tuning is not necessary in the case of higher supercriticality
of the dynamo. Numerical examples and physical arguments are compiled to show
that, with increasing magnetic Reynolds number, there is strong tendency for
the exceptional point and the associated local maximum to move close to the
zero growth rate line. Although exemplified again by the spherically symmetric
alpha^2 dynamo model, the main idea of this ''self-tuning'' mechanism of
saturated dynamos into a reversal-prone state seems well transferable to other
dynamos. As a consequence, reversing dynamos might be much more typical and may
occur much more frequently in nature than what could be expected from a purely
kinematic perspective.Comment: 11 pages, 10 figure
Structural Invariance of Sunspot Umbrae Over the Solar Cycle: 1993-2004
Measurements of maximum magnetic flux, minimum intensity, and size are
presented for 12 967 sunspot umbrae detected on the NASA/NSO
spectromagnetograms between 1993 and 2004 to study umbral structure and
strength during the solar cycle. The umbrae are selected using an automated
thresholding technique. Measured umbral intensities are first corrected for a
confirming observation of umbral limb-darkening. Log-normal fits to the
observed size distribution confirm that the size spectrum shape does not vary
with time. The intensity-magnetic flux relationship is found to be steady over
the solar cycle. The dependence of umbral size on the magnetic flux and minimum
intensity are also independent of cycle phase and give linear and quadratic
relations, respectively. While the large sample size does show a low amplitude
oscillation in the mean minimum intensity and maximum magnetic flux correlated
with the solar cycle, this can be explained in terms of variations in the mean
umbral size. These size variations, however, are small and do not substantiate
a meaningful change in the size spectrum of the umbrae generated by the Sun.
Thus, in contrast to previous reports, the observations suggest the equilibrium
structure, as testified by the invariant size-magnetic field relationship, as
well as the mean size (i.e. strength) of sunspot umbrae do not significantly
depend on solar cycle phase.Comment: 17 pages, 6 figures. Published in Solar Physic
Improving Oral Hygiene Skills by Computer-Based Training: A Randomized Controlled Comparison of the Modified Bass and the Fones Techniques
Background: Gingivitis and other plaque-associated diseases have a high prevalence in western communities even though the majority of adults report daily oral hygiene. This indicates a lack of oral hygiene skills. Currently, there is no clear evidence as to which brushing technique would bring about the best oral hygiene skills. While the modified Bass technique is often recommended by dentists and in textbooks, the Fones technique is often recommended in patient brochures. Still, standardized comparisons of the effectiveness of teaching these techniques are lacking.
Methodology/Principal Findings: In a final sample of n=56 students, this multidisciplinary, randomized, examiner-blinded, controlled study compared the effects of parallel and standardized interactive computer presentations teaching either the Fones or the modified Bass technique. A control group was taught the basics of tooth brushing alone. Oral hygiene skills (remaining plaque after thorough oral hygiene) and gingivitis were assessed at baseline and 6, 12, and 28 weeks after the intervention. We found a significant groupĂ—time interaction for gingivitis (F(4/102)=3.267; p=0.016; e=0.957; ?2=0.114) and a significant main effect of group for oral hygiene skills (F(2/51)=7.088; p=0.002; ?2=0.218). Fones was superior to Bass; Bass did not differ from the control group. Group differences were most prominent after 6 and 12 weeks.
Conclusions/Significance: The present trial indicates an advantage of teaching the Fones as compared to the modified Bass technique with respect to oral hygiene skills and gingivitis. Future studies are needed to analyze whether the disadvantage of teaching the Bass technique observed here is restricted to the teaching method employed.
Trial Registration: German Clinical Trials Register http://www.drks.de/DRKS0000348
Modeling the Subsurface Structure of Sunspots
While sunspots are easily observed at the solar surface, determining their
subsurface structure is not trivial. There are two main hypotheses for the
subsurface structure of sunspots: the monolithic model and the cluster model.
Local helioseismology is the only means by which we can investigate
subphotospheric structure. However, as current linear inversion techniques do
not yet allow helioseismology to probe the internal structure with sufficient
confidence to distinguish between the monolith and cluster models, the
development of physically realistic sunspot models are a priority for
helioseismologists. This is because they are not only important indicators of
the variety of physical effects that may influence helioseismic inferences in
active regions, but they also enable detailed assessments of the validity of
helioseismic interpretations through numerical forward modeling. In this paper,
we provide a critical review of the existing sunspot models and an overview of
numerical methods employed to model wave propagation through model sunspots. We
then carry out an helioseismic analysis of the sunspot in Active Region 9787
and address the serious inconsistencies uncovered by
\citeauthor{gizonetal2009}~(\citeyear{gizonetal2009,gizonetal2009a}). We find
that this sunspot is most probably associated with a shallow, positive
wave-speed perturbation (unlike the traditional two-layer model) and that
travel-time measurements are consistent with a horizontal outflow in the
surrounding moat.Comment: 73 pages, 19 figures, accepted by Solar Physic
Innate PD-L1 limits T cell–mediated adipose tissue inflammation and ameliorates diet-induced obesity
Obesity has become a major health problem in the industrialized world. Immune regulation plays an important role in adipose tissue homeostasis; however, the initial events that shift the balance from a noninflammatory homeostatic environment toward inflammation leading to obesity are poorly understood. Here, we report a role for the costimulatory molecule programmed death-ligand 1 (PD-L1) in the limitation of diet-induced obesity. Functional ablation of PD-L1 on dendritic cells (DCs) using conditional knockout mice increased weight gain and metabolic syndrome during diet-induced obesity, whereas PD-L1 expression on type 2 innate lymphoid cells (ILC2s), T cells, and macrophages was dispensable for obesity control. Using in vitro cocultures, DCs interacted with T cells and ILC2s via the PD-L1:PD-1 axis to inhibit T helper type 1 proliferation and promote type 2 polarization, respectively. A role for PD-L1 in adipose tissue regulation was also shown in humans, with a positive correlation between PD-L1 expression in visceral fat of people with obesity and elevated body weight. Thus, we define a mechanism of adipose tissue homeostasis controlled by the expression of PD-L1 by DCs, which may be a clinically relevant finding with regard to immune-related adverse events during immune checkpoint inhibitor therapy
Carnosine Prevents Apoptosis of Glomerular Cells and Podocyte Loss in STZ Diabetic Rats
Background/Aims: We identified carnosinase-1 (CN-1) as risk-factor for diabetic nephropathy (DN). Carnosine, the substrate for CN-1, supposedly is a protective factor regarding diabetic complications. In this study, we hypothesized that carnosine administration to diabetic rats might protect the kidneys from glomerular apoptosis and podocyte loss. Methods: We examined the effect of oral L-carnosine administration (1g/kg BW per day) on apoptosis, podocyte loss, oxidative stress, AGEs and hexosamine pathway in kidneys of streptozotocin-induced diabetic Wistar rats after 3 months of diabetes and treatment. Results: Hyperglycemia significantly reduced endogenous kidney carnosine levels. In parallel, podocyte numbers significantly decreased (-21% compared to non-diabetics,
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