346 research outputs found
Malnutrition as cause and consequence of sensory distorsiones
La malnutrición es una enfermedad provocada por un
exceso o defecto en el consumo o aprovechamiento de los
nutrientes. Habitualmente, se utiliza este término para
referirse a la desnutrición, es decir, a un trastorno derivado
del déficit de algún macro y o micronutrientes.
Las alteraciones quimiosensoriales pueden reducir de
forma importante la alimentación en el individuo, por lo
que es importante verificar que el aporte de nutrientes y, de
forma concreta, de algunos micronutrientes, sea suficiente,
ya que alguno de ellos, como el zinc, desempeñan un papel
primordial en las alteraciones del gusto y del olfato.
Además, el paciente malnutrido o con una alimentación
que excluya gran número de alimentos, tiene mayor
riesgo de presentar déficits de dichos micronutrientes.
Diversas enfermedades, tanto agudas como crónicas, se
asocian a alteraciones de la percepción sensorial, y pueden
llegar a afectar a más del 50% de las personas mayores de
65 años. Los efectos provocados por los fármacos y algunos
tratamientos como la quimioterapia y la radioterapia, juegan
también un papel muy importante en la distorsión sensorial
y en la incidencia de malnutriciónMalnutrition is a pathological condition caused by an
excess or deficiency in the consumption or the use of the
nutrients. Usually this term refers to a lack of adequate
nourishment, a disorder resulting from a deficiency of
some macro and/or micronutrients.
Chemo-sensory alterations can significantly reduce
food choice and intake, so it is very important to verify
that the supply of nutrients and specifically of some
micronutrients are sufficient. Some of them, such as
“zinc”, play a very important role in alterations in the
sense of taste and smell.
In addition malnutrition patients or a poorly-balanced
diet or faulty utilization of foods have increased the risk
of deficiencies in these micronutrients.
Several types of diseases, both acute and chronic ones,
are associated with sensory perception and can affect
more than 50% of people over 65 years old. The effects
caused by drugs and some treatments such as chemotherapy
and radiation therapy play an important role in sensory
distortion and the incidence of malnutritio
On multi-scale asymptotic structure of eigenfunctions in a boundary value problem with concentrated masses near the boundary
We construct two-term asymptotics ?? k = ?m?2(M + ??k + O(?3/2)) of eigenvalues of a mixed boundary-value problem in ? R2 with many heavy (m > 2) concentrated masses near a straight part of the boundary ? . ? is a small positive parameter related to size and periodicity of the masses; k ? N. The main term M > 0
is common for all eigenvalues but the correction terms ?k , which are eigenvalues of a limit problem with the spectral Steklov boundary conditions on , exhibit the effect of asymptotic splitting in the eigenvalue sequence enabling the detection of asymptotic forms of eigenfunctions. The justification scheme implies isolating and purifying singularities of eigenfunctions and leads to a new spectral problem in weighed spaces with a "strongly" singular weight.This research work has been partially supported by Spanish MINECO, MTM2013-44883-P. Also, the research work of the first author has been partially supported by Russian Foundation of Basic research (project 15–01–02175)
Homogenization of Variational Inequalities for the p-Laplace Operator in Perforated Media Along Manifolds
We address homogenization problems of variational inequalities for the p-Laplace operator in a domain of Rn (n ? 3, p ? [2, n)) periodically perforated by balls of radius O(??) where ? > 1 and ? is the size of the period. The perforations are distributed along a (n ? 1)-dimensional manifold ? , and we impose constraints for solutions and their fluxes (associated with the p-Laplacian) on the boundary of the perforations. These constraints imply that the solution is positive and that the flux is bounded from above by a negative, nonlinear monotonic function of the solution multiplied by a parameter ? ?? , ? ? R and ? is a small parameter that we shall make to go to zero. We analyze different relations between the parameters p, n, ?, ? and ?, and obtain homogenized problems which are completely new in the literature even for the case p = 2.This work has been partially supported by the Spanish grant MINECO:MTM2013-44883-P
Perioperative use of prothrombin complex concentrates
Prothrombin complex concentrates (PCCs) are purified drug products with hemostatic activity derived from a plasma pool. Today, PCCs contain a given and proportional amount of four non-activated vitamin K-dependent coagulation factors (II, VII, IX, and X), a variable amount of anticoagulant proteins (proteins C and S, and in some antithrombin) and low-dose heparin. In some countries PCC products contained only three clotting factors, II, IX, and X. Dosage recommendations are based on IU of F-IX, so that one IU of F-IX represents the activity of F-IX in 1 mL of plasma. Reversion of the anticoagulant effect of vitamin K antagonists (VKAs) in cases of symptomatic overdose, active bleeding episodes, or need for emergency surgery is the most important indication for PCCs and this effect of PCCs appears to be more complete and rapid than that caused by administration of fresh frozen plasma. They may be considered as safe preparations if they are used for their approved indications at the recommended dosage with adequate precautions for administration, and have been shown to be effective for reversing the effect of VKAs. Their adequate use based on decision algorithms in the perioperative setting allows a rapid normalization of International Normalized Ratio (INR) for performing emergency surgery, minimizing bleeding risk. This review aims to propose two algorithms for the use of PCCs in the perioperative setting, one to calculate the PCCs dose to be administered in a bleeding patient and/or immediately before urgent surgery, based on patient's clinical status, prior INR and INR target and another for reversing the action of oral anticoagulants depending on urgency of surgery
Conformal geodesics in spherically symmetric vacuum spacetimes with cosmological constant
An analysis of conformal geodesics in the Schwarzschild-de Sitter and
Schwarzschild-anti de Sitter families of spacetimes is given. For both families
of spacetimes we show that initial data on a spacelike hypersurface can be
given such that the congruence of conformal geodesics arising from this data
cover the whole maximal extension of canonical conformal representations of the
spacetimes without forming caustic points. For the Schwarzschild-de Sitter
family, the resulting congruence can be used to obtain global conformal
Gaussian systems of coordinates of the conformal representation. In the case of
the Schwarzschild-anti de Sitter family, the natural parameter of the curves
only covers a restricted time span so that these global conformal Gaussian
systems do not exist.Comment: 51 pages, 12 figures. Minor changes. File updated. To appear in CQ
Preembryo Personhood: An Assessment of the President’s Council Arguments
The President’s Council on Bioethics has addressed the moral status of human preembryos in its reports on stem cell research and human therapeutic cloning. Although the Council has been criticized for being hand-picked to favor the right-to-life viewpoint concerning human preembryos, it has embraced the idea that the right-to-life position should be defended in secular terms. This is an important feature of the Council’s work, and it demonstrates a recognition of the need for genuine engagement between opposing sides in the debate over stem cell research. To promote this engagement, the Council has stated in secular terms several arguments for the personhood of human preembryos. This essay presents and critiques those arguments, and it concludes that they are unsuccessful. If the best arguments in support of the personhood of human preembryos have been presented by the Council, then there are no reasonable secular arguments in support of that view
Petrov D vacuum spaces revisited: Identities and Invariant Classification
For Petrov D vacuum spaces, two simple identities are rederived and some new
identities are obtained, in a manageable form, by a systematic and transparent
analysis using the GHP formalism. This gives a complete involutive set of
tables for the four GHP derivatives on each of the four GHP spin coefficients
and the one Weyl tensor component. It follows directly from these results that
the theoretical upper bound on the order of covariant differentiation of the
Riemann tensor required for a Karlhede classification of these spaces is
reduced to two.Comment: Proof about the Karlhede upper bound improved and discussion of case
IIIA re-written. Acknowledgments section expanded. To appear in Classical and
Quantum Gravit
Ethylene supports colonization of plant roots by the mutualistic fungus Piriformospora indica
The mutualistic basidiomycete Piriformospora indica colonizes roots of mono- and dicotyledonous plants, and thereby improves plant health and yield. Given the capability of P. indica to colonize a broad range of hosts, it must be anticipated that the fungus has evolved efficient strategies to overcome plant immunity and to establish a proper environment for nutrient acquisition and reproduction. Global gene expression studies in barley identified various ethylene synthesis and signaling components that were differentially regulated in P. indica-colonized roots. Based on these findings we examined the impact of ethylene in the symbiotic association. The data presented here suggest that P. indica induces ethylene synthesis in barley and Arabidopsis roots during colonization. Moreover, impaired ethylene signaling resulted in reduced root colonization, Arabidopsis mutants exhibiting constitutive ethylene signaling, -synthesis or ethylene-related defense were hyper-susceptible to P. indica. Our data suggest that ethylene signaling is required for symbiotic root colonization by P. indica
Unifying inflation with dark energy in modified F(R) Horava-Lifshitz gravity
We study FRW cosmology for a non-linear modified F(R) Horava-Lifshitz gravity
which has a viable convenient counterpart. A unified description of early-time
inflation and late-time acceleration is possible in this theory, but the
cosmological dynamic details are generically different from the ones of the
convenient viable F(R) model. Remarkably, for some specific choice of
parameters they do coincide. The emergence of finite-time future singularities
is investigated in detail. It is shown that these singularities can be cured by
adding an extra, higher-derivative term, which turns out to be qualitatively
different when compared with the corresponding one of the convenient F(R)
theory.Comment: LaTeX 12 pages, typos are correcte
Entropy and Complexity Analyses in Alzheimer’s Disease: An MEG Study
Alzheimer’s disease (AD) is one of the most frequent disorders among elderly population and it is considered the main cause of dementia in western countries. This irreversible brain disorder is characterized by neural loss and the appearance of neurofibrillary tangles and senile plaques. The aim of the present study was the analysis of the magnetoencephalogram (MEG) background activity from AD patients and elderly control subjects. MEG recordings from 36 AD patients and 26 controls were analyzed by means of six entropy and complexity measures: Shannon spectral entropy (SSE), approximate entropy (ApEn), sample entropy (SampEn), Higuchi’s fractal dimension (HFD), Maragos and Sun’s fractal dimension (MSFD), and Lempel-Ziv complexity (LZC). SSE is an irregularity estimator in terms of the flatness of the spectrum, whereas ApEn and SampEn are embbeding entropies that quantify the signal regularity. The complexity measures HFD and MSFD were applied to MEG signals to estimate their fractal dimension. Finally, LZC measures the number of different substrings and the rate of their recurrence along the original time series. Our results show that MEG recordings are less complex and more regular in AD patients than in control subjects. Significant differences between both groups were found in several brain regions using all these methods, with the exception of MSFD (p-value < 0.05, Welch’s t-test with Bonferroni’s correction). Using receiver operating characteristic curves with a leave-one-out cross-validation procedure, the highest accuracy was achieved with SSE: 77.42%. We conclude that entropy and complexity analyses from MEG background activity could be useful to help in AD diagnosis
- …