Nuevas aportaciones al catálogo aeropalinológico de Córdoba: plantas exóticas

Se ha estudiado el pol en de 22 taxones de la flora exótica de la ciudad de Córdoba , posiblemente anemófilos. La presencia de estos taxones es importante en unos casos por su caracter al ergógeno ( Schinus, Ricinus, Aesculus, Elaeagnus y Acacia ); en otros por ser ti picamente en tornó filas (Tipuana, Sophora, Impatiens, Callistemon y Feijoa) y en otros casos por su problemática de recolección o determinación en los mues t reos ( Melia , Libocedrus, Taxodium, Carex, Cyperus, Tilia y Jacaranda).The pollen of 22 taxa posibly anemophilous of the Cór doba exotic flora are stud i ed. In sorne cases the presence of it are i mportant for their alergenic caracter (Schinus, Ricinus 1 Aesculus 1 Elaeagnus and Acacia} ; i n other cases for to be typically ent omoph i lous { Tipuana 1 Sophora, Impatiens, Callistemon and Feijoa ) and in other for t heir prob l ematic collecti ng or identification in the sampl ing ( Melia, Libocedrus 1 Taxodium 1 Carex 1 Cyperus, Tilia and Jacaraoda

Rhino-orbital mucormycosis in a Mexican patient with COVID-19: Case report

Background: A variety of bacterial and fungal co-infections may be attributed to the coronavirus disease 2019 (COVID-19), particularly in people who already have a medical condition such diabetes mellitus or those who received large dosages of steroids. Case report: We described a 52-year-old diabetic man who was receiving high doses of dexamethasone and antibiotics while receiving ambulatory care for COVID-19 pneumonia. His anterior rhinoscopy revealed a necrotic scab, and a sample confirmed Mucor spp. He underwent surgery and was given amphotericin as a result of the severity of the condition, palpebral ptosis, and right ocular palsy he was experiencing. Conclusions: pre-existing diabetes mellitus, previous steroid and antimicrobial use, as well as SARS-CoV-2 infection are some of the risk factors associated with Mucor spp. infection. Prompt detection of mucormycosis is important in the management of these affected patients

Centro de Integración Cultural en el Distrito de Guadalupe - Provincia de Pacasmayo - La Libertad

El proyecto tesis nace de la idea de la necesidad de la población por parte de un proyecto de Servicios Comunes; como lo indica el Reglamento Nacional de Edificaciones, este proyecto se realiza con el propósito de satisfacer a la población con la educación complementaria como danza, artesanía o música para incentivar a la población juvenil a una formación. El proyecto comenzó de un marco teórico de espacios públicos; donde el propósito es diseñar un proyecto que responda a la necesidad y que se cumpla la teoría. Luego de tener los puntos pensado; ubicamos el proyecto en la Provincia de Pacasmayo, Distrito de Guadalupe, para establecer en un terreno ya definido por la municipalidad; estas cuentas con los parámetros para poder diseñar; luego se pensó en la forma, en su composición volumétrica y espacios. Se planteó la idea primero de las zonas, que por resultado de un diagnostico situacional; nos dio las zonas que se necesita y ambientes que pueden satisfacer a los usuarios, siempre pensado en la base educativa y cultural. Las ideas principales son la que crea la forma y su composición partiendo de la cultura Pakatnamu; una forma básica y regular con un espacio céntrico para el mejor flujo del usuario dentro de la propuesta, la composición se basa en crear niveles con formas dinámicas, el nivel del sótano, con el juego de desniveles para ganar mayor espacio, luego el primer piso, con el juego también de desniveles y el patio central permitiendo crear un ambiente que origine una buena iluminación y ventilación, pero se debe considerar que el marco teórico es Espacio públicos, donde se relaciona el parque La Paz con el proyecto por medio de una planta en forma de “U”, orientada al parque, del segundo piso, se hace referencia del primero, ósea que las zonas de trabajo de su distribución se diseñe de manera vertical, creando espacios de doble altura y por último el tercer piso, con espacio relacionados al segundo relacionados a través de espacio y circulaciones verticales. De la composición volumétrica en resumen es compacta, pero con la relación de volúmenes crea una dinámica y resuelve a su vez el aspecto de fachadas quedando como resultado que el proyecto sea amigable al contexto y pueda satisfacer a la población al que se va dirigida el proyecto.The thesis project stems from the idea of the need of the population by a Common Services project; As indicated by the National Building Regulations, this project is carried out with the purpose of satisfying the population with complementary education such as dance, crafts or music to encourage the youth population to a formation. The project began from a theoretical framework of public spaces; where the purpose is to design a project that responds to the need and that the theory is fulfilled. After having the points thought; we located the project in the Province of Pacasmayo, District of Guadalupe, to establish in a land already defined by the municipality; these accounts with the parameters to be able to design; Then they thought about the shape, its volumetric composition and spaces. The idea of the zones was first raised, which as a result of a situational diagnosis; He gave us the areas that are needed and environments that can satisfy the users, always thinking of the educational and cultural base. The main ideas are the one that creates the form and its composition based on the Pakatnamu culture; A basic and regular way with a central space for the best flow of the user within the proposal, the composition is based on creating levels with dynamic shapes, the basement level, with the game of unevenness to gain more space, then the first floor , with the game also of unevenness and the central patio allowing to create an environment that originates good lighting and ventilation, but it should be considered that the theoretical framework is Public space, where the La Paz park is related to the project through a plant U-shaped, oriented to the park, on the second floor, reference is made to the first one, so that the work areas of its distribution are designed vertically, creating double-height spaces and finally the third floor, with space related to the second related through space and vertical circulations. The volumetric composition in summary is compact, but with the relationship of volumes it creates a dynamic and resolves the appearance of facades, resulting in the project being context friendly and satisfying the population to which the project is directed.Tesi

Cuckoo Search with Lévy Flights for Weighted Bayesian Energy Functional Optimization in Global-Support Curve Data Fitting

ABSTRACT. The problem of data fitting is very important in many theoretical and applied fields. In this paper, we consider the problem of optimizing a weighted Bayesian energy functional for data fitting by using global-support approximating curves. By global-support curves we mean curves expressed as a linear combination of basis functions whose support is the whole domain of the problem, as opposed to other common approaches in CAD/CAM and computer graphics driven by piecewise functions (such as B-splines and NURBS) that provide local control of the shape of the curve. Our method applies a powerful nature-inspired metaheuristic algorithm called cuckoo search, introduced recently to solve optimization problems. A major advantage of this method is its simplicity: cuckoo search requires only two parameters, many fewer than other metaheuristic approaches, so the parameter tuning becomes a very simple task.The paper shows that this new approach can be successfully used to solve our optimization problem. To check the performance of our approach, it has been applied to five illustrative examples of different types, including open and closed 2D and 3D curves that exhibit challenging features, such as cusps and self-intersections. Our results show that the method performs pretty well, being able to solve our minimization problem in an astonishingly straightforward way.This research has been kindly supported by the Computer Science National Program of the Spanish Ministry of Economy and Competitiveness, Project Ref. no. TIN2012-30768, Toho University (Funabashi, Japan), and the University of Cantabria (Santander, Spain)

Structural determinants of suicide during the global financial crisis in Spain: Integrating explanations to understand a complex public health problem

Introduction Suicide is a complex public health problem in contemporary societies. Macroeconomic downturns derived from the economic crisis have been found to be associated with growing suicide mortality in the United States and in Europe. The present work is aimed to assess the association between the recent economic downturns and suicide patterns using interrupted time series analysis and, particularly, adjusting this relationship by indicators of social cohesion and community values that might provide additional insights on the complex explanation of suicidal trends. Methods We combined suicide, social and economic data extracted from the National Statistics Institute (INE), the Eurostat database, and the World Values Survey to assess the association between the socio-economic factors and trends in suicide rates. To study the association between the financial crisis and changes in suicide rates in Spain, we used interrupted time series analysis (ITSA). Results Our findings confirm that suicides increased after the 2011 recession, but remained moderately constant after the 2008 economic downturn. Suicides particularly increased after the 2011 recession in the 10-14, and 45-64 years old intervals between males and females, and apparently in older groups. However, during the 2008-2011 time period suicide rates decreased during working years (specifically among 40-44, 45-49, and 55-59 years old groups). Our results highlight the importance of social protection against unemployment and, to a lesser extent, social protection in disability and family, in reducing suicides, as well as the economic prosperity of the country. Conclusion This result corroborates that the economic crisis has possibly impacted the growing suicide rates of the most vulnerable groups, but exclusively during the period characterised by economic cuts after the 2011 recession. This study highlights the need to implement tailored policies that protect these collectives against suicide

Gene-environment interaction analysis of redox-related metals and genetic variants with plasma metabolic patterns in a general population from Spain: The Hortega Study

Background: Limited studies have evaluated the joint influence of redox-related metals and genetic variation on metabolic pathways. We analyzed the association of 11 metals with metabolic patterns, and the interacting role of candidate genetic variants, in 1145 participants from the Hortega Study, a population-based sample from Spain. Methods: Urine antimony (Sb), arsenic, barium (Ba), cadmium (Cd), chromium (Cr), cobalt (Co), molybdenum (Mo) and vanadium (V), and plasma copper (Cu), selenium (Se) and zinc (Zn) were measured by ICP-MS and AAS, respectively. We summarized 54 plasma metabolites, measured with targeted NMR, by estimating metabolic principal components (mPC). Redox-related SNPs (N = 291) were measured by oligo-ligation assay. Results: In our study, the association with metabolic principal component (mPC) 1 (reflecting non-essential and essential amino acids, including branched chain, and bacterial co-metabolism versus fatty acids and VLDL subclasses) was positive for Se and Zn, but inverse for Cu, arsenobetaine-corrected arsenic (As) and Sb. The association with mPC2 (reflecting essential amino acids, including aromatic, and bacterial co-metabolism) was inverse for Se, Zn and Cd. The association with mPC3 (reflecting LDL subclasses) was positive for Cu, Se and Zn, but inverse for Co. The association for mPC4 (reflecting HDL subclasses) was positive for Sb, but inverse for plasma Zn. These associations were mainly driven by Cu and Sb for mPC1; Se, Zn and Cd for mPC2; Co, Se and Zn for mPC3; and Zn for mPC4. The most SNP-metal interacting genes were NOX1, GSR, GCLC, AGT and REN. Co and Zn showed the highest number of interactions with genetic variants associated to enriched endocrine, cardiovascular and neurological pathways. Conclusions: Exposures to Co, Cu, Se, Zn, As, Cd and Sb were associated with several metabolic patterns involved in chronic disease. Carriers of redox-related variants may have differential susceptibility to metabolic alterations associated to excessive exposure to metals.This work was supported by the Strategic Action for Research in Health sciences [CP12/03080, PI15/00071, PI10/0082, PI13/01848, PI14/00874, PI16/01402, PI21/00506 and PI11/00726], CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN) (CIBER-02-08-2009, CB06/03 and CB12/03/30,016), the State Agency for Research (PID2019-108973RB- C21 and C22), the Valencia Government (GRUPOS 03/101; PROM- ETEO/2009/029 and ACOMP/2013/039, IDIFEDER/ 2021/072 and GRISOLIAP/2021/119), the Castilla-Leon Government (GRS/279/A/08) and European Network of Excellence Ingenious Hypercare (EPSS- 037093) from the European Commission. The Strategic Action for Research in Health sciences, CIBERDEM and CIBEROBN are initiatives from Carlos III Health Institute Madrid and cofunded with European Funds for Regional Development (FEDER). The State Agency for Research and Carlos III Health Institute belong to the Spanish Ministry of Science and Innovation. ADR received the support of a fellowship from “la Caixa” Foundation (ID 100010434) (fellowship code “LCF/BQ/DR19/11740016”). MGP received the support of a fellowship from “la Caixa” Foundation (ID 100010434, fellowship code LCFLCF/BQ/DI18/11660001). The funding bodies had no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript

Calidad del servicio deportivo: La calidad percibida en las instalaciones de La Romareda

El fútbol profesional es uno de los mayores negocios de nuestro país, que maneja cifras astronómicas. No obstante, si nos alejamos de los grandes clubes y ponemos la vista en las categorías inferiores, se puede observar que existe una amplia diferencia en los presupuestos de los equipos, lo que condiciona la calidad del servicio que ofrecen a sus aficionados. En este trabajo, se va a analizar la calidad del servicio prestado por el estadio del Real Zaragoza, La Romareda. Para ello, se han planteado una serie de objetivos específicos que ayuden a profundizar en la investigación, analizando la importancia y la calidad percibida de los distintos atributos planteados. Además, se comprobará si existen diferencias en la percepción de la calidad según distintas variables demográficas, según la frecuencia con la que los aficionados asisten al estadio o si son abonados al club o no. Para averiguar estos datos, se ha realizado un cuestionario online, mediante el cual se ha podido determinar el perfil del espectador medio de La Romareda, la importancia otorgada a cada atributo, la calidad percibida de los mismos y las diferencias existentes según las variables planteadas. De esta manera se han podido determinar unas conclusiones y recomendaciones a seguir, que faciliten la elaboración de posibles mejoras para este servicio

Estrategias de aprendizaje utilizadas por estudiantes de educación media del ámbito científico en comunas vulnerables de la región de la Araucanía, Chile

La presente ponencia está basada en el proyecto de investigación FONDECYT Regular 1100378: “Hacia un aprendizaje de calidad en la Educación Científica. Estrategias didácticas para el desarrollo de capacidades y valores.” El objetivo general de esta investigación, es: “desarrollar en los alumnos de Segundo Ciclo de Educación Media de cuatro comunas vulnerables de la Región de la Araucanía, Chile, las capacidades y valores involucrados en un aprendizaje de calidad, a través de la práctica de adecuadas estrategias de aprendizaje por parte de los estudiantes y de adecuadas estrategias de enseñanza por parte de sus profesores de Biología.” Para esta ponencia, se ha seleccionado parte del objetivo especifico: “construir conocimiento, sobre el avance producido en la calidad del aprendizaje de los estudiantes, expresado en términos de conocimiento, selección y aplicación de estrategias cognitivas y afectivas de aprendizaje, como asimismo, sobre el avance producido en el proceso de mediación de los profesores, expresado en términos del conocimiento, selección y puesta en práctica de estrategias de enseñanza que faciliten el avance en la calidad del aprendizaje de sus alumnos.” La ponencia se centra en la presentación de resultados de una técnica de recolección de datos - en concreto ocho grupos focales aplicados a los estudiantes - se procede a su análisis y se discuten sus implicancias en el proceso educativo

Principal Criteria for Evaluating the Quality, Safety and E cacy of hMSC-Based Products in Clinical Practice: Current Approaches and Challenges

Human Mesenchymal Stem Cells (hMSCs) play an important role as new therapeutic alternatives in advanced therapies and regenerative medicine thanks to their regenerative and immunomodulatory properties, and ability to migrate to the exact area of injury. These properties have made hMSCs one of the more promising cellular active substances at present, particularly in terms of the development of new and innovative hMSC-based products. Currently, numerous clinical trials are being conducted to evaluate the therapeutic activity of hMSC-based products on specific targets. Given the rapidly growing number of hMSC clinical trials in recent years and the complexity of these products due to their cellular component characteristics and medicinal product status, there is a greater need to define more stringent, specific, and harmonized requirements to characterize the quality of the hMSCs and enhance the analysis of their safety and efficacy in final products to be administered to patients. These requirements should be implemented throughout the manufacturing process to guarantee the function and integrity of hMSCs and to ensure that the hMSC-based final product consistently meets its specifications across batches. This paper describes the principal phases involved in the design of the manufacturing process and updates the specific technical requirements needed to address the appropriate clinical use of hMSC-based products. The challenges and limitations to evaluating the safety, efficacy, and quality of hMSCs have been also reviewed and discussed.This work was supported by Ministerio de Ciencia, Innovación y Universidades. Plan Estatal I+D+I, Grant Number: RTI2018-095410-B-100; Spanish Ministry of Economy (MINECO), Grant Number: RD16/0011/0030; Spanish Ministry of Science, Innovation and Universities (to JAG) and by the Ministerio de Economía, Industria y Competitividad (FEDER funds, project RTC-2016-5451-1) (to BC and PG-M). Additional it has been developed in the context of AdvanceCat with the support of ACCIÓ (Catalonia Trade & Investment; Generalitat de Catalunya) under the Catalonian European Regional Development Fund operational program, 2014-2020 (to PG-M)

ANALYSIS MULTIRESOLUTION

Before the concept has been formalized Analysis Multiresolution AMR, base construction orthonormal wavelet should be too difficult. For Therefore, the study of AM R becomes important and therefore construction of Wavelets is viable. In the construction of a wavelet Ψ, we determine a scale function Φ, then build your Analysis Associated multiresolution; soon passed has built Ψ with desired properties for applications