PaintOmics 3: a web resource for the pathway analysis and visualization of multi-omics data

[EN] The increasing availability of multi-omic platforms poses new challenges to data analysis. Joint visualization of multi-omics data is instrumental in better understanding interconnections across molecular layers and in fully utilizing the multi-omic resources available to make biological discoveries. We present here PaintOmics 3, a web-based resource for the integrated visualization of multiple omic data types onto KEGG pathway diagrams. PaintOmics 3 combines server-end capabilities for data analysis with the potential of modern web resources for data visualization, providing researchers with a powerful framework for interactive exploration of their multi-omics information. Unlike other visualization tools, PaintOmics 3 covers a comprehensive pathway analysis workflow, including automatic feature name/identifier conversion, multi-layered feature matching, pathway enrichment, network analysis, interactive heatmaps, trend charts, and more. It accepts a wide variety of omic types, including transcriptomics, proteomics and metabolomics, as well as region-based approaches such as ATAC-seq or ChIP-seq data. The tool is freely available at www.paintomics.orgEuropean Union Seventh Framework Programme [FP7/2007-2013] under the grant agreement [306000-STATegra]; Marie Curie International Research Staff Exchange Scheme under grant agreement [612583-DEANN]; Spanish MINECO [BIO2012-40244]. INB Grant [PT17/0009/0015 - ISCIII-SGEFI / ERDF]. Funding for open access charge: MINECO [BIO2012-40244].Hernandez-De Diego, R.; Tarazona Campos, S.; Martínez-Mira, C.; Balzano-Nogueira, L.; Furió-Tarí, P.; Conesa, A.; Pappas, G. (2018). PaintOmics 3: a web resource for the pathway analysis and visualization of multi-omics data. Nucleic Acids Research. 46(W1):503-509. https://doi.org/10.1093/nar/gky466S50350946W

Good practice regarding smoking cessation management in Spain: Challenges and opportunities for primary care physicians and nurses

INTRODUCTION We analyze the activities carried out by primary care (PC) physicians and nurses with respect to smoking cessation and evaluate their self-reported training, knowledge, and behavior. METHODS A cross-sectional study was conducted including 1514 PC physicians and nurses from June 2016 to March 2017, in Spain. The main variable was Good Practice (GP) in attention to smokers. To identify associated factors, a multilevel logistic regression model was used adjusted for sex, age, type of center, contract, years of employment, tobacco consumption, and self-reported training/knowledge. RESULTS Of the 792 physicians and 722 nurses, 48.6% referred to GP in smoking cessation management. The finding related to: being a non-smoker (OR=1.8; 95% CI: 1.2-2.5) or ex-smoker (OR= 1.4; 95% CI: 1.02-2.1), having a good level of knowledge (OR=1.8; 95% CI: 1.3-2.4) and training (OR=2.4; 95% CI: 1.8-3.2), and, to a lesser extent, being female (OR=1.3; 95% CI: 1.03-1.7), and work experience >10 years (OR=1.4; 95% CI: 1.03-1.9). The main GP barriers were: lack of time (45.5%), organizational problems (48.4%), and 35.4% lack of training. CONCLUSIONS The GP of PC physicians and nurses regarding smoking cessation management is related to being non-smokers or ex-smokers, and having sufficient training and knowledge. Lack of time and organizational problems were considered to be the main barriers. The promotion of training activities in the Spanish National Health Service with the support of scientific societies is required

Tipología de narrativas didácticas para YouTube: formatos didácticos audiovisuales realizados por el alumnado para innovar en el aprendizaje a través de las plataformas de streaming

Realización de contenidos audiovisuales para la enseñanza virtual en plataformas de vídeo. El alumnado de Ciencias de la Información crea y difunde materiales narrativos educativos diseñados para cursos online innovadores en YouTube

Narrativas audiovisuales emergentes: creaciones didácticas multimedia realizadas por alumnos para enseñanza y aprendizaje en campus virtuales

Diseño, escritura y realización de contenidos videográficos y multimedia para la enseñanza virtual. El alumnado de Ciencias de la Información analiza, crea y difunde materiales narrativos creados para campus virtuales y cursos online innovadores

Vídeo educativo para enseñanza presencial y virtual: narrativas audiovisuales online tras COVID-19

Depto. de Teorías y Análisis de la ComunicaciónFac. de Ciencias de la InformaciónFALSEsubmitte

Implantación del sistema inteligente de gestión de grupos de matriculación de la Escuela Politécnica Superior de la Universidad de Alicante

En toda organización del espacio de educación superior existe un conjunto de procesos que conforman la cadena de valor de dicha institución. Aunque los procesos principales de dicha organización son los centrados con los tres ejes fundamentales de la institución universitaria como son la educación, la investigación y la transferencia del conocimiento, existen una serie de procesos de soporte que deben garantizar la correcta ejecución de los principales. Estos procesos son fundamentales en el funcionamiento de la organización, puesto que de no estar bien diseñados o haber alcanzado un alto grado de madurez, podrían afectar a los procesos principales de la cadena de valor. En este sentido, en el presente trabajo de investigación se ha llevado a cabo el rediseño y automatización de una parte del proceso de matriculación realizado en la Escuela Politécnica Superior de la Universidad de Alicante. La importancia de dicho proceso se sustenta en la hipótesis de que una distribución equitativa entre grupos de actividades de una misma asignatura, influirá en el proceso de enseñanza-aprendizaje

The SAGA/TREX-2 subunit Sus1 binds widely to transcribed genes and affects mRNA turnover globally

Abstract Background Eukaryotic transcription is regulated through two complexes, the general transcription factor IID (TFIID) and the coactivator Spt–Ada–Gcn5 acetyltransferase (SAGA). Recent findings confirm that both TFIID and SAGA contribute to the synthesis of nearly all transcripts and are recruited genome-wide in yeast. However, how this broad recruitment confers selectivity under specific conditions remains an open question. Results Here we find that the SAGA/TREX-2 subunit Sus1 associates with upstream regulatory regions of many yeast genes and that heat shock drastically changes Sus1 binding. While Sus1 binding to TFIID-dominated genes is not affected by temperature, its recruitment to SAGA-dominated genes and RP genes is significantly disturbed under heat shock, with Sus1 relocated to environmental stress-responsive genes in these conditions. Moreover, in contrast to recent results showing that SAGA deubiquitinating enzyme Ubp8 is dispensable for RNA synthesis, genomic run-on experiments demonstrate that Sus1 contributes to synthesis and stability of a wide range of transcripts. Conclusions Our study provides support for a model in which SAGA/TREX-2 factor Sus1 acts as a global transcriptional regulator in yeast but has differential activity at yeast genes as a function of their transcription rate or during stress conditions.VG-M was supported by the FPU program from MEC (AP2009-0917). This study was supported by funds from MINECO (BFU2011-23418 and BFU2014-57636 to SR-N, BIO2012-40244 to AC and BFU2016-77728-C3-3-P to JEP-O) and GV (PROMETEO/2012/061, PROMETEO/2016/093 and ACOMP/2014/061 to SR-N, and PROMETEOII/2015/006, ACOMP/2014/253 to JEP-O). The contributions of PF-T and AC were supported by the FP7 Project STATegra 306000. BFP was supported by NIH GM059055. BFP has a fnancial interest in Peconic, LLC, which utilizes the ChIP-exo technology implemented in this study and could potentially beneft from the outcomes of this research

Tecnologías y narrativas audiovisuales para aprendizaje virtual: storytelling para participación del alumnado en metodologías online

Análisis y producción de contenidos audiovisuales para la enseñanza virtual. La situación provocada por la COVID-19 demanda la puesta en marcha de metodologías activas que permitan el aprendizaje online a través de técnicas y formatos innovadores