Results from the Fertilizer demonstration experiment with maize at IOP Farm in Iringa, Tanzania in 2019

In 2019, an experiment was run at the IOP farm in Tanzania. Five nutrient management treatments were combined in a full factorial setup with two tillage options. The lowest maize yield was obtained under conventional tillage without fertilizer application, and the highest maize yield with reduced tillage and the highest NPK fertilizer level combined with micronutrients. This highest NKP fertilizer level targeted 70% of water-limited yield. Furthermore, it was shown that P and K were used more efficient under reduced tillage compared to conventional tillage, while there was no difference in N use efficiency between the two tillage options. In addition, a number of field visits was organized. From the six villages surrounding the farm a total of 120 farmers made at least 4 visits to the experiment once in every month between February and June. That brings the number of farmers that learned from the 2018 trial to 480+

Kinetic Inductance of Josephson Junction Arrays: Dynamic and Equilibrium Calculations

We show analytically that the inverse kinetic inductance $L^{-1}$ of an overdamped junction array at low frequencies is proportional to the admittance of an inhomogeneous equivalent impedance network. The $ij^{th}$ bond in this equivalent network has an inverse inductance $J_{ij}\cos(\theta_i^0-\theta_j^0-A_{ij})$, where $J_{ij}$ is the Josephson coupling energy of the $ij^{th}$ bond, $\theta_i^0$ is the ground-state phase of the grain $i$, and $A_{ij}$ is the usual magnetic phase factor. We use this theorem to calculate $L^{-1}$ for square arrays as large as $180\times 180$. The calculated $L^{-1}$ is in very good agreement with the low-temperature limit of the helicity modulus $\gamma$ calculated by conventional equilibrium Monte Carlo techniques. However, the finite temperature structure of $\gamma$, as a function of magnetic field, is \underline{sharper} than the zero-temperature $L^{-1}$, which shows surprisingly weak structure. In triangular arrays, the equilibrium calculation of $\gamma$ yields a series of peaks at frustrations $f = \frac{1}{2}(1-1/N)$, where $N$ is an integer $\geq 2$, consistent with experiment.Comment: 14 pages + 6 postscript figures, 3.0 REVTe

Monitoring the T-Cell Receptor Repertoire at Single-Clone Resolution

The adaptive immune system recognizes billions of unique antigens using highly variable T-cell receptors. The αβ T-cell receptor repertoire includes an estimated 10(6) different rearranged β chains per individual. This paper describes a novel micro-array based method that monitors the β chain repertoire with a resolution of a single T-cell clone. These T-arrays are quantitative and detect T-cell clones at a frequency of less than one T cell in a million, which is 2 logs more sensitive than spectratyping (immunoscope), the current standard in repertoire analysis. Using T-arrays we detected CMV-specific CD4+ and CD8+ T-cell clones that expanded early after viral antigen stimulation in vitro and in vivo. This approach will be useful in monitoring individual T-cell clones in diverse experimental settings, and in identification of T-cell clones associated with infectious disease, autoimmune disease and cancer

Complement activation during OKT3 treatment: A possible explanation for respiratory side effects

Complement activation during OKT3 treatment: A possible explanation for respiratory side effects. Respiratory side effects that sometimes occur during treatment with anti-CD3 MAb OKT3 might result from pulmonary sequestration of activated neutrophils. Therefore, we studied complement activation in relation to activation and pulmonary sequestration of neutrophils during antirejection treatment with OKT3. In each of nine patients studied, plasma C3a-desarg and C4b/c levels increased compared with pretreatment values already in the first sample taken 15 minutes after the first dose of OKT3 (P < 0.05), with peak values at 15 and 30 minutes, respectively. Levels of neutrophil degranulation product elastase (complexed to α1-antitrypsin) also increased already at 15 minutes after the first dose of OKT3 (P < 0.05), which is before elevated levels of the cytokines TNFα, IL-6 or IL-8 were detectable. In contrast, upon subsequent OKT3 administrations or in the control group treated with methylprednisolone, neither complement activation, cytokine release nor neutrophil degranulation occurred. In five studied patients treated with OKT3, pulmonary sequestration of radiolabeled granulocytes was observed from 3 until 15 minutes after the first dose of OKT3, together with peripheral blood granulocytopenia, which lasted at least 30 minutes. In conclusion, we demonstrate a simultaneous activation of complement and pulmonary sequestration of activated granulocytes immediately following the first dose of OKT3. These phenomena may be involved in the development of respiratory side effects complicating this therapy

LEGaTO: first steps towards energy-efficient toolset for heterogeneous computing

LEGaTO is a three-year EU H2020 project which started in December 2017. The LEGaTO project will leverage task-based programming models to provide a software ecosystem for Made-in-Europe heterogeneous hardware composed of CPUs, GPUs, FPGAs and dataflow engines. The aim is to attain one order of magnitude energy savings from the edge to the converged cloud/HPC.Peer ReviewedPostprint (author's final draft

Variability and decadal trends in the Isfjorden (Svalbard) ocean climate and circulation – An indicator for climate change in the European Arctic

Isfjorden, a broad Arctic fjord in western Spitsbergen, has shown significant changes in hydrography and inflow of Atlantic Water (AW) the last decades that only recently have been observed in the Arctic Ocean north of Svalbard. Variability and trends in this fjord’s climate and circulation are therefore analysed from observational and reanalysis data during 1987 to 2017. Isfjorden experienced a shift in summer ocean structure in 2006, from AW generally in the bottom layer to AW (with increasing thickness) higher up in the water column. This shift, and a concomitant shift to less fast ice in Isfjorden are linked to positive trends in the mean sea surface temperature (SST) and volume weighted mean temperature (VT) in winter (SSTw/VTw: 0.7 ± 0.1/0.9 ± 0.3 °C 10 yr−1) and summer (SSTS/VTS: 0.7 ± 0.1/0.6 ± 0.1 °C 10 yr−1). Hence, the local mean air temperature shows similar trends in winter (1.9 ± 0.4 °C 10 yr−1) and summer (0.7 ± 0.1 °C 10 yr−1). Positive trends in volume weighted mean salinity in winter (0.21 ± 0.06 10 yr−1) and summer (0.07 ± 0.05 10 yr−1) suggest increased AW advection as a main reason for Isfjorden’s climate change. Local mean air temperature correlates significantly with sea ice cover, SST, and VT, revealing the fjord’s impact on the local terrestrial climate. In line with the shift in summer ocean structure, Isfjorden has changed from an Arctic type fjord dominated by Winter Deep and Winter Intermediate thermal and haline convection, to a fjord dominated by deep thermal convection of Atlantic type water (Winter Open). AW indexes for the mouth and Isfjorden proper show that AW influence has been common in winter over the last decade. Alternating occurrence of Arctic and Atlantic type water at the mouth mirrors the geostrophic control imposed by the Spitsbergen Polar Current (carrying Arctic Water) relative to the strength of the Spitsbergen Trough Current (carrying AW). During high AW impact events, Atlantic type water propagates into the fjord according to the cyclonic circulation along isobaths corresponding to the winter convection. Tides play a minor role in the variance in the currents, but are important in the side fjords where exchange with the warmer Isfjorden proper occurs in winter. This study demonstrates that Isfjorden and its ocean climate can be used as an indicator for climate change in the Arctic Ocean. The used methods may constitute a set of helpful tools for future studies also outside the Svalbard Archipelago.publishedVersio