X-ray Spectral and Variability Properties of Low-Mass AGN

We study the X-ray properties of a sample of 14 optically-selected low-mass AGN whose masses lie within the range 1E5 -2E6 M(solar) with XMM-Newton. Only six of these low-mass AGN have previously been studied with sufficient quality X-ray data, thus, we more than double the number of low-mass AGN observed by XMM-Newton with the addition of our sample. We analyze their X-ray spectral properties and variability and compare the results to their more massive counterparts. The presence of a soft X-ray excess is detectable in all five objects which were not background dominated at 2-3 keV. Combined with previous studies, this gives a total of 8 low-mass AGN with a soft excess. The low-mass AGN exhibit rapid, short-term variability (hundreds to thousands of seconds) as well as long-term variability (months to years). There is a well-known anti-correlation between black hole mass and variability amplitude (normalized excess variance). Comparing our sample of low-mass AGN with this relation we find that all of our sample lie below an extrapolation of the linear relation. Such a flattening of the relation at low masses (below about 1E6 M(solar)) is expected if the variability in all AGN follows the same shape power spectrum with a break frequency that is dependent on mass. Finally, we also found two objects that show significant absorption in their X-ray spectrum, indicative of type 2 objects, although they are classified as type 1 AGN based on optical spectra.Comment: 12 pages, 5 figures, 7 tables, accepted for publication in MNRA

Numerical evolution of multiple black holes with accurate initial data

We present numerical evolutions of three equal-mass black holes using the moving puncture approach. We calculate puncture initial data for three black holes solving the constraint equations by means of a high-order multigrid elliptic solver. Using these initial data, we show the results for three black hole evolutions with sixth-order waveform convergence. We compare results obtained with the BAM and AMSS-NCKU codes with previous results. The approximate analytic solution to the Hamiltonian constraint used in previous simulations of three black holes leads to different dynamics and waveforms. We present some numerical experiments showing the evolution of four black holes and the resulting gravitational waveform.Comment: Published in PR

FOXP3+ T cells in uterine sarcomas are associated with favorable prognosis, low extracellular matrix expression and reduced YAP activation.

Uterine sarcomas are rare but deadly malignancies without effective treatment. Immunotherapy is a promising new approach to treat these tumors but has shown heterogeneous effects in sarcoma patients. With the goal of identifying key factors for improved patient treatment, we characterized the tumor immune landscape in 58 uterine sarcoma cases with full clinicopathological annotation. Immune cell characterization revealed the overall prevalence of FOXP3+ cells and pro-tumor M2-like macrophages. Hierarchical clustering of patients showed four tumor type-independent immune signatures, where infiltration of FOXP3+ cells and M1-like macrophages associated with favorable prognosis. High CD8+/FOXP3+ ratio in UUS and ESS correlated with poor survival, upregulation of immunosuppressive markers, extracellular matrix (ECM)-related genes and proteins, and YAP activation. This study shows that uterine sarcomas present distinct immune signatures with prognostic value, independent of tumor type, and suggests that targeting the ECM could be beneficial for future treatments

On the Role of the Accretion Disk in Black Hole Disk-Jet Connections

Models of jet production in black hole systems suggest that the properties of the accretion disk - such as its mass accretion rate, inner radius, and emergent magnetic field - should drive and modulate the production of relativistic jets. Stellar-mass black holes in the "low/hard" state are an excellent laboratory in which to study disk-jet connections, but few coordinated observations are made using spectrometers that can incisively probe the inner disk. We report on a series of 20 Suzaku observations of Cygnus X-1 made in the jet-producing low/hard state. Contemporaneous radio monitoring was done using the Arcminute MicroKelvin Array radio telescope. Two important and simple results are obtained: (1) the jet (as traced by radio flux) does not appear to be modulated by changes in the inner radius of the accretion disk; and (2) the jet is sensitive to disk properties, including its flux, temperature, and ionization. Some more complex results may reveal aspects of a coupled disk-corona-jet system. A positive correlation between the reflected X-ray flux and radio flux may represent specific support for a plasma ejection model of the corona, wherein the base of a jet produces hard X-ray emission. Within the framework of the plasma ejection model, the spectra suggest a jet base with v/c ~ 0.3, or the escape velocity for a vertical height of z ~ 20 GM/c^2 above the black hole. The detailed results of X-ray disk continuum and reflection modeling also suggest a height of z ~ 20 GM/c^2 for hard X-ray production above a black hole, with a spin in the range 0.6 < a < 0.99. This height agrees with X-ray time lags recently found in Cygnus X-1. The overall picture that emerges from this study is broadly consistent with some jet-focused models for black hole spectral energy distributions in which a relativistic plasma is accelerated at z = 10-100 GM/c^2.Comment: Accepted for publication in Ap

The Current Status of Binary Black Hole Simulations in Numerical Relativity

Since the breakthroughs in 2005 which have led to long term stable solutions of the binary black hole problem in numerical relativity, much progress has been made. I present here a short summary of the state of the field, including the capabilities of numerical relativity codes, recent physical results obtained from simulations, and improvements to the methods used to evolve and analyse binary black hole spacetimes.Comment: 14 pages; minor changes and corrections in response to referee

The performance of deterministic and stochastic interest rate risk measures : Another Question of Dimensions?

The efficiency of traditional and stochastic interest rate risk measures is compared under one-, two-, and three-factor no-arbitrage Gauss-Markov term structure models, and for different immunization periods. The empirical analysis, run on the German Treasury bond market from January 2000 to December 2010, suggests that: i) Stochastic interest rate risk measures provide better portfolio immunization than the Fisher-Weil duration; and ii) The superiority of the stochastic risk measures is more evident for multi-factor models and for longer investment horizons. These findings are supported by a first-order stochastic dominance analysis, and are robust against yield curve estimation errors.info:eu-repo/semantics/publishedVersio

Lymph node metastasis in grossly apparent clinical stage Ia epithelial ovarian cancer: Hacettepe experience and review of literature

Background Lymphadenectomy is an integral part of the staging system of epithelial ovarian cancer. However, the extent of lymphadenectomy in the early stages of ovarian cancer is controversial. The objective of this study was to identify the lymph node involvement in unilateral epithelial ovarian cancer apparently confined to the one ovary (clinical stage Ia). Methods A prospective study of clinical stage I ovarian cancer patients is presented. Patient's characteristics and tumor histopathology were the variables evaluated. Results Thirty three ovarian cancer patients with intact ovarian capsule were evaluated. Intraoperatively, neither of the patients had surface involvement, adhesions, ascites or palpable lymph nodes (supposed to be clinical stage Ia). The mean age of the study group was 55.3 ± 11.8. All patients were surgically staged and have undergone a systematic pelvic and paraaortic lymphadenectomy. Final surgicopathologic reports revealed capsular involvement in seven patients (21.2%), contralateral ovarian involvement in two (6%) and omental metastasis in one (3%) patient. There were two patients (6%) with lymph node involvement. One of the two lymph node metastasis was solely in paraaortic node and the other metastasis was in ipsilateral pelvic lymph node. Ovarian capsule was intact in all of the patients with lymph node involvement and the tumor was grade 3. Conclusion In clinical stage Ia ovarian cancer patients, there may be a risk of paraaortic and pelvic lymph node metastasis. Further studies with larger sample size are needed for an exact conclusion.PubMedWoSScopu

Treatment of two postoperative endophthalmitis cases due to Aspergillus flavus and Scopulariopsis spp. with local and systemic antifungal therapy

<p>Abstract</p> <p>Background</p> <p>Endophthalmitis is the inflammatory response to invasion of the eye with bacteria or fungi. The incidence of endophthalmitis after cataract surgery varies between 0.072–0.13 percent. Treatment of endophthalmitis with fungal etiology is difficult.</p> <p>Case Presentation</p> <p><b>Case 1: </b>A 71-year old male diabetic patient developed postoperative endophthalmitis due to <it>Aspergillus flavus</it>. The patient was treated with topical amphotericin B ophthalmic solution, intravenous (IV) liposomal amphotericin-B and caspofungin following vitrectomy.</p> <p><b>Case 2: </b>A 72-year old male cachectic patient developed postoperative endophthalmitis due to <it>Scopulariopsis </it>spp. The patient was treated with topical and IV voriconazole and caspofungin.</p> <p>Conclusion</p> <p><it>Aspergillus </it>spp. are responsible of postoperative fungal endophthalmitis. Endophthalmitis caused by <it>Scopulariopsis </it>spp. is a very rare condition. The two cases were successfully treated with local and systemic antifungal therapy.</p