TEDDY (The Task Force for Emotionally Disturbed and Potentially Delinquent Youth)

The Council on Correction of the National Council of Social Workers invited other Virginia organizations dealing with children to attend a meeting in December, 1969, to form a Task Force for Emotionally Disturbed and Potentially Delinquent Youth. Someone came up with the inspired acronym of TEDDY to avoid the long title while reminding people that this task force spoke for a group of children who need help

Nuclear Black Hole Formation in Clumpy Galaxies at High Redshift

Massive stellar clumps in high redshift galaxies interact and migrate to the center to form a bulge and exponential disk in <1 Gyr. Here we consider the fate of intermediate mass black holes (BHs) that might form by massive-star coalescence in the dense young clusters of these disk clumps. We find that the BHs move inward with the clumps and reach the inner few hundred parsecs in only a few orbit times. There they could merge into a supermassive BH by dynamical friction. The ratio of BH mass to stellar mass in the disk clumps is approximately preserved in the final ratio of BH to bulge mass. Because this ratio for individual clusters has been estimated to be ~10^{-3}, the observed BH-to-bulge mass ratio results. We also obtain a relation between BH mass and bulge velocity dispersion that is compatible with observations of present-day galaxies.Comment: 10 pages, 3 figures, accepted by Ap

Drinking in the dark: shedding light on young people’s alcohol consumption experiences

This paper draws on 12 months of ethnographic research to explore the drinking experiences of young people, aged 15-24, living in the suburban case study locations of Chorlton and Wythenshawe, Manchester, UK. This paper moves beyond the contemporary geographical imaginary of alcohol consumption as a city-centre issue, to explore suburban indoor and outdoor drinking cultures. Through paying attention to atmospheres of darkness and lightness, I show how drinkscapes are active constituents of young people’s drinking occasions, rather than passive backdrops. More than this, I illustrate how young people transform dark and light drinkscapes, thereby shaping the drinking practices of themselves and others. Through looking at the interplay between the curating of an atmosphere, and the experience of that atmosphere when bodies, and practices are inserted into it, this paper offers a different take on the ‘drinking at home is bad, drinking in public spaces is good’ argument, with original policy suggestions

Resolving Gas Dynamics in the Circumnuclear Region of a Disk Galaxy in a Cosmological Simulation

Using a hydrodynamic adaptive mesh refinement code, we simulate the growth and evolution of a galaxy, which could potentially host a supermassive black hole, within a cosmological volume. Reaching a dynamical range in excess of 10 million, the simulation follows the evolution of the gas structure from super-galactic scales all the way down to the outer edge of the accretion disk. Here, we focus on global instabilities in the self-gravitating, cold, turbulence-supported, molecular gas disk at the center of the model galaxy, which provide a natural mechanism for angular momentum transport down to sub-pc scales. The gas density profile follows a power-law scaling as r^-8/3, consistent with an analytic description of turbulence in a quasi-stationary circumnuclear disk. We analyze the properties of the disk which contribute to the instabilities, and investigate the significance of instability for the galaxy's evolution and the growth of a supermassive black hole at the center.Comment: 16 pages (includes appendix), submitted to ApJ. Figures here are at low resolution; for higher resolution version, download http://casa.colorado.edu/~levinerd/ms.pd

Toward precise constraints on growth of massive black holes

Growth of massive black holes (MBHs) in galactic centers comes mainly from gas accretion during their QSO/AGN phases. In this paper we apply an extended Soltan argument, connecting the local MBH mass function with the time-integral of the QSO luminosity function, to the demography of MBHs and QSOs from recent optical and X-ray surveys, and obtain robust constraints on the luminosity evolution (or mass growth history) of individual QSOs (or MBHs). We find that the luminosity evolution probably involves two phases: an initial exponentially increasing phase set by the Eddington limit and a following phase in which the luminosity declines with time as a power law (with a slope of -1.2--1.3) set by a self-similar long-term evolution of disk accretion. Neither an evolution involving only the increasing phase with a single Eddington ratio nor an exponentially declining pattern in the second phase is likely. The period of a QSO radiating at a luminosity higher than 10% of its peak value is about (2-3)x10^8 yr, during which the MBH obtains ~80% of its mass. The mass-to-energy conversion efficiency is $0.16\pm0.04 ^{+0.05}_{-0}$, with the latter error accounting for the maximum uncertainty due to Compton-thick AGNs. The expected Eddington ratios in QSOs from the constrained luminosity evolution cluster around a single value close to 0.5-1 for high-luminosity QSOs and extend to a wide range of lower values for low-luminosity ones. The Eddington ratios for high luminosity QSOs appear to conflict with those estimated from observations (~0.25) by using some virial mass estimators for MBHs in QSOs unless the estimators systematically over-estimate MBH masses by a factor of 2-4. We also infer the fraction of optically obscured QSOs ~60-80%. Further applications of the luminosity evolution of individual QSOs are also discussed.Comment: 25 pages, 13 figures, ApJ in pres

Direct cosmological simulations of the growth of black holes and galaxies

We investigate the coupled formation and evolution of galaxies and their embedded supermassive black holes using state-of-the-art hydrodynamic simulations of cosmological structure formation. For the first time, we self-consistently follow the dark matter dynamics, radiative gas cooling, star formation, as well as black hole growth and associated feedback processes, starting directly from initial conditions appropriate for the LambdaCDM cosmology. Our modeling of the black hole physics is based on an approach we have developed in simulations of isolated galaxy mergers. Here we examine: (i) the predicted global history of black hole mass assembly (ii) the evolution of the local black hole-host mass correlations and (iii) the conditions that allow rapid growth of the first quasars, and the properties of their hosts and descendants today. We find a total black hole mass density in good agreement with observational estimates. The black hole accretion rate density peaks at lower redshift and evolves more strongly at high redshift than the star formation rate density, but the ratio of black hole to stellar mass densities shows only a moderate evolution at low redshifts. We find strong correlations between black hole masses and properties of the stellar systems, agreeing well with the measured local M_BH-sigma and M_BH -M_* relationships, but also suggesting (dependent on the mass range) a weak evolution with redshift in the normalization and the slope. Our simulations also produce massive black holes at high redshift, due to extended periods of exponential growth in regions that collapse early and exhibit strong gas inflows. These first supermassive BH systems however are not necessarily the most massive ones today, since they are often overtaken in growth by quasars that form later. (abridged)Comment: 22 pages, 17 figures, submitted to Ap

Reciprocal regulation of PKA and rac signaling

Activated G protein-coupled receptors (GPCRs) and receptor tyrosine kinases relay extracellular signals through spatial and temporal controlled kinase and GTPase entities. These enzymes are coordinated by multifunctional scaffolding proteins for precise intracellular signal processing. The cAMP-dependent protein kinase A (PKA) is the prime example for compartmentalized signal transmission downstream of distinct GPCRs. A-kinase anchoring proteins tether PKA to specific intracellular sites to ensure precision and directionality of PKA phosphorylation events. Here, we show that the Rho-GTPase Rac contains A-kinase anchoring protein properties and forms a dynamic cellular protein complex with PKA. The formation of this transient core complex depends on binary interactions with PKA subunits, cAMP levels and cellular GTP-loading accounting for bidirectional consequences on PKA and Rac downstream signaling. We show that GTP-Rac stabilizes the inactive PKA holoenzyme. However, β-adrenergic receptor-mediated activation of GTP-Rac–bound PKA routes signals to the Raf-Mek-Erk cascade, which is critically implicated in cell proliferation. We describe a further mechanism of how cAMP enhances nuclear Erk1/2 signaling: It emanates from transphosphorylation of p21-activated kinases in their evolutionary conserved kinase-activation loop through GTP-Rac compartmentalized PKA activities. Sole transphosphorylation of p21-activated kinases is not sufficient to activate Erk1/2. It requires complex formation of both kinases with GTP-Rac1 to unleash cAMP-PKA–boosted activation of Raf-Mek-Erk. Consequently GTP-Rac functions as a dual kinase-tuning scaffold that favors the PKA holoenzyme and contributes to potentiate Erk1/2 signaling. Our findings offer additional mechanistic insights how β-adrenergic receptor-controlled PKA activities enhance GTP-Rac–mediated activation of nuclear Erk1/2 signaling

The mass assembly of galaxy groups and the evolution of the magnitude gap

We investigate the assembly of groups and clusters of galaxies using the Millennium dark matter simulation and the associated gas simulations and semi-analytic catalogues of galaxies. In particular, in order to find an observable quantity that could be used to identify early-formed groups, we study the development of the difference in magnitude between their brightest galaxies to assess the use of magnitude gaps as possible indicators. We select galaxy groups and clusters at redshift z=1 with dark matter halo mass M(R200) > 1E13/h Msun, and trace their properties until the present time (z=0). We consider only the systems with X-ray luminosity L_X> 0.25E42/h^2 erg/s at z=0. While it is true that a large magnitude gap between the two brightest galaxies of a particular group often indicates that a large fraction of its mass was assembled at an early epoch, it is not a necessary condition. More than 90% of fossil groups defined on the basis of their magnitude gaps (at any epoch between 0<z<1) cease to be fossils within 4 Gyr, mostly because other massive galaxies are assembled within their cores, even though most of the mass in their haloes might have been assembled at early times. We show that, compared to the conventional definition of fossil galaxy groups based on the magnitude gap Delta m(12)> 2 (in the R-band, within 0.5R200 of the centre of the group), an alternative criterion Delta m(14)>2.5 (within the same radius) finds 50% more early-formed systems, and those that on average retain their fossil phase longer. However, the conventional criterion performs marginally better at finding early-formed groups at the high-mass end of groups. Nevertheless, both criteria fail to identify a majority of the early-formed systems.Comment: 16 pages, 11 figures, 2 tables. Accepted for publication in MNRA

Leptin-induced lipolysis opposes the tonic inhibition of endogenous adenosine in white adipocytes

The aim of the present study was to gain insight into the signaling pathway used by leptin to stimulate lipolysis. The lipolytic rate of white adipocytes from sex- and age-matched lean (+/+) and fa/fa rats was determined in the absence or presence of leptin together with a number of agents acting at different levels of the signaling cascade. Leptin did not modify FSK-, dbcAMP-, and IBMX-stimulated lipolysis. Lipolysis can also be maximally stimulated by lowering media adenosine levels with adenosine deaminase (ADA), i.e., in the ligand-free state. Although ADA produced near maximal lipolysis in adipocytes of lean animals, only half of the maximal lipolytic rate (50.9+/-3.2%) was achieved in fat cells from fa/fa rats (P=0.0034). In adipocytes from lean animals preincubated with ADA, leptin caused a concentration-related stimulation of lipolysis (P=0.0001). However, leptin had no effect on the lipolytic activity of adipocytes in the ligand-free state from fa/fa rats. The adenosine A1 receptor agonist CPA effectively inhibited basal lipolysis in both lean and obese adipocytes (P=0.0001 and P=0.0090, respectively). Leptin had no effect on the lipolytic rate of adipocytes isolated from fa/fa rats and preincubated with CPA. When adipocytes were incubated with the A1 receptor antagonist DPCPX, a significant increase in glycerol release was observed in fa/fa fat cells (P=0.009), whereas cells isolated from lean rats showed no differences to ADA-stimulated lipolysis. After pretreatment with PTX, which inactivates receptor-mediated Gi function, adipocytes of obese rats became as responsive to the stimulatory actions of ISO as cells from lean rats (P=0.0090 vs. ISO in fa/fa rats; P=0.2416 vs. lean rats, respectively). PTX treatment of lean cells, however, did not alter their response to this lipolytic agent. It can be concluded that the lipolytic effect of leptin is located at the adenylate cyclase/Gi proteins level and that leptin-induced lipolysis opposes the tonic inhibition of endogenous adenosine in white adipocytes

Detecting quasars at very high redshift with next generation X-ray telescopes

The next generation of X-ray telescopes have the potential to detect faint quasars at very high redshift and probe the early growth of massive black holes (BHs). We present modelling of the evolution of the optical and X-ray AGN luminosity function at 2 < z < 6 based on a CDM merger-driven model for the triggering of nuclear activity combined with a variety of fading laws. We extrapolate the merger-driven models to z > 6 for a range of BH growth scenarios. We predict significant numbers of sources at z ~ 6 with fluxes just an order of magnitude below the current detection limits and thus detectable with XEUS and Constellation-X, relatively independently of the fading law chosen. The predicted number of sources at even higher redshift depends sensitively on the early growth history of BHs. For passive evolution models in which BHs grow constantly at their Eddington limit, detectable BHs may be rare beyond z ~ 10 even with Generation-X. However, in the more probable scenario that BH growth at z > 6 can be described by passive evolution with a small duty cycle, or by our merger driven accretion model, then we predict that XEUS and Generation-X will detect significant numbers of black holes out to z ~ 10 and perhaps beyond.Comment: 18 pages, 11 Figures. Version accepted to MNRAS; extra data plotted, XEUS and Con-X sensitivities corrected and predictions amended accordingl