Variants of transcription factor 7-like 2 (TCF7L2) gene and incident glucose intolerance in Japanese-Brazilians

Common variants of the transcription factor 7-like 2 (TCF7L2) gene have been found to be associated with type 2 diabetes in different ethnic groups. The Japanese-Brazilian population has one of the highest prevalence rates of diabetes. Therefore, the aim of the present study was to assess whether two single-nucleotide polymorphisms (SNPs) of TCF7L2, rs7903146 and rs12255372, could predict the development of glucose intolerance in Japanese-Brazilians. In a population-based 7-year prospective study, we genotyped 222 individuals (72 males and 150 females, aged 56.2 ± 10.5 years) with normal glucose tolerance at baseline. In the study population, we found that the minor allele frequency was 0.05 for SNP rs7903146 and 0.03 for SNP rs12255372. No significant allele or genotype association with glucose intolerance incidence was found for either SNP. Haplotypes were constructed with these two SNPs and three haplotypes were defined: CG (frequency: 0.94), TT (frequency = 0.027) and TG (frequency = 0.026). None of the haplotypes provided evidence for association with the incidence of glucose intolerance. Despite no associations between incidence of glucose intolerance and SNPs of the TCF7L2 gene in Japanese-Brazilians, we found that carriers of the CT genotype for rs7903146 had significantly lower insulin levels 2 h after a 75-g glucose load than carriers of the CC genotype. In conclusion, in Japanese-Brazilians, a population with a high prevalence of type 2 diabetes, common TCF7L2 variants did not make major contributions to the incidence of glucose tolerance abnormalities

Measurement of the solar 8B neutrino rate with a liquid scintillator target and 3 MeV energy threshold in the Borexino detector

We report the measurement of electron neutrino elastic scattering from 8B solar neutrinos with 3 MeV energy threshold by the Borexino detector in Gran Sasso (Italy). The rate of solar neutrino-induced electron scattering events above this energy in Borexino is 0.217 +- 0.038 (stat) +- 0.008 (syst) cpd/100 t, which corresponds to the equivalent unoscillated flux of (2.4 +- 0.4 (stat) +- 0.1 (syst))x10^6 cm^-2 s^-1, in good agreement with measurements from SNO and SuperKamiokaNDE. Assuming the 8B neutrino flux predicted by the high metallicity Standard Solar Model, the average 8B neutrino survival probability above 3 MeV is measured to be 0.29+-0.10. The survival probabilities for 7Be and 8B neutrinos as measured by Borexino differ by 1.9 sigma. These results are consistent with the prediction of the MSW-LMA solution of a transition in the solar electron neutrino survival probability between the low energy vacuum-driven and the high-energy matter-enhanced solar neutrino oscillation regimes.Comment: 10 pages, 8 figures, 6 table

Pulse-Shape discrimination with the Counting Test Facility

Pulse shape discrimination (PSD) is one of the most distinctive features of liquid scintillators. Since the introduction of the scintillation techniques in the field of particle detection, many studies have been carried out to characterize intrinsic properties of the most common liquid scintillator mixtures in this respect. Several application methods and algorithms able to achieve optimum discrimination performances have been developed. However, the vast majority of these studies have been performed on samples of small dimensions. The Counting Test Facility, prototype of the solar neutrino experiment Borexino, as a 4 ton spherical scintillation detector immersed in 1000 tons of shielding water, represents a unique opportunity to extend the small-sample PSD studies to a large-volume setup. Specifically, in this work we consider two different liquid scintillation mixtures employed in CTF, illustrating for both the PSD characterization results obtained either with the processing of the scintillation waveform through the optimum Gatti's method, or via a more conventional approach based on the charge content of the scintillation tail. The outcomes of this study, while interesting per se, are also of paramount importance in view of the expected Borexino detector performances, where PSD will be an essential tool in the framework of the background rejection strategy needed to achieve the required sensitivity to the solar neutrino signals.Comment: 39 pages, 17 figures, submitted to Nucl. Instr. Meth.

Impact of interaction between chronic variable stress and moderate intensity physical exercise on antibody production in Wistar rats

Stress in its chronic form has been an important factor in the onset of depression. In addition, it can lead to immunosuppression. On the other hand, physical exercise has a protective action on the immune system and reduces the signs and symptoms of stress. Studies on the effects of chronic variable stress (CVS) and moderate intensity physical exercise (MIPE) on humoral immunity are scarce. Thus, in this study, we investigated the interaction between the effects of CVS and MIPE on antibody production. Wistar rats were divided into four groups: control (C); physical exercise (P); stress (S); and physical exercise and stress (PS). The P and PS groups were trained in MIPE for six weeks. From the fourth week of the study, concomitant with the MIPE, the S and PS groups were subjected to CVS. To evaluate the production of antibodies, all groups were immunized. Regarding antibody production, it was observed that females in the C and S groups presented higher IgM antibody production in relation to males. Furthermore, the production of IgM was potentiated in males of the PS group. On the other hand, no significant differences were observed in relation to the production of IgG1 and IgG2a. We conclude that CVS prevented the increase in IgM production in male rats and MIPE was effective in reversing the effects of stress on the production of IgM in male rats. On the other hand, the production of IgG1 and IgG2a was not affected by MIPE or CVS

Interstellar MHD Turbulence and Star Formation

This chapter reviews the nature of turbulence in the Galactic interstellar medium (ISM) and its connections to the star formation (SF) process. The ISM is turbulent, magnetized, self-gravitating, and is subject to heating and cooling processes that control its thermodynamic behavior. The turbulence in the warm and hot ionized components of the ISM appears to be trans- or subsonic, and thus to behave nearly incompressibly. However, the neutral warm and cold components are highly compressible, as a consequence of both thermal instability in the atomic gas and of moderately-to-strongly supersonic motions in the roughly isothermal cold atomic and molecular components. Within this context, we discuss: i) the production and statistical distribution of turbulent density fluctuations in both isothermal and polytropic media; ii) the nature of the clumps produced by thermal instability, noting that, contrary to classical ideas, they in general accrete mass from their environment; iii) the density-magnetic field correlation (or lack thereof) in turbulent density fluctuations, as a consequence of the superposition of the different wave modes in the turbulent flow; iv) the evolution of the mass-to-magnetic flux ratio (MFR) in density fluctuations as they are built up by dynamic compressions; v) the formation of cold, dense clouds aided by thermal instability; vi) the expectation that star-forming molecular clouds are likely to be undergoing global gravitational contraction, rather than being near equilibrium, and vii) the regulation of the star formation rate (SFR) in such gravitationally contracting clouds by stellar feedback which, rather than keeping the clouds from collapsing, evaporates and diperses them while they collapse.Comment: 43 pages. Invited chapter for the book "Magnetic Fields in Diffuse Media", edited by Elisabete de Gouveia dal Pino and Alex Lazarian. Revised as per referee's recommendation

Measurement of CNGS muon neutrino speed with Borexino

We have measured the speed of muon neutrinos with the Borexino detector using short-bunch CNGS beams. The final result for the difference in time-of-flight between a =17 GeV muon neutrino and a particle moving at the speed of light in vacuum is {\delta}t = 0.8 \pm 0.7stat \pm 2.9sys ns, well consistent with zero.Comment: 6 pages, 5 figure

Observation of Geo-Neutrinos

Geo-neutrinos, electron anti-neutrinos produced in beta decays of naturally occurring radioactive isotopes in the Earth, are a unique direct probe of our planet's interior. We report the first observation at more than 3$\sigma$ C.L. of geo-neutrinos, performed with the Borexino detector at Laboratori Nazionali del Gran Sasso. Anti-neutrinos are detected through the neutron inverse beta decay reaction. With a 252.6 ton-yr fiducial exposure after all selection cuts, we detected 9.9^{+4.1}_{-3.4}(^{+14.6}_{-8.2}) geo-neutrino events, with errors corresponding to a 68.3%(99.73%) C.L. From the $\ln{\cal{L}}$ profile, the statistical significance of the Borexino geo-neutrino observation corresponds to a 99.997% C.L. Our measurement of the geo-neutrinos rate is 3.9^{+1.6}_{-1.3}(^{+5.8}_{-3.2}) events/(100ton-yr). This measurement rejects the hypothesis of an active geo-reactor in the Earth's core with a power above 3 TW at 95% C.L. The observed prompt positron spectrum above 2.6 MeV is compatible with that expected from european nuclear reactors (mean base line of approximately 1000 km). Our measurement of reactor anti-neutrinos excludes the non-oscillation hypothesis at 99.60% C.L.Comment: 8 pages, 4 figures, 3 table