Recommendations on seismic actions on port structures

The paper describes the main features of a Technical Recommendation first draft on Seismic Action on port structures promoted recently by the Spanish Ministry of Public Works (MOPT). Although much more research is needed to clarify the seismic behaviour of the vast class of problems present in port structures the current state of the art allows at least a classification of subjects and the establishment of minimum requirements to guide the design. Also the use of more refined methods for specially dangerous situations needs some general guidelines that contribute to mantein the design under reasonable safety margins. The Recommendations of the Spanish MOPT are a first try in those directions

Role of microRNAs in alcohol-induced liver disorders and non-alcoholic fatty liver disease

[EN]MicroRNAs (miRNAs) are small non-coding RNAs that regulate multiple physiological and pathological functions through the modulation of gene expression at the post-transcriptional level. Accumulating evidence has established a role for miRNAs in the development and pathogenesis of liver disease. Specifically, a large number of studies have assessed the role of miRNAs in alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD), two diseases that share common underlying mechanisms and pathological characteristics. The purpose of the current review is to summarize and update the body of literature investigating the role of miRNAs in liver disease. In addition, the potential use of miRNAs as biomarkers and/or therapeutic targets is discussed. Among all miRNAs analyzed, miR-34a, miR-122 and miR-155 are most involved in the pathogenesis of NAFLD. Of note, these three miRNAs have also been implicated in ALD, reinforcing a common disease mechanism between these two entities and the pleiotropic effects of specific miRNAs. Currently, no single miRNA or panel of miRNAs has been identified for the detection of, or staging of ALD or NAFLD. While promising results have been shown in murine models, no therapeutic based-miRNA agents have been developed for use in humans with liver disease

Land Cover Classification of Complex Agroecosystems in the Non-Protected Highlands of the Galapagos Islands

The humid highlands of the Galapagos are the islands’ most biologically productive regions and a key habitat for endemic animal and plant species. These areas are crucial for the region’s food security and for the control of invasive plants, but little is known about the spatial distribution of its land cover. We generated a baseline high-resolution land cover map of the agricultural zones and their surrounding protected areas. We combined the high spatial resolution of PlanetScope images with the high spectral resolution of Sentinel-2 images in an object-based classification using a RandomForest algorithm. We used images collected with an unmanned aerial vehicle (UAV) to verify and validate our classified map. Despite the astounding diversity and heterogeneity of the highland landscape, our classification yielded useful results (overall Kappa: 0.7, R2: 0.69) and revealed that across all four inhabited islands, invasive plants cover the largest fraction (28.5%) of the agricultural area, followed by pastures (22.3%), native vegetation (18.6%), food crops (18.3%), and mixed forest and pioneer plants (11.6%). Our results are consistent with historical trajectories of colonization and abandonment of the highlands. The produced dataset is designed to suit the needs of practitioners of both conservation and agriculture and aims to foster collaboration between the two areas

Acoustic noise-based detection of ferroresonance events in isolated neutral power systems with inductive voltage transformers

Power-quality events and operation transients in power systems (PS) with isolated neutral can saturate inductive voltage transformers (IVT), which, when interacting with the overhead and underground cable capacitances, can cause ferroresonance events in the local PS. This abnormal operating mode can partially or totally damage the transformers and switchgears within the affected PS. Distribution system operators (DSO) can minimize these effects by detecting ferroresonance events accurately and fast enough and changing the mode of operation accordingly. Direct detection methods, i.e., based on voltage measurements, are reliable, but the massive deployment of this solution is relatively expensive; i.e., power quality analyzers cost thousands of USD. Alternatively, indirect detection methods are also available, e.g., IVT vibration measurements with accelerometers costing hundreds of USD, but their reliability depends on the installation method used. This manuscript proposes using the acoustic noise caused by magnetostriction forces within the IVT core during ferroresonance events to detect their occurrence. Compared to other indirect methods, electret condenser microphones with preamplifying stage cost less than USD 10 and are less sensitive to the installation procedure. The proposed method is validated experimentally, and its performance compared to IVT vibration measurements one by using the same detection methodology.This work was partially financed by the EU Regional Development Fund (FEDER) and the Spanish Government under RETOS-COLABORACION RTC-2017-6782-3, the Spanish Ministry of Science and Innovation under project PID2021-128941OB-I00, and by the European Union’s Horizon 2020 research and innovation program under grant agreement No. 864579 (FLEXIGRID)

Modelado tridimensional de la combustión de gases con turbulencia Large Eddy Simulation

[ESP] La mecánica de fluidos computacional permite la resolución numérica de problemas cada vez más complejos. En el presente trabajo se presenta un ejemplo de aplicación de esta técnica mediante el modelado de una cámara de combustión de gases en el que se incluye turbulencia “Large Eddy Simulation” y modelo de radiación “Finite Volume Discrete Ordinates Model” (fvDOM) mediante la herramienta de código abierto OpenFOAM. [ENG] Computational Fluid Dynamics achieves numerical resolutions of more and more complex problems. In this work it is presented an application of this branch, which consists of modelling a gas combustion chamber including “Large Eddy Simulation” and “Finite Volume Discrete Ordinates Model” (fvDOM) as turbulence and radiation models. For this purpose, the open-source CFD toolbox OpenFOAM has been used.Escuela Técnica Superior de Ingeniería de Telecomunicación (ETSIT), Escuela Técnica Superior de Ingeniería Agronómica (ETSIA), Escuela Técnica Superior de Ingeniería Industrial (ETSII), Escuela Técnica Superior de Arquitectura y Edificación (ETSAE), Escuela Técnica Superior de Ingeniería de Caminos, Canales y Puertos y de Ingeniería de Minas (ETSICCPIM), Facultad de Ciencias de la Empresa (FCCE), Parque Tecnológico de Fuente Álamo (PTFA), Vicerrectorado de Estudiantes y Extensión de la UPCT, Vicerrectorado de Investigación e Innovación de la UPCT, y Vicerrectorado de Internacionalización y Cooperación al Desarrollo de la UPCT

Early Pliocene climatic optimum, cooling and early glaciation deduced by terrestrial and marine environmental changes in SW Spain

The Pliocene is a key period in Earth's climate evolution, as it records the transition from warm and stable conditions to the colder and more variable glaciated climate of the Pleistocene. Simultaneously, climate became more seasonal in the Mediterranean area, and Mediterranean-type seasonal precipitation rhythm with summer drought established. These climatic changes presumably had significant impacts on terrestrial environments. However, the response of terrestrial environments to such climate changes is still not fully understood due to the lack of detailed studies dealing with this period of time. In this study, multiproxy analyses of continuous core sampling from La Matilla (SW Spain) shows detailed and continuous record of pollen, sand content and abundance of benthic foraminifer Bolivina spathulata to describe paleoenvironmental and paleoclimate trends during the early Pliocene. This record shows warmest, most humid climate conditions and highest riverine nutrient supply at ~ 4.35 Ma, coinciding with the Pliocene climatic optimum and high global sea level. A climate cooling and aridity trend occurred subsequently and a significant glaciation occurred at ~ 4.1–4.0 Ma, during a period known by very little terrestrial evidence of glaciation. Our multiproxy data thus indicate that terrestrial and marine environments were significantly variable during the early Pliocene and that major glaciation-like cooling occurred before the intensification of northern hemisphere glaciation at the beginning of the Pleistocene (~2.7 Ma). This major climate cooling and aridity maxima between 4.1 and 4.0 Ma is independently validated by a coeval sea-level drop (third order Za2 sequence boundary). This sea level drawdown is supported by enhanced coarse sedimentation and minima in riverine nutrient supply, showing paired vegetation and sea-level changes and thus a strong land-ocean relationship. This study also shows that long-term climatic trends were interrupted by orbital-scale cyclic climatic variability, with eccentricity, obliquity and precession acting as the main triggers controlling climate and environmental change in the area.Peer ReviewedPostprint (author's final draft

A Single Nucleotide Polymorphism in the RASGRF2 Gene Is Associated with Alcoholic Liver Cirrhosis in Men

Background Genetic polymorphisms in the RAS gene family are associated with different diseases, which may include alcohol-related disorders. Previous studies showed an association of the allelic variant rs26907 in RASGRF2 gene with higher alcohol intake. Additionally, the rs61764370 polymorphism in the KRAS gene is located in a binding site for the let-7 micro-RNA family, which is potentially involved in alcohol-induced inflammation. Therefore, this study was designed to explore the association between these two polymorphisms and susceptibility to alcoholism or alcoholic liver disease (ALD). Methods We enrolled 301 male alcoholic patients and 156 healthy male volunteers in this study. Polymorphisms were genotyped by using TaqMan® PCR assays for allelic discrimination. Allelic and genotypic frequencies were compared between the two groups. Logistic regression analysis was performed to analyze the inheritance model. Results The A allele of the RASGRF2 polymorphism (rs26907) was significantly more prevalent among alcoholic patients with cirrhosis (23.2%) compared to alcoholic patients without ALD (14.2%). This difference remained significant in the group of patients with alcohol dependence (28.8% vs. 14.3%) but not in those with alcohol abuse (15.1% vs. 14.4%). Multivariable logistic regression analysis showed that the A allele of this polymorphism (AA or GA genotype) was associated with alcoholic cirrhosis both in the total group of alcoholics (odds ratio [OR]: 2.33, 95% confidence interval [CI]: 1.32–4.11; P = 0.002) and in the group of patients with alcohol dependence (OR: 3.1, 95% CI: 1.50–6.20; P = 0.001). Allelic distributions of the KRAS polymorphism (rs61764370) did not differ between the groups. Conclusions To our knowledge, this genetic association study represents the first to show an association of the RASGRF2 G>A (rs26907) polymorphism with ALD in men, particularly in the subgroup of patients with AD. The findings suggest the potential relevance of the RAS gene family in alcoholism and ALD

Human and experimental evidence supporting a role for osteopontin in alcoholic hepatitis: Hepatology

We identified in the transcriptome analysis of patients with alcoholic hepatitis (AH) osteopontin (OPN) as one of the most up-regulated genes. Here, we used a translational approach to investigate its pathogenic role. OPN hepatic gene expression was quantified in patients with AH and other liver diseases. OPN protein expression and processing were assessed by immmunohistochemistry, Western blotting and ELISA. OPN gene polymorphisms were evaluated in patients with alcoholic liver disease. The role of OPN was evaluated in OPN−/− mice with alcohol-induced liver injury. OPN biological actions were studied in human hepatic stellate cells and in precision-cut liver slices. Hepatic expression and serum levels of OPN were markedly increased in AH compared to normal livers and other types of chronic liver diseases and correlated with short-term survival. Serum levels of OPN also correlated with hepatic expression and disease severity. OPN was mainly expressed in areas with inflammation and fibrosis. Two proteases that process OPN (thrombin and MMP-7) and cleaved-OPN were increased in livers with AH. Patients with AH had a tendency of a lower frequency of the CC genotype of the +1239C SNP of the OPN gene compared to patients with alcohol abuse without liver disease. Importantly, OPN−/− mice were protected against alcohol-induced liver injury and showed decreased expression of inflammatory cytokines. Finally, OPN was induced by LPS and stimulated inflammatory actions in hepatic stellate cells

A protective personal factor against disability and dependence in the elderly: an ordinal regression analysis with nine geographically-defined samples from Spain

Background: Sense of Coherence (SOC) is defined as a tendency to perceive life experiences as comprehensible, manageable and meaningful. The construct is split in three major domains: Comprehensibility, Manageability, and Meaningfulness. SOC has been associated with successful coping strategies in the face of illness and traumatic events and is a predictor of self-reported and objective health in a variety of contexts. In the present study we aim to evaluate the association of SOC with disability and dependence in Spanish elders. Methods: A total of 377 participants aged 75 years or over from nine locations across Spain participated in the study (Mean age: 80.9 years; 65.3% women). SOC levels were considered independent variables in two ordinal logistic models on disability and dependence, respectively. Disability was established with the World health Organization-Disability Assessment Schedule 2.0 (36-item version), while dependence was measured with the Extended Katz Index on personal and instrumental activities of daily living. The models included personal (sex, age, social contacts, availability of an intimate confidant), environmental (municipality size, access to social resources) and health-related covariates (morbidity). Results: High Meaningfulness was a strong protective factor against both disability (Odds Ratio [OR] = 0.50; 95% Confidence Interval [CI] = 0.29-0.87) and dependence (OR = 0.33; 95% CI = 0.19-0.58) while moderate and high Comprehensibility was protective for disability (OR = 0.40; 95% CI = 0.22-0.70 and OR = 0.39; 95% CI = 0.21-0.74), but not for dependence. Easy access to social and health resources was also highly protective against both disability and dependence. Conclusions: Our results are consistent with the view that high levels of SOC are protective against disability and dependence in the elderly. Elderly individuals with limited access to social and health resources and with low SOC may be a group at risk for dependence and disability in Spain