Simulation of Man in the Middle Attack On Smart Grid Testbed

Over the past decade, the frequency of cyber attacks against power grids has steadily increased, requiring researchers to find and patch vulnerabilities before they can be exploited. Our research introduces the prototype of a man-in-the-middle attack to be implemented on a microgrid emulator of a smart grid. We present a method of violating the integrity and authentication of packets that are using the IEEE Synchrophasor Protocol in a controlled environment, but this same approach could be used on any other protocol that lacks the proper overhead to ensure the integrity and authenticity of packets. In future research, we plan to implement and test the attack on the previously mentioned smart grid testbed in order to assess the attacks feasibility and tangible effects on Wide Area Monitoring and Control applications, as well as propose possible countermeasures. For this paper, we developed a working simulation of our intended attack using the software ModelSim 10.4. The attack will modify network packet data coming from a Schweitzer Engineering Labs (SEL) Phasor Measurement Unit (PMU) hardware sensor, which provides a stream of precise timing values associated with current and voltage values, as these measured values are en route to the Open Phasor Data Concentrator (OpenPDC) application running on a Windows server. Our simulation provides and validates all of the necessary code in order to program a Field Programmable Gate Array and execute our attack on the testbed in future research

Variations in biocorona formation related to defects in the structure of single walled carbon nanotubes and the hyperlipidemic disease state

Ball-milling utilizes mechanical stress to modify properties of carbon nanotubes (CNTs) including size, capping, and functionalization. Ball-milling, however, may introduce structural defects resulting in altered CNT-biomolecule interactions. Nanomaterial-biomolecule interactions result in the formation of the biocorona (BC), which alters nanomaterial properties, function, and biological responses. The formation of the BC is governed by the nanomaterial physicochemical properties and the physiological environment. Underlying disease states such as cardiovascular disease can alter the biological milieu possibly leading to unique BC identities. In this ex vivo study, we evaluated variations in the formation of the BC on single-walled CNTs (SWCNTs) due to physicochemical alterations in structure resulting from ball-milling and variations in the environment due to the high-cholesterol disease state. Increased ball-milling time of SWCNTs resulted in enhanced structural defects. Following incubation in normal mouse serum, label-free quantitative proteomics identified differences in the biomolecular content of the BC due to the ball-milling process. Further, incubation in cholesterol-rich mouse serum resulted in the formation of unique BCs compared to SWCNTs incubated in normal serum. Our study demonstrates that the BC is modified due to physicochemical modifications such as defects induced by ball-milling and physiological disease conditions, which may result in variable biological responses

AVONET: morphological, ecological and geographical data for all birds

Functional traits offer a rich quantitative framework for developing and testing theories in evolutionary biology, ecology and ecosystem science. However, the potential of functional traits to drive theoretical advances and refine models of global change can only be fully realised when species‐level information is complete. Here we present the AVONET dataset containing comprehensive functional trait data for all birds, including six ecological variables, 11 continuous morphological traits, and information on range size and location. Raw morphological measurements are presented from 90,020 individuals of 11,009 extant bird species sampled from 181 countries. These data are also summarised as species averages in three taxonomic formats, allowing integration with a global phylogeny, geographical range maps, IUCN Red List data and the eBird citizen science database. The AVONET dataset provides the most detailed picture of continuous trait variation for any major radiation of organisms, offering a global template for testing hypotheses and exploring the evolutionary origins, structure and functioning of biodiversity

Vagus nerve stimulation primes platelets and reduces bleeding in hemophilia A male mice

Abstract Deficiency of coagulation factor VIII in hemophilia A disrupts clotting and prolongs bleeding. While the current mainstay of therapy is infusion of factor VIII concentrates, inhibitor antibodies often render these ineffective. Because preclinical evidence shows electrical vagus nerve stimulation accelerates clotting to reduce hemorrhage without precipitating systemic thrombosis, we reasoned it might reduce bleeding in hemophilia A. Using two different male murine hemorrhage and thrombosis models, we show vagus nerve stimulation bypasses the factor VIII deficiency of hemophilia A to decrease bleeding and accelerate clotting. Vagus nerve stimulation targets acetylcholine-producing T lymphocytes in spleen and α7 nicotinic acetylcholine receptors (α7nAChR) on platelets to increase calcium uptake and enhance alpha granule release. Splenectomy or genetic deletion of T cells or α7nAChR abolishes vagal control of platelet activation, thrombus formation, and bleeding in male mice. Vagus nerve stimulation warrants clinical study as a therapy for coagulation disorders and surgical or traumatic bleeding

The Year in Cardiothoracic and Vascular Anesthesia: Selected Highlights From 2017.

Evans, A. S., Weiner, M., Patel, P. A., Baron, E. L., Gutsche, J. T., Jayaraman, A., Renew, J. R., Martin, A. K., Fritz, A. V., Gordon, E. K., Riha, H., Patel, S., Ghadimi, K., Guelaff, E., Feinman, J. W., Dashell, J., Munroe, R., Lauter, D., Weiss, S. J., Silvay, G., … Ramakrishna, H. (2018). The Year in Cardiothoracic and Vascular Anesthesia: Selected Highlights From 2017. Journal of cardiothoracic and vascular anesthesia, 32(1), 1–13. https://doi.org/10.1053/j.jvca.2017.10.01