From a Domain Analysis to the Specification and Detection of Code and Design Smells

Code and design smells are recurring design problems in software systems that must be identified to avoid their possible negative consequences\ud on development and maintenance. Consequently, several smell detection\ud approaches and tools have been proposed in the literature. However,\ud so far, they allow the detection of predefined smells but the detection\ud of new smells or smells adapted to the context of the analysed systems\ud is possible only by implementing new detection algorithms manually.\ud Moreover, previous approaches do not explain the transition from\ud specifications of smells to their detection. Finally, the validation\ud of the existing approaches and tools has been limited on few proprietary\ud systems and on a reduced number of smells. In this paper, we introduce\ud an approach to automate the generation of detection algorithms from\ud specifications written using a domain-specific language. This language\ud is defined from a thorough domain analysis. It allows the specification\ud of smells using high-level domain-related abstractions. It allows\ud the adaptation of the specifications of smells to the context of\ud the analysed systems.We specify 10 smells, generate automatically\ud their detection algorithms using templates, and validate the algorithms\ud in terms of precision and recall on Xerces v2.7.0 and GanttProject\ud v1.10.2, two open-source object-oriented systems.We also compare\ud the detection results with those of a previous approach, iPlasma

Endothelial cell-derived microparticles induce plasmacytoid dendritic cell maturation: potential implications in inflammatory diseases

Microparticles derived from vascular endothelium are thought to play a role in common inflammatory disorders. In this study, the authors show that microparticles derived from vascular endothelium specifically induce the maturation of plasmacytoid dendritic cells and production of inflammatory cytokines, suggesting that endothelial microparticles may serve as therapeutic targets for immune modulation

Epidemiology of Chikungunya Virus Outbreaks in Guadeloupe and Martinique, 2014: An Observational Study in Volunteer Blood Donors

International audienceBackground: During Dec-2013, a chikungunya virus (CHIKV) outbreak was first detected in the French-West Indies. Subsequently, the virus dispersed to other Caribbean islands, continental America and many islands in the Pacific Ocean. Previous estimates of the attack rate were based on declaration of clinically suspected cases.Methods/Principal findings: Individual testing for CHIKV RNA of all (n = 16,386) blood donations between Feb-24th 2014 and Jan-31st 2015 identified 0·36% and 0·42% of positives in Guadeloupe and Martinique, respectively. The incidence curves faithfully correlated with those of suspected clinical cases in the general population of Guadeloupe (abrupt epidemic peak), but not in Martinique (flatter epidemic growth). No significant relationship was identified between CHIKV RNA detection and age-classes or blood groups. Prospective (Feb-2014 to Jan-2015; n = 9,506) and retrospective (Aug-2013 to Feb-2014; n = 6,559) seroepidemiological surveys in blood donors identified a final seroprevalence of 48·1% in Guadeloupe and 41·9% in Martinique. Retrospective survey also suggested the absence or limited "silent" CHIKV circulation before the outbreak. Parameters associated with increased seroprevalence were: Gender (M>F), KEL-1, [RH+1/KEL-1], [A/RH+1] and [A/RH+1/KEL-1] blood groups in Martiniquan donors. A simulation model based on observed incidence and actual seroprevalence values predicted 2·5 and 2·3 days of asymptomatic viraemia in Martiniquan and Guadeloupian blood donors respectively.Conclusions/Significance: This study, implemented promptly with relatively limited logistical requirements during CHIKV emergence in the Caribbean, provided unique information regarding retrospective and prospective epidemiology, infection risk factors and natural history of the disease. In the stressful context of emerging infectious disease outbreaks, blood donor-based studies can serve as robust and cost-effective first-line tools for public health surveys

Hepatitis A: an epidemiological survey in blood donors, France 2015 to 2017

International audienceSince mid-2016, hepatitis A virus (HAV) outbreaks, involving predominantly men who have sex with men (MSM), have affected countries in Europe and overseas. In France, HAV screening of blood donations in 2017 revealed a HAV-RNA prevalence ca fivefold higher than during 2015-16 (4.42/106 vs 0.86/106; p = 0.0005). In 2017, despite a higher male-to-female ratio (5.5 vs 0.7) and the identification of MSM-associated outbreak strains, only one of 11 infected male donors self-reported being a MSM. Since mid-2016, outbreaks involving mainly men who have sex with men (MSM) have been reported in European countries and overseas [1-6]. The outbreaks were associated with three genotype IA hepatitis A virus (HAV) strains: VDR_521_2016, RIVM_HAV16-090 and V16-25801. In this study, we report epidemiological and clinical findings pertaining to HAV infected blood donors before and during the recent outbreak in France

Temporal distribution of CHIK incident cases.

<p>Temporal distribution of CHIK incident cases.</p