Revoltierendes Anerkennen des Alter(n)s. Für eine unzeitgemäße Sicht auf das Alter

Das vielfach propagierte und gesellschaftlich positiv besetzte Bild des "aktiven Alterns" wird in diesem Beitrag kritisch betrachtet. Es wird die Frage aufgeworfen, inwiefern sich die Erwachsenenbildung mit ihrem Einsatz für ein aktives Altern in die Logiken einer neuen Sozialpolitik der Aktivierung verstrickt. Die Kritik aufgreifend, dass es mit den aktuell im Trend liegenden positiven Alterszuschreibungen zu einem Ausschluss von leidvollen Aspekten des Alterns kommt, wird aus einer bildungstheoretischen Perspektive für die Thematisierung von Körperlichkeit und die Anerkennung der Ambiguität menschlicher Existenz appelliert. "Revoltierendes Anerkennen des Alter(n)s" bietet der Erwachsenenbildung eine Sichtweise, die nicht zwischen Aktivität und Passivität polarisiert, sondern der Mehrdeutigkeit des Menschseins Rechnung trägt und damit auch einer möglichen ökonomischen und politischen Indienstnahme entgegentritt. (DIPF/Orig.)This article critically examines the idea of “active ageing” frequently propagated and positively seen by society. The question is raised to what extent adult education with its commitment to active ageing is caught up in the logic of a new social policy of activation. Responding to criticism that the current trend of attaching positive attributes to ageing leads to an exclusion of the painful aspects of ageing, the article employs an educational theory perspective to thematise physicality and to acknowledge the ambiguity of human existence. The “revolutionising acknowledgement of ageing and old age” provides adult education with a perspective that instead of polarising between activity and passivity accommodates the ambiguity of being human and thus takes steps against any possible economic and political exploitation. (DIPF/Orig.

"Siehst Du mich?" - "Hörst Du mich?": Videokonferenzen als Gegenstand kommunikationswissenschaftlicher Forschung

"Mit neuen Kommunikationstechnologien sind stets veränderte Verwirklichungsbedingungen von Mitteilungsprozessen verbunden. Die in diesem Artikel thematisierte Videokonferenz, eine Form audiovisueller Fernkommunikation, wird als ein spezifischer Fall interpersoneller Kommunikation begriffen und auf ihre Bedingungen, Realisierungsformen und -zwecke hin untersucht. Sie lässt sich verstehen als eigenständige Kommunikationsform, die durch a) die technischen Realisierungsbedingungen, b) die Leistungen und Kompetenzen der Kommunikationspartner und schließlich c) die jeweils verfolgten Kommunikationszwecke bestimmt werden kann." (Autorenreferat

Makerspaces zur Wissenschaftsvermittlung und Innovationsraum der neuen Generation

Der vorliegende Beitrag skizziert die Landschaft der Schüler*innen-Labore und betrachtet Makerspaces als neue Variante davon. Der Beitrag versucht dabei, Makerspace systematisch einzuordnen. Dabei fällt auf, dass in Makerspaces insbesondere die Interdisziplinarität eine wachsende Bedeutung erhält und dass der pädagogisch-didaktische Ansatz der Maker Education offener ist als in herkömmlichen Schüler*innen-Labor-Konzepten. Im Beitrag werden dazu auch Beispiele für Makerspaces als Schüler*innen-Labore genannt. (DIPF/Orig.

Twin study reveals non-heritable immune perturbations in multiple sclerosis

Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system underpinned by partially understood genetic risk factors and environmental triggers and their undefined interactions$^{1,2}$. Here we investigated the peripheral immune signatures of 61 monozygotic twin pairs discordant for MS to dissect the influence of genetic predisposition and environmental factors. Using complementary multimodal high-throughput and high-dimensional single-cell technologies in conjunction with data-driven computational tools, we identified an inflammatory shift in a monocyte cluster of twins with MS, coupled with the emergence of a population of IL-2 hyper-responsive transitional naive helper T cells as MS-related immune alterations. By integrating data on the immune profiles of healthy monozygotic and dizygotic twin pairs, we estimated the variance in CD25 expression by helper T cells displaying a naive phenotype to be largely driven by genetic and shared early environmental influences. Nonetheless, the expanding helper T cells of twins with MS, which were also elevated in non-twin patients with MS, emerged independent of the individual genetic makeup. These cells expressed central nervous system-homing receptors, exhibited a dysregulated CD25–IL-2 axis, and their proliferative capacity positively correlated with MS severity. Together, our matched-pair analysis of the extended twin approach allowed us to discern genetically and environmentally determined features of an MS-associated immune signature

Immune signatures predict development of autoimmune toxicity in patients with cancer treated with immune checkpoint inhibitors.

BACKGROUND Immune checkpoint inhibitors (ICIs) are among the most promising treatment options for melanoma and non-small cell lung cancer (NSCLC). While ICIs can induce effective anti-tumor responses, they may also drive serious immune-related adverse events (irAEs). Identifying biomarkers to predict which patients will suffer from irAEs would enable more accurate clinical risk-benefit analysis for ICI treatment and may also shed light on common or distinct mechanisms underpinning treatment success and irAEs. METHODS In this prospective multi-center study, we combined a multi-omics approach including unbiased single-cell profiling of over 300 peripheral blood mononuclear cell (PBMC) samples and high-throughput proteomics analysis of over 500 serum samples to characterize the systemic immune compartment of patients with melanoma or NSCLC before and during treatment with ICIs. FINDINGS When we combined the parameters obtained from the multi-omics profiling of patient blood and serum, we identified potential predictive biomarkers for ICI-induced irAEs. Specifically, an early increase in CXCL9/CXCL10/CXCL11 and interferon-γ (IFN-γ) 1 to 2 weeks after the start of therapy are likely indicators of heightened risk of developing irAEs. In addition, an early expansion of Ki-67+ regulatory T cells (Tregs) and Ki-67+ CD8+ T cells is also likely to be associated with increased risk of irAEs. CONCLUSIONS We suggest that the combination of these cellular and proteomic biomarkers may help to predict which patients are likely to benefit most from ICI therapy and those requiring intensive monitoring for irAEs. FUNDING This work was primarily funded by the European Research Council, the Swiss National Science Foundation, the Swiss Cancer League, and the Forschungsförderung of the Kantonsspital St. Gallen

Path to AWAKE : evolution of the concept

This paper describes the conceptual steps in reaching the design of the AWAKE experiment currently under construction at CERN. We start with an introduction to plasma wakefield acceleration and the motivation for using proton drivers. We then describe the self-modulation instability - a key to an early realization of the concept. This is then followed by the historical development of the experimental design, where the critical issues that arose and their solutions are described. We conclude with the design of the experiment as it is being realized at CERN and some words on the future outlook. A summary of the AWAKE design and construction status as presented in this conference is given in Gschwendtner et al. [1]

Association of genomic domains in BRCA1 and BRCA2 with prostate cancer risk and aggressiveness

Pathogenic sequence variants (PSV) in BRCA1 or BRCA2 (BRCA1/2) are associated with increased risk and severity of prostate cancer. Weevaluated whether PSVs inBRCA1/2 were associated with risk of overall prostate cancer or high grade (Gleason 8+) prostate cancer using an international sample of 65 BRCA1 and 171 BRCA2 male PSV carriers with prostate cancer, and 3,388 BRCA1 and 2,880 BRCA2 male PSV carriers without prostate cancer. PSVs in the 30 region of BRCA2 (c.7914+) were significantly associated with elevated risk of prostate cancer compared with reference bin c.1001c.7913 [HR = 1.78; 95% confidence interval (CI), 1.25-2.52; P = 0.001], as well as elevated risk of Gleason 8+ prostate cancer (HR = 3.11; 95% CI, 1.63-5.95; P = 0.001). c.756-c.1000 was also associated with elevated prostate cancer risk (HR = 2.83; 95% CI, 1.71-4.68; P = 0.00004) and elevated risk of Gleason 8+prostate cancer (HR = 4.95; 95% CI, 2.12-11.54; P = 0.0002). No genotype-phenotype associations were detected for PSVs in BRCA1. These results demonstrate that specific BRCA2 PSVs may be associated with elevated risk of developing aggressive prostate cancer. Significance: Aggressive prostate cancer risk in BRCA2 mutation carriers may vary according to the specific BRCA2 mutation inherited by the at-risk individual.Peer reviewe