Riqueza y rareza florísticas en los afloramientos dolomíticos de las Cordilleras Béticas (sur de España): ensayo preliminar.

RESUMEN. Riqueza y rareza florísticas en los afloramientos dolomíticos de las Cordilleras Béticas (sur de España): ensayo preliminar. Sobre los afloramientos dolomíticos de las Cordilleras Béticas se desarrollan comunidades vegetales muy específicas y ricas en endemismos. Dichas comunidades no han sido estudiadas desde un punto de vista conservacionista. Este trabajo aborda su distribución, riqueza y grado de protección actuales permitiendo evaluar la eficacia de la red de espacios protegidos. Para ello, se ha creado una base de datos de presencia/ausencia de dolomitófilos en cuadrículas UTM de 10 km. de lado que han sido definidas como unidades geográficas operacionales (UGOs). Posteriormente, se ha evaluado la riqueza, la rareza en continuo y la rareza en discontinuo de las UGOs. Los resultados obtenidos han subrayado la importancia del sector Malacitano-Almijarense de la provincia Bética (en especial la zona del Trevenque) como centro de riqueza y endemicidad de dolomitófilos. Por otra parte, la red de espacios naturales abarca casi la totalidad de las localidades de mayor interés en la Comunidad Autónoma de Andalucía, mientras que tiene importantes lagunas en la Región de Murcia y en la provincia de Albacete (perteneciente a la Comunidad Autónoma de Castilla-La Mancha).Palabras clave. Dolomitófilo, dolomías, selección de reservas, endemismo, espacios naturales protegidos, flora.ABSTRACT. Floral richness and rarity in the dolomitic outcrops of the Baetic Ranges (southern Spain): a preliminary essay. The dolomitic areas of the Baetic Ranges house extremely peculiar plant communities. These communities are diverse and especially rich in endemic species. The vegetation and flora of the dolomitic outcrops have not been studied from a conservation point of view. This work is focused on the distribution, richness and current level of protection of these areas, consequently, it allows us to evaluate the efficacy of the protected areas network. In order to meet this goal, a “presence/absence” database of the dolomitic taxa has been carried out, according to UTM cells sized an area of 10 × 10 km. These cells have been used as “Operational Geographic Units” (OGU’s). In due course, the richness, the continuous and discontinuous rarity of every OGU have been evaluated. The results depicted the great importance of the Malacitano-Almijarense sector of the Baetic province (especially where the Trevenque mountain is located) as a spot of richness and endemicity of dolomitic taxa. In addition, the protected areas network appears to be quite efficient in meeting conservation objectives in the Region of Andalusia, whilst it is clearly deficient in the Region of Murcia and the Province of Albacete (included in the Region of Castilla-La Mancha).Key words. Dolomitic species, dolomites, selection of reserves, endemism, natural protected areas, flora

Recensiones [Revista de Historia Económica Año XIV Primavera-Verano 1996 n. 2 pp. 477-528]

Editada en la Fundación Empresa PúblicaBeatriz Cárceles de Gea. Fraude y administración fiscal en Castilla La Comisión de Millones (1632-1658): Poder fiscal y privilegio jurídico-político (Por Juan Zafra Oteyza).-- Enric Tello. Cervera i la Segarra al segle XVIII. En els origens d`una Catalunya pobra, 1700-1860 (Por Tomás Peris Albentosa).-- Ángela Atienza. Propiedad y Señorío en Aragón. El clero regular entre la expansión y la crisis (1700-1835) (Por José Manuel Latorre Ciria).-- Michel Zylberberg. Une si duouce domination. Les milieux d'affaires français et l`Espagne vers 1780-1808 (Por Joan Caries Maixé Altes).-- Paloma Pastor Rey de Viñas. Historia de la Fábrica de Cristales de San Ildefonso durante la época de la Ilustración (1727-1810) (Por Juan Helguera Quijada).-- Ricardo Robledo Hernández. Economistas y reformadores españoles: La cuestión agraria (1760-1935) (Por Juan Antonio Carmona Pidal).-- Juan Pan Montojo. La bodega del mundo (1800-1936) (Por José Pujol Andréu).-- Moisés Llordén Miñambres. Desarrollo económico y urbano de Gijón en los siglos XIX y XX (Por Carlos Larrinaga Rodríguez).-- Manuel Montero. La California del hierro. Las minas y la modernización económica y social de Vizcaya (Por Antonio Escudero).-- Salvador Cruz Artacho. Caciques y campesinos. Poder político, modernización agraria y conflictividad rural en Granada. 1890-1923 (Por Luis Garrido González).-- Miguel Muñoz Rubio. Renfe (1941-1991). Medio siglo de ferrocarril público (Por Francisco Javier Vidal Olivares).-- Eric Hobsbawn. Historia del siglo XX. 1914-1991 (Por Gabriel Tortella).-- Marjorie Grice-Hutchinson. Ensayos sobre el pensamiento económico en España (Por José Luis García Ruiz).-- Richard N. Langlois y Paul L. Robertson. Firms, Markets and Economic Change. A Dynamic Theory of Business Institutions (Por Jesús M. Valdaliso).-- John Komlos (ed.). Stature, Living Standards, and Economic Development: Essays in Anthropometric History, y John Komlos (ed.). The Biological Standard of Living on Three Continents: Further Explorations in Anthropometric History (Por James Simpson)Publicad

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research

Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic

This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic